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1 erminant in discriminating self versus viral nucleic acid.
2 o those of other protein complexes that bind nucleic acid.
3 lated to the starting amount of the template nucleic acid.
4 only in the presence of the specific target nucleic acid.
5 ocesses of biomolecules such as proteins and nucleic acids.
6 cellular and intracellular space for foreign nucleic acids.
7 e systems that target and deactivate foreign nucleic acids.
8 n biological systems by the encapsulation of nucleic acids.
9 s in biophysics, biochemistry and biology of nucleic acids.
10 omposed of specialized lipids, proteins, and nucleic acids.
11 which is followed by a selective cleavage of nucleic acids.
12 cusing primarily on intracellular sensors of nucleic acids.
13 g advantage of gaps between the RNAP and the nucleic acids.
14 mics of guanine amino groups in G-quadruplex nucleic acids.
15 of carbohydrates and oxidation of lipids and nucleic acids.
16 ide a platform for the cytosolic delivery of nucleic acids.
17 te immune system that sense pathogen-derived nucleic acids.
18 urface of fibrils, comparable to polymerized nucleic acids.
19 h as polyphosphate (polyP) and extracellular nucleic acids.
20 oteins, vaccines, monoclonal antibodies, and nucleic acids.
21 as developed based on a pyrrolidinyl peptide nucleic acid (acpcPNA)/polypyrrole (PPy)/silver nanofoam
23 nt nucleobases that can be incorporated into nucleic acids alongside their natural counterparts have
25 Direct molecular assay (ST Direct) relies on nucleic acid amplification and solid array-based amplico
26 broad range of assays, including isothermal nucleic acid amplification techniques, enzyme-based immu
27 cluding both antigen detection and multiplex nucleic acid amplification techniques, is becoming more
28 sitive for stx by an alternative FDA-cleared nucleic acid amplification test (NAAT) but were negative
29 ple, sample-to-answer, on-demand, multiplex, nucleic acid amplification test for syndromic diagnosis
30 Here we report the development of a mobile nucleic acid amplification testing (mobiNAAT) platform u
31 rator for improving the harmonization of BKV nucleic acid amplification testing (NAAT) and enabling c
34 chomatis infection in certain populations by nucleic acid amplification testing (NAAT), as they invol
35 the introduction of diagnostic M. genitalium nucleic acid amplification testing including antimicrobi
38 DTs), digital immunoassays (DIAs), and rapid nucleic acid amplification tests (NAATs) in children and
39 a CT (ACT) (Hologic Inc., San Diego, CA) are nucleic acid amplification tests (NAATs) that detect Chl
42 retrospectively using enzyme immunoassay and nucleic acid amplification tests on stored specimens.
44 ey components necessary to expand the use of nucleic acid amplification-based detection assays toward
46 ion of glycol nucleic acid (GNA), an acyclic nucleic acid analogue, as a modification of siRNA duplex
48 hemistries that will facilitate fast, simple nucleic acids analysis in a clinical setting are needed.
49 on sorter device to separate a wide range of nucleic acid analytes into distinct microchannel outlets
50 es various biosensors designed for detecting nucleic acid and protein-based cancer biomarkers for can
51 made in developing microfluidic systems for nucleic acid and whole bacteria immunoassay tests, their
52 nherent chemical differences between charged nucleic acids and hydrophobic drugs have hindered entrap
55 ransfusion medicine but also for delivery of nucleic acids and other molecules to HSPCs for targeted
56 emergence of functional interactions between nucleic acids and polypeptides was a key transition in t
59 d vesicles with lipid bilayers encapsulating nucleic acids and proteins, both with and without glycos
62 odel the electrostatic potential surrounding nucleic acids and the effects of the surrounding ion atm
64 valent complexes drawn from a broad class of nucleic acids and transient protein complexes found in a
65 served that in vivo administration of locked nucleic acid anti-miR-181b retarded both the development
67 primary FLT3-ITD(+) AML samples using locked nucleic acid antisense inhibitors, results in an elevate
68 rates the most differentially functionalized nucleic acid aptamer discovered by in vitro selection an
70 nt lateral flow assay (DRELFA) which pairs a nucleic acid aptamer with an antibody for use as a point
72 perature, and the extinction coefficients of nucleic acids are also affected by temperature, which ma
73 enzymes that metabolize or modify endogenous nucleic acids are essential for preventing inappropriate
77 e formulated nanoparticles to carry specific nucleic acid barcodes, administered the pool of particle
80 biophysical insights into nuclear crowding, nucleic acid based pharmaceutical development, and nucle
81 ading to point-of-care kits that incorporate nucleic acid-based assays, including polymerase chain re
84 Expression of miRNA was determined by locked nucleic acid-based quantitative real-time polymerase cha
88 protein, E3, which contains an N-terminal Z-nucleic acid binding (Zalpha) domain that is critical fo
91 ne, which reveals a novel positively charged nucleic acid binding site distal to the active center th
93 -inducible tumor-associated protein, harbors nucleic acid-binding domains for left-handed helix (Z-fo
94 with a femtosecond-pulsed laser to bleach a nucleic acid-binding dye causing dose-dependent apoptosi
95 ese changes also affected the degradation of nucleic acid-binding protein substrates of Lon, intracel
98 scribed are completely generalizable to many nucleic acid biomarkers, and could be adapted to provide
99 tion between transition metal nanosheets and nucleic acids, biosensing systems can be easily assemble
101 system for the intradermal administration of nucleic acids, both plasmid DNA (pDNA) and siRNA, to tre
102 l PCR estimate the concentration of a target nucleic acid by digitizing the end-point fluorescence of
104 is of the impact of deletions on proteins or nucleic acids can reveal important functional regions an
105 g systems (e.g., polypeptides, proteins, and nucleic acids) cannot occur without enrichment of chemic
114 mobile structural elements in mtRNAP and the nucleic acid components of the elongation complex (EC).
117 ection of viruses with relatively low plasma nucleic acid concentrations, it may have broad potential
118 eted exosomes carrying lipids, proteins, and nucleic acids conduct cell-cell communications within th
119 nd virus detection and analysis, and probing nucleic acid conformations and binding interactions.
120 :1 charge balance across the protein and the nucleic acid constituents, and can thus be maximal at di
121 nteractions between the involved protein and nucleic acid constituents, as well as net changes in ent
122 ample/target combinations with low levels of nucleic acids (Cq >/= 29) and/or variable amounts of che
124 mote the necessary conformational change for nucleic acid delivery to Pol alpha and subsequent DNA sy
126 to examine how the molecular conductance of nucleic acids depends on the composition of their backbo
131 atures (i.e., brackish vs. freshwaters), and nucleic acids (DNA vs. RNA), suggesting niche differenti
136 lification reactor that combines solid-phase nucleic acid extraction, concentration, and purification
139 cm, yet it efficiently recovers proteins and nucleic acids from a variety of pathogenic bacteria and
144 this review, we summarize recent advances of nucleic acid-functionalized transition metal nanosheets
147 and an assay of complementary gamma-peptide nucleic acid (gamma-PNA) probes conjugated to polystyren
148 Here we report the investigation of glycol nucleic acid (GNA), an acyclic nucleic acid analogue, as
149 is the extremely low capture efficiency for nucleic acids (>10 bases), which severely lowers the sen
152 enzyme-free, template-directed synthesis of nucleic acids have been limited by 'strand inhibition',
153 ion sequencing of circulating, tumor-derived nucleic acids hold promise for addressing the challenge
157 es oligonucleotide probes to enrich specific nucleic acids in heterogeneous extracts and can therefor
159 ination of the relative proportion of duplex nucleic acids in mixed ds/ss nucleic acid solutions, dem
160 In particular, the emergence of functional nucleic acids in the 1980s, especially aptamers, has sub
162 (TREX1) is an anti-viral enzyme that cleaves nucleic acids in the cytosol, preventing accumulation an
163 stranded structures formed by certain G-rich nucleic acids in vitro, but the sequence and structural
164 se (DraRnl) seals 3-OH/5-PO4 nicks in duplex nucleic acids in which the 3-OH nick terminus consists o
165 our data unveil the APE2 Zf-GRF domain as a nucleic acid interaction module in the regulation of a k
166 reveal the structural relationships between nucleic acid interactions and catalytic activity of A3F.
167 used to simultaneously detect multiple viral nucleic acid intermediates, characterize the effects of
168 livery of biomacromolecules (e.g., proteins, nucleic acids) into cell cytosol remains a critical chal
172 sult, chirality, a key intrinsic property of nucleic acids, is often overlooked as a design element f
174 th chaotropic agents is filtered through the nucleic acid isolation membrane, the membrane binds nucl
178 inhibition of the let-7 family with a locked nucleic acid (LNA)-anti-miR has the opposite effect.
179 structure, assembly and function of protein-nucleic acid macromolecular machines requires multidimen
180 uses (dengue, mumps, and measles viruses) or nucleic acid material (Nipah and chikungunya viruses).
181 ules into phase-separated protein or protein/nucleic acid "membraneless organelles" that regulate a h
183 H structural fold defines a large family of nucleic acid metabolizing enzymes that catalyze phosphor
184 lecular structures, including complexes with nucleic acids, micelles, vesicles, hybrid nanoparticles,
185 sensitive platform used to quantify specific nucleic acid molecules amplified by polymerase chain rea
186 e formulations have been designed to deliver nucleic acids, most nanoparticles have been tested in ce
189 soluble proteins (PN), polysaccharides (PS), nucleic acids (NA) and humic-like substances (HS) in the
190 This work provides access to a new set of nucleic acid-nanoparticle conjugates, which may be usefu
191 ntroduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary
192 s have revealed the potential in integrating nucleic acid nanostructures in cells and in vivo where t
193 tegy for constructing complex and replicable nucleic acid nanostructures, and expands the design spac
196 he molecular conductance differences between nucleic acids of different backbones correlate with diff
197 In situ hybridization analysis, using locked nucleic acid oligo probes complementary to the n1-src mi
198 seful for site-specific production of dA* in nucleic acid oligomers and/or polymers and also for the
201 However, mechanistic details regarding how nucleic acids or polyP modulate the individual reactions
203 al synthesis and the selection of functional nucleic acids, our strategy extends these principles to
205 n the strand replacement of dsDNA by peptide nucleic acid (PNA) and the in situ growth of electroacti
207 meric repeat complementing (CCCTAA)3 peptide nucleic acid (PNA) probe coupled with cardiac-specific a
208 In the current study, we describe a peptide nucleic acids (PNA)-based approach to block the ability
209 , molecularly-imprinted polymers and Peptide nucleic acid (PNAs) were developed as an attractive rece
211 el active-site configuration among different nucleic acid polymerase families, (b) the origin and phy
212 f water, proteins, lipids, carbohydrates and nucleic acids present in a cell, and is tightly linked t
215 ic acid sensors based on fluorogenic peptide nucleic acid probes embedded in permeable, physically cr
216 cleotide-templated reactions between peptide nucleic acid probes embedded within permeable agarose an
217 tions of this model, we assay the ability of nucleic acid processing enzymes, including a DNA polymer
218 a pharmacophore modelling and information of nucleic acid properties into our graph-based signatures,
221 ication and characterization of cross-linked nucleic acid-protein heteroconjugates within a complex s
222 ristics of exosomes, their associated cargo (nucleic acids, proteins, and lipids), and downstream fun
223 ng at specific locations within G-quadruplex nucleic acids, providing valuable probes for local struc
225 progress of the HPO project since the debut Nucleic Acids Research database article in 2014, includi
227 microwell, allowing for analysis of precious nucleic acid samples in shorter amounts of time relative
228 or rapid fractionation of size-heterogeneous nucleic acid samples into specific and narrow size distr
229 ecule-mediated stabilization of G-quadruplex nucleic acid secondary structures triggers local epigene
230 eport a hybridization-based assay exploiting nucleic acid self-assembly circuitry and enzyme exonucle
231 at germ cells express negative regulators of nucleic acid sensing (NAS) in steady state and applied a
233 e show that this methodology can be used for nucleic acid sensing extending the analyte recognition b
234 d that NLRP14 interacted physically with the nucleic acid sensing pathway and targeted TBK1 (TANK bin
236 mmation is independent of type I IFN and the nucleic acid sensing TLRs, blocking these pathways rescu
237 s rare human diseases caused by dysregulated nucleic acid sensing, focusing primarily on intracellula
243 n clinical utility, new methods of detecting nucleic acid sequences are being developed in order to r
244 omic next generation sequencing, we detected nucleic acid sequences from 2 novel viruses in the famil
246 ds that can rapidly and specifically analyze nucleic acid sequences will revolutionize the diagnosis
247 computing is to design biomolecules, such as nucleic acid sequences, that can be used to perform comp
248 correlation analysis to assess covariance of nucleic acid sequencing datasets such as chromatin immun
251 A one-pot synthesis of micellar spherical nucleic acid (SNA) nanostructures using Pluronic F127 as
254 rtion of duplex nucleic acids in mixed ds/ss nucleic acid solutions, demonstrating significant advant
256 le polyelectrolytes, such as single-stranded nucleic acids (ssNAs), is complicated by the interplay o
259 erse transcriptase of the telomerase and its nucleic acid substrates leading to loss of telomerase ac
260 tructural approaches to report AID-preferred nucleic acid substrates, illuminating AID targeting mech
263 ystems are efficient and easily programmable nucleic acid-targeting tools, with uses reaching beyond
266 , and achieved 10-fold signal enhancement in nucleic acid testing of HBV as compared to the unmodifie
268 ect can be rapidly reversed by complementary nucleic acids that break the aptamers' secondary structu
273 on the future of combinational therapy using nucleic acid therapeutics, articulating the main challen
274 employed in combination cancer therapy using nucleic acids therapeutics for successful clinical trans
275 candidate features computed from a number of nucleic acid, thermodynamic and secondary structure mode
279 ance of both the unstructured and structured nucleic acids to accurately measure their hypochromicity
280 imultaneous delivery of drug and therapeutic nucleic acids to promote axonal regeneration and plastic
282 ially extended the recognition capability of nucleic acids to various targets, ranging from small org
283 ies can reveal atomic details of protein and nucleic acid topology and interactions between specific
284 carry donor origin-proteins, cytokines, and nucleic acids, transport these cargos to adjacent or dis
287 l method which rapidly amplifies and detects nucleic acids using a simple device in near real-time.
288 ys protect prokaryotic cells against foreign nucleic acids using CRISPR RNA (crRNA)-guided nucleases.
289 rtant to its procoagulant activity, and that nucleic acids versus polyP may differentially modulate s
290 When terminally attached to double-stranded nucleic acids via the 5' phosphate group these fluoropho
291 o extracellular matrix proteins, lipids, and nucleic acids were tracked over pregnancy and found to b
293 owed to be a reliable carrier for delivering nucleic acids with cytoplasmic activity such as the mRNA
294 achieving widespread delivery of therapeutic nucleic acids within brain tumors and provide a promisin
295 ding our ability to agnostically interrogate nucleic acids within diverse sample types, but in the cl
297 an evolution experiments carried out on xeno-nucleic acid (XNA) polymers require engineered polymeras
298 opy genetic information between DNA and xeno-nucleic acids (XNA) hold tremendous value as reagents in
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