ライフサイエンスコーパス: nuclear transport

1 ggesting this amino acid plays a key role in nuclear transport.

2 substrate specificity and rapid evolution in nuclear transport.

3 e replication proteins that are regulated by nuclear transport.

4 he requirements for FG repeat domains in Ty3 nuclear transport.

5 s neither NLSII nor NLSIII have roles in p53 nuclear transport.

6 -translational modification shown to control nuclear transport.

7 Hsp40/DnaJB6 in the regulation of HIV-2 PIC nuclear transport.

8 scription 1 (STAT1) and be involved in STAT1 nuclear transport.

9 led us to analyze the role of acetylation in nuclear transport.

10 rgeting of integral INM proteins and soluble nuclear transport.

11 lization, consistent with a role for SAD2 in nuclear transport.

12 main family protein likely to be involved in nuclear transport.

13 suppressing tumor growth by regulating NICD nuclear transport.

14 suggesting that glycosylation may influence nuclear transport.

15 ritical for its proteolysis beyond a role in nuclear transport.

16 lar receptors, disrupt membranes, or enhance nuclear transport.

17 NUP214, NUP358, NUP153, and p62, involved in nuclear transport.

18 entical to that used in classical NLS-driven nuclear transport.

19 functional classes, including olfaction and nuclear transport.

20 onditional proteolysis, cellular uptake, and nuclear transport.

21 he shuttling transport receptors involved in nuclear transport.

22 es an efficient energetic unit in support of nuclear transport.

23 odified nucleoporins to proteins involved in nuclear transport.

24 ession besides their established function in nuclear transport.

25 ffectively compete with and inhibit PY-STAT1 nuclear transport.

26 PIC may proceed concurrently with the normal nuclear transport.

27 l (Tl) signaling pathway, which regulates Dl nuclear transport.

28 NA5 that is necessary for efficient PY-STAT1 nuclear transport.

29 ociated with essential recognition events in nuclear transport.

30 e when SHMT1 undergoes SUMO modification and nuclear transport.

31 Cs), membrane-embedded channels that mediate nuclear transport across the nuclear envelope.

32 STAT1, in a reaction that is competed by the nuclear transport adapter importin alpha5.

33 s studies have described a role for importin nuclear transport adaptors in mediating the retrograde t

34 This novel mechanism of inhibiting nuclear transport also shows that the nuclear pore compl

35 ominant negative importin beta that inhibits nuclear transport, also prevents pronucleus formation an

36 We show that WNT10B causes nuclear transport and binding of RAC1 and beta-catenin i

37 a small G protein best known for its role in nuclear transport and can be found at the nuclear pore t

38 rongly suggesting a mechanistic link between nuclear transport and cell-to-cell movement.

39 ate motor activity to achieve unidirectional nuclear transport and demonstrate a direct link between

40 F-M, GAP-43) by compromising their efficient nuclear transport and disrupting their loading onto poly

41 A library to silence 82 proteins involved in nuclear transport and found that knockdowns of karyopher

42 tates the re-evaluation of current models of nuclear transport and how this process is regulated.

43 iferating cells, formin inhibition abolishes nuclear transport and initiation of DNA replication, as

44 e found to be critical in determining Syk(L) nuclear transport and invasion suppression activity; mut

45 regulated by mechanisms similar to those of nuclear transport and is dependent on nucleoporins (NUPs

46 ical eukaryotic cellular functions including nuclear transport and mitosis through the creation of a

47 d form (RanGTP) and plays important roles in nuclear transport and mitosis.

48 otein (eVP24) binds KPNA to inhibit PY-STAT1 nuclear transport and render cells refractory to IFNs.

49 C patients at least in part by inhibiting AR nuclear transport and signaling.

50 In this work, we have investigated SLBP nuclear transport and subcellular localization during th

51 nk between two major cell-fate determinants: nuclear transport and the Ras/ERK/RSK and PI3K/Akt signa

52 The intrinsic signals directing mTOR nuclear transport and the underlying mechanisms are unkn

53 orresponding chromosomes to ensure efficient nuclear transport and thereby overcome the need for a st

54 roteins involved in numerous roles including nuclear transport and transcriptional regulation.

55 IP30), a proapoptotic factor, which inhibits nuclear transport and, consequently, Notch1-mediated oli

56 TCL1 family proteins regulate nuclear transport and/or activation of AKT.

57 nvolved in translation, ribosome biogenesis, nuclear transport, and amino acid metabolism are more li

58 processes, including cell cycle progression, nuclear transport, and autophagy.

59 asmic RNA processing, vesicular trafficking, nuclear transport, and DNA maintenance.

60 protein degradation, translation, splicing, nuclear transport, and mRNA homeostasis converge on P-gr

61 l signaling, cytoskeletal self-organization, nuclear transport, and the cell cycle.

62 critical for the stabilization, processing, nuclear transport, and translation of the transcript.

63 olding, proteolysis, nucleolar function, and nuclear transport as well as several other cellular proc

64 elaborate mechanism that involves regulated nuclear transport as well as SUMOylation and ubiquitinat

65 In a nuclear transport assay, we have determined that Maelstr

66 Nuclear transport assays showed that this IBB mutant is

67 We found that in in vitro nuclear transport assays tyrosine-phosphorylated STAT1al

68 Spindle assembly and nuclear transport both utilize the same simple device: R

69 e addition of Nup210 to NPCs does not affect nuclear transport but is required for the induction of g

70 y, NUP88 overexpression did not alter global nuclear transport, but was a potent inducer of aneuploid

71 respectively, modulate the Ran gradient and nuclear transport by interacting with, phosphorylating,

72 Importin alpha's mediate nuclear transport by linking nuclear localization signal

73 contribute to the anomalously high rates of nuclear transport by, e.g., stirring of molecules next t

74 is important for the correct localization of nuclear transport cargoes and of components of the NPC.

75 Nuclear transport carriers interact with proteins of the

76 ay, soluble cargo proteins are recognized by nuclear transport carriers, called importins, which medi

77 lps are multifunctional proteins linking the nuclear transport channel to multiple macromolecular com

78 Nuclear pore complexes (NPCs) emerged as nuclear transport channels in eukaryotic cells approxima

79 We tested the nuclear transport characteristics of full-length phyB as

80 hey fall into four major functional classes: nuclear transport, chromatin binding/structure, transcri

81 t by controlling assembly and disassembly of nuclear transport complexes.

82 -containing nucleoporin that, in addition to nuclear transport, contributes to multiple aspects of ge

83 This adds nuclear transport control to the mitotic roles of Mad1.

84 ocorticoid responsiveness, changes in GRbeta nuclear transport could influence subsequent responses t

85 a dominant-negative mutant of Ran, causes a nuclear transport defect of ErbB-2.

86 The nuclear transport domain (NTD) of RHA is known to be nec

87 ther, these studies reveal that specific NPC nuclear transport events directly influence aging.

88 ally, genes involved in stress responses and nuclear transport exhibited mostly changes in alternativ

89 ting that at least two different pathways of nuclear transport exist for cell surface receptors.

90 One such carrier is nuclear transport factor 2 (NTF2), whose import cargo is

91 an relies on a small RanGDP-binding protein, Nuclear Transport Factor 2 (NTF2).

92 for the nuclear import of RanGDP mediated by nuclear transport factor 2 (NTF2).

93 is applied to study the stoichiometry of the nuclear transport factor 2 in a cell-free system over a

94 ), density-regulated protein 1, P150(glued), nuclear transport factor 2, binder of ARL 2, Paxillin, a

95 determine the oligomerization of cytoplasmic nuclear transport factor 2.

96 Ets 2, and the Ras nuclear transport factor, nuclear transport factor 2.

97 ly assays, we have identified a role for the nuclear transport factor importin alpha in the regulatio

98 s overlapping binding sites for Acl4 and the nuclear transport factor Kap104, facilitating its contin

99 m cell-derived cardiac cells distributed the nuclear transport factor Ran in the nucleus, decreased t

100 This suggests that G3BP is a nuclear transport factor, as hypothesized previously, an

101 ctor Hox C6, the oncogene Ets 2, and the Ras nuclear transport factor, nuclear transport factor 2.

102 Drosophila melanogaster subgroup, Drosophila nuclear transport factor-2-related (Dntf-2r).

103 complex proteins (nucleoporins) and soluble nuclear transport factors (karyopherins, importins, and

104 ed, we find that overexpression of different nuclear transport factors can suppress the temperature-s

105 enes with the nuclear pore complex (NPC) and nuclear transport factors has been implicated in transcr

106 We determined that NUP88 and the nuclear transport factors NUP98 and RAE1 comprise a regu

107 Nuclear transport factors recognize nuclear targeting si

108 ins termed nucleoporins (or "Nups"), and (2) nuclear transport factors that recognize the cargoes to

109 fect nondividing cells by commandeering host nuclear transport factors to facilitate the passage of t

110 proteins, cytoskeleton-associated proteins, nuclear transport factors, lipid metabolism regulators,

111 sslinking between FG-repeat nucleoporins and nuclear transport factors, suggesting that O-GlcNAc resi

112 t also may serve as storage compartments for nuclear transport factors.

113 Consistent with the proposed nuclear transport function for ferritoid, co-transfectio

114 udies to provide the first evidence that the nuclear transport function of eIF4E contributes to human

115 have a novel mitotic role in addition to its nuclear transport functions.

116 particular instance in Drosophila, X-linked nuclear transport genes (Ntf-2 and ran) have given rise

117 ans closed mitosis, a systematic analysis of nuclear transport genes has been completed.

118 he degradation events or the requirement for nuclear transport has not been resolved.

119 Factors involved in nuclear transport have been well studied, but systems an

120 mainly with PER proteins and directs PER/CRY nuclear transport in a circadian fashion.

121 The results suggest a role for nuclear transport in ABA signal transduction, and the po

122 a hindrance in importin-mediated cytoplasmic-nuclear transport in AD.

123 explain the alterations in permeability and nuclear transport in enterovirus-infected cells and how

124 he mechanisms responsible for alterations in nuclear transport in enterovirus-infected cells that lea

125 To gain insight into the role of nuclear transport in replication, we investigated whethe

126 D of PER that is a potent regulator of PER's nuclear transport in S2 cells.

127 a qualitative insight and interpretation of nuclear transport in the cellular context.

128 tional factors might be responsible for phyB nuclear transport in the plant.

129 chain uPA, but not uPA variants incapable of nuclear transport, increases the expression of cell surf

130 iation in concentrations of freely diffusing nuclear transport intermediates among cells indicates th

131 s suggest that formation of freely diffusing nuclear transport intermediates is in competition with b

132 These findings suggest that the rate of nuclear transport is a critical factor affecting growth

133 When nuclear transport is inhibited, reverse transcription is

134 fate; however, little is known regarding how nuclear transport is regulated by or regulates these pat

135 lpha1, an essential component of cytoplasmic-nuclear transport, is abnormally accumulated in Hirano b

136 We discuss nuclear transport issues recently addressed by single-mo

137 e additional insight on how AdV exploits the nuclear transport machinery for infection.

138 ted that there is failure of the cytoplasmic-nuclear transport machinery in AD.

139 xamined the association of components of the nuclear transport machinery including karyopherins, nucl

140 retroviruses like HIV, may utilize cellular nuclear transport machinery to import their essential nu

141 Nuclear transport machinery was the sole process-level d

142 le formation system that uses the Ran-GTPase nuclear transport machinery, but no targets of Ran for s

143 the transport receptor TAP of the host cell nuclear transport machinery, several aspects of ICP27 tr

144 rtin beta and importin alpha, members of the nuclear transport machinery.

145 is coupled via transcriptional state to the nuclear transport machinery.

146 ns destined for active nuclear import to the nuclear transport machinery.

147 relationship between the NPC and the soluble nuclear transport machinery.

148 esses, including transcriptional regulation, nuclear transport, maintenance of genome integrity, and

149 susceptibility protein associated defective nuclear transport may play a mechanistic role in the pat

150 y of IAV structural components, regulated by nuclear transport mechanisms and host factor binding.

151 Thus, nuclear transport mechanisms are physiological regulator

152 sion coefficients provides new insights into nuclear transport mechanisms.

153 We have now determined that this involves a nuclear transport molecule we have termed ferritoid.

154 ate into living mammalian cells triggers the nuclear transport of a Gal4 DNA binding domain-glucocort

155 us nuclear localization signal to facilitate nuclear transport of a heterologous protein.

156 translocation of caspase-3, indicating that nuclear transport of active caspase-3 required proteolyt

157 We also found that TRIM3 suppressed nuclear transport of active NOTCH1 (NICD) in glioblastom

158 Blocking nuclear transport of ANG inhibited latent ORF73 gene exp

159 ) distinct cell-dependent mechanisms for the nuclear transport of apelin, AT(1), and B(2) receptors;

160 osphorylation by PKD1 and is associated with nuclear transport of AR resulting in increased AR transc

161 at small GTPases with a PBR can regulate the nuclear transport of armadillo proteins.

162 nuclear GTPases, Rap1a/b, to facilitate the nuclear transport of beta-catenin, defining a parallel n

163 FKBP51 was involved in constitutive nuclear transport of both GRalpha and -beta in the absen

164 is and endosomal sorting are involved in the nuclear transport of cell surface RTKs.

165 The nuclear transport of classical nuclear localization sign

166 gether, our results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucle

167 The purpose of this study was to compare the nuclear transport of EGFR family proteins with that of F

168 the cytoplasm and has been shown to inhibit nuclear transport of FGFR-1, had no effects on EGFR nucl

169 estigated the process mediated by the active nuclear transport of Gal-3 and have identified a nuclear

170 he present study, the roles of FKBP51 in the nuclear transport of GRbeta and glucocorticoid responsiv

171 Nuclear transport of GRbeta represents a novel mechanism

172 In this study, the roles of Hsp90 in the nuclear transport of GRbeta were investigated.

173 is an essential molecular chaperone for the nuclear transport of GRbeta.

174 We propose a model in which Nap1p links the nuclear transport of H2A and H2B to chromatin assembly.

175 contribute to the model whereby the induced nuclear transport of HCF-1 in sensory neurons may be cri

176 a novel role for importin-4 in governing the nuclear transport of HE4.

177 d C-terminal cleavage was also necessary for nuclear transport of HO-1.

178 We show that the mimetic mediates the nuclear transport of IFNGR-1 through its interaction wit

179 Nuclear transport of immune receptors, signal transducer

180 xts, proteolysis controls the cytoplasmic-to-nuclear transport of important transcription factors or

181 Nuclear transport of KAP-GFP could be due to a putative

182 52 appeared to be solely responsible for the nuclear transport of ligand-activated GRalpha.

183 e initiated in the nucleus, we asked whether nuclear transport of MLH1 and PMS2 is limiting for the n

184 sociated proteins with roles in assembly and nuclear transport of multisubunit eukaryotic RNA polymer

185 e been elucidated, mechanisms regulating the nuclear transport of NF-kappaB remain elusive.

186 Because calcineurin induces nuclear transport of NFATc proteins, whose expression pa

187 epression of CYP7A1 by cholate, and blocking nuclear transport of nitrosylated GAPDH reduced cholate-

188 increasing protein expression and enhancing nuclear transport of Notch intracellular domain (NICD).

189 ent of head and neck cancer cells results in nuclear transport of p16 leading to a molecular modifica

190 Nuclear transport of PER is also believed to be an essen

191 versatile to elucidate the mechanism of the nuclear transport of phyB.

192 epeat circles implies that the impairment of nuclear transport of preintegration complexes is respons

193 Excessive ROS production also facilitates nuclear transport of proatherogenic transcription factor

194 Several studies suggest that the nuclear transport of proteins from synapses is involved

195 This location would provide nuclear transport of putative truncated proteins encoded

196 hat extent DNA damage-induced cytoplasmic to nuclear transport of Rad51 may contribute to this proces

197 the amino terminus is important in mediating nuclear transport of RAP80.

198 rolyze it are inviable and unable to support nuclear transport of RNAPII.

199 Blocking of sumoylation and nuclear transport of S100A4 inhibited the IL-1beta-induc

200 monstrate that nucleolin is required for the nuclear transport of scuPA.

201 SUMO2 modification at K68, which facilitates nuclear transport of SHP and its interaction with repres

202 lear import of Smad3 and Smad4 suggests that nuclear transport of Smad3 and Smad4 is subject to contr

203 n signal (NLS) sequence, we investigated the nuclear transport of SmgGDS with Rac1 or RhoA.

204 uclear morphology, chromatin remodeling, and nuclear transport of soluble signaling intermediates usi

205 , is directly involved as a chaperone in the nuclear transport of STAT1alpha and shares this mechanis

206 whether differentiated cells facilitate the nuclear transport of tegument-delivered pp71.

207 t endocytosis plays an essential role in the nuclear transport of the ErbB family members, such as ep

208 gest a model of VZV capsid assembly in which nuclear transport of the major capsid protein and associ

209 The nuclear transport of the non-ligand-binding GRbeta is st

210 The nuclear transport of the phytochromes upon light activat

211 , indicating that this deletion affected the nuclear transport of the portal protein.

212 activities during viral infection, including nuclear transport of the proviral integration complex, i

213 y structures.Importin alpha3 facilitates the nuclear transport of the Ran guanine nucleotide exchange

214 We previously reported that nuclear transport of the Rous sarcoma virus (RSV) Gag pr

215 receptor-1 (PAR1) and PAR3, which inhibited nuclear transport of the Sp1 transcription factor.

216 Nuclear transport of the vector was evident by transgene

217 ts transduction by AAV2 vectors by impairing nuclear transport of the vectors.

218 Nuclear transport of the viral tegument protein VP16, tr

219 ed by cAMP, calcium, or GPCR activation, and nuclear transport of TORC1 was sufficient to activate CR

220 gous deletion strain are devoid of O-GlcNAc, nuclear transport of transcription factors appears norma

221 defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-phosphorylated STAT1 (PY-S

222 l adhesion kinase phosphorylation and led to nuclear transport of viral capsids and viral gene expres

223 new structures shed additional light on the nuclear transport of viral transcripts.

224 ported protein, which determines both active nuclear transport of YAP and passive transport of small

225 nucleoporin mobility makes to the process of nuclear transport or how such mobility is regulated.

226 ing this modification had no consequences on nuclear transport or NPC organization but strongly affec

227 he cytoplasm to the nucleus, suggesting that nuclear transport or retention of Xmeis1b may depend upo

228 ied a nuclear pool of CXCR4 and we defined a nuclear transport pathway for CXCR4.

229 1 mutant and highlight the importance of the nuclear transport pathway for virulence of eukaryotic pa

230 sis of a number of features of the classical nuclear transport pathway specific to plants.

231 ansport of beta-catenin, defining a parallel nuclear transport pathway to Ran.

232 to nucleocytoplasmic shuttling via the CRM1 nuclear transport pathway.

233 ing infection, leading to disruption of host nuclear transport pathways and alterations in nuclear pe

234 Although the nuclear transport pathways are just beginning to be unra

235 his contributes to the disruption of certain nuclear transport pathways.

236 ate additional levels of complexity in these nuclear transport pathways.

237 , and disruption of actin dynamics abrogates nuclear transport, preventing NLS (nuclear localisation

238 We further found that nuclear transport, primarily through this novel NLS, is

239 Nuclear transport proceeds through nuclear pore complexe

240 ork of random coils at the NPC through which nuclear transport proceeds.

241 rin/importin alpha, is the most well studied nuclear transport process.

242 Nuclear transport processes can have a major impact on t

243 uired for nuclear translocation and that the nuclear transport properties of the mimetic correlated w

244 ins with diverse functional roles, including nuclear transport, prostaglandin synthesis, ubiquitinati

245 n-dispensable region of RAG-2 identified the nuclear transport protein Importin 5.

246 sensus site and by association with Kpna6/1, nuclear transport proteins that did not co-purify with o

247 Nuclear transport requires freely diffusing nuclear transport proteins to facilitate movement of car

248 5 (IPO5), a member of the importin family of nuclear transport proteins, as an intracellular binding

249 n (C) by the host importin (IMP) alpha/beta1 nuclear transport proteins.

250 etween DENV nonstructural protein 5 and host nuclear transport proteins.

251 diverse set of cellular processes, including nuclear transport, proteolysis, translation, autophagy,

252 transport of FGFR-1, had no effects on EGFR nuclear transport, raising the possibility that EGFR and

253 e to selectively facilitate translocation of nuclear transport receptor (NTR)-bearing macromolecules.

254 and revealed age-associated decreases in the nuclear transport receptor RanBP17.

255 he interaction of the cargo with the classic nuclear transport receptor, importin alpha.

256 ortin beta, once thought to be exclusively a nuclear transport receptor, is emerging as a global regu

257 eptide is chaperoned through the nanopore by nuclear transport receptors (e.g., importins) owing to t

258 Nuclear transport receptors (NTRs) carry cargos through

259 Nuclear transport receptors (NTRs) mediate nucleocytopla

260 o nuclear pore complex (NPC) function, where nuclear transport receptors (NTRs) move through the NPC

261 tively analyzed the binding of two different nuclear transport receptors (NTRs), NTF2 and Importin be

262 FG Nups interact promiscuously with various nuclear transport receptors (NTRs), such as karyopherins

263 duct massive transport mediated by shuttling nuclear transport receptors (NTRs), while keeping nuclea

264 as distant similarity with flexible S-shaped nuclear transport receptors (NTRs).

265 Added nuclear transport receptors accumulate on the intact tra

266 rogel that allows highly selective access of nuclear transport receptors and their cargos, but reject

267 Here, we report the involvement of nuclear transport receptors belonging to the importin-al

268 Soluble nuclear transport receptors bind signal-dependent cargos

269 t 1-microm-sized colloidal particles bearing nuclear transport receptors called karyopherins can exhi

270 omain self-assembly and selective binding of nuclear transport receptors is largely unexplored.

271 ore protein and are associated with cellular nuclear transport receptors karyopherin-alpha and -beta.

272 regulating interactions between cargoes and nuclear transport receptors of the importin-beta family.

273 macromolecules is mainly mediated by soluble nuclear transport receptors of the karyopherin-beta supe

274 barrier, which is selectively permeable for nuclear transport receptors that interact with these rep

275 larger than approximately 5 nm must bind to nuclear transport receptors to overcome a selective barr

276 l for cell viability and which interact with nuclear transport receptors.

277 phenylalanine-glycine (FG) binding sites for nuclear transport receptors.

278 to what extent cargos compete for binding to nuclear transport receptors.

279 Mediator complex; E3 ubiquitin ligase Nedd4; nuclear transport regulator RanGap1; and several protein

280 s undergo structural adaptation and mobilize nuclear transport regulators in support of nucleocytopla

281 tion, the mechanisms regulating beta-catenin nuclear transport remain undefined.

282 f p53 cytoplasmic sequestration that impairs nuclear transport rendering cells functionally deficient

283 Nuclear transport requires freely diffusing nuclear tran

284 Although major nuclear transport routes are not regulated by Nup60 modi

285 eath, strongly indicating that inhibition of nuclear transport serves as a potent apoptotic signal.

286 To address this question, we analyzed the nuclear transport signals in Exd, including a divergent

287 eat germ agglutinin and thus required active nuclear transport, similarly to the assembly of full-siz

288 Ran GTPase is required for nuclear assembly, nuclear transport, spindle assembly, and mitotic regulat

289 iphosphatase and performs essential roles in nuclear transport, spindle organization, and nuclear env

290 intermediates among cells indicates that the nuclear transport system is sufficiently robust to funct

291 function provides an alternative pathway for nuclear transport that can be utilized by membrane-embed

292 and how enteroviruses exert these effects on nuclear transport, the mechanisms and consequences of Nu

293 rther find that importin beta regulates EGFR nuclear transport to the INM in addition to the nucleus/

294 dent and -independent mechanisms of RelA/p65 nuclear transport using the proinflammatory mediators, t

295 S, these data suggest that progerin inhibits nuclear transport via oxidative stress.

296 owing viral attachment, internalization, and nuclear transport was assayed by detecting newly synthes

297 gered an intracellular calcium response, but nuclear transport was inhibited.

298 ssible Brca2-independent mechanism for Rad51 nuclear transport, we analyzed subcellular fractions for

299 To determine requirements for nuclear transport, we tagged ERK2 with green fluorescent

300 NA picornaviruses, encode factors that alter nuclear transport with the aim of suppressing synthesis