ライフサイエンスコーパス: nuclear receptor

1 ) and transcription regulation (particularly nuclear receptors).

2 n induction of SREBP-1c requires LXRalpha, a nuclear receptor.

3 controlled by RORgammat, a ligand-regulated nuclear receptor.

4 from human enzymes, ion channels, GPCRs and nuclear receptors.

5 , but it also acts as a coactivator for some nuclear receptors.

6 hrough synergistic activation of RAR and RXR nuclear receptors.

7 at are enriched in motifs for unexpected non-nuclear receptors.

8 sm establishes a mechanism for modulation of nuclear receptors.

9 is a member of the "metabolic" subfamily of nuclear receptors.

10 m the transcriptional action of estrogens on nuclear receptors.

11 environmental sensing as a novel function of nuclear receptors.

12 oupled receptors, kinases, ion channels, and nuclear receptors.

13 ayer, alpha-helical ligand-binding domain of nuclear receptors.

14 Overexpression of the nuclear receptor 4A1 (NR4A1) in breast cancer patients i

15 We demonstrated previously that hepatocyte nuclear receptor-4alpha (HNF-4alpha) controls intestinal

16 udy, we elucidate a novel mechanism by which nuclear receptors act to enhance phagocytosis in the AD

17 el view of factors involved in mechanisms of nuclear receptor action and pathophysiology.

18 Liver X receptors (LXRs) alpha and beta are nuclear receptors activated by oxysterols that originate

19 s, we replicated several genes implicated in nuclear receptor activations, acute phase response pathw

20 to quantitatively screen for chemicals with nuclear receptor activity in environmental samples.

21 vated hepatic copper levels exhibit impaired nuclear receptor activity.

22 Importantly, in an ex vivo slice assay, nuclear receptor agonist treatment reversed the AD-relat

23 e shown that treatment of myeloid cells with nuclear receptor agonists increases expression of phagoc

24 egulates apoA-IV gene expression through its nuclear receptor alpha (ERalpha), which requires co-acti

25 FXR controls bile acid homeostasis, but both nuclear receptors also regulate numerous other metabolic

26 to function as a physiological ligand for a nuclear receptor and direct environmental sensing as a n

27 The glucocorticoid receptor (GR), a nuclear receptor and major drug target, has a highly con

28 ates at 15 concentrations against a panel of nuclear receptor and stress response pathway assays, pro

29 -related orphan receptor alpha (RORalpha), a nuclear receptor and transcription factor, is a novel tr

30 ts on cells expressing a coactivator and two nuclear receptors and applied heterospecies partition an

31 as NOR-1) is a member of the Nr4a family of nuclear receptors and is expressed in myeloid and lympho

32 Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leadin

33 Thyroid hormone binds to nuclear receptors and regulates gene transcription.

34 his Review, we describe the role of specific nuclear receptors and their coregulators in the dynamic

35 s conserved in the repressor class of orphan nuclear receptors, and mutations of corresponding residu

36 teins (GFPs), beta-lactamase inhibitors, and nuclear receptors, and we observed that the alteration o

37 NR4A family orphan nuclear receptors are an important class of transcriptio

38 Furthermore, nuclear receptors are encoded in the genomes of primitiv

39 Nuclear receptors are transcription factors that regulat

40 that implicates DAF-12 and potentially other nuclear receptors as novel anthelmintic targets.

41 Mediator binds to nuclear receptors at target response elements and recrui

42 Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2), is a tightly

43 Nuclear receptor-binding SET domain protein 2 (NSD2) is

44 tes in cortical chromatin, we show that this nuclear receptor binds both differentially expressed ene

45 ares structural similarity with noncanonical nuclear receptor box in AR-antagonizes AR transcriptiona

46 en histamine receptors and other membrane or nuclear receptors can be envisaged as a way to modulate

47 The nuclear receptor CAR (NR1I3) regulates hepatic drug and

48 or-activated receptor gamma (PPARgamma) is a nuclear receptor central to fatty acid and glucose homeo

49 Nuclear receptor co-activator peroxisome proliferator-ac

50 irectly facilitates its interaction with the nuclear receptor co-repressor (NCoR1), resulting in repr

51 Here we show that the specific deletion of nuclear receptor co-repressor 1 (NCoR1) in T cells cause

52 ROR-gamma recruits nuclear receptor coactivator 1 and 3 (NCOA1 and NCOA3, a

53 Increased reactivity toward nuclear receptor coactivator 2 was also observed in pati

54 NA-seq in human reticulocytes and identified nuclear receptor coactivator 4 (NCOA4) as a critical reg

55 the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the auto

56 ith higher affinity than to the coactivator, nuclear receptor coactivator-2 (Tif2), in coregulator pe

57 We recently reported that a nuclear receptor cofactor-glucocorticoid receptor (GR)-i

58 fferent coactivator activities to engage the nuclear receptor complex at different steps of transcrip

59 ling are context-dependent and influenced by nuclear receptor conformation, DNA sequence, and the exp

60 Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic re

61 se to exposure to xenobiotic agonists of the nuclear receptors constitutive androstane receptor (CAR)

62 Nr4a nuclear receptors contribute to long-term memory formati

63 and global liver metabolic dysfunction, with nuclear receptor-controlled cholesterol/bile acid and xe

64 s reveal a novel role of AEG-1 in regulating nuclear receptors controlling lipid metabolism.

65 etinoic acid (RA), which through ligation of nuclear receptors controls transcriptional expression of

66 RERE is a widely-expressed nuclear receptor coregulator that positively regulates r

67 irect DNA binding of the receptor along with nuclear receptor corepressor (NCoR) and silencing mediat

68 the interaction of the MeCP2 with DNA or the nuclear receptor corepressor (NCoR)/silencing mediator o

69 acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor 1 (N-CoR) that accumulated

70 Moreover, targeted inhibition of BCL6/nuclear receptor corepressor 1 (NCoR) complex by peptido

71 ember 1 (Rev-Erbalpha) with its cosuppressor nuclear receptor corepressor 1 (NCOR).

72 study, we report that deletion of intestinal nuclear receptor corepressor 1 (NCoR1) completely dimini

73 which heme binding to Rev-erbalpha recruits nuclear receptor corepressor 1 (NCoR1) into an active re

74 Nuclear receptor corepressor 1 (NCoR1) is considered to

75 The nuclear receptor corepressor 1 (NCOR1) was reported to m

76 ely ablated in skin keratinocytes for either nuclear receptor corepressor 1 (NCoR1)/silencing mediato

77 ant mice and in mice ablated selectively for nuclear receptor corepressor 1 (NCoR1)/silencing mediato

78 tes the complex mediator of transcription 13/nuclear receptor corepressor 1 axis, which in turn promo

79 Knockdown of nuclear receptor corepressor 1 in primary male T cells a

80 nd the nuclear receptor-interacting protein, nuclear receptor corepressor 1, to specific cis-regulato

81 creased the interaction between TR-alpha and nuclear receptor corepressor 2 (NCOR2) and suppressed Pl

82 RF7 promoter region through interaction with nuclear receptor corepressor 2/histone deacetylase 3 for

83 via downregulation of the tumor-suppressive nuclear receptor corepressor NCOR1.

84 iptional activity through the recruitment of nuclear receptor corepressor protein and silencing media

85 NCoR1 (nuclear receptor corepressor) and SMRT (silencing mediat

86 d the formation of a functional complex with nuclear receptor corepressors (NCORs) were critical in r

87 e effects of SUMOylation on other classes of nuclear receptors, dexamethasone (Dex)-induced trans-rep

88 these data demonstrate that copper-mediated nuclear receptor dysfunction disrupts liver function in

89 n can regulate transcription by binding to 2 nuclear receptors, ERalpha and ERbeta, which differentia

90 d receptor-gamma co-activator-1beta) and the nuclear receptor ERRalpha (estrogen receptor-related rec

91 g process, we show that the estrogen-related nuclear receptors (ERRalpha and ERRgamma) and their part

92 The orphan nuclear receptor estrogen-related receptor alpha (ERRalp

93 e cardiac muscle system, we demonstrate that nuclear receptors estrogen-related receptor alpha (ERRal

94 Finally, we determined that the orphan nuclear receptor, estrogen related receptor alpha (ERRal

95 e transcriptional activity of their liganded nuclear receptors, estrogens, such as estradiol (E2), mo

96 As a member of the nuclear receptor family of ligand-dependent transcriptio

97 Nur77 is an orphan member of the nuclear receptor family that lacks a BH3 domain but neve

98 rs through COUP-TFII, a member of the orphan nuclear receptors family.

99 lso as signaling molecules that activate the nuclear receptor farnesoid X receptor (FXR).

100 Nuclear receptors farnesoid X receptor (FXR) and small h

101 dipose tissue binding sites for PPARgamma, a nuclear receptor for anti-diabetic drugs.

102 The nuclear receptor FXR (farnesoid X receptor), a multiple

103 such aberrantly elevated acetylation of the nuclear receptor FXR as a model.

104 vate the transmembrane receptor TGR5 and the nuclear receptor FXR.

105 al animals and reveal opposing roles for the nuclear receptors FXR and CAR in disease progression fro

106 Here, we found decreased binding of the nuclear receptors FXR, RXR, HNF4alpha, and LRH-1 to prom

107 Despite increased hepatic nuclear receptors (FXR, CAR, SHP), and FGF19, neither CY

108 m of human peroxisome proliferator-activated nuclear receptor gamma (PPARgamma1) was recently observe

109 for human peroxisome proliferator-activated nuclear receptor gamma (PPARgamma1).

110 factor Retineic acid receptor-related orphan nuclear receptor gamma (RORgammat) and Forkhead box prot

111 orm of retinoic acid receptor-related orphan nuclear receptor gamma (RORgammat) antagonists suppressi

112 Retinoid-related orphan nuclear receptor gamma t (RORgammat) is required for Th1

113 w that retinoic acid receptor-related orphan nuclear receptor gamma t (RORgammat)-dependent effector

114 rneurons (INs) expressing the RORbeta orphan nuclear receptor gate sensory feedback to the spinal mot

115 concept for personalized medicine related to nuclear receptor genomic occupancy.

116 s well-known therapeutic targets in mammals, nuclear receptors have begun to be studied in parasitic

117 Despite intensive efforts, most nuclear receptors have no known ligand, suggesting new l

118 ed in Daphnia by the interaction between the nuclear receptor heterodimer EcR:RXR and MfR.

119 e we describe a novel Caenorhabditis elegans nuclear receptor, HIZR-1, that is a high zinc sensor in

120 Meanwhile, research on nuclear receptor hormones has led to the development of

121 GFAP mRNA expression is regulated by several nuclear-receptor hormones, growth factors, and lipopolys

122 This novel mechanism in which a nuclear receptor impinges on a signaling pathway by co-o

123 scular pleiotropic effects by activating its nuclear receptor in cardiomyocytes and vascular endothel

124 and >200-fold selectivity over 25 additional nuclear receptors in a cell assay panel.

125 tes the expression of NR4A1, 2, and 3 orphan nuclear receptors in myeloid cells, and this modulation

126 Here, we identify roles of Rev-erb nuclear receptors in regulating responses of mouse macro

127 tastatic process and establish lipid-sensing nuclear receptors in the microenvironmental regulation o

128 y germ cell nuclear factor (GCNF), an orphan nuclear receptor, in hES cells.

129 s) have been shown to activate or inactivate nuclear receptors, including Nurr1, in cancer cells and

130 Some nuclear receptors, including peroxisome proliferator-act

131 these pathogenic processes are regulated by nuclear receptors, including the liver X receptors (LXRs

132 ption as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator

133 We previously showed that Nur77, an orphan nuclear receptor, induces apoptosis by targeting mitocho

134 ting mutation (c.279delG, p.Trp93fs*) of the nuclear receptor interacting protein 1 gene (NRIP1) in a

135 Furthermore, disruption of the LXXLL nuclear receptor-interacting motif present in ACTN4 resu

136 induced the recruitment of PPARalpha and the nuclear receptor-interacting protein, nuclear receptor c

137 es suggested that differential expression of nuclear receptors involved in adipogenesis underlie the

138 One such nuclear receptor is DAF-12, which is required for normal

139 (PXR, NR1I2), a member of the superfamily of nuclear receptors, is a transcription factor governing t

140 Primary HSCs were treated with nuclear receptor ligands, transfected with small interfe

141 The nuclear receptor liver receptor homolog 1 (LRH-1) is an

142 The orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2)

143 nt evidence points to a central role for the nuclear receptor liver receptor homolog-1 (LRH-1) in int

144 are unusual signaling hormones sensed by the nuclear receptor liver receptor homolog-1 (LRH-1), which

145 The nuclear receptor liver-X-receptor (LXR) directly regulat

146 The nuclear receptor LXR is necessary for Srebf-1c transcrip

147 ating intracellular cholesterol homeostasis, nuclear receptor LXR-alpha was up-regulated significantl

148 Agonists of nuclear receptors LXR:RXR and PPAR:RXR act to ameliorate

149 Fos decreases expression and activity of the nuclear receptor LXRalpha, leading to increased hepatic

150 ment, and cell signaling via two pathways: a nuclear receptor mechanism and genome-independent signal

151 Among all the nuclear-receptor mediated endocrine disruptive effects,

152 endent prostate cancer growth by suppressing nuclear receptor-mediated oxidative stress.

153 Here the authors show that the nuclear receptor NCoR1 suppresses Bim1 to inhibit negati

154 We show that the nuclear receptor nhr-67/tlx directs the AC into G1 arres

155 7 deficiency, deletion of the highly related nuclear receptor NOR1 (Nr4a3) had minimal effect on musc

156 ; NCoR2) are well-recognized coregulators of nuclear receptor (NR) action.

157 However, the nuclear receptor (NR) binding partner of RXR-gamma has n

158 Understanding the nature of allostery in DNA-nuclear receptor (NR) complexes is of fundamental import

159 Following the first isolation of nuclear receptor (NR) genes, genetic disorders caused by

160 nd allosteric communications in multi-domain nuclear receptor (NR) polypeptides has remained challeng

161 Nuclear receptor (NR) signaling pathways impact cellular

162 Members of the nuclear receptor (NR) superfamily of ligand-regulated tr

163 critical for biological functions, including nuclear receptor (NR)-regulated transcription.

164 to form domain-domain interactions with DBDs.Nuclear receptors (NR) are multidomain proteins, which m

165 Phosphatidic acid (PA) or Nuclear Receptors (NR) PPARalpha/RXRalpha/LXRalpha, enha

166 ev-erbalpha and Rev-erbbeta are heme-binding nuclear receptors (NR) that repress the transcription of

167 A mutation in a nuclear receptor (NR1H3) gene was detected in a familial

168 The nuclear receptor NR2E1 (also known as TLX or tailless) c

169 xpression of phagocytosis receptor Mertk and nuclear receptor Nr4a1 in cardiac macrophages, the latte

170 this study, we report overexpression of the nuclear receptor NR4A1 in rhabdomyosarcomas that is suff

171 The orphan nuclear receptor Nr4a2 is known to modulate both inflamm

172 we observed significant coexpression of six nuclear receptors (NRs) [androgen receptor (Ar), estroge

173 Various synthetic chemicals are ligands for nuclear receptors (NRs) and can cause adverse effects in

174 Nuclear receptors (NRs) are critically involved in the r

175 A subset of nuclear receptors (NRs) function as obligate heterodimer

176 Nuclear receptors (NRs) have historically been at the fo

177 Nuclear receptors (NRs) sense changing levels of nutrien

178 Atp7b(-/-) mice identified dysregulation of nuclear receptors (NRs), especially the liver X receptor

179 This fine-tuning is controlled by the nuclear receptors (NRs), liver receptor homolog-1 (LRH-1

180 We previously showed that the orphan nuclear receptor Nur77 (Nr4a1) plays an important role i

181 over a novel and critical role of the orphan nuclear receptor Nur77 in mediating an NFATc1 self-limit

182 Nuclear receptor Nur77 plays a pivotal role in distinct

183 The orphan nuclear receptor Nur77 plays critical roles in cardiovas

184 horylated Spleen tyrosine kinase (pSyk), and nuclear receptor Nur77.

185 abolism in skeletal muscle by inhibiting the nuclear receptor NURR1 and the MEF2 transcription factor

186 The nuclear receptor Nurr1 can be activated by RXR via heter

187 ing to the glucocorticoid receptor (GR), the nuclear receptor of endogenous cortisol.

188 g the main biological process, and canonical nuclear receptor pathways as their potential mediators.

189 ng the main biological process and canonical nuclear receptor pathways as their potential mediators.

190 The nuclear receptor peroxisome proliferator activated recep

191 The nuclear receptor peroxisome proliferator-activated recep

192 show that insulin restored expression of the nuclear receptor peroxisome proliferator-activated recep

193 The nuclear receptor peroxisome proliferator-activated recep

194 tic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated recep

195 lly regulates and interacts with the hepatic nuclear receptors peroxisome proliferator-activated rece

196 dence has linked photoreceptor cell-specific nuclear receptor (PNR/NR2E3), an orphan nuclear hormone

197 lipase (ATGL) increases the activity of the nuclear receptor PPAR-alpha, a PGC-1alpha binding partne

198 The nuclear receptor PPAR-beta/delta (PPARD) has essential r

199 es are insulin sensitizers that activate the nuclear receptor PPAR-gamma and have been shown to parti

200 PA induces a conformational change in the nuclear receptor PPARalpha (increase of alpha-helices at

201 27 is a direct transcriptional target of the nuclear receptor PPARalpha (peroxisome proliferator-acti

202 This stimulates overexpression of the nuclear receptor PPARalpha and nuclear translocation of

203 The nuclear receptors PPARalpha (encoded by NR1C1) and farne

204 nge the presumption that the function of the nuclear receptor PPARbeta/delta in cancer is dictated by

205 Nuclear receptor PPARgamma has been proven to affect met

206 oblast growth factor 1 (FGF1) as a target of nuclear receptor PPARgamma in visceral adipose tissue an

207 The PPARG gene encoding the nuclear receptor PPARgamma is activated in bladder cance

208 racellular domain of Lrp1 interacts with the nuclear receptor Ppargamma, a central regulator of lipid

209 of murine models of AD with agonists of the nuclear receptors PPARgamma, PPARdelta, LXR, and RXR sti

210 In this study, we investigated the role of nuclear receptor, pregnane X receptor (PXR), in M. tuber

211 as it is exported out of the nucleus by the nuclear receptor protein crm-1.

212 Accumulation of PIP3 in complex with the nuclear receptor protein, SF1, at damage sites requires

213 paper, we reported the cloning of the human nuclear receptor PXR and demonstrated that it mediates C

214 Thus, our study suggests that nuclear receptor RARgamma provides a key checkpoint for

215 Nuclear receptors recruit multiple coactivators sequenti

216 wo decades ago, the mechanisms by which this nuclear receptor regulates glucose homeostasis remain un

217 These data demonstrate that besides nuclear receptor regulation, DC-SCRIPT also modulates ac

218 at the promoters, and that decreased NURR1 (nuclear receptor related-1) expression also contributed

219 Here we report that Nuclear receptor-related 1 (Nurr1):Retinoid X receptor a

220 Here, the authors show that the nuclear receptor retinoic acid receptor gamma is release

221 The nuclear receptor retinoid acid receptor-related orphan r

222 rising residues Gln275, Arg316 and Arg371 in nuclear receptor retinoid X receptor alpha (RXRalpha), w

223 usly reported that selective ablation of the nuclear receptors retinoid X receptor (RXR)-alpha and RX

224 The nuclear receptor REV-ERB suppresses myoblast differentia

225 ssue, but not in liver, are modulated by the nuclear receptor Rev-erbalpha, a potent transcriptional

226 of these genes are targets of the circadian nuclear receptor Rev-erbalpha, and binding of Rev-erbalp

227 We recently reported that the circadian nuclear receptor REV-ERBbeta plays an unexpected role in

228 uss and colleagues describe the roles of the nuclear receptor ROR1C in the regulation of MDSC differe

229 ere we show that liver-specific depletion of nuclear receptors RORalpha and RORgamma, key components

230 The orphan nuclear receptor RORgamma is a key regulator for T helpe

231 ry of a novel allosteric binding site on the nuclear receptor RORgammat.

232 7A and retinoic acid receptor-related orphan nuclear receptor, RORgammat encoded by Rorc, by acting a

233 The use of an agonist to the nuclear receptor RXR, bexarotene, as monotherapy against

234 PK/PI3K compared to JAK/STAT with the orphan nuclear receptor RXRalpha playing a central role in medi

235 Inhibiting the nuclear receptor's activity using a chemical antagonist

236 A subset of cardiac-enriched nuclear receptors serve to match mitochondrial fuel pref

237 Nuclear receptor SET domain containing protein 2 (NSD2)

238 receptor (RXR) and farnesoid X receptor/RXR nuclear receptor signaling among pleiotropic genes and f

239 Substantial evidence indicates that nuclear receptor signaling is integral to dynamic change

240 eration of the gut microbiota, modulation of nuclear receptor signaling, and disruption of host metab

241 to modulate podocyte glucocorticoid-mediated nuclear receptor signaling.

242 nd as a precursor for steroids that activate nuclear receptor signaling.

243 thogenic molecular pathways elicited by this nuclear receptor.Significance: These findings challenge

244 rnal plasma triglyceride fluctuation through nuclear receptor small heterodimer partner (Shp; Nr0b2).

245 The unusual orphan nuclear receptor, small heterodimer partner (SHP), acts

246 An orphan nuclear receptor, Small Heterodimer Partner (SHP), plays

247 ypically exhibit characterized activities of nuclear receptors, some of which (PPARalpha, LXRbeta) re

248 dafachronic acid, an agonist of the parasite nuclear receptor Ss-DAF-12, significantly reduced the wo

249 The nuclear receptor steroidogenic factor 1 (Sf1, Nr5a1, Ad4

250 Our findings highlight that nuclear receptor structure and function are dictated by

251 nvestigated whether the core clock component nuclear receptor subfamily 1 group D member 1 (NR1D1, al

252 me-mediated regulation of the interaction of nuclear receptor subfamily 1 group d member 1 (Rev-Erbal

253 BACKGROUND & AIMS: The nuclear receptor subfamily 1 group H member 4 (NR1H4 or

254 tivation of expression of the PCC components nuclear receptor subfamily 1, group D, member 1 (Nr1d1/R

255 The nuclear receptor subfamily 1, group H, members 2 and 3 (

256 ent increases mRNA and protein expression of nuclear receptor subfamily 2 group F member 6, whereas t

257 TC1-dependent transcription of c-fos and the nuclear receptor subfamily 4 (Nr4a) genes Nr4a1-3 in the

258 ns encoded by Tsp signature genes, including nuclear receptor subfamily 4 group A member 1 (NR4A1) an

259 Nuclear receptor subfamily 4 group A member 2 (NR4A2) is

260 eric association with several members of the nuclear receptor superfamily, including the human vitami

261 Unique among the nuclear receptor superfamily, the glucocorticoid (GC) re

262 cocorticoid receptor (GR) is a member of the nuclear receptor superfamily, which controls programs re

263 ralocorticoid receptor (MR), a member of the nuclear receptor superfamily.

264 humans, leading to the identification of the nuclear receptor superfamily.

265 vated transcription factor and member of the nuclear receptor superfamily.

266 se elements and decreased mRNA expression of nuclear receptor target genes in Atp7b(-)/(-) mice, as w

267 The farnesoid X receptor (FXR) is a nuclear receptor that acts as a master regulator of bile

268 eceptor-related receptor alpha (ERRalpha), a nuclear receptor that cooperates with the transcription

269 n pregnane X receptor (PXR) is a promiscuous nuclear receptor that functions as a sensor to a wide va

270 er receptor homologue 1 (LRH-1) is an orphan nuclear receptor that has been implicated in the progres

271 mily 4 group A member 2 (NR4A2) is an orphan nuclear receptor that is over-expressed in cancer and pr

272 rodimer partner (SHP) (NR0B2) is an atypical nuclear receptor that lacks a DNA-binding domain.

273 eceptor (PXR, NR1I2) is a xenobiotic-sensing nuclear receptor that modulates the metabolic response t

274 te the glucocorticoid receptor, a ubiquitous nuclear receptor that not only causes widespread changes

275 n receptor C (RORc, RORgamma, or NR1F3) is a nuclear receptor that plays a major role in the producti

276 pal among these is NR0B1, an atypical orphan nuclear receptor that we show engages in a multimeric pr

277 We studied nuclear receptors that mediate oscillatory control of ho

278 er X receptors (LXR) are oxysterol-activated nuclear receptors that play a central role in reverse ch

279 atory heterodimerization partner for several nuclear receptors that regulate drug and lipid metabolis

280 y, we identify the regulatory cascade of the nuclear receptor TLX and the DNA hydroxylase Ten eleven

281 We show here that the nuclear receptor TLX, an essential regulator of NSC prol

282 demonstrate that MVI directly interacts with nuclear receptors to drive expression of target genes, t

283 that these receptors exist and function with nuclear receptors to provide the full impact of all ster

284 e show that fusing ligand-binding domains of nuclear receptors to split Cas9 protein fragments can pr

285 tly, we were the first to report that orphan nuclear receptor TR3/Nur77 is a critical mediator of ang

286 that deletion in mice of the thyroid hormone nuclear receptors TRalpha1 and TRbeta (the main thyroid

287 Steroid nuclear receptor trans-effects on inflammatory signaling

288 the liver X receptors (LXRs), members of the nuclear receptor transcription factor family.

289 actor 4 (HNF4) is the most ancient family of nuclear receptor transcription factors with important ro

290 e of dietary vitamin A, acts as a ligand for nuclear receptor transcription factors with more than 50

291 which competitive recruitment of DNA-binding nuclear receptors/transcription factors in trans to hot

292 NRIP1 encodes a nuclear receptor transcriptional cofactor that directly

293 ed glucocorticoid signaling due to increased nuclear receptor translocation, activating glucocorticoi

294 riiodothyronine (T3), through binding to its nuclear receptors (TRs), is able to antagonize transcrip

295 hormone (TH) due to its high affinity for TH nuclear receptors (TRs), new data suggest that 3,5-diiod

296 The nuclear receptor unfulfilled (unf) represents a regulato

297 tor-activated receptor (PPAR)-delta, a lipid nuclear receptor, up-regulates IL-6.

298 he last decade of the twentieth century, two nuclear receptors were discovered in our laboratory and,

299 Nuclear receptors were originally defined as endocrine s

300 ptor-gamma (PPARgamma) is a ligand-activated nuclear receptor which controls lipid and glucose metabo

301 ctivation function 1 (AF-1) in a full-length nuclear receptor, which supports a role for AF-1 in SRC-