ライフサイエンスコーパス: nuclear speckle

1 called DRS and MemA; a protein localized in nuclear speckles).

2 noticeably only after initial contact with a nuclear speckle.

3 omatin that enables clustering around common nuclear speckles.

4 ein for proteosomal degradation, possibly in nuclear speckles.

5 - a property essential for its assembly into nuclear speckles.

6 oss and relocalizes to splicing antigen-rich nuclear speckles.

7 results in its subnuclear localization into nuclear speckles.

8 SR proteins do not immediately colocalize in nuclear speckles.

9 a rapid exchange rate of splicing factors in nuclear speckles.

10 with delayed localization of SR proteins to nuclear speckles.

11 issue, where they interact and colocalize in nuclear speckles.

12 tention of hypophosphorylated SR proteins in nuclear speckles.

13 nto subnuclear foci which are reminiscent of nuclear speckles.

14 full-length protein accumulates in distinct nuclear speckles.

15 in about 10% of the cells EVI1 localizes in nuclear speckles.

16 colocalizes with the splicing factor SC35 in nuclear speckles.

17 monstrated that ER81 and p300 colocalized to nuclear speckles.

18 tion of their signals are colocalized within nuclear speckles.

19 in coiled bodies and nucleoli, and later in nuclear speckles.

20 inositol signaling pathways are localized at nuclear speckles.

21 ion between them, indicate they associate at nuclear speckles.

22 mDEAH9 and splicing factor SC35 in punctate nuclear speckles.

23 ecessary nor sufficient for targeting to the nuclear speckles.

24 population of Tax is tightly associated with nuclear speckles.

25 ncreased dephosphorylation of SR proteins in nuclear speckles.

26 of phosphorylated SC35, which is retained in nuclear speckles.

27 into a compartment enriched in SC35-positive nuclear speckles.

28 and Malat1, a large ncRNA that localizes to nuclear speckles.

29 bserved for HSP70 transgenes associated with nuclear speckles.

30 ple genes and in a higher number of enlarged nuclear speckles.

31 a DNA- and RNA-binding protein localized in nuclear speckles.

32 aled costaining between PABP1 and markers of nuclear speckles.

33 s the assembly of mRNA processing factors in nuclear speckles.

34 ns and RNA components in the organization of nuclear speckles.

35 speckles and are visible as doughnuts around nuclear speckles.

36 antly nuclear and localized to SC35-positive nuclear speckles.

37 iquitinated, stabilized, and rerouted to the nuclear speckles.

38 In addition, RCs coalesce at and reorganize nuclear speckles.

39 , the endogenous FRG1 is not associated with nuclear speckles.

40 on-human primate ISG15 from the cytoplasm to nuclear speckles.

41 nt of the speckle-type POZ protein (SPOP) to nuclear speckles.

42 olding protein for RNA processing factors in nuclear speckles.

43 ganization of pre-mRNA processing factors in nuclear speckles.

44 gulation by sequestering its constituents in nuclear speckles.

45 -3 reveals localization of these isoforms to nuclear speckles.

46 promyelocytic leukemia nuclear bodies (38), nuclear speckles (27), paraspeckles (24), Cajal bodies (

47 ed Ubc9 depletion effectively suppresses WT1 nuclear speckles, a SUMO-1-deficient WT1(+KTS)(K73, 177R

48 ng motif protein 39 (RBM39) and localizes to nuclear speckles adjacent to spliceosomes.

49 pendent association of HSP70 transgenes with nuclear speckles after heat shock.

50 lear with specific enrichment of alphaCP1 in nuclear speckles, alphaCP3 and alphaCP4 are restricted t

51 The finding that FAST is concentrated at nuclear speckles also supports this contention.

52 AML1b and AML1b(Del179-242) are localized to nuclear speckles, AML1b(Del179-242) was observed to have

53 Rounding of nuclear speckles, an indication of transcriptional arres

54 Tax co-localized with phospho-DNA-PK into nuclear speckles and a nuclear excluded Tax mutant seque

55 rtially colocalizes with splicing factors in nuclear speckles and assembles into spliceosomal complex

56 Accumulation of HIPK2 in nuclear speckles and association with promyelocytic leuk

57 2 were co-expressed, CtBP1 was restricted to nuclear speckles and co-localized with Glis2.

58 homologous alpha-globin loci that occurs at nuclear speckles and correlates with transcription.

59 with the nuclear matrix fail to localize to nuclear speckles and exhibit reduced transcriptional act

60 overexpressing either isoform displayed both nuclear speckles and GFP fluorescence throughout the nuc

61 mises the association of splicing factors to nuclear speckles and influences the levels and activity

62 he expression of Vpr excludes SAP49 from the nuclear speckles and inhibits the formation of the SAP14

63 Here we show that PIPKIalpha co-localizes at nuclear speckles and interacts with a newly identified n

64 The longer Ania-6 protein colocalizes with nuclear speckles and is associated with key elements of

65 orylate SR domain-containing proteins in the nuclear speckles and mediate the pre-mRNA splicing.

66 osphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing.

67 In cultured cells, HIPKs localize to nuclear speckles and potentiate the repressor activities

68 est that SR proteins mediate the assembly of nuclear speckles and regulate gene expression by influen

69 Our results demonstrate that nuclear speckles and their surrounding regions are major

70 esicle stage, PARP-1 protein associates with nuclear speckles and upon meiotic resumption, undergoes

71 ein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SS

72 nteraction with Pi04089, its localization to nuclear speckles, and its increased accumulation when co

73 aining functional splice sites accumulate in nuclear speckles, and our data suggest that splicing occ

74 AD3 and PCBP1 to colocalize in SC35-positive nuclear speckles, and the two proteins interact in the v

75 N displayed close localization in and around nuclear speckles, and their physical association in prot

76 hysiological substrate Gli3, suggesting that nuclear speckles are hotspots of ubiquitination.

77 These changes in the nucleolus and nuclear speckles are reversible and dependent on both ti

78 Given that nuclear speckles are storage sites for splicing factors,

79 Since nuclear speckles are storage sites for splicing factors,

80 Nuclear speckles are subnuclear domains that contain pre

81 ibution, suggesting that CGBP accumulates at nuclear speckles as a result of protein/protein interact

82 cells, hPrp17 is highly concentrated in the nuclear speckles, as is SC35 and many other splicing fac

83 py reveals that CFP1 and Set1 co-localize to nuclear speckles associated with euchromatin.

84 Pnn/DRS (Pnn) is a "nuclear speckle"-associated protein involved in mRNA pro

85 nd SPOP (speckle-type POZ domain protein), a nuclear speckle-associated protein that recruits substra

86 Pinin (Pnn), a nuclear speckle-associated protein, has been shown to fu

87 accumulates in a hyperphosphorylated form in nuclear speckle-associated structures.

88 paper, we dissect cis-elements required for nuclear speckle association of the heat shock protein 70

89 ribonucleoprotein modifications, leading to nuclear speckle association.

90 ar compartment, where it resides in distinct nuclear speckles at or near sites of DNA replication.

91 rsisting for 15-20 min before dissipating as nuclear speckles began to form in G1.

92 e of NAPs in splicing factor trafficking and nuclear speckle biogenesis.

93 n, we show that Par 6 localizes precisely to nuclear speckles, but not to other nuclear structures, a

94 s, including nucleoli, the nuclear envelope, nuclear speckles, centrosomes, mitochondria, the endopla

95 although only the C terminus accumulates as nuclear speckles characteristic of the intact protein.

96 Some CGBP-containing nuclear speckles co-localize with splicing factor SC-35

97 the nucleus acts as a scaffolding protein in nuclear speckle complexes, similar to its role in the cy

98 cleotides, results in the mislocalization of nuclear speckle constituents in a transcription-dependen

99 Many of the nuclear speckle constituents work in concert to coordina

100 nucleoli, nucleoplasmic transcription sites, nuclear speckles, constitutive heterochromatin domains,

101 these sites overlap with a subset of larger nuclear speckles containing phosphorylated polymerase II

102 together with SUMO1 and SUMO2 into enlarged nuclear speckles containing polyadenylated RNA.

103 ive in transcription and DNA replication and nuclear speckles containing pre-mRNA splicing factors we

104 ction leads to sequestration of PABP1 in the nuclear speckles, creating a state within the cell that

105 LL-ELL fusion gene delocalized EAF1 from its nuclear speckled distribution to a diffuse nucleoplasmic

106 and cyclin T1), at the splicing-factor-rich nuclear speckle domain.

107 nefficiently exported, do not associate with nuclear speckle domains but are instead distributed thro

108 l co-activator CREB-binding protein (CBP) in nuclear speckle domains in the developing brain and in n

109 complex colocalizes with splicing factors in nuclear speckle domains in vivo.

110 components, a portion of CIP29 localizes in nuclear speckle domains, and its efficient recruitment t

111 sibility that pre-mRNA undergoes splicing in nuclear speckle domains, before their release by TREX co

112 Ps, and colocalizes with splicing factors in nuclear speckle domains.

113 as well as total polyA+ RNA, accumulates in nuclear speckle domains.

114 ution of these and other splicing factors in nuclear speckle domains.

115 concentrated in 20-50 discrete foci known as nuclear speckle domains.

116 A subpopulation of pol IIo was localized to nuclear "speckle" domains enriched in splicing factors,

117 We demonstrate that HIPK2 localizes to nuclear speckles (dots) by means of a speckle-retention

118 by SUMO-1, which directs its localization to nuclear speckles (dots).

119 of HIPK2 correlates with its localization to nuclear speckles (dots).

120 %) were associated with splicing factor-rich nuclear speckles even though the speckles occupied <10%

121 induce this PIF3 phosphorylation, as well as nuclear speckle formation and degradation, by direct int

122 Moreover, the vast majority of nuclear speckles (>90%) had moderate to high levels of a

123 ion stress induces the release of SF3B1 from nuclear speckles in a manner that depends on FANCI and o

124 nce assays revealed the emergence of H3K9me2 nuclear speckles in committed HSPCs, consistent with pro

125 cells, followed by increasing BRCA1-positive nuclear speckles in late S phase and G2/M phase cells.

126 KIIbeta and SPOP interact and co-localize at nuclear speckles in mammalian cells, and SPOP mediates t

127 d system, and is co-localized with U1-70K in nuclear speckles in mammalian cells.

128 The characteristic rounding up of nuclear speckles in response to inhibition of RNA polyme

129 in a direct path over long distances toward nuclear speckles in response to transcriptional activati

130 t regulates the formation and maintenance of nuclear speckles in the interphase nucleus is poorly und

131 anscript 1 RNA, can nucleate the assembly of nuclear speckles in the interphase nucleus.

132 pre-mRNA splicing factors are recruited from nuclear speckles, in which they are concentrated, to sit

133 Significantly, however, the structure of nuclear speckles is lost when Par 6 levels are reduced b

134 Hsp70 transgenes and their transcripts with nuclear speckles is transcription dependent, independent

135 olocalizes with pre-mRNA splicing factors in nuclear speckles, its depletion by RNAi leads to cell cy

136 e to trap TNNT3 pre-mRNA, driving it outside nuclear speckles, leading to an altered SC35-mediated sp

137 HRAP3 by siRNA resulted in a decrease in the nuclear speckle localization of WTAP, whereas the nuclea

138 A protein and demonstrate that it exhibits a nuclear speckled localization and possesses the ability

139 ng pathway that targets the viral M1 mRNA to nuclear speckles, mediates splicing at these nuclear bod

140 ng pathway that targets the viral M1 mRNA to nuclear speckles, mediates splicing at these nuclear bod

141 Many mammalian genes localize near nuclear speckles, nuclear bodies enriched in ribonucleic

142 REBP-2 heterodimer localize predominantly to nuclear speckles or foci, with some cells showing a diff

143 We have identified 7SK RNA to be enriched in nuclear speckles or interchromatin granule clusters (IGC

144 ions , association of some active genes with nuclear speckles or transcription "factories", and assoc

145 Nuclear speckles, or interchromatin granule clusters, ar

146 HSP70 transgenes moving curvilinearly toward nuclear speckles over approximately 0.5-6 mum distances

147 hat endogenous EAF2 and ELL colocalized in a nuclear speckled pattern.

148 enous EAF1 and ELL colocalized in a distinct nuclear speckled pattern.

149 nti-RNAP I/III antibody-positive sera showed nuclear speckled patterns, but nucleolar staining was re

150 ear bodies including nucleoli, Cajal bodies, nuclear speckles, Polycomb bodies, and paraspeckles are

151 Aly is a nuclear speckle protein implicated in mRNA export.

152 expression is tightly regulated by acinus, a nuclear speckle protein.

153 of residual Ser-2-phosphorylated RNAP II to nuclear speckles reflects a host response to the inhibit

154 HIC colocalizes with cyclin T1 in nuclear speckle regions and with Tat in the nucleolus.

155 Instead, localization of CGBP to nuclear speckles requires signals within the acidic, bas

156 results suggest that the assembly of EVI1 in nuclear speckles requires the intact HAT activity of the

157 n of HDAC5 and co-localization with MEF2s in nuclear speckles requiring serine residues 259 and 498,

158 g but not Akt phosphorylation dictates Aly's nuclear speckle residency.

159 , we provide evidence for the involvement of nuclear speckle resident proteins and RNA components in

160 Formation of the SMRTe nuclear speckles results in recruitment of several class

161 Here, we show that the nuclear speckle RNA-binding protein (NSR) and the AS com

162 While wild-type SPOP localizes to liquid nuclear speckles, self-association-deficient SPOP mutant

163 ere ANA positive; 96% of ANA positives had a nuclear speckled staining pattern.

164 sed exclusively in the nucleus, and within a nuclear speckle structure that has recently been describ

165 rated that Tax localizes to a multicomponent nuclear speckled structure (Tax speckled structure [TSS]

166 Monomeric actin probes concentrate in nuclear speckles, suggesting an interaction of monomers

167 tors including U2AF65B, U2A', and U2AF35A in nuclear speckles, suggesting SFPS might be involved in t

168 a largely non-overlapping set of euchromatic nuclear speckles, suggesting that Set1A and Set1B each b

169 ) polymerase, which we have termed Star-PAP (nuclear speckle targeted PIPKIalpha regulated-poly(A) po

170 copy, we show that phyB and cry2 interact in nuclear speckles that are formed in a light-dependent fa

171 orylation of Nrd1 and the formation of novel nuclear speckles that contain Nrd1 and Nab3.

172 odified TEL localizes to cell-cycle-specific nuclear speckles that we named TEL bodies.

173 ingers three and four, localizes to discrete nuclear speckles, the function of which is unknown.

174 ough the long MALAT1 transcript localizes to nuclear speckles, the small RNA is found exclusively in

175 . elegans RRM proteins, localizes to dynamic nuclear speckles; this localization pattern supports a r

176 s PABII protein molecules to relocalize from nuclear speckles to a uniform distribution throughout th

177 ridging of transcriptionally active RCs with nuclear speckles to form structures that enhance export

178 or efficient recruitment of SR proteins from nuclear speckles to nascent RNA.

179 We show that influenza virus utilizes nuclear speckles to promote post-transcriptional splicin

180 We show that the influenza virus uses nuclear speckles to promote post-transcriptional splicin

181 genes, we reveal a functional subversion of nuclear speckles to promote viral gene expression.

182 genes, we reveal a functional subversion of nuclear speckles to promote viral gene expression.

183 RNA splicing, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin

184 Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damagi

185 S105-ERbeta nuclear speckles were also seen in MCF-7 cells and marke

186 c-Myc nuclear speckles were distinct from SC-35 domains involv

187 ar speckle localization of WTAP, whereas the nuclear speckles were intact.

188 Distinct S105-ERbeta nuclear speckles were seen in some higher grade tumors.

189 d to direct this protein to the periphery of nuclear speckles, where coordinated transcription/RNA pr

190 here that T1L, but not T3D, mu2 localizes to nuclear speckles, where it forms a complex with the mRNA

191 express a protein variant that localizes to nuclear speckles, where it targets a cell mRNA splicing

192 itions PGC-1alpha is located within discrete nuclear speckles, whereas the expression of ERR-alpha re

193 RTe antibody reveal discrete cytoplasmic and nuclear speckles, which contain RARalpha in an RA-sensit

194 distinct subnuclear domains, identified as "nuclear speckles," which also contained pre-mRNA process

195 nalysis demonstrated that Glis2 localized to nuclear speckles while in most cells CtBP1 was found dif

196 70 transgenes associate with the exterior of nuclear speckles, with Hsp70 transcripts accumulating wi

197 In the nucleus Pnn is concentrated in the "nuclear speckles," zones of accumulation of transcriptio