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1 ) and transcription regulation (particularly nuclear receptors).
2 n induction of SREBP-1c requires LXRalpha, a nuclear receptor.
3 controlled by RORgammat, a ligand-regulated nuclear receptor.
4 from human enzymes, ion channels, GPCRs and nuclear receptors.
5 , but it also acts as a coactivator for some nuclear receptors.
6 hrough synergistic activation of RAR and RXR nuclear receptors.
7 at are enriched in motifs for unexpected non-nuclear receptors.
8 sm establishes a mechanism for modulation of nuclear receptors.
9 is a member of the "metabolic" subfamily of nuclear receptors.
10 m the transcriptional action of estrogens on nuclear receptors.
11 environmental sensing as a novel function of nuclear receptors.
12 oupled receptors, kinases, ion channels, and nuclear receptors.
13 ayer, alpha-helical ligand-binding domain of nuclear receptors.
15 We demonstrated previously that hepatocyte nuclear receptor-4alpha (HNF-4alpha) controls intestinal
16 udy, we elucidate a novel mechanism by which nuclear receptors act to enhance phagocytosis in the AD
18 Liver X receptors (LXRs) alpha and beta are nuclear receptors activated by oxysterols that originate
19 s, we replicated several genes implicated in nuclear receptor activations, acute phase response pathw
23 e shown that treatment of myeloid cells with nuclear receptor agonists increases expression of phagoc
24 egulates apoA-IV gene expression through its nuclear receptor alpha (ERalpha), which requires co-acti
25 FXR controls bile acid homeostasis, but both nuclear receptors also regulate numerous other metabolic
26 to function as a physiological ligand for a nuclear receptor and direct environmental sensing as a n
28 ates at 15 concentrations against a panel of nuclear receptor and stress response pathway assays, pro
29 -related orphan receptor alpha (RORalpha), a nuclear receptor and transcription factor, is a novel tr
30 ts on cells expressing a coactivator and two nuclear receptors and applied heterospecies partition an
31 as NOR-1) is a member of the Nr4a family of nuclear receptors and is expressed in myeloid and lympho
32 Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leadin
34 his Review, we describe the role of specific nuclear receptors and their coregulators in the dynamic
35 s conserved in the repressor class of orphan nuclear receptors, and mutations of corresponding residu
36 teins (GFPs), beta-lactamase inhibitors, and nuclear receptors, and we observed that the alteration o
42 Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2), is a tightly
44 tes in cortical chromatin, we show that this nuclear receptor binds both differentially expressed ene
45 ares structural similarity with noncanonical nuclear receptor box in AR-antagonizes AR transcriptiona
46 en histamine receptors and other membrane or nuclear receptors can be envisaged as a way to modulate
48 or-activated receptor gamma (PPARgamma) is a nuclear receptor central to fatty acid and glucose homeo
50 irectly facilitates its interaction with the nuclear receptor co-repressor (NCoR1), resulting in repr
51 Here we show that the specific deletion of nuclear receptor co-repressor 1 (NCoR1) in T cells cause
54 NA-seq in human reticulocytes and identified nuclear receptor coactivator 4 (NCOA4) as a critical reg
55 the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the auto
56 ith higher affinity than to the coactivator, nuclear receptor coactivator-2 (Tif2), in coregulator pe
58 fferent coactivator activities to engage the nuclear receptor complex at different steps of transcrip
59 ling are context-dependent and influenced by nuclear receptor conformation, DNA sequence, and the exp
61 se to exposure to xenobiotic agonists of the nuclear receptors constitutive androstane receptor (CAR)
63 and global liver metabolic dysfunction, with nuclear receptor-controlled cholesterol/bile acid and xe
65 etinoic acid (RA), which through ligation of nuclear receptors controls transcriptional expression of
67 irect DNA binding of the receptor along with nuclear receptor corepressor (NCoR) and silencing mediat
68 the interaction of the MeCP2 with DNA or the nuclear receptor corepressor (NCoR)/silencing mediator o
69 acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor 1 (N-CoR) that accumulated
72 study, we report that deletion of intestinal nuclear receptor corepressor 1 (NCoR1) completely dimini
73 which heme binding to Rev-erbalpha recruits nuclear receptor corepressor 1 (NCoR1) into an active re
76 ely ablated in skin keratinocytes for either nuclear receptor corepressor 1 (NCoR1)/silencing mediato
77 ant mice and in mice ablated selectively for nuclear receptor corepressor 1 (NCoR1)/silencing mediato
78 tes the complex mediator of transcription 13/nuclear receptor corepressor 1 axis, which in turn promo
80 nd the nuclear receptor-interacting protein, nuclear receptor corepressor 1, to specific cis-regulato
81 creased the interaction between TR-alpha and nuclear receptor corepressor 2 (NCOR2) and suppressed Pl
82 RF7 promoter region through interaction with nuclear receptor corepressor 2/histone deacetylase 3 for
84 iptional activity through the recruitment of nuclear receptor corepressor protein and silencing media
86 d the formation of a functional complex with nuclear receptor corepressors (NCORs) were critical in r
87 e effects of SUMOylation on other classes of nuclear receptors, dexamethasone (Dex)-induced trans-rep
88 these data demonstrate that copper-mediated nuclear receptor dysfunction disrupts liver function in
89 n can regulate transcription by binding to 2 nuclear receptors, ERalpha and ERbeta, which differentia
90 d receptor-gamma co-activator-1beta) and the nuclear receptor ERRalpha (estrogen receptor-related rec
91 g process, we show that the estrogen-related nuclear receptors (ERRalpha and ERRgamma) and their part
93 e cardiac muscle system, we demonstrate that nuclear receptors estrogen-related receptor alpha (ERRal
95 e transcriptional activity of their liganded nuclear receptors, estrogens, such as estradiol (E2), mo
105 al animals and reveal opposing roles for the nuclear receptors FXR and CAR in disease progression fro
106 Here, we found decreased binding of the nuclear receptors FXR, RXR, HNF4alpha, and LRH-1 to prom
108 m of human peroxisome proliferator-activated nuclear receptor gamma (PPARgamma1) was recently observe
110 factor Retineic acid receptor-related orphan nuclear receptor gamma (RORgammat) and Forkhead box prot
111 orm of retinoic acid receptor-related orphan nuclear receptor gamma (RORgammat) antagonists suppressi
113 w that retinoic acid receptor-related orphan nuclear receptor gamma t (RORgammat)-dependent effector
114 rneurons (INs) expressing the RORbeta orphan nuclear receptor gate sensory feedback to the spinal mot
116 s well-known therapeutic targets in mammals, nuclear receptors have begun to be studied in parasitic
119 e we describe a novel Caenorhabditis elegans nuclear receptor, HIZR-1, that is a high zinc sensor in
121 GFAP mRNA expression is regulated by several nuclear-receptor hormones, growth factors, and lipopolys
123 scular pleiotropic effects by activating its nuclear receptor in cardiomyocytes and vascular endothel
125 tes the expression of NR4A1, 2, and 3 orphan nuclear receptors in myeloid cells, and this modulation
127 tastatic process and establish lipid-sensing nuclear receptors in the microenvironmental regulation o
129 s) have been shown to activate or inactivate nuclear receptors, including Nurr1, in cancer cells and
131 these pathogenic processes are regulated by nuclear receptors, including the liver X receptors (LXRs
132 ption as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator
133 We previously showed that Nur77, an orphan nuclear receptor, induces apoptosis by targeting mitocho
134 ting mutation (c.279delG, p.Trp93fs*) of the nuclear receptor interacting protein 1 gene (NRIP1) in a
136 induced the recruitment of PPARalpha and the nuclear receptor-interacting protein, nuclear receptor c
137 es suggested that differential expression of nuclear receptors involved in adipogenesis underlie the
139 (PXR, NR1I2), a member of the superfamily of nuclear receptors, is a transcription factor governing t
143 nt evidence points to a central role for the nuclear receptor liver receptor homolog-1 (LRH-1) in int
144 are unusual signaling hormones sensed by the nuclear receptor liver receptor homolog-1 (LRH-1), which
147 ating intracellular cholesterol homeostasis, nuclear receptor LXR-alpha was up-regulated significantl
149 Fos decreases expression and activity of the nuclear receptor LXRalpha, leading to increased hepatic
150 ment, and cell signaling via two pathways: a nuclear receptor mechanism and genome-independent signal
155 7 deficiency, deletion of the highly related nuclear receptor NOR1 (Nr4a3) had minimal effect on musc
158 Understanding the nature of allostery in DNA-nuclear receptor (NR) complexes is of fundamental import
160 nd allosteric communications in multi-domain nuclear receptor (NR) polypeptides has remained challeng
164 to form domain-domain interactions with DBDs.Nuclear receptors (NR) are multidomain proteins, which m
166 ev-erbalpha and Rev-erbbeta are heme-binding nuclear receptors (NR) that repress the transcription of
169 xpression of phagocytosis receptor Mertk and nuclear receptor Nr4a1 in cardiac macrophages, the latte
170 this study, we report overexpression of the nuclear receptor NR4A1 in rhabdomyosarcomas that is suff
172 we observed significant coexpression of six nuclear receptors (NRs) [androgen receptor (Ar), estroge
173 Various synthetic chemicals are ligands for nuclear receptors (NRs) and can cause adverse effects in
178 Atp7b(-/-) mice identified dysregulation of nuclear receptors (NRs), especially the liver X receptor
181 over a novel and critical role of the orphan nuclear receptor Nur77 in mediating an NFATc1 self-limit
185 abolism in skeletal muscle by inhibiting the nuclear receptor NURR1 and the MEF2 transcription factor
188 g the main biological process, and canonical nuclear receptor pathways as their potential mediators.
189 ng the main biological process and canonical nuclear receptor pathways as their potential mediators.
192 show that insulin restored expression of the nuclear receptor peroxisome proliferator-activated recep
194 tic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated recep
195 lly regulates and interacts with the hepatic nuclear receptors peroxisome proliferator-activated rece
196 dence has linked photoreceptor cell-specific nuclear receptor (PNR/NR2E3), an orphan nuclear hormone
197 lipase (ATGL) increases the activity of the nuclear receptor PPAR-alpha, a PGC-1alpha binding partne
199 es are insulin sensitizers that activate the nuclear receptor PPAR-gamma and have been shown to parti
200 PA induces a conformational change in the nuclear receptor PPARalpha (increase of alpha-helices at
201 27 is a direct transcriptional target of the nuclear receptor PPARalpha (peroxisome proliferator-acti
204 nge the presumption that the function of the nuclear receptor PPARbeta/delta in cancer is dictated by
206 oblast growth factor 1 (FGF1) as a target of nuclear receptor PPARgamma in visceral adipose tissue an
208 racellular domain of Lrp1 interacts with the nuclear receptor Ppargamma, a central regulator of lipid
209 of murine models of AD with agonists of the nuclear receptors PPARgamma, PPARdelta, LXR, and RXR sti
210 In this study, we investigated the role of nuclear receptor, pregnane X receptor (PXR), in M. tuber
212 Accumulation of PIP3 in complex with the nuclear receptor protein, SF1, at damage sites requires
213 paper, we reported the cloning of the human nuclear receptor PXR and demonstrated that it mediates C
216 wo decades ago, the mechanisms by which this nuclear receptor regulates glucose homeostasis remain un
218 at the promoters, and that decreased NURR1 (nuclear receptor related-1) expression also contributed
222 rising residues Gln275, Arg316 and Arg371 in nuclear receptor retinoid X receptor alpha (RXRalpha), w
223 usly reported that selective ablation of the nuclear receptors retinoid X receptor (RXR)-alpha and RX
225 ssue, but not in liver, are modulated by the nuclear receptor Rev-erbalpha, a potent transcriptional
226 of these genes are targets of the circadian nuclear receptor Rev-erbalpha, and binding of Rev-erbalp
227 We recently reported that the circadian nuclear receptor REV-ERBbeta plays an unexpected role in
228 uss and colleagues describe the roles of the nuclear receptor ROR1C in the regulation of MDSC differe
229 ere we show that liver-specific depletion of nuclear receptors RORalpha and RORgamma, key components
232 7A and retinoic acid receptor-related orphan nuclear receptor, RORgammat encoded by Rorc, by acting a
234 PK/PI3K compared to JAK/STAT with the orphan nuclear receptor RXRalpha playing a central role in medi
238 receptor (RXR) and farnesoid X receptor/RXR nuclear receptor signaling among pleiotropic genes and f
240 eration of the gut microbiota, modulation of nuclear receptor signaling, and disruption of host metab
243 thogenic molecular pathways elicited by this nuclear receptor.Significance: These findings challenge
244 rnal plasma triglyceride fluctuation through nuclear receptor small heterodimer partner (Shp; Nr0b2).
247 ypically exhibit characterized activities of nuclear receptors, some of which (PPARalpha, LXRbeta) re
248 dafachronic acid, an agonist of the parasite nuclear receptor Ss-DAF-12, significantly reduced the wo
251 nvestigated whether the core clock component nuclear receptor subfamily 1 group D member 1 (NR1D1, al
252 me-mediated regulation of the interaction of nuclear receptor subfamily 1 group d member 1 (Rev-Erbal
254 tivation of expression of the PCC components nuclear receptor subfamily 1, group D, member 1 (Nr1d1/R
256 ent increases mRNA and protein expression of nuclear receptor subfamily 2 group F member 6, whereas t
257 TC1-dependent transcription of c-fos and the nuclear receptor subfamily 4 (Nr4a) genes Nr4a1-3 in the
258 ns encoded by Tsp signature genes, including nuclear receptor subfamily 4 group A member 1 (NR4A1) an
260 eric association with several members of the nuclear receptor superfamily, including the human vitami
262 cocorticoid receptor (GR) is a member of the nuclear receptor superfamily, which controls programs re
266 se elements and decreased mRNA expression of nuclear receptor target genes in Atp7b(-)/(-) mice, as w
268 eceptor-related receptor alpha (ERRalpha), a nuclear receptor that cooperates with the transcription
269 n pregnane X receptor (PXR) is a promiscuous nuclear receptor that functions as a sensor to a wide va
270 er receptor homologue 1 (LRH-1) is an orphan nuclear receptor that has been implicated in the progres
271 mily 4 group A member 2 (NR4A2) is an orphan nuclear receptor that is over-expressed in cancer and pr
273 eceptor (PXR, NR1I2) is a xenobiotic-sensing nuclear receptor that modulates the metabolic response t
274 te the glucocorticoid receptor, a ubiquitous nuclear receptor that not only causes widespread changes
275 n receptor C (RORc, RORgamma, or NR1F3) is a nuclear receptor that plays a major role in the producti
276 pal among these is NR0B1, an atypical orphan nuclear receptor that we show engages in a multimeric pr
278 er X receptors (LXR) are oxysterol-activated nuclear receptors that play a central role in reverse ch
279 atory heterodimerization partner for several nuclear receptors that regulate drug and lipid metabolis
280 y, we identify the regulatory cascade of the nuclear receptor TLX and the DNA hydroxylase Ten eleven
282 demonstrate that MVI directly interacts with nuclear receptors to drive expression of target genes, t
283 that these receptors exist and function with nuclear receptors to provide the full impact of all ster
284 e show that fusing ligand-binding domains of nuclear receptors to split Cas9 protein fragments can pr
285 tly, we were the first to report that orphan nuclear receptor TR3/Nur77 is a critical mediator of ang
286 that deletion in mice of the thyroid hormone nuclear receptors TRalpha1 and TRbeta (the main thyroid
289 actor 4 (HNF4) is the most ancient family of nuclear receptor transcription factors with important ro
290 e of dietary vitamin A, acts as a ligand for nuclear receptor transcription factors with more than 50
291 which competitive recruitment of DNA-binding nuclear receptors/transcription factors in trans to hot
293 ed glucocorticoid signaling due to increased nuclear receptor translocation, activating glucocorticoi
294 riiodothyronine (T3), through binding to its nuclear receptors (TRs), is able to antagonize transcrip
295 hormone (TH) due to its high affinity for TH nuclear receptors (TRs), new data suggest that 3,5-diiod
298 he last decade of the twentieth century, two nuclear receptors were discovered in our laboratory and,
300 ptor-gamma (PPARgamma) is a ligand-activated nuclear receptor which controls lipid and glucose metabo
301 ctivation function 1 (AF-1) in a full-length nuclear receptor, which supports a role for AF-1 in SRC-
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