ライフサイエンスコーパス: nuclear receptor coactivator

1 atisfies a number of important criteria as a nuclear receptor coactivator.

2 rginine methyltransferase 1 (PRMT1), another nuclear receptor coactivator.

3 activation in vivo and suggest redundancy in nuclear receptor coactivators.

4 or 2, thereby establishing a novel family of nuclear receptor coactivators.

5 istence of a new complex of novel functional nuclear receptor coactivators.

6 omoters, which can be further potentiated by nuclear receptor coactivators.

7 NRC and PNRC2 are members of a new family of nuclear receptor coactivators.

8 sitivity, in part, by reducing levels of key nuclear receptor coactivators.

9 ng consistently enables PPARgamma to recruit nuclear receptor coactivators.

10 ceptors is mediated by the 160-kDa family of nuclear receptor coactivators.

11 vation surface for binding the p160 class of nuclear receptor coactivators.

12 ROR-gamma recruits nuclear receptor coactivator 1 and 3 (NCOA1 and NCOA3, a

13 me 8q13 (rs10091374; P=9.06x10(-9)) near the nuclear receptor coactivator 2 (NCOA2) gene.

14 Here we determined that nuclear receptor coactivator 2 (NCoA2, also known as SRC

15 Increased reactivity toward nuclear receptor coactivator 2 was also observed in pati

16 PNRC2 (Proline-rich Nuclear Receptor Coactivator 2) was previously identifie

17 ith higher affinity than to the coactivator, nuclear receptor coactivator-2 (Tif2), in coregulator pe

18 regulators, including RNA polymerase II and nuclear receptor coactivator-3.

19 NA-seq in human reticulocytes and identified nuclear receptor coactivator 4 (NCOA4) as a critical reg

20 the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the auto

21 Like known cargo receptors, nuclear receptor coactivator 4 (NCOA4) was highly enrich

22 In addition, knockdown of nuclear receptor coactivator 4, the adaptor protein for

23 Nuclear receptor coactivator 6 (NCOA6) also known as PRI

24 Nuclear receptor coactivator 6 (NCOA6) is a multifunctio

25 Here, we identify Nuclear receptor coactivator 6 (Ncoa6), a subunit of the

26 The nuclear receptor coactivator 6 (NCoA6; also AIB3, PRIP,

27 We show that nuclear receptor coactivator-6 (NCOA6), a reported coact

28 ing site of PRMT1 substantially crippled its nuclear receptor coactivator activity.

29 The nuclear receptor coactivator AIB1 (amplified in breast c

30 were validated with a probe specific for the nuclear receptor coactivator AIB1 that maps to chromosom

31 y be mediated through MAPK activation of the nuclear receptor coactivator AIB1.

32 cer often requires the overexpression of the nuclear receptor coactivator AIB1/SRC-3 acting in conjun

33 The DRIPs are distinct from known nuclear receptor coactivators, although like these coact

34 The amplified-in-breast cancer 3 (AIB3) is a nuclear receptor coactivator amplified and overexpressed

35 The nuclear receptor coactivator amplified in breast cancer

36 The nuclear receptor coactivator amplified in breast cancer

37 Here, we show that the nuclear receptor coactivator amplified in breast cancer

38 receptor (GR) is able to interact with both nuclear receptor coactivators and the BRG1 chromatin-rem

39 properties that are consistent with those of nuclear receptor coactivators and with RNA spliceosome c

40 id-, leucine-rich protein 1 (PELP1), a novel nuclear receptor coactivator, and its expression is dere

41 ectly involve, at the transcriptional level, nuclear receptors, coactivators, and proteins of the cel

42 omoted by the estrogen receptor pathway, and nuclear receptor coactivators are thought to participate

43 anism is competition for limiting amounts of nuclear receptor coactivators between the 5' D-I promote

44 omain (TAD) of p53, the TAZ1, TAZ2, KIX, and nuclear receptor coactivator binding domains of CBP, and

45 Our study also reveals that a nuclear receptor coactivator can act in the periphery of

46 naling by the essential C-terminal AD of the nuclear receptor coactivator CoCoA; they indicate that p

47 Three components of the p160 nuclear receptor coactivator complex, including CARM1, p

48 we report that another component of the p160 nuclear receptor coactivator complex, the coiled-coil co

49 R function by preventing the assembly of CBP-nuclear receptor coactivator complexes, revealing differ

50 (MLL2/ALR), a core component of COMPASS-like nuclear receptor coactivator complexes.

51 ing the probabilistic formation of transient nuclear receptor-coactivator complexes with its molecula

52 e report the cloning and analysis of a novel nuclear receptor coactivator (designated NRIF3) that exh

53 In common with other nuclear receptor coactivators, DRIP205 interaction occur

54 entification and characterization of a novel nuclear receptor coactivator, ERAP140.

55 Members of the 160-kDa nuclear receptor coactivator family (p160 coactivators)

56 vator-3 (SRC-3)/AIB1 is a member of the p160 nuclear receptor coactivator family involved in developm

57 in breast cancer 1, is a member of the p160 nuclear receptor coactivator family involved in transcri

58 dies indicate that steroid receptors require nuclear receptor coactivators for efficient transcriptio

59 BAF57 has previously been implicated in nuclear receptor coactivator function, and we show that,

60 AIB1 (amplified in breast cancer 1) is a nuclear receptor coactivator gene amplified and overexpr

61 bind the C-terminal activation domain of the nuclear receptor coactivator GRIP1, we identified a new

62 In the past few years, many nuclear receptor coactivators have been identified and s

63 d the hSP-B promoter with RARalpha, CBP, and nuclear receptor coactivators in H441 cells.

64 Nuclear receptor coactivators include histone acetyltran

65 TTF-1 is acetylated by nuclear receptor coactivators including the activator of

66 Members of the p160 nuclear receptor coactivators interact with liganded nuc

67 In this study, we report the isolation of a nuclear receptor coactivator-interacting protein from a

68 new structural parameters for modulating the nuclear receptor-coactivator interaction based on linear

69 -activated receptor binding protein (PBP), a nuclear receptor coactivator, interacts with estrogen re

70 Acetylation of transcription factors by nuclear receptor coactivators is an important mechanism

71 nduced blockade of GR transactivation at the nuclear receptor coactivator level, upstream and indepen

72 rst LXXLL motif is the most potent among all nuclear receptor coactivator motifs tested, and only thi

73 ound receptor, which subsequently recruits a nuclear receptor coactivator (NCoA) complex.

74 d receptor coactivators (SRCs) SRC-1, SRC-2 [nuclear receptor coactivator (NCOA)2], and SRC-3 [amplif

75 Steroid and nuclear receptor coactivators (NCoAs) have been implicat

76 , including CREB-binding protein (CBP/p300), nuclear receptor coactivators (NCoAs), and p300/CBP-asso

77 p160 nuclear receptor coactivators on the other hand, contrib

78 truncated mutant BRCA2, synergizes with the nuclear receptor coactivator p160 GRIP1 to enhance trans

79 partner of PPAR (retinoid X receptor) or the nuclear receptor coactivators P300 and SRC-1, suggesting

80 Furthermore, nuclear receptor coactivators p300/CBP and steroid recep

81 The nuclear receptor coactivators participate in the transcr

82 Nuclear receptor coactivator PBP (peroxisome proliferato

83 To investigate the role of nuclear receptor coactivator peroxisome proliferator-act

84 n of the gluconeogenic programme through the nuclear receptor coactivator PGC-1, which is shown here

85 indicates that in addition to functioning as nuclear receptor coactivator, PNRC2 may also play a role

86 We report that p160 nuclear receptor coactivators potentiate the transactiva

87 iferator-activated receptors (PPARs) and the nuclear receptor coactivator, PPARgamma coactivator-1alp

88 Nuclear receptor coactivator PRIP (peroxisome proliferat

89 , has been shown previously to interact with nuclear receptor coactivator PRIP (peroxisome proliferat

90 Nuclear receptor coactivator PRIP (peroxisome proliferat

91 (ERalpha) requires the previously described nuclear receptor coactivator protein Flightless-I (Fli-I

92 ) is a putative vitamin D receptor (VDR) and nuclear receptor coactivator protein that is unrelated t

93 The nuclear receptor coactivator RAC3 (also known as AIB1/AC

94 activator receptor interacting protein) is a nuclear receptor coactivator required for mammary gland

95 determine the functional significance of the nuclear receptor coactivator SRC-1 in developing brain,

96 tor PPARgamma with two peptides derived from nuclear receptor coactivators SRC1 and TRAP220.

97 protein complexes, one of which contains the nuclear receptor coactivator steroid receptor coactivato

98 AIB3 is not redundant with other classes of nuclear receptor coactivators such as PBP and members of

99 gnature motif LXXLL also present in cellular nuclear receptor coactivators, such as steroid receptor

100 to p/CAF or to members of the p160 family of nuclear receptor coactivators, such as steroid receptor

101 hat of the ligand-binding domain-interacting nuclear receptor coactivators, such as TRBP, CBP, and SR

102 hway and specific phosphorylation sites in a nuclear receptor coactivator that can regulate steroid r

103 NCOA7 encodes a nuclear receptor coactivator that interacts with estroge

104 ar receptor coregulatory protein (PNRC) is a nuclear receptor coactivator that interacts with nuclear

105 GT198 is a tissue-specific, kinase-regulated nuclear receptor coactivator that interacts with the DNA

106 ene amplified in breast cancer 1 (AIB1) is a nuclear receptor coactivator that plays a major role in

107 ceptor coactivator 3 (SRC-3) is an oncogenic nuclear receptor coactivator that plays a significant ro

108 that ERAP140 represents a distinct class of nuclear receptor coactivators that mediates receptor sig

109 tion of ER-alpha activity, whereas two other nuclear receptor coactivators, the p300/CBP-associated f

110 the nuclear receptor corepressor, SMRT, and nuclear receptor coactivator, TRAM-1.

111 high levels of the androgen receptor and two nuclear receptor coactivators, transcriptional intermedi

112 C3/TRAM-1) is a member of the p160 family of nuclear receptor coactivators, which includes SRC-1 (NCo

113 multiple nuclear receptors and with the p160 nuclear receptor coactivators, which upon cloning have p

114 These observations identify AIB1 as a nuclear receptor coactivator whose altered expression ma

115 PGC-1alpha is an inducible nuclear receptor coactivator with direct functions in bo