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1 ggesting this amino acid plays a key role in nuclear transport.
2 substrate specificity and rapid evolution in nuclear transport.
3 e replication proteins that are regulated by nuclear transport.
4 he requirements for FG repeat domains in Ty3 nuclear transport.
5 s neither NLSII nor NLSIII have roles in p53 nuclear transport.
6 -translational modification shown to control nuclear transport.
7 Hsp40/DnaJB6 in the regulation of HIV-2 PIC nuclear transport.
8 scription 1 (STAT1) and be involved in STAT1 nuclear transport.
9 led us to analyze the role of acetylation in nuclear transport.
10 rgeting of integral INM proteins and soluble nuclear transport.
11 lization, consistent with a role for SAD2 in nuclear transport.
12 main family protein likely to be involved in nuclear transport.
13 suppressing tumor growth by regulating NICD nuclear transport.
14 suggesting that glycosylation may influence nuclear transport.
15 ritical for its proteolysis beyond a role in nuclear transport.
16 lar receptors, disrupt membranes, or enhance nuclear transport.
17 NUP214, NUP358, NUP153, and p62, involved in nuclear transport.
18 entical to that used in classical NLS-driven nuclear transport.
19 functional classes, including olfaction and nuclear transport.
20 onditional proteolysis, cellular uptake, and nuclear transport.
21 he shuttling transport receptors involved in nuclear transport.
22 es an efficient energetic unit in support of nuclear transport.
23 odified nucleoporins to proteins involved in nuclear transport.
24 ession besides their established function in nuclear transport.
25 ffectively compete with and inhibit PY-STAT1 nuclear transport.
26 PIC may proceed concurrently with the normal nuclear transport.
27 l (Tl) signaling pathway, which regulates Dl nuclear transport.
28 NA5 that is necessary for efficient PY-STAT1 nuclear transport.
29 ociated with essential recognition events in nuclear transport.
30 e when SHMT1 undergoes SUMO modification and nuclear transport.
33 s studies have described a role for importin nuclear transport adaptors in mediating the retrograde t
35 ominant negative importin beta that inhibits nuclear transport, also prevents pronucleus formation an
37 a small G protein best known for its role in nuclear transport and can be found at the nuclear pore t
39 ate motor activity to achieve unidirectional nuclear transport and demonstrate a direct link between
40 F-M, GAP-43) by compromising their efficient nuclear transport and disrupting their loading onto poly
41 A library to silence 82 proteins involved in nuclear transport and found that knockdowns of karyopher
42 tates the re-evaluation of current models of nuclear transport and how this process is regulated.
43 iferating cells, formin inhibition abolishes nuclear transport and initiation of DNA replication, as
44 e found to be critical in determining Syk(L) nuclear transport and invasion suppression activity; mut
45 regulated by mechanisms similar to those of nuclear transport and is dependent on nucleoporins (NUPs
46 ical eukaryotic cellular functions including nuclear transport and mitosis through the creation of a
48 otein (eVP24) binds KPNA to inhibit PY-STAT1 nuclear transport and render cells refractory to IFNs.
51 nk between two major cell-fate determinants: nuclear transport and the Ras/ERK/RSK and PI3K/Akt signa
53 orresponding chromosomes to ensure efficient nuclear transport and thereby overcome the need for a st
55 IP30), a proapoptotic factor, which inhibits nuclear transport and, consequently, Notch1-mediated oli
57 nvolved in translation, ribosome biogenesis, nuclear transport, and amino acid metabolism are more li
60 protein degradation, translation, splicing, nuclear transport, and mRNA homeostasis converge on P-gr
62 critical for the stabilization, processing, nuclear transport, and translation of the transcript.
63 olding, proteolysis, nucleolar function, and nuclear transport as well as several other cellular proc
64 elaborate mechanism that involves regulated nuclear transport as well as SUMOylation and ubiquitinat
69 e addition of Nup210 to NPCs does not affect nuclear transport but is required for the induction of g
70 y, NUP88 overexpression did not alter global nuclear transport, but was a potent inducer of aneuploid
71 respectively, modulate the Ran gradient and nuclear transport by interacting with, phosphorylating,
73 contribute to the anomalously high rates of nuclear transport by, e.g., stirring of molecules next t
74 is important for the correct localization of nuclear transport cargoes and of components of the NPC.
76 ay, soluble cargo proteins are recognized by nuclear transport carriers, called importins, which medi
77 lps are multifunctional proteins linking the nuclear transport channel to multiple macromolecular com
78 Nuclear pore complexes (NPCs) emerged as nuclear transport channels in eukaryotic cells approxima
80 hey fall into four major functional classes: nuclear transport, chromatin binding/structure, transcri
82 -containing nucleoporin that, in addition to nuclear transport, contributes to multiple aspects of ge
84 ocorticoid responsiveness, changes in GRbeta nuclear transport could influence subsequent responses t
88 ally, genes involved in stress responses and nuclear transport exhibited mostly changes in alternativ
93 is applied to study the stoichiometry of the nuclear transport factor 2 in a cell-free system over a
94 ), density-regulated protein 1, P150(glued), nuclear transport factor 2, binder of ARL 2, Paxillin, a
97 ly assays, we have identified a role for the nuclear transport factor importin alpha in the regulatio
98 s overlapping binding sites for Acl4 and the nuclear transport factor Kap104, facilitating its contin
99 m cell-derived cardiac cells distributed the nuclear transport factor Ran in the nucleus, decreased t
101 ctor Hox C6, the oncogene Ets 2, and the Ras nuclear transport factor, nuclear transport factor 2.
103 complex proteins (nucleoporins) and soluble nuclear transport factors (karyopherins, importins, and
104 ed, we find that overexpression of different nuclear transport factors can suppress the temperature-s
105 enes with the nuclear pore complex (NPC) and nuclear transport factors has been implicated in transcr
108 ins termed nucleoporins (or "Nups"), and (2) nuclear transport factors that recognize the cargoes to
109 fect nondividing cells by commandeering host nuclear transport factors to facilitate the passage of t
110 proteins, cytoskeleton-associated proteins, nuclear transport factors, lipid metabolism regulators,
111 sslinking between FG-repeat nucleoporins and nuclear transport factors, suggesting that O-GlcNAc resi
114 udies to provide the first evidence that the nuclear transport function of eIF4E contributes to human
116 particular instance in Drosophila, X-linked nuclear transport genes (Ntf-2 and ran) have given rise
123 explain the alterations in permeability and nuclear transport in enterovirus-infected cells and how
124 he mechanisms responsible for alterations in nuclear transport in enterovirus-infected cells that lea
129 chain uPA, but not uPA variants incapable of nuclear transport, increases the expression of cell surf
130 iation in concentrations of freely diffusing nuclear transport intermediates among cells indicates th
131 s suggest that formation of freely diffusing nuclear transport intermediates is in competition with b
134 fate; however, little is known regarding how nuclear transport is regulated by or regulates these pat
135 lpha1, an essential component of cytoplasmic-nuclear transport, is abnormally accumulated in Hirano b
139 xamined the association of components of the nuclear transport machinery including karyopherins, nucl
140 retroviruses like HIV, may utilize cellular nuclear transport machinery to import their essential nu
142 le formation system that uses the Ran-GTPase nuclear transport machinery, but no targets of Ran for s
143 the transport receptor TAP of the host cell nuclear transport machinery, several aspects of ICP27 tr
148 esses, including transcriptional regulation, nuclear transport, maintenance of genome integrity, and
149 susceptibility protein associated defective nuclear transport may play a mechanistic role in the pat
150 y of IAV structural components, regulated by nuclear transport mechanisms and host factor binding.
153 We have now determined that this involves a nuclear transport molecule we have termed ferritoid.
154 ate into living mammalian cells triggers the nuclear transport of a Gal4 DNA binding domain-glucocort
156 translocation of caspase-3, indicating that nuclear transport of active caspase-3 required proteolyt
159 ) distinct cell-dependent mechanisms for the nuclear transport of apelin, AT(1), and B(2) receptors;
160 osphorylation by PKD1 and is associated with nuclear transport of AR resulting in increased AR transc
162 nuclear GTPases, Rap1a/b, to facilitate the nuclear transport of beta-catenin, defining a parallel n
166 gether, our results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucle
167 The purpose of this study was to compare the nuclear transport of EGFR family proteins with that of F
168 the cytoplasm and has been shown to inhibit nuclear transport of FGFR-1, had no effects on EGFR nucl
169 estigated the process mediated by the active nuclear transport of Gal-3 and have identified a nuclear
170 he present study, the roles of FKBP51 in the nuclear transport of GRbeta and glucocorticoid responsiv
174 We propose a model in which Nap1p links the nuclear transport of H2A and H2B to chromatin assembly.
175 contribute to the model whereby the induced nuclear transport of HCF-1 in sensory neurons may be cri
180 xts, proteolysis controls the cytoplasmic-to-nuclear transport of important transcription factors or
183 e initiated in the nucleus, we asked whether nuclear transport of MLH1 and PMS2 is limiting for the n
184 sociated proteins with roles in assembly and nuclear transport of multisubunit eukaryotic RNA polymer
187 epression of CYP7A1 by cholate, and blocking nuclear transport of nitrosylated GAPDH reduced cholate-
188 increasing protein expression and enhancing nuclear transport of Notch intracellular domain (NICD).
189 ent of head and neck cancer cells results in nuclear transport of p16 leading to a molecular modifica
192 epeat circles implies that the impairment of nuclear transport of preintegration complexes is respons
193 Excessive ROS production also facilitates nuclear transport of proatherogenic transcription factor
196 hat extent DNA damage-induced cytoplasmic to nuclear transport of Rad51 may contribute to this proces
201 SUMO2 modification at K68, which facilitates nuclear transport of SHP and its interaction with repres
202 lear import of Smad3 and Smad4 suggests that nuclear transport of Smad3 and Smad4 is subject to contr
204 uclear morphology, chromatin remodeling, and nuclear transport of soluble signaling intermediates usi
205 , is directly involved as a chaperone in the nuclear transport of STAT1alpha and shares this mechanis
207 t endocytosis plays an essential role in the nuclear transport of the ErbB family members, such as ep
208 gest a model of VZV capsid assembly in which nuclear transport of the major capsid protein and associ
212 activities during viral infection, including nuclear transport of the proviral integration complex, i
213 y structures.Importin alpha3 facilitates the nuclear transport of the Ran guanine nucleotide exchange
219 ed by cAMP, calcium, or GPCR activation, and nuclear transport of TORC1 was sufficient to activate CR
220 gous deletion strain are devoid of O-GlcNAc, nuclear transport of transcription factors appears norma
221 defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-phosphorylated STAT1 (PY-S
222 l adhesion kinase phosphorylation and led to nuclear transport of viral capsids and viral gene expres
224 ported protein, which determines both active nuclear transport of YAP and passive transport of small
225 nucleoporin mobility makes to the process of nuclear transport or how such mobility is regulated.
226 ing this modification had no consequences on nuclear transport or NPC organization but strongly affec
227 he cytoplasm to the nucleus, suggesting that nuclear transport or retention of Xmeis1b may depend upo
229 1 mutant and highlight the importance of the nuclear transport pathway for virulence of eukaryotic pa
233 ing infection, leading to disruption of host nuclear transport pathways and alterations in nuclear pe
237 , and disruption of actin dynamics abrogates nuclear transport, preventing NLS (nuclear localisation
243 uired for nuclear translocation and that the nuclear transport properties of the mimetic correlated w
244 ins with diverse functional roles, including nuclear transport, prostaglandin synthesis, ubiquitinati
246 sensus site and by association with Kpna6/1, nuclear transport proteins that did not co-purify with o
247 Nuclear transport requires freely diffusing nuclear transport proteins to facilitate movement of car
248 5 (IPO5), a member of the importin family of nuclear transport proteins, as an intracellular binding
251 diverse set of cellular processes, including nuclear transport, proteolysis, translation, autophagy,
252 transport of FGFR-1, had no effects on EGFR nuclear transport, raising the possibility that EGFR and
253 e to selectively facilitate translocation of nuclear transport receptor (NTR)-bearing macromolecules.
256 ortin beta, once thought to be exclusively a nuclear transport receptor, is emerging as a global regu
257 eptide is chaperoned through the nanopore by nuclear transport receptors (e.g., importins) owing to t
260 o nuclear pore complex (NPC) function, where nuclear transport receptors (NTRs) move through the NPC
261 tively analyzed the binding of two different nuclear transport receptors (NTRs), NTF2 and Importin be
262 FG Nups interact promiscuously with various nuclear transport receptors (NTRs), such as karyopherins
263 duct massive transport mediated by shuttling nuclear transport receptors (NTRs), while keeping nuclea
266 rogel that allows highly selective access of nuclear transport receptors and their cargos, but reject
269 t 1-microm-sized colloidal particles bearing nuclear transport receptors called karyopherins can exhi
271 ore protein and are associated with cellular nuclear transport receptors karyopherin-alpha and -beta.
272 regulating interactions between cargoes and nuclear transport receptors of the importin-beta family.
273 macromolecules is mainly mediated by soluble nuclear transport receptors of the karyopherin-beta supe
274 barrier, which is selectively permeable for nuclear transport receptors that interact with these rep
275 larger than approximately 5 nm must bind to nuclear transport receptors to overcome a selective barr
279 Mediator complex; E3 ubiquitin ligase Nedd4; nuclear transport regulator RanGap1; and several protein
280 s undergo structural adaptation and mobilize nuclear transport regulators in support of nucleocytopla
282 f p53 cytoplasmic sequestration that impairs nuclear transport rendering cells functionally deficient
285 eath, strongly indicating that inhibition of nuclear transport serves as a potent apoptotic signal.
286 To address this question, we analyzed the nuclear transport signals in Exd, including a divergent
287 eat germ agglutinin and thus required active nuclear transport, similarly to the assembly of full-siz
288 Ran GTPase is required for nuclear assembly, nuclear transport, spindle assembly, and mitotic regulat
289 iphosphatase and performs essential roles in nuclear transport, spindle organization, and nuclear env
290 intermediates among cells indicates that the nuclear transport system is sufficiently robust to funct
291 function provides an alternative pathway for nuclear transport that can be utilized by membrane-embed
292 and how enteroviruses exert these effects on nuclear transport, the mechanisms and consequences of Nu
293 rther find that importin beta regulates EGFR nuclear transport to the INM in addition to the nucleus/
294 dent and -independent mechanisms of RelA/p65 nuclear transport using the proinflammatory mediators, t
296 owing viral attachment, internalization, and nuclear transport was assayed by detecting newly synthes
298 ssible Brca2-independent mechanism for Rad51 nuclear transport, we analyzed subcellular fractions for
300 NA picornaviruses, encode factors that alter nuclear transport with the aim of suppressing synthesis
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