ライフサイエンスコーパス: nuclear receptor corepressor

1 cid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor).

2 or retinoid and thyroid receptor) and N-CoR (nuclear receptor corepressor).

3 mediator for retinoid and thyroid receptors/nuclear receptor corepressor.

4 Atrophin proteins represent a novel class of nuclear receptor corepressors.

5 s to repressed genes by the HDAC activity of nuclear receptor corepressors.

6 acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor 1 (N-CoR) that accumulated

7 Moreover, targeted inhibition of BCL6/nuclear receptor corepressor 1 (NCoR) complex by peptido

8 ember 1 (Rev-Erbalpha) with its cosuppressor nuclear receptor corepressor 1 (NCOR).

9 study, we report that deletion of intestinal nuclear receptor corepressor 1 (NCoR1) completely dimini

10 The nuclear receptor corepressor 1 (Ncor1) functions as an a

11 which heme binding to Rev-erbalpha recruits nuclear receptor corepressor 1 (NCoR1) into an active re

12 Nuclear receptor corepressor 1 (NCoR1) is considered to

13 The nuclear receptor corepressor 1 (NCOR1) was reported to m

14 ant mice and in mice ablated selectively for nuclear receptor corepressor 1 (NCoR1)/silencing mediato

15 ely ablated in skin keratinocytes for either nuclear receptor corepressor 1 (NCoR1)/silencing mediato

16 tes the complex mediator of transcription 13/nuclear receptor corepressor 1 axis, which in turn promo

17 Knockdown of nuclear receptor corepressor 1 in primary male T cells a

18 nd the nuclear receptor-interacting protein, nuclear receptor corepressor 1, to specific cis-regulato

19 SUMOylation of LXRs, but not the presence of nuclear receptor corepressor 1, was required for repress

20 creased the interaction between TR-alpha and nuclear receptor corepressor 2 (NCOR2) and suppressed Pl

21 encing Transcription Factor (CoREST) and the Nuclear Receptor Corepressor 2 (NCOR2).

22 NCOR2 (nuclear receptor corepressor 2) SNP rs150954431 was asso

23 RF7 promoter region through interaction with nuclear receptor corepressor 2/histone deacetylase 3 for

24 l coactivator) and the dissociation of NCoR (nuclear receptor corepressor, a transcriptional corepres

25 expression in vivo and indicates a role for nuclear receptor corepressors and associated histone dea

26 NCoR1 (nuclear receptor corepressor) and SMRT (silencing mediat

27 The corepressors N-CoR (nuclear receptor corepressor) and SMRT (silencing mediat

28 local chromatin condensation, recruitment of nuclear receptor corepressor, and histone deacetylase co

29 T (switching-defective protein 3, adaptor 2, nuclear receptor corepressor, and transcription factor I

30 Depletion of the nuclear receptor corepressor by specific short interferi

31 histone deacetylase shown to be part of the nuclear receptor corepressor complex.

32 clock, and regulates its interaction with a nuclear receptor corepressor complex.

33 ults suggest that atrophin-1 associates with nuclear receptor corepressor complexes and is involved i

34 Cytokine-induced clearance of nuclear receptor corepressor complexes was inhibited by

35 stem, we identified ETO/MTG8, a component of nuclear receptor corepressor complexes, as an atrophin-1

36 These data suggest that the nuclear receptor corepressors decrease PPARgamma transcr

37 To explore this possibility, we examined nuclear receptor corepressor expression in a panel of no

38 a structurally and functionally more related nuclear receptor corepressor family and suggest an addit

39 HDAC3 complex that contained members of the nuclear receptor corepressor family.

40 ly associated with glutathione S-transferase-nuclear receptor corepressor fragments harboring one of

41 utually exclusive and sequential manner: the nuclear receptor corepressor-HDAC3 complex followed by n

42 ther, our results demonstrate involvement of nuclear receptor corepressor/histone deacetylase complex

43 The Hairless (Hr) gene encodes a nuclear receptor corepressor (HR) that is essential for

44 th coactivators, the GyK gene is targeted by nuclear receptor corepressors in adipocytes.

45 e of another class of nuclear cofactors, the nuclear receptor corepressors, in modulating PPARgamma t

46 in immunoprecipitation assays indicated that nuclear receptor corepressor is present on the endogenou

47 N-CoR (nuclear receptor corepressor) is a corepressor for multi

48 Moreover, SMRT, but not the related Nuclear Receptor Corepressor, is required for cellular r

49 -like nuclear export signal that resembles a nuclear receptor corepressor motif (aa 86-95) impaired t

50 oncogenic fusion proteins interact with the nuclear receptor corepressor N-CoR and, in comparison wi

51 The nuclear receptor corepressor N-CoR plays a crucial role

52 more, we demonstrate that DAX-1 recruits the nuclear receptor corepressor N-CoR to SF-1, whereas natu

53 the binding of RXR ligands and recruits the nuclear receptor corepressor N-CoR, PPAR permits the bin

54 e we demonstrate that ETO interacts with the nuclear receptor corepressor N-CoR, the mSin3 corepresso

55 ruitment of a corepressor complex, including nuclear receptor corepressor N-CoR, which, unexpectedly,

56 nal sequence that is highly conserved to the nuclear receptor corepressor N-CoR.

57 Nuclear receptor corepressors N-CoR and SAFB1 were bound

58 nd cell-based assays to demonstrate that the nuclear receptor corepressors N-CoR and SMRT interact wi

59 ze that corepressor complexes containing the nuclear receptor corepressor (N-CoR) are key factors in

60 Detection of nuclear receptor corepressor (N-CoR) association with RA

61 Several lines of evidence indicate that the nuclear receptor corepressor (N-CoR) complex imposes lig

62 Nuclear receptor corepressor (N-CoR) depletion increased

63 he tamoxifen-mediated association of ER with nuclear receptor corepressor (N-CoR) in the antiestrogen

64 Reduced H4 acetylation and increased HDAC1/nuclear receptor corepressor (N-CoR) occupancy at some T

65 nuclear receptors correlates with levels of nuclear receptor corepressor (N-CoR) protein.

66 tivated ERalpha, HDAC inhibitor (HDAC1), and nuclear receptor corepressor (N-CoR) that bound the slug

67 knowledge, that the HDAC3 complex, including nuclear receptor corepressor (N-CoR), transducin-beta-li

68 ETO binds to the human homolog of the murine nuclear receptor corepressor (N-CoR).

69 onserved MYND domain that interacts with the nuclear receptor corepressor (N-CoR).

70 TR) actively represses transcription via the nuclear receptor corepressor (N-CoR)/histone deacetylase

71 s similar to the binding motifs proposed for nuclear receptor corepressors (N-CoR and SMRT).

72 Nuclear receptor corepressors (N-CoR) and silencing medi

73 erving to mediate a required exchange of the nuclear receptor corepressors, N-CoR and SMRT, for coact

74 on requires signal-dependent turnover of the nuclear receptor corepressor NCoR from target promoters,

75 Mutations abolishing interactions with the nuclear receptor corepressor (NCOR or SMRT) render HDAC3

76 Here, we report that, while the nuclear receptor corepressor (NCoR) and silencing mediat

77 ance AR recruitment of corepressor proteins [nuclear receptor corepressor (NCoR) and silencing mediat

78 irect DNA binding of the receptor along with nuclear receptor corepressor (NCoR) and silencing mediat

79 eptor interacting motifs of the corepressors nuclear receptor corepressor (NCoR) and silencing mediat

80 The nuclear receptor corepressor (NCoR) and the related fact

81 using a mammalian two-hybrid assay, that the nuclear receptor corepressor (NCoR) and the silencing me

82 Such corepressors include the nuclear receptor corepressor (NCoR) and the silencing me

83 LXRs are dependent on interactions with the nuclear receptor corepressor (NCoR) and the silencing me

84 and thyroid hormone receptor (SMRT) and the nuclear receptor corepressor (NCoR) are negative regulat

85 HDAC3, HDAC4, and the nuclear receptor corepressor (NCoR) are required for eff

86 ted the binding of the histone deacetylase 3-nuclear receptor corepressor (NCoR) complex to the COX-2

87 We demonstrate that nuclear receptor corepressor (NCoR) enhances thyroid hor

88 )-dependent derepression of AP-1 by removing nuclear receptor corepressor (NCoR) from the chemokine p

89 We generated adipocyte-specific Nuclear Receptor Corepressor (NCoR) knockout (AKO) mice

90 The nuclear receptor corepressor (NCoR) regulates the activi

91 Nuclear receptor corepressor (NCoR) was demonstrated to

92 ory proteins in HeLa S3 cells, including the nuclear receptor corepressor (NCoR), TIF1beta/KAP-1, HDA

93 -binding domain, which targets PPAR-gamma to nuclear receptor corepressor (NCoR)-histone deacetylase-

94 actions of TH as well as in mice with mutant nuclear receptor corepressor (NCoR).

95 the interaction of the MeCP2 with DNA or the nuclear receptor corepressor (NCoR)/silencing mediator o

96 on of PPRE-bound PV with corepressors [e.g., nuclear receptor corepressor (NCoR)] that led to transcr

97 n in human breast cancer cells by recruiting nuclear receptor corepressors (NCoR and SMRT) and histon

98 We show that the nuclear receptor corepressor NCoR1 is a key target of pr

99 via downregulation of the tumor-suppressive nuclear receptor corepressor NCOR1.

100 its derived mouse model harboring a mutated nuclear receptor corepressor (NCOR1DeltaID) (Thra1(PV/+)

101 d the formation of a functional complex with nuclear receptor corepressors (NCORs) were critical in r

102 Transcriptional repression by nuclear receptor corepressors plays a critical role in T

103 noid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor protein (NCoR) are corepres

104 iptional activity through the recruitment of nuclear receptor corepressor protein and silencing media

105 f retinoid and thyroid receptors) and N-CoR (nuclear receptor corepressor) recruit histone deacetylas

106 Results from these studies indicate that nuclear receptor corepressor recruitment is a key featur

107 MEK1 interacts with the nuclear receptor corepressor silencing mediator of retin

108 The nuclear receptor corepressor, silencing mediator of reti

109 using the conserved carboxyl terminus of the nuclear receptor corepressor SMRT as a bait led to the i

110 Histone deacetylase 3 (HDAC3) requires the nuclear receptor corepressor SMRT for HDAC enzyme activi

111 The recruitment of nuclear receptor corepressor SMRT/N-CoR and subsequent r

112 ne deacetylases (HDAC)5 and 7 along with the nuclear receptor corepressors SMRT (silencing mediator f

113 Nuclear receptor corepressors SMRT (silencing mediator o

114 ETO interacts with nuclear receptor corepressors SMRT and N-CoR, which recr

115 on of target genes via interactions with the nuclear receptor corepressors SMRT and NCoR.

116 well as its molecular interactions with the nuclear receptor corepressor, SMRT, and nuclear receptor

117 highlight an unexpected new function of the nuclear receptor corepressor SMRTe for its role in regul

118 We describe here the cloning of a nuclear receptor corepressor that we call SUN-CoR (Small

119 expression, Hr likely defines a new class of nuclear receptor corepressors that serve a more speciali

120 n serve as an adapter molecule that recruits nuclear receptor corepressors to DNA-bound nuclear recep

121 repressor that we call SUN-CoR (Small Unique Nuclear receptor CoRepressor), which shows no homology t