ライフサイエンスコーパス: nuclear lamina

1 he chromatin was left "naked" (free from the nuclear lamina).

2 tin containing lineage-relevant genes to the nuclear lamina.

3 insights into their role in scaffolding the nuclear lamina.

4 impaired assembly of mutant lamins into the nuclear lamina.

5 this protein may be a novel component of the nuclear lamina.

6 k underneath the inner nuclear membrane, the nuclear lamina.

7 ner layer of the nuclear envelope called the nuclear lamina.

8 esults in dissociation of LASs/LADs from the nuclear lamina.

9 lls also had significantly less HDAC3 at the nuclear lamina.

10 d nuclear elements (LINEs) to the neutrophil nuclear lamina.

11 into inactive chromosomal domains along the nuclear lamina.

12 ement with a role for NE81 in formation of a nuclear lamina.

13 of the LMNA gene, are key components of the nuclear lamina.

14 tienzyme complex that is associated with the nuclear lamina.

15 ve protein that changes the structure of the nuclear lamina.

16 proposed to connect the cytoskeleton to the nuclear lamina.

17 be modulated by compositional changes in the nuclear lamina.

18 ns and contributing to the disruption of the nuclear lamina.

19 18 but not 19 is dependent on such a stable nuclear lamina.

20 products of Lmna, are key components of the nuclear lamina.

21 y the LMNA gene, are basic components of the nuclear lamina.

22 in (Vh) locus regularly colocalizes with the nuclear lamina.

23 repeat RNA, is pathogenic by disrupting the nuclear lamina.

24 amin A, which is a structural protein of the nuclear lamina.

25 d by an intact host cell chromatin layer and nuclear lamina.

26 he INM by rapamycin-mediated trapping at the nuclear lamina.

27 omatin domains are in close contact with the nuclear lamina.

28 A to lamin A, a structural component of the nuclear lamina.

29 nnecting splicing speckles with sites at the nuclear lamina.

30 ts in loss of integrity and deformity of the nuclear lamina.

31 oding A-type lamins, major components of the nuclear lamina.

32 organization of lamin B1 into domains of the nuclear lamina.

33 in the nucleus, such as nuclear pores or the nuclear lamina.

34 jor filamentous component of the trypanosome nuclear lamina.

35 niations were associated with defects in the nuclear lamina.

36 essential for localization of emerin to the nuclear lamina.

37 nuclear and partially co-localizes with the nuclear lamina.

38 ce from dynamic cytoskeletal networks to the nuclear lamina.

39 asmic domain of SUN2 that interacts with the nuclear lamina.

40 c DNA did not reveal an interaction with the nuclear lamina.

41 ed with estrogen establish contacts with the nuclear lamina.

42 d the domain of SUN2 that interacts with the nuclear lamina.

43 ner nuclear membrane in association with the nuclear lamina.

44 ssociated domains (LADs) are directed to the nuclear lamina.

45 roles in maintaining the organization of the nuclear lamina.

46 mina component lamin A/C, which disrupts the nuclear lamina.

47 C that is not associated with the peripheral nuclear lamina.

48 and UL53 are required for disruption of the nuclear lamina.

49 ex evolutionary trajectories for the NPC and nuclear lamina.

50 clear egress that includes disruption of the nuclear lamina.

51 les that were partially dissociated from the nuclear lamina.

52 in A and C are fundamental components of the nuclear lamina, a dynamic meshwork of intermediate filam

53 amin B2 are essential building blocks of the nuclear lamina, a filamentous meshwork lining the nucleo

54 ells, lamin B1 is the major component of the nuclear lamina, a filamentous network underlying the nuc

55 Surrounding the chromatin layer is the nuclear lamina, a further host cell barrier to egress.

56 the regulation of nuclear morphology is the nuclear lamina, a meshwork of intermediate lamin filamen

57 Nuclear lamins are components of the nuclear lamina, a structural scaffolding for the cell nu

58 Lamin A/C is a major constituent of the nuclear lamina, a thin filamentous protein layer that li

59 defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathol

60 ilament protein that is a constituent of the nuclear lamina, an important structural element of the n

61 One such structure is the nuclear lamina, an intermediate filament meshwork compos

62 The main function of the nuclear lamina, an intermediate filament meshwork lying

63 Lamins are key structural components of the nuclear lamina, an intermediate filament meshwork that l

64 ormation of a faint DNA halo surrounding the nuclear lamina and a dispersive effect on the characteri

65 Lamins build the nuclear lamina and are required for chromatin organizati

66 f highly structured fibers, connected to the nuclear lamina and built on an underlying network of bra

67 ilencing by recruiting the inactive X to the nuclear lamina and by doing so enables Xist to spread to

68 The nuclear lamina and chromatin interactions are regulated

69 e filament proteins in the cytoplasm and the nuclear lamina and copurifies with the lamins both durin

70 n of a hole nucleated by deformations of the nuclear lamina and estimate the herniation of chromatin

71 own a correlation between positioning at the nuclear lamina and gene repression, the functional conse

72 The nuclear lamina and its associated proteins are important

73 entify additional roles for lamin A/C of the nuclear lamina and linkers of nucleus to cytoskeleton (L

74 nuclear defects including disorganization of nuclear lamina and loss of heterochromatin.

75 prophase, which promotes disassembly of the nuclear lamina and nuclear envelope breakdown (NEBD).

76 4/dDis3 and dRrp41/dSki6 colocalize with the nuclear lamina and often exhibit a restricted and asymme

77 ear envelope (NE) proteins interact with the nuclear lamina and participate in the architectural comp

78 irus nuclear egress, including disruption of nuclear lamina and particle budding through the inner nu

79 uently and stochastically associate with the nuclear lamina and pericentromeric heterochromatin in CD

80 e inner nuclear membrane with the underlying nuclear lamina and peripheral heterochromatin.

81 o the nuclear rim both for disruption of the nuclear lamina and phosphorylation of the NEC.

82 Lamin B1 is a component of the nuclear lamina and plays a critical role in maintaining

83 to phosphorylate lamin B to help modify the nuclear lamina and promote budding of nucleocapsids at t

84 NA regions that associate chromatin with the nuclear lamina and repress gene activity in fibroblasts.

85 n proteins leading to the disassembly of the nuclear lamina and subsequent nuclear envelope breakdown

86 ms assemble into complex networks within the nuclear lamina and that A- and B-type lamins have distin

87 e disorganized, suggesting links between the nuclear lamina and the cytoskeleton were disrupted.

88 ear envelope in higher eukaryotic cells, the nuclear lamina and the heterochromatin are adjacent to t

89 idence supporting an interaction between the nuclear lamina and the U(L)31/U(L)34 protein complex inc

90 ed to Xi chromosomes localized away from the nuclear lamina and were not observed in checkpoint-defic

91 UL53 colocalization, prevented disruption of nuclear lamina, and halted productive virus replication

92 her insulator proteins, association with the nuclear lamina, and insulator activity in vivo.

93 n B1 being required for the integrity of the nuclear lamina, and lamin B2 being important for resista

94 dTopors associates with the nuclear lamina, and mutations in lamin disrupt dTopors l

95 min B receptor, an integral component of the nuclear lamina, and that this interaction is required fo

96 individual mitochondria, undulations in the nuclear lamina, and the HER2 receptor on membrane protru

97 f is associated with its detachment from the nuclear lamina, and translocation toward the nucleus cen

98 of expanded CGG repeats into FMRpolyG alters nuclear lamina architecture and drives pathogenesis in F

99 lamina protein LAP2beta and disorganizes the nuclear lamina architecture in neurons differentiated fr

100 uclear envelope, nuclear pore complexes, and nuclear lamina are coordinately disassembled.

101 Chromatin domains associated with the nuclear lamina are generally heterochromatic and transcr

102 cells, the main protein constituents of the nuclear lamina are lamins A, C, B1, and B2.

103 show BAF-1 localization and mobility at the nuclear lamina are regulated by stress and unexpectedly

104 B-type lamins, the major components of the nuclear lamina, are believed to be essential for cell pr

105 As nuclear lamina assembled, but preceding DNA synthesis, a

106 on of the MN, which is induced by defects in nuclear lamina assembly, drastically reduces nuclear fun

107 inatorial patterns of histone modifications, nuclear lamina-associated domains, organization of large

108 Here we demonstrate that the nuclear lamina-associated nuclear envelope transmembrane

109 logies between emerin, thymopoietins and the nuclear lamina-associated protein, LAP2, we suggest that

110 defects in telomere clustering and telomere-nuclear-lamina associations.

111 role of PKC-delta in the disassembly of the nuclear lamina at apoptosis.

112 We show that dTopors localizes to the nuclear lamina at prophase, and also transiently to intr

113 lament proteins that form a scaffold, termed nuclear lamina, at the nuclear periphery.

114 me aggregation, gamma-tubulin relocated to a nuclear lamina-bounded compartment in which meiosis-1 sp

115 een proposed to facilitate disruption of the nuclear lamina by recruiting cellular protein kinase C (

116 Because alterations to the nuclear lamina can affect both nuclear morphology and ge

117 es suggest that compositional changes in the nuclear lamina can influence both the steady-state level

118 here it interferes with the integrity of the nuclear lamina, causes misshapen cell nuclei, and leads

119 eal direct control of a conserved LEM domain nuclear lamina component by beta-N-acetylglucosaminyltra

120 n be explained by its phosphorylation of the nuclear lamina component lamin A/C, which disrupts the n

121 nogaster YA protein is a maternally provided nuclear lamina component that is essential during the tr

122 The Drosophila YA protein is a nuclear lamina component whose function is essential to

123 identifying NUP-2 as a second trypanosomatid nuclear lamina component.

124 autophagy machinery mediates degradation of nuclear lamina components in mammals.

125 Coincident with these changes, the nuclear lamina components lamin A/C and lamin-associated

126 Our data is consistent with mutations of nuclear lamina components leading to destabilization of

127 Spatiotemporal changes in nuclear lamina composition underlie cell-type-specific c

128 The nuclear lamina consists of A- and B-type lamins.

129 lation at the inner nuclear membrane and the nuclear lamina contributes to the aging process.

130 cytoskeleton) complex and components of the nuclear lamina couple cell spreading or integrin activat

131 n bundles or the LINC complex did not rescue nuclear lamina defects, a previously identified determin

132 and nuclear membrane ruptures at sites with nuclear lamina defects.

133 ng cells lacked nucleosomal DNA cleavage and nuclear lamina degradation.

134 ers in the interphase nucleus to disrupt the nuclear lamina, demonstrating the importance of the lami

135 tivation at G2 phase is required for mitotic nuclear lamina disassembly and entry into mitosis and th

136 Consistent with this finding, nuclear lamina disassembly in the transition from propha

137 ar lamins are hyperphosphorylated leading to nuclear lamina disassembly, a process required for nucle

138 te mitotic lamin phosphorylation and mitotic nuclear lamina disassembly.

139 mediated lamin B phosphorylation and mitotic nuclear lamina disassembly.

140 imuli, we show that deregulated Cdk5 induces nuclear lamina dispersion by direct phosphorylation of l

141 In this study, we show that nuclear lamina dispersion is an early and irreversible t

142 g nuclear defects including aberrant shapes, nuclear lamina disruption and reductions to peripheral h

143 (HCMV) kinase UL97 is required for efficient nuclear lamina disruption during nuclear egress.

144 which kinases that normally disassemble the nuclear lamina during apoptosis are recruited to the nuc

145 ase (Hdac3) organizes heterochromatin at the nuclear lamina during cardiac progenitor lineage restric

146 equired for nuclear egress and disruption of nuclear lamina during HCMV infection, and they recruit U

147 , which is associated with disruption of the nuclear lamina during infection, and phosphorylation of

148 retaining chromatin within the bounds of the nuclear lamina during neuronal migration.

149 sis, the nuclear lamins assemble to form the nuclear lamina during nuclear envelope formation in daug

150 tment of heterochromatin and nucleoli to the nuclear lamina facilitates the folding of the neutrophil

151 urrently limited, there is evidence that the nuclear lamina filament protein Lamin A/C protects RB fr

152 otein lamin B, a component of the interphase nuclear lamina, functions in spindle assembly.

153 rmal function of LAP2 involves regulation of nuclear lamina growth.

154 The association of Rif1 with insoluble nuclear lamina has thus far hampered exhaustive characte

155 f the genome dynamically associated with the nuclear lamina have been identified.

156 ochromatin proteins SUV39H1 and HP1alpha and nuclear lamina-heterochromatin anchoring protein LAP2bet

157 B-type lamins are major constituents of the nuclear lamina in all metazoan cells, yet have specific

158 with late replication and attachment to the nuclear lamina in human cell lines.

159 L)34 proteins modify the conformation of the nuclear lamina in infected cells, possibly by direct int

160 ible system to target a genetic locus to the nuclear lamina in living mammalian cells.

161 The nuclear lamina in migrating neurons was pulled away from

162 s that disruption of the organisation of the nuclear lamina in neurons, perhaps through abnormal neur

163 microscopy reveals a significantly disrupted nuclear lamina in postmortem tissue from human Alzheimer

164 How the perturbation of the nuclear lamina in progeria is transduced into cellular c

165 oundation for redefining the function of the nuclear lamina in the context of tissue building and hom

166 Thus, we have uncovered a role for the nuclear lamina in the integration of EGF signaling to re

167 ur results suggest a mechanistic role of the nuclear lamina in the organization of chromosome territo

168 ter nuclei and becomes incorporated into the nuclear lamina in unfertilized eggs and embryos.

169 e useful models for studying the role of the nuclear lamina in various cellular processes.

170 s nucleosome chains and the filaments of the nuclear lamina, in situ.

171 ctase, SHMT, and thymidylate synthase to the nuclear lamina, indicating that SHMT serves as scaffold

172 regulated in part through dynamic chromatin-nuclear lamina interactions and that competence of a pro

173 These include the loss of DNA-nuclear lamina interactions, the distension of centromer

174 ere, the portion of CTCF associated with the nuclear lamina interacts with enhancer regions, limiting

175 E24 processes prelamin A, a component of the nuclear lamina intermediate filaments, by cleaving it at

176 The nuclear lamina is a fibrous structure that lies at the i

177 The nuclear lamina is a filamentous structure subtending the

178 The nuclear lamina is a fundamental constituent of metazoan

179 Disassembly of the nuclear lamina is a key step during open mitosis in high

180 The nuclear lamina is a key structural element of the metazo

181 The nuclear lamina is a meshwork of intermediate-type filame

182 The nuclear lamina is a network of structural filaments, the

183 The nuclear lamina is a protein meshwork lining the nucleopl

184 The nuclear lamina is an approximately 10 nm thick proteinac

185 The nuclear lamina is composed mainly of lamins A and C (A-t

186 The nuclear lamina is disassembled during mitosis and apopto

187 fusion, we provide direct evidence that the nuclear lamina is disrupted during HSV-1 infection and t

188 However, the structural organization of the nuclear lamina is poorly understood.

189 kinetics of transcriptional induction at the nuclear lamina is similar to that observed at an interna

190 cytoplasmic assembly compartment, where the nuclear lamina is specifically rearranged, the outer nuc

191 The nuclear lamina is thought to be the primary mechanical d

192 Thus, a key function of the nuclear lamina is to serve as a "fence" and prevent the

193 Lamin A, a key component of the nuclear lamina, is generated from prelamin A by four pos

194 exclusively in very discrete regions of the nuclear lamina lacking lamin A/C in the absence of US3 k

195 Studying a key component of the nuclear lamina lamin B1 (LMNB1), we report dynamic alter

196 del that the accumulation of progerin in the nuclear lamina leads to altered H3K27me3 marks in hetero

197 a signaling node and that abnormality in the nuclear lamina leads to dysregulated signaling pathways

198 n of the nuclear envelope, thickening of the nuclear lamina, loss of peripheral heterochromatin, and

199 e results suggest that disintegration of the nuclear lamina mediated by gamma134.5 promotes HSV repli

200 ve vesicles, likely through interaction with nuclear lamina, modulate CENPF localization and levels a

201 N-terminal domain localized proteins to the nuclear lamina near sites where mRNA leaves the nucleus.

202 Emerin, a membrane component of nuclear "lamina" networks with lamins and barrier to aut

203 The nuclear lamina (NL) consists of lamin polymers and prote

204 mins, the major structural components of the nuclear lamina (NL) found beneath the nuclear envelope,

205 ian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large lamina-ass

206 the mammalian genome is associated with the nuclear lamina (NL), it is interesting to study how nati

207 iption, and increase FXN localization at the nuclear lamina (NL).

208 The opening lacks nuclear lamina, nuclear pore complexes, and nuclear memb

209 d, HSV induced conformational changes in the nuclear lamina of infected cells, as viewed after staini

210 trosomes with nuclei or the structure of the nuclear lamina of migrating nuclei.

211 phology and gene expression, we examined the nuclear lamina of senescent cells.

212 tochastically and at high frequency with the nuclear lamina or with pericentromeric heterochromatin i

213 nuclear substructures, such as nucleoli, the nuclear lamina, or the nuclear matrix.

214 st likely acts by inhibiting dynamics of the nuclear lamina, our results suggest that a normal functi

215 Lamin B1, a key component of the nuclear lamina, plays an important role in brain develop

216 Lamin B1, a key component of the nuclear lamina, plays an important role in brain develop

217 nsation and blocks the formation of both the nuclear lamina-pore complex and nuclear membranes.

218 The reduced deformability of the HGPS nuclear lamina possibly could be due to the inability of

219 Given that the nuclear lamina potentially excludes nucleocapsids from e

220 It is well established that the nuclear lamina preferentially associates with repressed

221 (AGPAT2), a nuclear receptor (PPARgamma), a nuclear lamina protein (LMNA) and its processing endopro

222 The 72-kDa nuclear lamina protein lamin A is synthesized as a 74-kD

223 Prelamin A, the unprocessed form of the nuclear lamina protein lamin A, accumulated in calcifyin

224 The nuclear lamina protein lamin A/C is required for FSHD re

225 The mammalian nuclear lamina protein lamin B1 is posttranslationally m

226 the nucleus and directly interacts with the nuclear lamina protein lamin B1, and binds to lamin-asso

227 ype, or SASP), and reduced expression of the nuclear lamina protein LaminB1 (LMNB1) [1].

228 FMRpolyG interacts with the nuclear lamina protein LAP2beta and disorganizes the nuc

229 The Drosophila nuclear lamina protein YA binds to chromatin and is uniq

230 The Drosophila nuclear lamina protein YA is essential for the transitio

231 i formation, whereas the distribution of the nuclear lamina protein, lamin B, remained unchanged.

232 In this study, we used a maternally encoded nuclear lamina protein, YA, in parallel with another lam

233 imilarity to the chromatin binding region of nuclear lamina proteins and with the A.T-rich DNA-bindin

234 n, Arg527His, in the LMNA gene which encodes nuclear lamina proteins lamins A and C has been reported

235 M proteins EMR-1 and LEM-2, depletion of the nuclear lamina proteins LMN-1 or BAF-1, or the depletion

236 ntify factors that affect the recruitment of nuclear lamina proteins to the male pronucleus, we exami

237 ely, lamin dephosphorylation is required for nuclear lamina reassembly at the completion of mitosis.

238 sphates from lamin B, a process required for nuclear lamina reassembly.

239 pathophysiology underlying HGPS, and how the nuclear lamina regulates proliferation and chromatin org

240 e chromatin formation and maintenance at the nuclear lamina remain poorly understood.

241 tead, the nuclear envelope collapsed and the nuclear lamina remained intact.

242 The nuclear lamina represents a protein network required for

243 gerin adversely affects the integrity of the nuclear lamina, resulting in misshapen nuclei and nuclea

244 E7 failed to restore gaps in the nuclear lamina seen in wild-type but not UL97-null virus

245 nvolves disruption of the host chromatin and nuclear lamina so that the RC can approach the nuclear e

246 ain protein emerin, a conserved component of nuclear "lamina" structure, or with a complex containing

247 DNA and LAP2, a protein associated with the nuclear lamina, suggests a role for LAP2 in chromosome o

248 actor (BAF) is an essential component of the nuclear lamina that binds lamins, LEM-domain proteins, h

249 ns of emerin, another component of the inner nuclear lamina that directly interacts with LMNA.

250 repositioning of chromosomal regions to the nuclear lamina that is dependent on breakdown and reform

251 ci enriched in cell cycle regulator genes to nuclear lamina that mediates the CTCF function.

252 ) show disruption of the organization of the nuclear lamina that underlies the nuclear envelope.

253 leation around the nucleus that disrupts the nuclear lamina, the main structure limiting nuclear defo

254 ms that determine their association with the nuclear lamina, their dynamic links with other nuclear c

255 Igh relocated from the nuclear lamina to central domains only at the pro-B cell

256 nt, unanticipated interplay between CTCF and nuclear lamina to control the transcription of ER target

257 bridge the nuclear envelope, connecting the nuclear lamina to cytoskeletal components.

258 heterochromatin enhances the ability of the nuclear lamina to maintain the sturdiness and shape of t

259 ponent of the LINC complex that connects the nuclear lamina to the actin cytoskeleton.

260 and cytoskeleton (LINC) complex connects the nuclear lamina to the cytoskeleton, in part to aid in nu

261 toskeleton (LINC) complex--which connect the nuclear lamina to the cytoskeleton.

262 nd the outer nuclear membranes, connects the nuclear lamina to the cytoskeleton.

263 s localized to mitochondria-ER junctions and nuclear lamina, two compartments that are recalcitrant t

264 us, where it mediates the degradation of the nuclear lamina upon oncogenic insults to reinforce cellu

265 In animals, NPCs are anchored by the nuclear lamina, which ensures their even distribution an

266 The peripheral nuclear lamina, which is largely but not entirely associ

267 The nuclear lamina, which provides a structural scaffolding

268 at the nuclear periphery in contact with the nuclear lamina, which provides mechanical stability to t

269 n, depend critically on the integrity of the nuclear lamina, which suggest the existence of a functio

270 B cell factor (Ebf1) was sequestered at the nuclear lamina, which thereby preserved their multipoten

271 this is due to its role in disruption of the nuclear lamina, which would otherwise impede nuclear egr