ライフサイエンスコーパス: nuclear pore

1 m for cargo protection during passage of the nuclear pore.

2 he unique possibility of blocking EMT at the nuclear pore.

3 solutions, mimicking the environment of the nuclear pore.

4 nuclear periphery via interactions with the nuclear pore.

5 ites required for ratcheting mRNA across the nuclear pore.

6 ) that is critical for capsid routing to the nuclear pore.

7 level of its nuclear entry and exit via the nuclear pore.

8 K) and the transport of viral capsids to the nuclear pore.

9 rt receptors ferry protein cargo through the nuclear pore.

10 ne-glycine dipeptides (FG domains) fills the nuclear pore.

11 he genome once the capsid interacts with the nuclear pore.

12 ent NPC module, forms the outer rings of the nuclear pore.

13 G-nucleoporins to facilitate passage through nuclear pores.

14 -nucleoporins to facilitate movement through nuclear pores.

15 sing the viral genome from capsids docked at nuclear pores.

16 shuttles between unattached kinetochores and nuclear pores.

17 ribution of specific nucleoporins within the nuclear pores.

18 otherwise arrest CRM1 transport complexes at nuclear pores.

19 or increasing flux of molecules through the nuclear pores.

20 Displacing Mad1-Mad2 from nuclear pores accelerated anaphase onset, prevented effe

21 The nuclear pores act as a conduit of this transport, both f

22 long the nuclear periphery, likely to find a nuclear pore allowing export.

23 is (ALS) binds to the central channel of the nuclear pore and inhibits the movement of macromolecules

24 rization of actin to propel nucleocapsids to nuclear pores and entry into the nucleus.

25 We conclude that nuclear pores and kinetochores both emit "wait anaphase"

26 gans germline, cytoplasmic P granules at the nuclear pores and perinuclear Mutator foci contribute to

27 y depended on the number and permeability of nuclear pores and the availability of nuclear binding si

28 ation together with targeting transcripts to nuclear pores and their export to the cytoplasm.

29 manner involving their physical proximity to nuclear pores and transcribed chromatin.

30 NPC, structural arrangements of Nups in the nuclear pore, and mechanisms of nucleocytoplasmic transp

31 to the cytoplasm, docking of the capsid at a nuclear pore, and release of the viral genome into the n

32 f mRNAs are more than 0.5 microm away from a nuclear pore, and we do so for the first time accounting

33 uclear periphery, shortens residency time at nuclear pores, and results in frequent release of mRNAs

34 nal regulation, key components of C. elegans nuclear pores are required for processing of a subset of

35 plex, components of mitotic kinetochores and nuclear pores, are blocked from binding to kinetochores

36 stent with the Mlp1/2 role in gene gating to nuclear pores, artificial tethering to the nuclear perip

37 orts a model in which animal genomes use the nuclear pore as an organizing scaffold for inducible poi

38 agues describe a surveillance pathway during nuclear pore assembly and, in doing so, identify a new r

39 Nuclear pore assembly can go awry, but how the cell hand

40 that mitotic spindle, nuclear membrane, and nuclear pore assembly occur exclusively around chromatin

41 abilize the Nup82-Nsp1-Nup159 complex of the nuclear pore assembly through its interaction with nucle

42 Nuclear pores associate with active protein-coding genes

43 f a fraction of Vps15-GFP and Vps34-GFP with nuclear pores at nucleus-vacuole (NV) junctions in live

44 In this study, we show that the nuclear pore basket component Alm1 is required to mainta

45 enes were found to be stably associated with nuclear pores before and after activation.

46 Both helicase and nuclear pore-binding activities of Ddx19 are dispensable

47 We report a novel role for torsin in nuclear pore biology.

48 Transport of macromolecules through the nuclear pore by importins and exportins plays a critical

49 leoporins, Nup62, Nup54, and Nup58, line the nuclear pore channel.

50 ycle model for structure and dynamics of the nuclear pore channel.

51 architectures ranging from bacteriophages to nuclear pores, cilia, and synaptonemal complexes in larg

52 exerts its function and whether it modulates nuclear pore complex (NPC) activity remain unknown.

53 Multiple components of the nuclear pore complex (NPC) and a second coiled-coil prot

54 uncover two metformin response elements: the nuclear pore complex (NPC) and acyl-CoA dehydrogenase fa

55 ding yeast, targeting of active genes to the nuclear pore complex (NPC) and interchromosomal clusteri

56 We detected two exceptions: the nuclear pore complex (NPC) and the spindle pole body (SP

57 The molecular structure of the yeast nuclear pore complex (NPC) and the translocation of mode

58 generated nanobodies against the vertebrate nuclear pore complex (NPC) and used them in STORM imagin

59 e associated with shedding of NUP62 from the nuclear pore complex (NPC) and/or retention of NUP62 in

60 The nuclear pore complex (NPC) arose in evolution as the cel

61 However, how nuclear pore complex (NPC) barrier selectivity, Kap traf

62 show that PfSR1 is localized adjacent to the Nuclear Pore Complex (NPC) clusters in the nucleus of ea

63 Here, we show that nuclear pore complex (NPC) components Nup93 and Nup153 b

64 The nuclear pore complex (NPC) constitutes the sole gateway

65 The key component of the nuclear pore complex (NPC) controlling permeability, sel

66 The nuclear pore complex (NPC) controls the transport of mac

67 mechanism to explain how a component of the nuclear pore complex (NPC) could cause Htx/CHD was undef

68 esized membrane proteins traffic through the nuclear pore complex (NPC) en route to the inner nuclear

69 Here we tested if the nuclear pore complex (NPC) facilitates the targeting of

70 /RanGAP1*SUMO1/Ubc9 localizes at cytoplasmic nuclear pore complex (NPC) filaments and is a docking si

71 nterest and represents a central paradigm to nuclear pore complex (NPC) function, where nuclear trans

72 nucleocytoplasmic information transfer, the nuclear pore complex (NPC) has been studied in great det

73 The nuclear pore complex (NPC) has dual roles in nucleocytop

74 l T cell signaling, direct regulation of the nuclear pore complex (NPC) has not been reported.

75 lluring proposal outlining functions for the nuclear pore complex (NPC) in transcription and nuclear

76 At the center of the nuclear pore complex (NPC) is a uniquely versatile centr

77 The basket of the nuclear pore complex (NPC) is generally depicted as a di

78 nups) that line the transport channel of the nuclear pore complex (NPC) is investigated by means of c

79 Binding of the capsid to the nuclear pore complex (NPC) is mediated by the capsid pro

80 The nuclear pore complex (NPC) is responsible for nucleocyto

81 The nuclear pore complex (NPC) is the gate for transport bet

82 The nuclear pore complex (NPC) is the principal gateway for

83 The nuclear pore complex (NPC) is the proteinaceous nanopore

84 The prevailing model poses that the nuclear pore complex (NPC) is the sole gatekeeper for tr

85 The nuclear pore complex (NPC) mediates nucleocytoplasmic tr

86 The nuclear pore complex (NPC) plays a critical role in gene

87 Tpr is a conserved nuclear pore complex (NPC) protein implicated in the spi

88 iated Esc1, the SUMO E3 ligase Siz2, and the nuclear pore complex (NPC) protein Nup170-physically and

89 enterovirus 2A protease directly cleaves the nuclear pore complex (NPC) protein, Nup98, at amino acid

90 ring Aspergillus nidulans mitosis peripheral nuclear pore complex (NPC) proteins (Nups) disperse from

91 Enteroviruses proteolyze nuclear pore complex (NPC) proteins (Nups) during infect

92 The nuclear pore complex (NPC) regulates transport between t

93 his process is regulated at the level of the nuclear pore complex (NPC) remains unclear.

94 in receptor (p75(NTR)) is a component of the nuclear pore complex (NPC) required for glial scar forma

95 Lectin blockade of the nuclear pore complex (NPC) resulted in inhibition of nuc

96 The nuclear pore complex (NPC) selectively gates the transpo

97 The nuclear pore complex (NPC) serves as both the unique gat

98 es for some ER proteins in the NE for proper nuclear pore complex (NPC) structure and function.

99 The nuclear pore complex (NPC) tethers chromatin to create a

100 nsport, however, is tightly regulated by the nuclear pore complex (NPC) with the hydrophobic transpor

101 novirus (AdV) to the cytoplasmic face of the nuclear pore complex (NPC), a key step during delivery o

102 etic modifiers that encode components of the nuclear pore complex (NPC), as well as the machinery tha

103 The nuclear pore complex (NPC), assembled from approximately

104 ls involves regulatory interactions with the nuclear pore complex (NPC), followed by translocation to

105 2, a component of the central channel of the nuclear pore complex (NPC), for forced dimerization by t

106 g, transport, and cytoplasmic release from a nuclear pore complex (NPC), is fast ( approximately 200

107 this study we used BioID to study the human nuclear pore complex (NPC), one of the largest macromole

108 ic reticulum to the Golgi apparatus, and the nuclear pore complex (NPC), which facilitates nucleo-cyt

109 rved assembly at the cytoplasmic face of the nuclear pore complex (NPC).

110 repeats that fill the central channel of the nuclear pore complex (NPC).

111 hat localizes to the cytoplasmic side of the nuclear pore complex (NPC).

112 s) are exported to the cytoplasm through the nuclear pore complex (NPC).

113 o transport cargos directionally through the nuclear pore complex (NPC).

114 nslocation of transport complexes across the nuclear pore complex (NPC).

115 of a non-dividing cell, is exclusive to the nuclear pore complex (NPC).

116 Nucleoporins are essential components of the nuclear pore complex (NPC).

117 mammalian nucleoporin 98, a component of the nuclear pore complex (NPC).

118 Grima et al. (2017) describe defects in the nuclear pore complex and impaired nucleocytoplasmic tran

119 ependent on the Nup107-160 subcomplex of the nuclear pore complex and is modulated through interactio

120 t of nucleoporins (Nups) can detach from the nuclear pore complex and move into the nuclear interior

121 s, might help vaults safely pass through the nuclear pore complex and potentiate their role as self-r

122 mbrane-less organelles such as nucleoli, the nuclear pore complex and stress granules.

123 modeling as they are first acted upon by the nuclear pore complex and then by the ribosome.

124 tosol by employing anti-beta-tubulin or anti-nuclear pore complex antibody as cargo.

125 e nuclear periphery and interaction with the nuclear pore complex are prerequisites for gene clusteri

126 lar or identical to those needed for de novo nuclear pore complex assembly.

127 Moreover, we provide evidence that a nuclear pore complex associates with the duplicating SPB

128 nk between the Torsin/cofactor system and NE/nuclear pore complex biogenesis or homeostasis and estab

129 east, some inducible genes interact with the nuclear pore complex both when active and for several ge

130 Nuclear pore complex components (Nups) have been implica

131 The Hog1 SAPK associates with nuclear pore complex components and directly phosphoryla

132 The nuclear pore complex controls the passage of molecules v

133 The NIMA kinase is required for mitotic nuclear pore complex disassembly and potentially control

134 While NUP107 is required for nuclear pore complex function in somatic cells of flies

135 Here, we genetically show that an intact nuclear pore complex is important for cell survival and

136 The nuclear pore complex is the primary conduit for nuclear

137 The nuclear pore complex mediates nucleocytoplasmic transpor

138 Because NIMA triggers nuclear pore complex opening during mitosis, our finding

139 rins implicated in maintaining the selective nuclear pore complex permeability barrier.

140 Our finding suggested that the nuclear pore complex plays an important role in mammalia

141 The nuclear pore complex protein NUP88 is frequently elevate

142 that the Arabidopsis (Arabidopsis thaliana) nuclear pore complex protein Nup88/MOS7 is essential for

143 Rodriguez-Bravo et al. report that the nuclear pore complex scaffolds spindle assembly checkpoi

144 provided a high-resolution understanding of nuclear pore complex structure and transport, revealing

145 rate complicated molecular gates such as the nuclear pore complex to control the transport of biologi

146 mprehensive architectural model of the human nuclear pore complex to date.

147 onsiderations when studying the mechanism of nuclear pore complex transport in vivo.

148 onal hsp-16.2/41 promoter interacts with the nuclear pore complex upon activation by heat shock in th

149 entary studies that Plk1 is recruited to the nuclear pore complex upon mitotic entry, where it acts w

150 itulate "dilation" and "constriction" of the nuclear pore complex's central transport channel.

151 NUP107 is a component of the nuclear pore complex, and the NUP107-associated protein

152 ous intracellular compartments including the nuclear pore complex, COPII-coated vesicles, and inside

153 omolecular complexes with an emphasis on the nuclear pore complex, holding great potential for applic

154 , which is shared by several proteins of the nuclear pore complex, including those in the central cha

155 uding capsid transport, decapsidation at the nuclear pore complex, particle assembly, and secondary e

156 Here we review transport through the nuclear pore complex, pointing out vulnerabilities that

157 ssical nuclear import pathway, involving the nuclear pore complex, the small GTPase Ran, and cellular

158 the cellular substrates, particularly in the nuclear pore complex, used by these proteases were indee

159 are stacked ER-derived membranes containing nuclear pore complex-like structures whose fate and func

160 Analysis of a large dynamic structure-the nuclear pore complex-revealed variations detectable at t

161 sically interacts with key components of the nuclear pore complex.

162 rtin beta1 and Ran-GTPase, components of the nuclear pore complex.

163 and in achieving proper configuration of the nuclear pore complex.

164 and is stabilized by an interaction with the nuclear pore complex.

165 erlie mechanistic and kinetic control in the nuclear pore complex.

166 l channel, or on the cytoplasmic face of the nuclear pore complex.

167 ng protein cargoes for transport through the nuclear pore complex.

168 eptor TAP/NXF, which guides mRNA through the nuclear pore complex.

169 clear periphery through interaction with the nuclear pore complex.

170 beta1, which drives the receptor through the nuclear pore complex.

171 Nup35 gene, which encodes a component of the nuclear pore complex.

172 ontaining nucleoporin proteins (Nups) within nuclear pore complexes (NPC).

173 Nuclear pore complexes (NPCs) allow selective import and

174 lasmic reticulum (ER), translocation through nuclear pore complexes (NPCs) and retention on nuclear p

175 ic systems such as Saccharomyces cerevisiae, nuclear pore complexes (NPCs) and the spindle pole body

176 eraction of non-chromosomal DNA circles with nuclear pore complexes (NPCs) and thereby promotes their

177 hp1:Sem1:Sus1:Cdc31 (TREX2) complex binds to nuclear pore complexes (NPCs) and, in addition to integr

178 Nuclear pore complexes (NPCs) are 110-megadalton assembl

179 Nuclear pore complexes (NPCs) are approximately 100 MDa

180 Nuclear pore complexes (NPCs) are composed of several co

181 Nuclear pore complexes (NPCs) are huge assemblies formed

182 Nuclear Pore Complexes (NPCs) are key cellular transport

183 long-term protein persistence, we found that nuclear pore complexes (NPCs) are maintained over a cell

184 Nuclear pore complexes (NPCs) are multiprotein channels

185 e nucleus, possibly due to delocalization of nuclear pore complexes (NPCs) at the nuclear envelope.

186 Nuclear pore complexes (NPCs) conduct massive transport

187 The transport channel of nuclear pore complexes (NPCs) contains a high density of

188 The permeability barrier of nuclear pore complexes (NPCs) controls bulk nucleocytopl

189 Transport through nuclear pore complexes (NPCs) during interphase is facil

190 of mitosis and modulates distribution of the nuclear pore complexes (NPCs) during mitotic NE expansio

191 Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs) embedded in the nuclear en

192 Nuclear pore complexes (NPCs) emerged as nuclear transpo

193 Nuclear pore complexes (NPCs) form a selective filter th

194 Nuclear pore complexes (NPCs) form gateways for material

195 Here we show that nuclear pore complexes (NPCs) in interphase cells also f

196 es can lead to an uneven distribution of the nuclear pore complexes (NPCs) in the interphase nuclear

197 Here, we have shown that during mitosis nuclear pore complexes (NPCs) in the mother nucleus are

198 Nuclear pore complexes (NPCs) influence gene expression

199 artmentalization by the nuclear envelope and nuclear pore complexes (NPCs) is essential for cell func

200 epletions suggest that translocation through nuclear pore complexes (NPCs) is rate-limiting and restr

201 Passive macromolecular diffusion through nuclear pore complexes (NPCs) is thought to decrease dra

202 cleus and cytoplasm, is tightly regulated by nuclear pore complexes (NPCs) made up of nucleoporins (N

203 Nuclear pore complexes (NPCs) mediate the exchange of ma

204 er RNA:protein complexes (mRNPs) through the nuclear pore complexes (NPCs) of eukaryotic cells.

205 Nuclear pore complexes (NPCs) perforate the nuclear enve

206 Chromatin and nuclear pore complexes (NPCs) undergo dramatic changes d

207 to p53-SUMO-1 and their accumulation in the nuclear pore complexes (NPCs), as well as their persiste

208 horylation-driven partial disassembly of the nuclear pore complexes (NPCs), increasing their permeabi

209 ucleocytoplasmic transport are maintained by nuclear pore complexes (NPCs), large structures composed

210 known as the constituent building blocks of nuclear pore complexes (NPCs), membrane-embedded channel

211 ucleocytoplasmic transport is facilitated by nuclear pore complexes (NPCs), which are massive protein

212 nuclei showed a round shape and presence of nuclear pore complexes (NPCs).

213 ar envelope, so Mad1 does not anchor them to nuclear pore complexes (NPCs).

214 when tRNA synthesis peaks, tDNAs localize at nuclear pore complexes (NPCs).

215 selective and efficient biomachines known as nuclear pore complexes (NPCs).

216 les and contribute to the quality control of nuclear pore complexes (NPCs); whether these processes a

217 vealing the octameric arrangement of Xenopus nuclear pore complexes and by quantifying the diffusion

218 istic step in Gle1's mRNA export function at nuclear pore complexes and directly implicate altered ex

219 compaction that facilitates movement through nuclear pore complexes and the length of transcript poly

220 Nuclear pore complexes are composed of approximately 30

221 Nuclear pore complexes are fundamental components of all

222 umulate in a storage of improperly assembled nuclear pore complexes compartment, or SINC.

223 rdered Phe-Gly nucleoporins (FG Nups) within nuclear pore complexes exert multivalent interactions wi

224 fission yeast, and surveillance of defective nuclear pore complexes in budding yeast.

225 that facilitate selective transport through nuclear pore complexes in eukaryotic cells.

226 entional fluorophores, we have imaged single nuclear pore complexes in the nuclear membrane and aggre

227 Recording nanobody-labeled nuclear pore complexes in Xenopus laevis cells showed th

228 Nuclear pore complexes tightly regulate nucleo-cytoplasm

229 ion of identical daughter nuclei by coupling nuclear pore complexes to the segregating chromosomes.

230 ants, and 3) transcripts being enriched near nuclear pore complexes when components of the mRNA expor

231 Tpr, a component of the NPCs (nuclear pore complexes), facilitates the formation of th

232 stration between fluorescently labeled mRNA, nuclear pore complexes, and chromatin, we obtained globa

233 The opening lacks nuclear lamina, nuclear pore complexes, and nuclear membrane, but it is

234 ddition to its well-defined interaction with nuclear pore complexes, here we find that Gle1 is enrich

235 lo-like kinase 1 (PLK-1) is recruited to the nuclear pore complexes, just prior to NEBD, through its

236 Beyond their role at nuclear pore complexes, some nucleoporins function in th

237 oscopy (AFM) to the nuclear envelope and the nuclear pore complexes, we demonstrate that disposition

238 al properties of the permeability barrier of nuclear pore complexes.

239 ery and requires Nup2, suggesting a role for nuclear pore complexes.

240 cient to ensure the even distribution of the nuclear pore complexes.

241 senger RNAs (mRNAs) to the cytoplasm through nuclear pore complexes.

242 mRNAs bound to the transport factor NXF1 to nuclear pore complexes.

243 of the AAL signal localizes in proximity to nuclear pore complexes.

244 air; neuron pruning; extraction of defective nuclear pore complexes; nuclear envelope reformation; pl

245 ins and exportins, Ran-GTP cycle regulators, nuclear pore components, and arginine methylases in medi

246 cipitation of NPP-13 and NPP-3, two integral nuclear pore components, and importin-beta IMB-1 provide

247 pecific transcription complexes and show how nuclear pore composition changes can be exploited to reg

248 e standards was demonstrated by showing that nuclear pores contain 32 copies of the Nup107 complex.

249 scission in response to lagging chromosomes, nuclear pore defects, and tension forces at the midbody.

250 echanosensing mechanism mediated directly by nuclear pores, demonstrated for YAP but with potential g

251 in mitotic prophase, significantly ahead of nuclear pore disassembly.

252 gh the cytoplasmic environment and dock with nuclear pores for transport of their genomes into the nu

253 the expression of multiple genes involved in nuclear pore formation and is required for nuclear impor

254 e identified SLP-76 as a direct regulator of nuclear pore function in T cells.

255 ur results demonstrate a requirement for the nuclear pore function of Sec13 in development of the ret

256 at proximity of transcribed chromatin to the nuclear pore helps restrain pathological R loops.

257 With the building blocks of nuclear pores identified, one challenge is to decipher h

258 ced the number of viral capsids reaching the nuclear pore if added at the time of viral entry and tha

259 After induction, colocalization with nuclear pores increased significantly at the promoter an

260 Knowing the configuration of the nuclear pore is essential for appreciating the underlyin

261 cells of sec13(sq198) failed to form proper nuclear pores, leading to a nuclear accumulation of tota

262 tor binding, rather than permeability of the nuclear pores, may be rate-limiting for nucleo-cytoplasm

263 envelope (NE) specifically during G2 via two nuclear pore-mediated mechanisms involving RanBP2-BicD2

264 high-resolution structure of the cytoplasmic nuclear pore-mRNA export holo-complex, challenging our t

265 Prior to export through the nuclear pore, mRNPs undergo several obligatory remodelin

266 us and exit it either by passing through the nuclear pores or by rupturing the nuclear envelope.

267 and reversed PRn-mediated enhancement of the nuclear pore permeability barrier.

268 y confirmed that the relocation of damage to nuclear pores plays an important role in a naturally occ

269 In this study, we show that the nuclear pore protein ALADIN is a novel spatial regulator

270 sential for the association of Rph1 with the nuclear pore protein Nup1.

271 triggering aberrant hyperphosphorylation of nuclear pore proteins (Nup).

272 Nuclear pore proteins (Nups) interact with chromosomes t

273 Our data suggest that integral nuclear pore proteins act to coordinate transcription an

274 Nuclear pore proteins at the base of cilia were thought

275 with the presence of a central condensate of nuclear pore proteins in the NPC channel.

276 t from its ability to lock the FG repeats of nuclear pore proteins in the polymerized state.

277 n HeLa cells, we detect cleavage of specific nuclear pore proteins known to be cleaved during poliovi

278 tained in the nucleoplasm, requires distinct nuclear pore proteins, and is regulated differently thro

279 e NPC and depends critically on unstructured nuclear pore proteins, and is therefore not well underst

280 rdered phenylalanine-glycine-rich repeats of nuclear pore proteins.

281 nal memory often relies on interactions with nuclear pore proteins.

282 ng (NCT) by inducing hyperphosphorylation of nuclear pore proteins.

283 signaling and programmed cell death require nuclear pore rearrangement and release of sequestered cy

284 leads to nuclear flattening, which stretches nuclear pores, reduces their mechanical resistance to mo

285 sm and regulation of Nup mobility on and off nuclear pores remain unclear.

286 e of nucleocytoplasmic transport through the nuclear pore, revealing a novel mechanism of neurodegene

287 paired nuclear import kinetics, although the nuclear pore-size exclusion barrier was maintained.

288 lates the nuclear entry rates of YAP/TAZ via nuclear pore stretching, clarifying how forces affect ge

289 ry mechanisms might control septal pores and nuclear pores such that they are opened and closed out o

290 n microscopy revealed capsids accumulated at nuclear pores that retained the viral genome for at leas

291 hey are also found in the central channel of nuclear pores, the nexus points of intermediate filament

292 FRAP studies revealed that, unlike at nuclear pores, the Y-complex shuttles into and out of GL

293 linking the ratio of constricted to dilated nuclear pores to cellular transport need.

294 by decreasing the mechanical restriction of nuclear pores to molecular transport.

295 t cold-stress responses, associates with the nuclear pores to regulate mRNA export, and regulates the

296 (Y-complex), a major scaffold module of the nuclear pore, together with its partner Elys, colocalize

297 Both restricted nuclear pore transit and upregulation of ACAD10 are requ

298 teins too large to passively diffuse through nuclear pores were readily imported into the nucleus thr

299 mutations caused a depletion of hGle1 at the nuclear pore where it carries out an essential role in n

300 nd both proteins localize to the nucleus and nuclear pores, where they interact with Tpr (translocate