ライフサイエンスコーパス: nucleic acid base

1 potential of 4-methylindole relative to the nucleic acid bases.

2 asure of aromatic stacking interactions with nucleic acid bases.

3 RNA due to stacking of its Trp residue with nucleic acid bases.

4 ations interact favorably with pi-systems of nucleic acid bases.

5 or their first hydration shells to faces of nucleic acid bases.

6 tadienes, substituted in the 4 position with nucleic acid bases 1-6, have been synthesized via Mitsun

7 at capacities of hydration (dCp) of the five nucleic acid bases A, G, C, T, and U, the sugars ribose

8 suggesting that the tryptophan stacking with nucleic acid base accompanies electrostatic contacts.

9 rtebrate animals, RNA silencing is a form of nucleic acid-based adaptive immunity.

10 repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are wide

11 o observed for the intrinsic emission of the nucleic acid bases adenine and thymine and for single-st

12 Our results identified a new nucleic acid-based agent (CD8 aptamer-GNLY siRNA chimera

13 argeting GNLY(+) CTLs, we aimed to develop a nucleic acid-based agent consisting of an anti-CD8 aptam

14 Efforts to identify nucleic acid-based agents capable of more specifically m

15 Several nucleic acid-based amplification tests are available for

16 -care rapid tests for tuberculosis including nucleic acid-based amplification tests, imaging, and bre

17 Fluorescent nucleic acid base analogues are important spectroscopic

18 Molecular interaction between nucleic acid bases and amino acids is a fundamental proc

19 ms of the abiotic formation of the remaining nucleic acid bases and other biologically relevant molec

20 Sequencing both the nucleic acid bases and the positions of any 3'-O-thioate

21 irect consequence of oxidative damage to the nucleic acid bases and/or deoxyribose sugars.

22 ing rectangular block representations of the nucleic-acid bases and base pairs and all-atom models wi

23 ies and rigid-body parameters of interacting nucleic-acid bases and base-pair steps, the nucleotides

24 tion and quantification of the commonly used nucleic acid base- and sugar-protecting groups: benzoyl,

25 Conversely, locked nucleic acid-based anti-miR-34a treatment diminished pos

26 A silencing, implicating this mechanism as a nucleic acid-based antiviral immunity in mammalian cells

27 A nucleic acid-based approach to end-labelling is desirabl

28 Apart from nucleic acid based approaches, community proteomics has

29 overcome before applying the scaling used in nucleic acid based approaches.

30 Several compelling nucleic acid-based approaches have recently been develop

31 genome editing and the application of other nucleic acid-based approaches to influence the coagulati

32 Nucleic acid-based aptamers offer many advantageous feat

33 hort DNA-like oligomers in which the natural nucleic acid bases are replaced by interacting fluoresce

34 This site-size is independent of the type of nucleic acid base as well as the salt concentration and

35 dies, show that independently of the type of nucleic acid base, as well as salt concentration and typ

36 dies, show that independently of the type of nucleic acid base, as well as the salt concentration, th

37 A new nucleic acid-based assay (simple amplification-based ass

38 We compared a DNA-based assay with a total nucleic acid-based assay for early detection of infant h

39 We have developed a nucleic acid-based assay that is rapid, sensitive, and s

40 me platform, streamlining development of any nucleic acid-based assay.

41 ation of phenotypic, mass spectrometric, and nucleic acid-based assays and exhibited high-level resis

42 g novel DNA-based methodologies are adopted, nucleic acid-based assays depend critically on the quali

43 ble to those of other commercially available nucleic acid-based assays for these organisms.

44 creening of potential donors with the use of nucleic acid-based assays for West Nile virus may reduce

45 Among them immunoassays and Nucleic acid-based assays provide results within 24h, bu

46 ading to point-of-care kits that incorporate nucleic acid-based assays, including polymerase chain re

47 g strain distribution present a challenge to nucleic acid-based assays.

48 ent methods, such as antigen-based tests and nucleic acid-based assays.

49 Previously studied nucleic acid-based automata include game-playing molecul

50 ying interactions of urea (component 3) with nucleic acid bases, base analogues, nucleosides, and nuc

51 Nucleic acid-based biochemical assays are crucial to mod

52 Nucleic acid-based biomarkers of allograft status have b

53 c acid based pharmaceutical development, and nucleic acid based biosensor device design.

54 Functional nucleic acid-based biosensors are emerging tools that ar

55 presented here should be applicable to other nucleic acid-based biosensors to decrease background flu

56 Nucleic-acid-based biosensors have enabled rapid and sen

57 CSA tensors for protonated nucleic acid base carbons have been derived from measure

58 ion of such analyte selectivity spectrum for nucleic acid-based chiral separation tools.

59 perimental scale of hydrophobicities for the nucleic acid bases, comparable with a scale developed ea

60 of functionally important RNAs to bind short nucleic acid-based compounds tightly and more specifical

61 y revisit several milestones in the field of nucleic acid-based computation, but also highlight how t

62 Microarray-based multiplexing and nucleic-acid-based deep-sequencing methods allow simulta

63 ded when designing DNA hairpins as probes in nucleic acid based detection assays, such as microarrays

64 he TaqMan assay with some of the alternative nucleic acid-based detection techniques of microarray, c

65 The application of nucleic-acid based detection methods in seed health test

66 Diagnosis of tularemia by blood culture and nucleic acid-based diagnostic tests is insufficiently se

67 eir use in DNA-targeting applications within nucleic acid based diagnostics, therapeutics, and materi

68 lysis platform for rapid field deployment of nucleic acid-based diagnostics using consumer-class quad

69 e-chain dichotomy polar/nonpolar matches the nucleic acid base dichotomy purine/pyrimidine at the sec

70 d specific binding site for a synthetic, non-nucleic acid-based DNA binding molecule, but with a sign

71 homopurine ssRNAs indicates that the type of nucleic acid base dramatically affects the enzyme orient

72 ents and stent coatings, conventional drugs, nucleic acid-based drugs and gene transfer.

73 d technologies for large-scale production of nucleic acid-based drugs have been exploited for various

74 esents a comprehensive characterization of a nucleic acid-based endonuclease that prefers transition

75 will prove to be as useful and ubiquitous in nucleic-acid-based engineering as it is in biology.

76 ons of whether different tautomeric forms of nucleic acid bases exist to any significant extent in DN

77 ults demonstrate the potential of the locked nucleic acid bases for nucleic acid design for surface i

78 enetic code extension and the development of nucleic acid-based functional nanodevices, DNA duplexes

79 ence (EGS) bound to mRNA represents a unique nucleic acid-based gene interference approach for modula

80 h external guide sequence (EGS) represents a nucleic acid-based gene interference approach to knock-d

81 rapy is to develop approaches for delivering nucleic acid-based gene interfering agents, such as smal

82 and contrast the efficacies of a wide range nucleic acid-based gene silencing reagents in the skin o

83 ral issue for the therapeutic application of nucleic-acid-based gene interfering agents, such as ribo

84 resulted in the successful development of a nucleic acid-based high-performance bivalent protein inh

85 ter than those of the commercially available nucleic acid-based HIV-1 diagnostic tests.

86 me and that natural HIV-1 infection provokes nucleic acid-based immunity in human cells.

87 arlo calculations of the association between nucleic acid bases in a nonpolar solvent (CCl4) are desc

88 n of NMR to investigate the base stacking of nucleic acid bases in solution, the dynamic structure of

89 e played by the products of mutator genes in nucleic acid-based inheritance.

90 d perhaps be exploited in the development of nucleic acid-based inhibitors.

91 ith literature values for the free energy of nucleic acid base interactions as well as the calculated

92 le side chain of the tryptophan residue with nucleic acid bases is demonstrated by a characteristic a

93 transposases guarantee to thrive so long as nucleic acid-based life forms exist.

94 enerating the last universal ancestor of all nucleic-acid-based life.

95 a folded RNA that are accessible toward the nucleic acid-based ligand.

96 Aptamers are nucleic acid-based ligands that exhibit promising featur

97 s an impediment toward binding of the RNA by nucleic acid-based ligands.

98 Oligonucleotides containing locked nucleic acid bases (LNAs) have increased affinity for co

99 Essentially, this new design adds locked nucleic acid bases (LNAs) to the beacon structure, resul

100 e development of amplified DNA sensors using nucleic acid-based machineries, involving the isothermal

101 Nucleic acid-based markers may prove to be valuable tool

102 ion is yielding new and potentially powerful nucleic acid-based markers of neoplastic disease.

103 acy, these studies highlight that optimizing nucleic acid-based medicines for safety in humans presen

104 screens to identify in vivo functions of non-nucleic acid-based metabolites beyond their metabolic ro

105 d subgroup identifications were confirmed by nucleic acid-based methods and included nine group A and

106 Other nucleic acid-based methods were expensive and required t

107 study (SMART) was examined using an in vitro nucleic acid-based microarray.

108 Nucleic acid-based molecular diagnostics are particularl

109 One of the major obstacles to implement nucleic acid-based molecular diagnostics at the point-of

110 eloping technologies that are dependent upon nucleic acid-based molecular recognition.

111 elicase, and for simulations of a variety of nucleic-acid-based molecular motors.

112 owed the creation of a stunning diversity of nucleic acid-based nanodevices.

113 ts a new route in the development of 'smart' nucleic acid-based nanoparticles and switches for variou

114 owledge will impact our understanding of how nucleic acid-based nanostructures, and SNAs in particula

115 the second section, the characterization of nucleic acid-based nanostructures, nucleic acid-function

116 Nucleic acid-based nanotechnology has always been percei

117 We report on the use of nucleic acid bases (NBs) in organic light emitting diode

118 Anionic states of guanine, which is the only nucleic acid base of which the anions have not yet been

119 we introduce a platform for the detection of nucleic acids based on a magnetic barcoding strategy.

120 rapid, sensitive and selective detection of nucleic acids based on an ionic diode feature of an anio

121 ws the detection and discrimination of small nucleic acids based on differences in their physical dim

122 ended reference frame for the description of nucleic acid base pair geometry and a rigorous matrix-ba

123 To investigate nucleic acid base pairing and stacking via atom-specific

124 acid sequence, the impact of the protein on nucleic acid base pairing, the end-to-end distance distr

125 d that salt stress affected the stability of nucleic acid base pairing.

126 rom the dominant role of hydrogen bonding in nucleic-acid base pairing, as well as in the secondary s

127 The rules of nucleic acid base-pairing have been used to construct na

128 ge in the enzyme, rather than the changes in nucleic-acid base-pairing that accompany backtracking.

129 or a covalently connected linear sequence of nucleic acid base pairs.

130 terization toward downstream applications in nucleic acid based pathogen detection.

131 ective inhibitory PCR (siPCR) using a locked nucleic acid-based PCR blocker to selectively inhibit th

132 biophysical insights into nuclear crowding, nucleic acid based pharmaceutical development, and nucle

133 ce reader, an important requirement toward a nucleic-acid-based point-of-care diagnostic system.

134 Furthermore, because these nucleic acid-based polymeric nanoparticles exhibited enh

135 ) building blocks have been combined to form nucleic acid-based polymeric nanoparticles without the n

136 rativity and enhanced specificity to improve nucleic acid based probe and drug design.

137 ichment (SELEX) method, which can generate a nucleic acid-based probe (aptamer) that possess numerous

138 may prove useful in the development of other nucleic acid-based probes for intracellular, toxicologic

139 Oxidative damage to purine nucleic acid bases proceeds through quinoidal intermedia

140 Expression of miRNA was determined by locked nucleic acid-based quantitative real-time polymerase cha

141 Aptamers are nucleic acid-based reagents that bind to target molecule

142 plex and subtly different analytes for which nucleic acid-based receptors exist.

143 A current limitation of protein- and nucleic acid-based recognition, however, is that the use

144 antitatively from the knowledge of component nucleic acid base resonance Raman cross sections.

145 Nucleic acid-based RNA detection is a promising field in

146 conjunction with routine chlamydia/gonorrhea nucleic acid-based screening are likely to have the most

147 est reported binding site for synthetic, non-nucleic-acid-based, sequence-specific DNA-binding molecu

148 should prove tractable as an alternative to nucleic-acid based sequencing for the multiplexed identi

149 ncluding humanized monoclonal antibodies and nucleic acid-based strategies (antisense and RNA interfe

150 l as cell-type selectivity unavailable using nucleic acid-based strategies.

151 l expression patterns distinct from previous nucleic acid-based studies and identified new facets of

152 a specialized RNA-binding protein is a novel nucleic-acid-based surveillance mechanism of RQC.

153 APD-PCR and TaqMan assay offers promise as a nucleic acid-based system that can be used for the ident

154 In nucleic acids-based systems, stemming from DNA computati

155 To circumvent this problem, nucleic acid based techniques have been developed that e

156 methods utilizing classical microbiology and nucleic acid-based techniques.

157 d this capacity lies at the heart of several nucleic acid-based technologies that are finding applica

158 Control of protein levels by nucleic-acid-based technologies has proven to be a usefu

159 A second-generation signal amplification, nucleic acid-based test for the rapid detection and typi

160 viral loads undetectable by a gold standard nucleic acid-based test.

161 However, HIV nucleic acid-based testing is widely used to screen for

162 Nucleic acid-based tests for infectious diseases current

163 study was to evaluate three FDA-approved HPV nucleic acid-based tests for the ability to predict high

164 We evaluated the ability of two FDA-cleared nucleic acid-based tests, the semiautomated respiratory

165 ing light microscopy, culture, serology, and nucleic acid-based tests.

166 micelles (CP-mag-micelles) that can deliver nucleic acid-based therapeutic agents and also provide m

167 f messenger RNA (mRNA), an emerging class of nucleic acid-based therapeutics, have been poorly charac

168 cal utility of DNA vaccines as well as other nucleic-acid-based therapeutics against viral infections

169 ers, a number of chemotherapeutic agents and nucleic acid-based therapies are rapidly being synthesiz

170 rgeted delivery platform for siRNAs or other nucleic acid-based therapies.

171 isense oligonucleotides to cells in culture, nucleic acid-based therapy is still often limited by the

172 3 nm light causes photoionisation of all the nucleic acid bases, these results indicate that guanine

173 vel DNA binding to investigate how RRMs bind nucleic acid bases through their highly conserved RNP co

174 l HSV-2 infection provided by an alternative nucleic acid-based TLR agonist, polyinosine-poly(C) (PIC

175 mprove the accuracy of identification of the nucleic acid bases, to feed each released nucleotide int

176 In recent years, some useful nucleic-acid-based tools including antisense oligonucleo

177 Establishing tautomerism of nucleic acid bases under physiological conditions has be

178 Nucleic acid-based vaccines are effective in infectious

179 The protein environments around the two nucleic acid bases were significantly different, in term