ライフサイエンスコーパス: nuclear localization

1 beta-catenin while CHIR99021 increased it in nuclear localization.

2 n Ser207, release of LysRS from the MSC, and nuclear localization.

3 antiviral action to be through inhibiting C nuclear localization.

4 e cells, phosphorylates it, and enhances its nuclear localization.

5 pendent phosphorylation regulate its dynamic nuclear localization.

6 Phosphorylated Runx2 had an exclusively nuclear localization.

7 matrix stiffness perturbations regulate YAP nuclear localization.

8 and or receptor, respectively, inhibited YAP nuclear localization.

9 e of the same class, does not influence NADH nuclear localization.

10 the mitochondria and thereby increasing p53 nuclear localization.

11 induced its cellular protein expression and nuclear localization.

12 increased CAPN6 induction and impaired CWC22 nuclear localization.

13 or contractility-mediated regulation of YAP nuclear localization.

14 appropriate receptor protein expression and nuclear localization.

15 so support that BMAL1 is important for CLOCK nuclear localization.

16 biquitination of SMAD4, which can impair its nuclear localization.

17 hat had the most significant increase in YAP nuclear localization.

18 s key residues for inducing host shutoff and nuclear localization.

19 ibitors promote 14-3-3 dissociation and TFEB nuclear localization.

20 ygenase-2 (COX-2)/PGE2 axis and inducing its nuclear localization.

21 s mRNA and protein expression and favors its nuclear localization.

22 an colorectal cancers and correlate with DVL nuclear localization.

23 e Esrp1 peptide that is sufficient to confer nuclear localization.

24 but one mutant in the cytoplasm, as well as nuclear localization.

25 prevented decorin-evoked TFEB induction and nuclear localization.

26 we confirmed that stauprimide inhibits NME2 nuclear localization.

27 -113 is essential for catalytic activity and nuclear localization.

28 cade to control YAP-S397 phosphorylation and nuclear localization.

29 55 and Baf170 and displayed differential sub-nuclear localization.

30 ased TFEB promoter activity, expression, and nuclear localization.

31 ine residues 421 and 423 as critical for its nuclear localization.

32 and promoted transcription factor EB (TFEB) nuclear localization.

33 X observed in 3 patients led to constitutive nuclear localization and activation of both canonical an

34 via activation of JNK1 and causes increased nuclear localization and activity of androgen receptor.

35 Surprisingly, MML-1 regulates nuclear localization and activity of HLH-30/TFEB, a conv

36 adhesion molecule expression while reducing nuclear localization and activity of NFkappaB, which is

37 Here we report that exercise increases the nuclear localization and activity of p53 by acutely down

38 cologic inhibition of PKCiota decreases YAP1 nuclear localization and blocks OSC tumor growth in vitr

39 dependent regarding their protein stability, nuclear localization and chromatin recruitment and contr

40 e that TAZ-CAMTA1 (TC) fusion results in its nuclear localization and constitutive activation.

41 BR treatment promotes the accumulation, nuclear localization and dephosphorylation/phosphorylati

42 mbled the unliganded AR (apo-AR), precluding nuclear localization and DNA binding.

43 B pathway and consequently reduces NF-kappaB nuclear localization and downregulates NF-kappaB targets

44 box deletion of MAF1 leads to increased MAF1 nuclear localization and enhanced repression of ACC1 and

45 ctor 4 alpha (HNF4A) through increased ROCK1 nuclear localization and enhanced ROCK1 association with

46 tuent of ORC but displays S-phase restricted nuclear localization and expression, suggesting it posit

47 t a SUMOylation-mediated mechanism regulates nuclear localization and function of the ICD of ErbB4 re

48 h mature HMR rescues both its plastidial and nuclear localization and functions.

49 Two proteins involved in NF-kappaB nuclear localization and IL-6 expression, IkappaBalpha a

50 essed STAT3 phosphorylation, decreased STAT3 nuclear localization and inhibited STAT3 transcriptional

51 In HPK1ARas cells, 1alpha,25(OH)2D3-induced nuclear localization and interaction of hRXRalpha are re

52 tance to genotoxic agents by modulating YB-1 nuclear localization and interaction with the splicing f

53 Oylation) in Sox11, which suppresses Sox11's nuclear localization and its ability to promote RGC diff

54 ge tumor suppressor homolog) reduces Yap/Taz nuclear localization and minimizes their cytoplasmic lev

55 SIRT1 at Ser-164 substantially inhibited its nuclear localization and modestly affected its deacetyla

56 Nuclear localization and nucleosome remodeling and histo

57 erminus (AAs 23-40) that mediates the CASZ1b nuclear localization and NuRD interaction.

58 , and NUP43 transcripts is uncorrelated with nuclear localization and paraspeckle association.

59 hat drug binding to FABP1 and FABP2 promotes nuclear localization and PPARalpha activation in a drug-

60 dings reveal RET as a novel dual kinase with nuclear localization and provide mechanisms by which RET

61 Here we show unique nuclear localization and regulation of gene transcriptio

62 did not affect heat-induced oligomerization, nuclear localization and specific DNA binding but inhibi

63 M2 are dispensable for the exclusive protein nuclear localization and speckle-like distribution.

64 tion to K63 ubiquitination and thus promotes nuclear localization and stabilization of Bcl3.

65 ABL also enhanced TAZ nuclear localization and the formation of the TAZ-TEAD c

66 s provide a mechanism for regulation of Bag6 nuclear localization and the functional integrity of the

67 d DNA binding, transcriptional activity, and nuclear localization and the possible formation of cytop

68 cid, and this binding was required for IP6K1 nuclear localization and the regulation of mIno1 transcr

69 d downstream Akt activation, increased FOXO1 nuclear localization and transcriptional activation, and

70 posttranslational modification controls its nuclear localization and transcriptional activation.

71 logical inhibition both decrease expression, nuclear localization and transcriptional activity of YAP

72 region (UTR) plays dual roles in CDC20 mRNA nuclear localization and translation.

73 Yes-associated protein (YAP) nuclear localization and up-regulation of canonical targ

74 Pyruvate is essential for this nuclear localization, and a failure of TCA cycle enzymes

75 ough Erk1/2 and Stat3 leads to upregulation, nuclear localization, and activation of the transcriptio

76 cytoskeletal integrity is essential for YAP nuclear localization, and can override phosphoregulation

77 and OGT led to p53 stabilization, increased nuclear localization, and increased protein and mRNA lev

78 Endogenous FUS expression, nuclear localization, and splicing activity were not alt

79 lation cycle by promoting TDG function, TET1 nuclear localization, and TET/TDG association.

80 ACLY phosphorylation and nuclear localization are necessary for its role in promo

81 -cell studies demonstrate that mDia2 and its nuclear localization are required to maintain CENP-A lev

82 enced by decreased percent androgen receptor nuclear localization (%ARNL) and increased microtubule b

83 sponsive transcription factor Crz1 undergoes nuclear localization bursts during the pheromone respons

84 he C-terminal region play a critical role in nuclear localization, but additional basic residues were

85 the first 9 amino acids were sufficient for nuclear localization, but an additional 6 residues were

86 d AAP2BR2 play the most influential role for nuclear localization, but either one of the two AAP2BRs

87 lements that contributed multiplicatively to nuclear localization, but the conserved DNA binding resi

88 activity through phosphorylation of general nuclear localization clusters.

89 ncta and the shorter isoform displays higher nuclear localization compared to the longer isoform.

90 Mutant IPMK had reduced kinase activity and nuclear localization, compared with the full-length prot

91 ows that the inability to disrupt Aux/IAA CC nuclear localization correlates with a reduced ability t

92 iously described nuclear functions because a nuclear localization-defective mutant BMI1 rescued sever

93 Moreover, TH increased FOXO1 nuclear localization, DNA binding, and target gene trans

94 Moreover, ACOT1 exhibited partial nuclear localization during fasting and cAMP/cAMP-depend

95 Sequences within two of the nuclear localization elements defined a new form of bipa

96 own cells showed an increase in beta-catenin nuclear localization, enhanced transcriptional activity,

97 mous NLS activity and the fourth served as a nuclear localization enhancer.

98 expressed de novo in macrophages with early nuclear localization followed by later translocation to

99 a cis-acting role, we showed a preferential nuclear localization for two selected candidates.

100 ctional nuclear localization signal and that nuclear localization impairs the ability of ICAP1 to sup

101 a statistically significant increase in YAP nuclear localization in 100% of tumors.

102 and FANCD2, phosphorylation of p53 or BRCA1 nuclear localization in response to DNA damage caused by

103 AIRE nuclear localization in the human thymic epithelial cell

104 keletal integrity-mediated regulation of YAP nuclear localization independent of contractility.

105 Blocking AURKA nuclear localization inhibits this newly discovered tran

106 F) whose function was previously ascribed to nuclear localization, instead plays multiple essential r

107 a phosphorylation significantly disrupts its nuclear localization, interaction with VDR, intra-nuclea

108 Furthermore, CC Aux/IAA nuclear localization is disrupted upon infection with an

109 onine and adenine auxotrophy of Ppmet6 Thus, nuclear localization is essential for the stability and

110 Mutational analyses reveal that cFLIPL nuclear localization is necessary and sufficient for inh

111 Its nuclear localization is required for enhanced P. infesta

112 on at the molecular level to regulate YAP1's nuclear localization is still puzzling.

113 Our results also demonstrate that ErbB3 nuclear localization is transient as it is exported out

114 a transcription activation domain but retain nuclear localization motifs and are expressed from genes

115 f the virus life cycle thus rely on distinct nuclear localization motifs of NP.

116 An ORF2 stop codon mutant, an ORF2 nuclear localization mutant, or a mutant lacking the 5 p

117 between the cytoplasm and nucleus due to its nuclear localization (NLS) and export sequences (NES).

118 IFN-alpha-induced nuclear localization of activated STAT1 is markedly redu

119 , and promoted protein expression as well as nuclear localization of AHRR.

120 The nuclear localization of beta-catenin is the defining ste

121 Stabilization and nuclear localization of beta-catenin result in the expre

122 ted ERK1/2 in all types of liver tumors, but nuclear localization of beta-catenin, a sign of malignan

123 in transfected cells, which resulted in the nuclear localization of beta-catenin.

124 in various cell lines specifically increases nuclear localization of BMP receptor-activated SMADs (R-

125 Mutations in BRCA2, FANCC and NBN decreased nuclear localization of BRCA1 in response to drug treatm

126 Mutations in BRCA1 decreased nuclear localization of BRCA1 in response to individual

127 port by leptomycin B resulted in predominant nuclear localization of C3G.

128 ws the timing of muscle relaxation, promotes nuclear localization of calcineurin target Nfatc3, and/o

129 Our results suggest that AMP inhibits the nuclear localization of ChREBP through an allosteric act

130 Nuclear localization of ChREBP was rapidly inhibited whe

131 ating that SPA proteins are not required for nuclear localization of COP1 in darkness.

132 This association disturbs the nuclear localization of CWC22, thereby suppressing the s

133 Consistent with this possibility, nuclear localization of cyclin B1 was increased.

134 al TDP-43 and restores normal solubility and nuclear localization of endogenous TDP-43.

135 dephosphorylate phospho-Ser-322 and promote nuclear localization of Fam13a.

136 However, the mechanisms controlling the nuclear localization of FLIL33 or its stability in cells

137 t of the FLIL33 protein, is not required for nuclear localization of FLIL33, and protects FLIL33 from

138 PO5 knockdown in cell culture did not affect nuclear localization of FLIL33.

139 serine 124 to leucine promotes constitutive nuclear localization of Foxc2 and expression of mesenchy

140 We also report that nuclear localization of FOXO1 correlated with PTEN mutat

141 rom aberrant PI3K signaling, which decreases nuclear localization of FOXO3A and decreases catalase ex

142 ignant cells in culture and in vivo and that nuclear localization of Gal-1 promotes a transformed phe

143 The nuclear localization of Gene 33 also provides a spatial

144 We also found that the nuclear localization of Gene 33 is regulated by its 14-3

145 logical hypertrophy were assessed, including nuclear localization of GRK5, and compared with TAC.

146 d less reactive oxygen species, resulting in nuclear localization of HDAC4 and miR-206 repression.

147 Notch1, Notch2, Notch4, DLL-1 and nuclear localization of Hes1 were significantly elevated

148 bly, polyinosinic:polycytidylic acid induced nuclear localization of iNOS, and its binding to, and ni

149 P inhibits IRF7 function by antagonizing the nuclear localization of IRF7.

150 Moreover, we find that ICAP1 drives the nuclear localization of KRIT1 in a manner dependent upon

151 function and mechanism for regulation of the nuclear localization of LANA will enhance our understand

152 Heat inactivation of HIV-1 blocks nuclear localization of LysRS, but treatment with a reve

153 Here, we demonstrate that nuclear localization of Mre11 (Mre11-NLS) is able to byp

154 d function primarily inside the nucleus, but nuclear localization of mRNAs has been considered rare i

155 We conclude that nuclear localization of MS is a unique feature of respir

156 iquitination increases protein stability and nuclear localization of mutant PTEN.

157 We further discovered increased nuclear localization of mutant TNNT2 and epigenetic modi

158 ive hypertrophic astrocytes showed increased nuclear localization of NF-kappaB and elevated chemokine

159 iously reported that genotoxic agents induce nuclear localization of NF-kappaB essential modulator (N

160 Nuclear localization of NF-kappaB, a major downstream ta

161 Unlike monocytic THP-1 cells with prominent nuclear localization of NLRP1, melanoma cells expressed

162 Nuclear localization of P. pastoris MS (PpMS) was abroga

163 w that long term Cn infection induces stable nuclear localization of p65 and IkappaBalpha proteins in

164 In this case, nuclear localization of p65 is not accompanied by TNFalp

165 cytoplasm and nucleus of the cells, but the nuclear localization of PA-X mediated by its C-terminal

166 atment significantly elevated expression and nuclear localization of PAK4 in correlation with inducti

167 NF-kappaB reporter activity and nuclear localization of phosphorylated NF-kappaB subunit

168 Moreover, the nuclear localization of PINN-1 is altered in dapk-1 muta

169 at R742A as well as D113R mutations abrogate nuclear localization of PpMS and its ability to reverse

170 Nuclear localization of PsbZIP1 was determined by a cent

171 Nuclear localization of RBM45 is mediated by a bipartite

172 croscopy, we confirmed the mitochondrial and nuclear localization of RIbeta in cultured neurons.

173 lular analysis showed that TCS inhibited the nuclear localization of SKN-1/Nrf2 and the expression of

174 nd this effect was supported by an increased nuclear localization of Skp2, disruption of Skp2 interac

175 beta) pathway, exposure to ligand stimulates nuclear localization of Smad proteins, which then regula

176 effects in our cytological studies, and the nuclear localization of ssDNA-FITC suggest that nano-LDH

177 emia/reperfusion injury in vivo This induced nuclear localization of TAZ and increased expression of

178 Finally, a predominant nuclear localization of TFEB is unveiled in fully fed pa

179 Nuclear localization of TFPI-2 contributed to inhibition

180 te how this setup can be used to control the nuclear localization of the budding yeast transcription

181 The nuclear localization of the MEF2 corepressor HDAC4 is im

182 tem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME

183 However, there was strong nuclear localization of the NFkappaB subunit p65 in the

184 eactive oxygen species production, increased nuclear localization of the NRF2 transcription factor, i

185 OSC cells is regulated by PKCiota-dependent nuclear localization of the oncogenic transcription fact

186 Importantly, forced nuclear localization of the PA-X C-terminal deletion mut

187 itant with decreased aggregation and reduced nuclear localization of the pathogenic protein.

188 osis and lipid-loaded Huh7 cells had reduced nuclear localization of the pregnane X receptor (PXR), a

189 We demonstrate that nuclear localization of the Repressor Element 1-Silencin

190 tream mediator of this response by promoting nuclear localization of the TAZ transcriptional modulato

191 re kinases hippo or warts leads to premature nuclear localization of the transcriptional co-activator

192 ility are paralleled by modifications in the nuclear localization of the transcriptional regulator YA

193 man cancers, and normally the expression and nuclear localization of these proteins is tightly regula

194 Finally, an impaired nuclear localization of TRADD triggers cell death throug

195 tically, we found that DMF treatment reduced nuclear localization of transcriptional coactivator with

196 (IL6) beta2SP(+/-) LSCs not only exhibited nuclear localization of Twist and Slug, markers of epith

197 e demonstrated that both photoactivation and nuclear localization of UVR8 are required for UV-B-induc

198 Altering the nuclear localization of villin affects the expression an

199 Bcl-6, c-Myc), reduced proliferation (Ki67), nuclear localization of XPO1 cargos (p53, PTEN), and inc

200 In particular, ARF knockdown reduced non-nuclear localization of YAP which led to an increase in

201 in nucleus that may further lead to the non-nuclear localization of YAP.

202 of mouse arteries demonstrated an increased nuclear localization of YAP/TAZ and elevated levels of t

203 kPa) led to a decrease in the cell area and nuclear localization of YAP/TAZ, and subsequent stiffeni

204 . 3.5 to 28 kPa) increased the cell area and nuclear localization of YAP/TAZ.

205 interactions caused either AHR constitutive nuclear localization or failure to translocate to nucleu

206 localization of HLD2 with the addition of a nuclear localization or nuclear export sequence demonstr

207 and Sr50 CC domains fused to YFP and either nuclear localization or nuclear export signals in N bent

208 ng early mitosis and then displays different nuclear localization patterns at different times during

209 ourse spanned the onset of mutant huntingtin nuclear localization phenotypes and somatic CAG-length i

210 A subset of these mutations lacked nuclear localization, prompting us to examine the role o

211 ower protein expression levels and increased nuclear localization, providing a mechanism for accessin

212 n to be in part due to impaired beta-catenin nuclear localization resulting from alterations in the a

213 with p53 and promotes its mitochondrial and nuclear localization, resulting in transcription of p53-

214 binding of Cdh1 but inactivated a bipartite nuclear localization sequence (NLS) and thereby controll

215 Monopartite C-terminal nuclear localization sequence (NLS) motifs conserved in

216 e LSD1 complex through its domain containing nuclear localization sequence and phosphorylation sites.

217 is critical not only for occluding the Bag6 nuclear localization sequence from karyopherin alpha to

218 ation in length of the lysine stretch of the nuclear localization sequence is a determinant for impor

219 ely accrues from a phosphorylation-sensitive nuclear localization sequence located in the PLD.

220 fused to a yellow fluorescent protein and a nuclear localization sequence to simplify quantitative n

221 trol, PELP1-wt, or mutant PELP1 in which the nuclear localization sequence was altered, resulting in

222 fluorescent protein), protein translocation (nuclear localization sequence), DNA recombination (Cre)

223 umulate in the cytoplasm because they lack a nuclear localization sequence.

224 he fusion protein required that it contain a nuclear localization sequence.

225 lization of RBM45 is mediated by a bipartite nuclear-localization sequence (NLS) located at the C-ter

226 lypeptide sequences that implicate mammalian nuclear localization sequences and many cell penetrating

227 gineered variants of Cas9 with multiple SV40 nuclear localization sequences enabled a tenfold increas

228 h a kinase substrate is fused to a bipartite nuclear localization signal (bNLS) and nuclear export si

229 mouse overexpressing exogenous FUS without a nuclear localization signal (DeltaNLS-FUS), which develo

230 t at residues 11-27 and an isoleucine-lysine nuclear localization signal (IK-NLS) motif at residues 3

231 In these proteins, a nuclear localization signal (NLS) and an intrinsically d

232 N-terminal region of FMDV 3D that acts as a nuclear localization signal (NLS) and in template bindin

233 Anillin contains a conserved nuclear localization signal (NLS) at its C-terminus that

234 leasing importin alpha/beta from a bipartite nuclear localization signal (NLS) located in the tail do

235 uctural analysis suggests that a monopartite nuclear localization signal (NLS) may reside in the N-te

236 s simplex virus 1 (HSV-1) mutant lacking the nuclear localization signal (NLS) on the ICP0 gene (0Del

237 e analyzed the structure and conservation of nuclear localization signal (NLS) sequences previously i

238 scent protein (GFP) reporter fusion assays a nuclear localization signal (NLS) that was mapped to a 2

239 ted mutant mouse, nBmp2NLS(tm), in which the nuclear localization signal (NLS) was inactivated to pre

240 Both HDAgs contain a nuclear localization signal (NLS), but only HDAg-L conta

241 he CTD of topo IIalpha, while preserving the nuclear localization signal (NLS), enhances the decatena

242 Notably, the PB2 nuclear localization signal (NLS)-containing domain tran

243 triphosphate (RanGTP) gradient that imports nuclear localization signal (NLS)-specific cargoes (NLS-

244 amino-terminal residues (1-45) including the nuclear localization signal (NLS1) are dispensable.

245 Here, we show that the PY-type nuclear localization signal (PY-NLS)/karyopherinbeta2 (K

246 n of a TDP-43 variant with a mutation in the nuclear localization signal (TDP-43-NLS).

247 ivities of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nuclear expor

248 vely spliced Set-beta transcript lacking the nuclear localization signal and demonstrated that the fu

249 One of its isoforms, DNAJB6a, contains a nuclear localization signal and regulates beta-catenin s

250 try to show that ICAP1 contains a functional nuclear localization signal and that nuclear localizatio

251 s to the N-terminal DNA-binding domains, the nuclear localization signal becomes more highly exchangi

252 Mutation of the nuclear localization signal in CELF1 abolished the abili

253 nt manner through an atypical basic patch PY nuclear localization signal motif.

254 e these sequences do not correspond to known nuclear localization signal motifs, they represent a new

255 ) phosphorylation at S659, which exposed the nuclear localization signal of ACSS2 for importin alpha5

256 e novo predicted deleterious variants in the nuclear localization signal of Heterogeneous Nuclear Rib

257 BPN1 but not a truncated version lacking the nuclear localization signal protects from pathogenic TDP

258 ed cereals showed that all of them contain a nuclear localization signal sequence flanking to the K1

259 The C terminus encompassing the nuclear localization signal sequesters the enzyme in the

260 found that residues (20)KY(21) constitute a nuclear localization signal that is not required for the

261 nteracts with importin alpha via a classical nuclear localization signal that recruits importin alpha

262 rions parallels effects of the attachment of nuclear localization signal to Sis1, indicating that Cur

263 xpression, which could be reversed after the nuclear localization signal was deleted.

264 e N-terminal 25 amino acids to function as a nuclear localization signal was not required for restric

265 referred to as pUL31, containing a bipartite nuclear localization signal, an intrinsically disordered

266 A longer DCL4 transcript isoform encoding a nuclear localization signal, DCL4(NLS), is present in Ar

267 One isoform loses the putative nuclear localization signal, generating c-Drosha.

268 We fuse the ADAR2 domain, tagged with a nuclear localization signal, to an RNA binding peptide f

269 were full length, containing the N-terminal nuclear localization signal.

270 calize TRAF3 to the nucleus via a functional nuclear localization signal.

271 es its C-terminal transmembrane domain and a nuclear localization signal.

272 MRKTKLAPT (residues 16 to 24) that acts as a nuclear localization signal.

273 way for mediating ligand-induced exposure of nuclear localization signal.

274 both the C-terminal basic stretch and basic nuclear localization signal.

275 minal 25 amino acids of MxB to function as a nuclear localization signal; however, the ability of the

276 urn (HT), proline/serine (PS) domain and two nuclear localization signals (NLS).

277 ycete plant pathogen Phytophthora sojae uses nuclear localization signals (NLSs) for translocation of

278 , unlike their bacterial homologues, possess nuclear localization signals (NLSs) to enter the cell nu

279 l strains of influenza A viruses contain two nuclear localization signals (NLSs): a well-studied mono

280 e splicing, but specific Rbfox isoforms lack nuclear localization signals and accumulate in the cytop

281 This is because the predicted nuclear localization signals of HMR are nonfunctional, a

282 karyopherins for Rrp6 nuclear import and the nuclear localization signals recognized by them.

283 the cargo proteins, including the classical nuclear localization signals, recognized by the adaptor

284 ed by the adaptor importin-alpha, and the PY nuclear localization signals, recognized by transportin-

285 e the nuclear import of viral genome via its nuclear localization signals.

286 to potentiate each other to block NF-kappaB nuclear localization stimulated by inflammatory cytokine

287 Furthermore, the GRP88 nuclear localization suggests nonclassical GPCR modes of

288 ced MET, glandular redifferentiation, and AR nuclear localization that was inhibited by androgen depr

289 In addition to its nuclear localization, the protein unexpectedly localizes

290 DNA polymerase beta (pol beta) requires nuclear localization to fulfil its DNA repair function.

291 f cells have both been shown to regulate YAP nuclear localization to modulate cell proliferation.

292 Mutations lacking nuclear localization uncover a novel mechanism whereby l

293 tus loss-of-function alleles decrease Dorsal nuclear localization ventrally, where Toll signals are h

294 In addition, enhanced Yap1 nuclear localization was also evident in 7,12-dimethylbe

295 d dipeptides were present in the nucleus and nuclear localization was necessary and sufficient for th

296 Based on Ki67 co-localization studies YAP nuclear localization was not simply a marker of prolifer

297 ed the ability to downregulate Cx43 mRNA, so nuclear localization was required for its function.

298 To show the functional significance of nuclear localization, we demonstrated that downregulatio

299 ppressor activity has been attributed to its nuclear localization, where it helps to maintain genome

300 al effects required combined cytoplasmic and nuclear localization, whereas the effects on cell moveme