ライフサイエンスコーパス: nuclear reprogramming

1 o be reactivated in differentiated cells via nuclear reprogramming.

2 n from oxidative to glycolytic metabolism in nuclear reprogramming.

3 ency is required to achieve a high degree of nuclear reprogramming.

4 aining healthy mtDNA, to induce somatic cell nuclear reprogramming.

5 of cellular identity during development and nuclear reprogramming.

6 fferentiation and proliferation, meiosis and nuclear reprogramming.

7 asmic components of the oocyte in supporting nuclear reprogramming.

8 odifiers to enhance chromatin remodeling and nuclear reprogramming.

9 lly, we show that enhancers are reset during nuclear reprogramming.

10 ed for pluripotency gene reactivation during nuclear reprogramming.

11 is important for the comprehensive study of nuclear reprogramming.

12 e factors affecting cell differentiation and nuclear reprogramming.

13 ities, cell cycle asynchronies, and improper nuclear reprogramming.

14 vo myomaker-mediated heterologous fusion and nuclear reprogramming.

15 mmonly considered a consequence of errors in nuclear reprogramming.

16 eactivation will help improve the success of nuclear reprogramming.

17 urrently particular interest in the field of nuclear reprogramming, a process by which the identity o

18 modify the donor chromatin structure to help nuclear reprogramming and allow development.

19 ipotent stem cells (iPSCs) undergo extensive nuclear reprogramming and are generally indistinguishabl

20 Here, we introduce the field of nuclear reprogramming and briefly discuss six of the pro

21 CD4(+) T lymphocyte donor cell, we observed nuclear reprogramming and efficient contribution of the

22 e emerging principles which appear to govern nuclear reprogramming and production of clones, and will

23 4 methylation imposes a barrier to efficient nuclear reprogramming and suggest approaches for improvi

24 s during mitosis may facilitate somatic cell nuclear reprogramming and the acquisition of new cell fa

25 s spectacular organismal transition requires nuclear reprogramming and the initiation of RNAPII at th

26 clear organization in meiosis, the events of nuclear reprogramming and the spatio-temporal regulation

27 ) are necessary for lineage differentiation, nuclear reprogramming, and embryonic development.

28 can catalyze cellular de-differentiation and nuclear reprogramming by acting at the cell surface.

29 but attempts to recapitulate this process of nuclear reprogramming by molecular means have failed.

30 We review the efficiency of nuclear reprogramming by nuclear transfer.

31 Here we review the recent literature on nuclear reprogramming by SCNT, including studies of gene

32 at the NT embryos have undergone significant nuclear reprogramming by the blastocyst stage; however,

33 mbryos, indicating defects in the process of nuclear reprogramming by the recipient ooplasm.

34 Nuclear reprogramming by the transplantation of somatic

35 otent stem cells (PSCs) can be generated via nuclear reprogramming by transcription factors (i.e., in

36 ether, these data demonstrate that extensive nuclear reprogramming can be achieved independently of p

37 Our data demonstrate that direct nuclear reprogramming can restore terminal differentiati

38 provide invaluable models of human disease, nuclear reprogramming could limit the usefulness of iPSC

39 Nuclear reprogramming describes a switch in gene express

40 Zygotic genome activation (ZGA) is a nuclear reprogramming event that transforms the genome f

41 ms, underscoring the value of nonintegrative nuclear reprogramming for derivation of competent cardio

42 he original fibroblasts are revealed through nuclear reprogramming, generating mutant hiPSCs with a d

43 newly introduced nonmuscle nuclei undergoes nuclear reprogramming has not been investigated.

44 We conclude that nuclear reprogramming in heterokaryons is rapid, extensi

45 ammatory pathways are required for efficient nuclear reprogramming in the induction of pluripotency.

46 recovered in screens for genes required for nuclear reprogramming in Xenopus and mouse embryonic ste

47 Somatic cell nuclear 'reprogramming' in livestock species is now rout

48 Nuclear reprogramming inculcates pluripotent capacity by

49 An understanding of nuclear reprogramming is fundamental to the use of cells

50 However, the success of nuclear reprogramming is limited by epigenetic mechanism

51 Nuclear reprogramming is of great medical interest, as i

52 epigenetic repression restrict somatic cell nuclear reprogramming is poorly understood.

53 Nuclear reprogramming is relatively inefficient, and the

54 Many cell types can undergo nuclear reprogramming, leading to the question of whethe

55 At the heart of this nuclear reprogramming lies chromatin remodeling as chrom

56 Knowledge regarding cellular fusion and nuclear reprogramming may aid in cell therapy strategies

57 Finally, these findings suggest that nuclear reprogramming may be a broadly applicable therap

58 Thus, incomplete nuclear reprogramming may generate abnormal epigenetic m

59 ather than unfertilized eggs, as a source of nuclear reprogramming molecules and for the eventual ide

60 Our results represent successful nuclear reprogramming of adult somatic cells into plurip

61 th distinct histone modifications as well as nuclear reprogramming of erythroid transcription factors

62 o change cell fate may be the key to routine nuclear reprogramming of human somatic cells.

63 Vertebrate eggs can induce the nuclear reprogramming of somatic cells to enable product

64 tion by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells.

65 study provides definite proof for the direct nuclear reprogramming of terminally differentiated adult

66 estoration was not detected in vivo although nuclear reprogramming of the muscle-specific myosin ligh

67 as a starting point to more fully assess how nuclear reprogramming overcomes the multitude of genetic

68 ls, but also a thorough understanding of the nuclear reprogramming process taking place during nuclea

69 Nuclear reprogramming provides an emerging strategy to p

70 ciency, and comments on prospects for future nuclear reprogramming research.

71 owards understanding the mechanisms by which nuclear reprogramming takes place.

72 alogy to classical descriptions of amphibian nuclear reprogramming, the propensity of committed cells

73 they participate actively in the process of nuclear reprogramming to pluripotency by increasing epig

74 r active DNA demethylation and initiation of nuclear reprogramming towards pluripotency in human soma

75 rived from various types of somatic cells by nuclear reprogramming using defined transcription factor

76 t a signaling pathway required for efficient nuclear reprogramming was activated by the retroviral, b

77 To help understand the mechanism of nuclear reprogramming, we have asked whether the nuclei

78 To elucidate the extent and timing of nuclear reprogramming, we used microarrays to analyze th

79 chimera assays, indicating a high degree of nuclear reprogramming, with no evidence of passage throu