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1 potential of 4-methylindole relative to the nucleic acid bases.
2 asure of aromatic stacking interactions with nucleic acid bases.
3 RNA due to stacking of its Trp residue with nucleic acid bases.
4 ations interact favorably with pi-systems of nucleic acid bases.
5 or their first hydration shells to faces of nucleic acid bases.
6 tadienes, substituted in the 4 position with nucleic acid bases 1-6, have been synthesized via Mitsun
7 at capacities of hydration (dCp) of the five nucleic acid bases A, G, C, T, and U, the sugars ribose
8 suggesting that the tryptophan stacking with nucleic acid base accompanies electrostatic contacts.
10 repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are wide
11 o observed for the intrinsic emission of the nucleic acid bases adenine and thymine and for single-st
13 argeting GNLY(+) CTLs, we aimed to develop a nucleic acid-based agent consisting of an anti-CD8 aptam
16 -care rapid tests for tuberculosis including nucleic acid-based amplification tests, imaging, and bre
19 ms of the abiotic formation of the remaining nucleic acid bases and other biologically relevant molec
22 ing rectangular block representations of the nucleic-acid bases and base pairs and all-atom models wi
23 ies and rigid-body parameters of interacting nucleic-acid bases and base-pair steps, the nucleotides
24 tion and quantification of the commonly used nucleic acid base- and sugar-protecting groups: benzoyl,
26 A silencing, implicating this mechanism as a nucleic acid-based antiviral immunity in mammalian cells
31 genome editing and the application of other nucleic acid-based approaches to influence the coagulati
33 hort DNA-like oligomers in which the natural nucleic acid bases are replaced by interacting fluoresce
34 This site-size is independent of the type of nucleic acid base as well as the salt concentration and
35 dies, show that independently of the type of nucleic acid base, as well as salt concentration and typ
36 dies, show that independently of the type of nucleic acid base, as well as the salt concentration, th
38 We compared a DNA-based assay with a total nucleic acid-based assay for early detection of infant h
41 ation of phenotypic, mass spectrometric, and nucleic acid-based assays and exhibited high-level resis
42 g novel DNA-based methodologies are adopted, nucleic acid-based assays depend critically on the quali
44 creening of potential donors with the use of nucleic acid-based assays for West Nile virus may reduce
46 ading to point-of-care kits that incorporate nucleic acid-based assays, including polymerase chain re
50 ying interactions of urea (component 3) with nucleic acid bases, base analogues, nucleosides, and nuc
55 presented here should be applicable to other nucleic acid-based biosensors to decrease background flu
59 perimental scale of hydrophobicities for the nucleic acid bases, comparable with a scale developed ea
60 of functionally important RNAs to bind short nucleic acid-based compounds tightly and more specifical
61 y revisit several milestones in the field of nucleic acid-based computation, but also highlight how t
63 ded when designing DNA hairpins as probes in nucleic acid based detection assays, such as microarrays
64 he TaqMan assay with some of the alternative nucleic acid-based detection techniques of microarray, c
66 Diagnosis of tularemia by blood culture and nucleic acid-based diagnostic tests is insufficiently se
67 eir use in DNA-targeting applications within nucleic acid based diagnostics, therapeutics, and materi
68 lysis platform for rapid field deployment of nucleic acid-based diagnostics using consumer-class quad
69 e-chain dichotomy polar/nonpolar matches the nucleic acid base dichotomy purine/pyrimidine at the sec
70 d specific binding site for a synthetic, non-nucleic acid-based DNA binding molecule, but with a sign
71 homopurine ssRNAs indicates that the type of nucleic acid base dramatically affects the enzyme orient
73 d technologies for large-scale production of nucleic acid-based drugs have been exploited for various
74 esents a comprehensive characterization of a nucleic acid-based endonuclease that prefers transition
76 ons of whether different tautomeric forms of nucleic acid bases exist to any significant extent in DN
77 ults demonstrate the potential of the locked nucleic acid bases for nucleic acid design for surface i
78 enetic code extension and the development of nucleic acid-based functional nanodevices, DNA duplexes
79 ence (EGS) bound to mRNA represents a unique nucleic acid-based gene interference approach for modula
80 h external guide sequence (EGS) represents a nucleic acid-based gene interference approach to knock-d
81 rapy is to develop approaches for delivering nucleic acid-based gene interfering agents, such as smal
82 and contrast the efficacies of a wide range nucleic acid-based gene silencing reagents in the skin o
83 ral issue for the therapeutic application of nucleic-acid-based gene interfering agents, such as ribo
84 resulted in the successful development of a nucleic acid-based high-performance bivalent protein inh
87 arlo calculations of the association between nucleic acid bases in a nonpolar solvent (CCl4) are desc
88 n of NMR to investigate the base stacking of nucleic acid bases in solution, the dynamic structure of
91 ith literature values for the free energy of nucleic acid base interactions as well as the calculated
92 le side chain of the tryptophan residue with nucleic acid bases is demonstrated by a characteristic a
99 Essentially, this new design adds locked nucleic acid bases (LNAs) to the beacon structure, resul
100 e development of amplified DNA sensors using nucleic acid-based machineries, involving the isothermal
103 acy, these studies highlight that optimizing nucleic acid-based medicines for safety in humans presen
104 screens to identify in vivo functions of non-nucleic acid-based metabolites beyond their metabolic ro
105 d subgroup identifications were confirmed by nucleic acid-based methods and included nine group A and
109 One of the major obstacles to implement nucleic acid-based molecular diagnostics at the point-of
113 ts a new route in the development of 'smart' nucleic acid-based nanoparticles and switches for variou
114 owledge will impact our understanding of how nucleic acid-based nanostructures, and SNAs in particula
115 the second section, the characterization of nucleic acid-based nanostructures, nucleic acid-function
118 Anionic states of guanine, which is the only nucleic acid base of which the anions have not yet been
119 we introduce a platform for the detection of nucleic acids based on a magnetic barcoding strategy.
120 rapid, sensitive and selective detection of nucleic acids based on an ionic diode feature of an anio
121 ws the detection and discrimination of small nucleic acids based on differences in their physical dim
122 ended reference frame for the description of nucleic acid base pair geometry and a rigorous matrix-ba
124 acid sequence, the impact of the protein on nucleic acid base pairing, the end-to-end distance distr
126 rom the dominant role of hydrogen bonding in nucleic-acid base pairing, as well as in the secondary s
128 ge in the enzyme, rather than the changes in nucleic-acid base-pairing that accompany backtracking.
131 ective inhibitory PCR (siPCR) using a locked nucleic acid-based PCR blocker to selectively inhibit th
132 biophysical insights into nuclear crowding, nucleic acid based pharmaceutical development, and nucle
133 ce reader, an important requirement toward a nucleic-acid-based point-of-care diagnostic system.
135 ) building blocks have been combined to form nucleic acid-based polymeric nanoparticles without the n
137 ichment (SELEX) method, which can generate a nucleic acid-based probe (aptamer) that possess numerous
138 may prove useful in the development of other nucleic acid-based probes for intracellular, toxicologic
140 Expression of miRNA was determined by locked nucleic acid-based quantitative real-time polymerase cha
146 conjunction with routine chlamydia/gonorrhea nucleic acid-based screening are likely to have the most
147 est reported binding site for synthetic, non-nucleic-acid-based, sequence-specific DNA-binding molecu
148 should prove tractable as an alternative to nucleic-acid based sequencing for the multiplexed identi
149 ncluding humanized monoclonal antibodies and nucleic acid-based strategies (antisense and RNA interfe
151 l expression patterns distinct from previous nucleic acid-based studies and identified new facets of
153 APD-PCR and TaqMan assay offers promise as a nucleic acid-based system that can be used for the ident
157 d this capacity lies at the heart of several nucleic acid-based technologies that are finding applica
159 A second-generation signal amplification, nucleic acid-based test for the rapid detection and typi
163 study was to evaluate three FDA-approved HPV nucleic acid-based tests for the ability to predict high
164 We evaluated the ability of two FDA-cleared nucleic acid-based tests, the semiautomated respiratory
166 micelles (CP-mag-micelles) that can deliver nucleic acid-based therapeutic agents and also provide m
167 f messenger RNA (mRNA), an emerging class of nucleic acid-based therapeutics, have been poorly charac
168 cal utility of DNA vaccines as well as other nucleic-acid-based therapeutics against viral infections
169 ers, a number of chemotherapeutic agents and nucleic acid-based therapies are rapidly being synthesiz
171 isense oligonucleotides to cells in culture, nucleic acid-based therapy is still often limited by the
172 3 nm light causes photoionisation of all the nucleic acid bases, these results indicate that guanine
173 vel DNA binding to investigate how RRMs bind nucleic acid bases through their highly conserved RNP co
174 l HSV-2 infection provided by an alternative nucleic acid-based TLR agonist, polyinosine-poly(C) (PIC
175 mprove the accuracy of identification of the nucleic acid bases, to feed each released nucleotide int
179 The protein environments around the two nucleic acid bases were significantly different, in term
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