ライフサイエンスコーパス: nucleic acid binding

1 Y182A mutations only moderately affected A3G nucleic acid binding.

2 imal for high ( approximately 1 nM)-affinity nucleic acid binding.

3 with positive charge runs, are enriched for nucleic acid binding.

4 ntification of specific residues involved in nucleic acid binding.

5 hydration models for specific vs nonspecific nucleic acid binding.

6 at the KH domain in DDX43 is responsible for nucleic acid binding.

7 formation of a positively charged cavity for nucleic acid binding.

8 ot use positive dipoles of alpha-helices for nucleic acid binding.

9 on is a prerequisite to, or a consequence of nucleic acid binding.

10 d with cell growth, signal transduction, and nucleic acid binding.

11 tions for alterations in enzyme activity and nucleic acid binding.

12 e molecular functions of kinase activity and nucleic acid binding.

13 main, perhaps pointing to a role for YloQ in nucleic acid binding.

14 eatures for surface charge, dimerization and nucleic acid binding.

15 e Rho protein that occur upon nucleotide and nucleic acid binding.

16 al residues for structural stability and for nucleic acid binding.

17 of the contribution of histidine residues to nucleic acid binding.

18 protein may also play a significant role in nucleic acid binding.

19 was shown to be necessary and sufficient for nucleic acid binding.

20 domain is required for maximal activity and nucleic acid binding.

21 region (residues 150-183) is responsible for nucleic acid binding.

22 tion of SHOCT, including oligomerisation and nucleic acid binding.

23 due W127 that likely acts through regulating nucleic acid binding.

24 ient folds and enriched for iron-sulfur- and nucleic acid-binding.

25 sive molecular analysis of the deaminase and nucleic acid binding activities of human APO3G using a p

26 cytidine deaminase and single-stranded (ss) nucleic acid binding activities.

27 to further characterize A3A's deaminase and nucleic acid binding activities.

28 main protein DPP1, which has single-stranded nucleic acid binding activity, suppresses heterochromati

29 -terminal region (C-1/3 domain) contains the nucleic acid binding activity.

30 Q772X, C772-1455, retains the differentiated nucleic acid-binding activity (RNA > ssDNA > dsDNA), ind

31 TEN domain unmasks a functionally important nucleic acid-binding activity in Est3.

32 Biochemical and NMR results establish the nucleic acid-binding activity of the Zf-GRF domain.

33 We conclude that FUS has quite general nucleic acid-binding activity, with the various proposed

34 otein products localize to the nucleus, have nucleic-acid binding activity, and are involved in trans

35 nce anisotropy was used to determine protein-nucleic acid binding affinities for the RFX subunits and

36 ts of mutations in protein coding regions on nucleic acid binding affinities.

37 ults obtained for HIV-1 Gag, due to the weak nucleic acid binding affinity of the RSV MA domain, inos

38 hing analyses indicated that NC has a higher nucleic acid binding affinity than A3G, but more importa

39 rget cleavage; the binding groove, to modify nucleic acid binding affinity; and surface allosteric si

40 of the four cysteines to alanine diminished nucleic acid binding and catalytic activity.

41 structural features are compatible with the nucleic acid binding and chaperone activities of L1 ORF1

42 he two ORF1 proteins were purified and their nucleic acid binding and chaperone activities were exami

43 th RNase H2A in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-p

44 terize the functional significance of IMPDH1 nucleic acid binding and its potential relationship to r

45 istent with the primary function of Gag as a nucleic acid binding and packaging protein and the prima

46 lin action in vertebrate cells, we performed nucleic acid binding and RNA interference studies.

47 These phenylalanines are critical for nucleic acid binding and the observed alternative side c

48 Helicases couple ATP hydrolysis to nucleic acid binding and unwinding via molecular mechani

49 f rA3G-CD1 is important for oligomerization, nucleic acid binding and Vif-mediated degradation.

50 conserved protein with domains homologous to nucleic-acid-binding and exonuclease proteins.

51 s Cys(2)His(2)zinc fingers which function in nucleic acid binding, and a C-terminal region involved i

52 s have been studied extensively; the ATPase, nucleic acid binding, and helicase activities have been

53 g DAI or containing DAI mutants deficient in nucleic acid binding are resistant to IAV-triggered necr

54 ved in cellular signaling, organization, and nucleic acid binding are the most highly represented in

55 We also used direct telomerase activity and nucleic acid binding assays to explain how naturally occ

56 Nucleic acid binding assays using [(35) S]-labeled AtC3H

57 /visible spectroscopy, NMR spectroscopy, and nucleic acid binding assays.

58 -CD1) is responsible for oligomerization and nucleic acid binding, both of which are essential for an

59 We have investigated the energetics of nucleic acid binding by HCV helicase to understand how t

60 We observe two distinct modes of nucleic acid binding by mycobacterial PNPase: (i) metal-

61 ions may serve as a mechanism for regulating nucleic acid binding by RRM-containing proteins.

62 The Cp, via its nucleic acid-binding C-terminal domain, also affects nuc

63 BPCs, and its R3H domain, which has putative nucleic acid binding capabilities, to increase hTERT mRN

64 Based on its nucleic acid binding capacity, we propose a dual locatio

65 rroring that of AGO2, but not a well-defined nucleic acid-binding channel.

66 The nucleic-acid-binding channel between the PAZ- and PIWI-c

67 se DNA guide strand, thereby identifying the nucleic-acid-binding channel positioned between the PAZ-

68 he dynamic motions of Ago domains around the nucleic-acid-binding channel.

69 ion segment, resulting in the opening of the nucleic-acid-binding channel.

70 1/L2 'hinge' and a subsequent opening of the nucleic-acid-binding channel.

71 ently of sigma factor and away from the main nucleic-acids-binding channel of RNAP.

72 teract with RNAP at or near its three major, nucleic acid-binding channels: Mfd near the upstream ope

73 Rev can effectively compete with the general nucleic acid binding/chaperone functions of the nucleoca

74 n, signaling, metabolism, protein synthesis, nucleic acid binding, chromatin structure, protein foldi

75 l connecting the NNRTI-binding pocket to the nucleic acid-binding cleft.

76 The nucleic-acid-binding cleft of RNAP samples distinct conf

77 tiguous set of anti-parallel single-stranded nucleic acid binding clefts.

78 61) to elucidate the role of amine number on nucleic acid binding, complex formation, stability, and

79 for rapidly screening the selectivity of new nucleic acid binding compounds.

80 idyl-anthraquinones are a promising class of nucleic acid-binding compounds that act as NC inhibitors

81 OB and/or Zn-binding domains participate in nucleic acid binding consistent with a possible role for

82 ggests that it can be developed as a modular nucleic acid binding device with general utility.

83 Pt(II) center can be developed as a modular nucleic acid binding device with general utility.

84 se (HIV-1 RT) was proposed to be a conserved nucleic acid binding domain among several nucleotide pol

85 an alpha-helix in the third KH-motif of the nucleic acid binding domain and a tyrosine-rich motif in

86 consisting of a targeted K16 peptide with a nucleic acid binding domain and plasmid-DNA, minicircle-

87 These experiments showed that NC (the nucleic acid binding domain derived from Gag) binds with

88 The nucleic acid binding domain of Nup475 consists of two CC

89 novel protein containing a putative OB-fold nucleic acid binding domain, is an integral component of

90 The amino terminus of E3L has a Z-form nucleic acid binding domain, which has been shown to be

91 ructurally repeated MTERF-motifs that form a nucleic acid binding domain.

92 It consists of a nucleic acid-binding domain and a protein-protein intera

93 and G4 J proteins by virtue of an additional nucleic acid-binding domain at the amino terminus.

94 y (RNA > ssDNA > dsDNA), indicating that the nucleic acid-binding domain of FANCA is located primaril

95 An NPM mutant lacking its carboxyl-terminal nucleic acid-binding domain oligomerizes with endogenous

96 The K-homology (KH) domain is a nucleic acid-binding domain present in many proteins but

97 en the integrin-binding ligand and the K(16) nucleic acid-binding domain to promote intracellular dis

98 cleic acid, but replacement of its principal nucleic acid-binding domain with a dimerizing leucine zi

99 Recruited through FBP's nucleic acid-binding domain, FIR formed a ternary comple

100 wer affinity to ssRNA, making it a versatile nucleic acid-binding domain.

101 ing hydrolases (e.g. NlpC/P60 peptidases) or nucleic acid binding domains (e.g. Zn-ribbons).

102 study demonstrate that affinities of various nucleic acid binding domains for ASO depend on chemical

103 D-associated TDP-43 mutations in the central nucleic acid binding domains lead to elevated half-life

104 ify multivalency of acidic tracts and folded nucleic acid binding domains, mediated by N-terminal dom

105 related, but non-identical, K-homology (KH) nucleic acid binding domains.

106 with reverse transcriptase, endonuclease and nucleic acid binding domains.

107 -inducible tumor-associated protein, harbors nucleic acid-binding domains for left-handed helix (Z-fo

108 e between RapA's SWI/SNF and double-stranded nucleic acid-binding domains significantly alter ATP hyd

109 function that contains DNA/RNA helicase and nucleic acid-binding domains.

110 construct consists of two domains similar to nucleic acid-binding domains.

111 reverse transcriptase, DNA endonuclease and nucleic acid-binding domains.

112 reverse transcriptase, DNA endonuclease and nucleic acid-binding domains.

113 belongs to a previously unnoticed family of nucleic-acid-binding domains, which also includes HEH do

114 h they may still be capable of high affinity nucleic acid binding, duplex destabilization, and/or nuc

115 with a femtosecond-pulsed laser to bleach a nucleic acid-binding dye causing dose-dependent apoptosi

116 ide binding to this site functionally alters nucleic acid binding, electrophoretic mobility shift ass

117 Interior nucleic acid-binding elements spiral around six bases of

118 antitermination in vitro is determined by a nucleic acid binding equilibrium with one molecule of N

119 The area spans the nucleic acid binding face of the OB fold, including the

120 Both ZFs contribute to the nucleic acid binding free energy of NCp8, albeit in a no

121 studies showed that the "helix clamp" has a nucleic acid binding function that may not be sequence s

122 c residues on the protein surface suggests a nucleic acid-binding function.

123 conservation in fungi and an enrichment for "nucleic acid-binding" function.

124 Our studies reveal differences in the nucleic acid binding groove that could have implications

125 The nucleic acid binding groove was further mapped by chemic

126 portant insertions that result in a narrower nucleic acid binding groove.

127 thepsin B, connected to oligo-(L)-lysine for nucleic acid binding, (ii) pHCath(D)K(10), containing th

128 Nucleic acid-binding innate immune receptors such as Tol

129 ata presented here suggest that the specific nucleic acid binding interactions of Tat and Rev can eff

130 uggests that these residues line a potential nucleic acid-binding interface.

131 Thus, high-affinity nucleic acid binding is a conserved and functionally imp

132 identification and characterization of novel nucleic acid binding ligands.

133 nient and practical tool for identifying new nucleic acid-binding ligands.

134 logical activity through proper targeting of nucleic acids binding ligands or drug molecules.

135 Here, we discuss how nucleic acid binding might influence protein misfolding

136 MH1 of Smad3 and I-PpoI exhibit similar nucleic acid binding mode and interact with DNA major gr

137 SL2-4), consistent with their characteristic nucleic acid binding modes.

138 ndle with homology to the structure-specific nucleic acid binding module of RecQ helicases.

139 a single open reading frame with a putative nucleic acid binding motif (CCHC) and restriction enzyme

140 Several variants of a nucleic acid binding motif (RRM1) of putative transcript

141 that C-Ala forms an ancient single-stranded nucleic acid binding motif that promotes cooperative bin

142 ch could represent a nuclear localization or nucleic acid binding motif, and a pair of CXXC motifs th

143 -binding proteins and may represent a common nucleic acid binding motif.

144 The PUR domain is a nucleic acid-binding motif found in critical regulatory

145 nd elongated protein, with several potential nucleic acid binding motifs clustered at one end, includ

146 in sequence and in the lack of recognizable nucleic acid binding motifs.

147 Furthermore, nucleic acid binding mutants destabilize the association

148 We present an automated approach to predict nucleic-acid-binding (NA-binding) proteins, specifically

149 we report the structure of two single-strand nucleic acid-binding OB-folds from interaction proteins

150 for screening compounds that may inhibit the nucleic acid binding or elongation activities of polymer

151 RNAP, away from the catalytic center and the nucleic acid binding path.

152 ains as modules to construct single-stranded nucleic acid binding peptides.

153 n shell interactions within ZBDs, as well as nucleic acid binding, play important roles in determinin

154 s random binding of charged molecules to the nucleic acid-binding pocket and coordinates nucleic acid

155 D2 contains a nucleic-acid-binding pocket that is formed by conserved

156 These studies indicate that nucleic acid-binding polymers are able to scavenge effec

157 Previously, we demonstrated that nucleic acid-binding polymers can act as molecular scave

158 Herein we demonstrate that certain nucleic acid-binding polymers can inhibit activation of

159 anticoagulant and antithrombotic activity of nucleic acid-binding polymers in vitro and in vivo.

160 Full spectra of nucleic acid binding preferences were determined by comp

161 make important contributions to many protein-nucleic acid binding processes.

162 The results suggested that nucleic acid binding promotes a structural change of the

163 addition, AL2/L2 suppression phenotypes and nucleic acid binding properties are shown to be differen

164 ), the first of which has been shown to have nucleic acid binding properties in vitro.

165 We have probed the nucleic acid binding properties of a yeast protein, Nab2

166 is determined by critical differences in the nucleic acid binding properties of A3G, NC and RT.

167 how that these activities correlate with the nucleic acid binding properties of F/E.

168 o this role, several reports have implicated nucleic acid binding properties to retroviral MAs.

169 ere prepared, and catalytic efficiencies and nucleic acid binding properties were compared with the w

170 beta share substantial sequence homology and nucleic acid binding properties, genomic promoter and ci

171 er understanding of APOBEC3A's deaminase and nucleic acid-binding properties, which is central to its

172 ncodes a novel nucleolar-matrix protein with nucleic-acid binding properties has been characterised i

173 lter the recently identified single-stranded nucleic acid binding property of IMPDH.

174 king the shell-forming 'core' domain and the nucleic acid-binding 'protamine' domain, has such a role

175 We recently demonstrated that Cellular Nucleic acid Binding Protein (CNBP)(-/-) mouse embryos e

176 by disruption of the gene encoding cellular nucleic acid binding protein (CNBP); Cnbp transgenic mic

177 ecific interaction between AGIL and cellular nucleic acid binding protein (CNBP/ZNF9), a zinc-finger

178 of the TJ-associated protein ZO-1-associated nucleic acid binding protein (ZONAB) were evaluated usin

179 e Y-box transcription factor ZO-1-associated nucleic acid binding protein (ZONAB).

180 ZO-1-associated nucleic acid binding protein (ZONAB)/DbpA is a Y-box tra

181 rgenic region on chromosome 2q32.3, close to nucleic acid binding protein 1 (most significant single

182 study, we associated polymorphisms close to nucleic acid binding protein 1 (which encodes a DNA-bind

183 ferences that exist between the two types of nucleic acid binding protein at the atomic contact level

184 ecificity of these proteases for cleavage of nucleic acid binding protein substrates that play essent

185 Translin is a recently identified nucleic acid binding protein that appears to be involved

186 YB-1 is a nucleic acid binding protein that regulates transcriptio

187 The human DEK proto-oncogene is a nucleic acid binding protein with suspected roles in hum

188 CCUG repeats also decrease amounts of the nucleic acid binding protein ZNF9.

189 3L (a membrane scaffold protein), and L4R (a nucleic acid binding protein).

190 SE) binding protein (FBP), a single-stranded nucleic acid binding protein, is recruited to the c-myc

191 n-coding region of the CCHC-type zinc finger nucleic acid-binding protein (CNBP) gene.

192 in various organisms suggests that cellular nucleic acid-binding protein (CNBP) plays a fundamental

193 Y-box transcription factor, ZO-1-associated nucleic acid-binding protein (ZONAB), in a GTP-dependent

194 and functionally characterized the borrelial nucleic acid-binding protein BpuR, a PUR domain-containi

195 o contains multiple structural alignments of nucleic acid-binding protein families with annotations o

196 eport evidence that ribosomal protein S1 and nucleic acid-binding protein Hfq copurify in molar ratio

197 tivity associated with the Sm-like hexameric nucleic acid-binding protein Hfq.

198 psid (NC) protein of retroviruses is a small nucleic acid-binding protein important in virion assembl

199 ese changes also affected the degradation of nucleic acid-binding protein substrates of Lon, intracel

200 us nuclear ribonucleoprotein K (hnRNPK) is a nucleic acid-binding protein that acts as a docking plat

201 em by coding for a highly positively charged nucleic acid-binding protein that is packaged along with

202 om Escherichia coli K12 is a single-stranded nucleic acid-binding protein that plays a role in chromo

203 has previously been shown to be an abundant nucleic acid-binding protein whose synthesis is induced

204 It should facilitate the identification of a nucleic acid-binding protein within approximately 4 d.

205 conservation, suggest that RbfA is indeed a nucleic acid-binding protein, and identify a potential R

206 regulates AR at this site, we identified the nucleic acid-binding protein, heterogeneous nuclear ribo

207 is testicular variant of the multifunctional nucleic acid-binding protein, KSRP, serves as a decay-pr

208 as a G4 quadruplex and purine motif triplex nucleic acid-binding protein.

209 viously been identified as G4p2, a G-quartet nucleic acid-binding protein.

210 l tRNA synthetases suggest that Maf may be a nucleic acid-binding protein.

211 ty is allied to conversion of the endogenous nucleic-acid-binding protein PrP to an infectious modifi

212 A family of cellular nucleic acid binding proteins (CNBPs) contains seven Zn(

213 eviously, we have identified ZO-1-associated nucleic acid binding proteins (ZONAB), a Y-box transcrip

214 e role of metal ions in the function of both nucleic acid binding proteins and their enzymes.

215 tion termination factor (mTERF) proteins are nucleic acid binding proteins characterized by degenerat

216 glutamate on DNA binding by Escherichia coli nucleic acid binding proteins has been extensively docum

217 We performed a biochemical screen for novel nucleic acid binding proteins present in cell extracts o

218 ucleoproteins (hnRNPs) are a large family of nucleic acid binding proteins that are often found in, b

219 Many nucleic acid binding proteins use short peptide sequence

220 Instead, they are highly enriched in nucleic acid binding proteins with large intrinsically d

221 Many known Gzm substrates are nucleic acid binding proteins, and the Gzms accumulate i

222 is a member of a previously unknown class of nucleic acid binding proteins, composed of a single glob

223 ences were overrepresented by those encoding nucleic acid binding proteins, cytoskeleton components,

224 bearing proteins are a large superfamily of nucleic acid binding proteins, which constitute a major

225 of the function of individual KH domains in nucleic acid binding proteins.

226 hed to influence the activity of nuclear and nucleic acid binding proteins.

227 ods and findings can be generalized to other nucleic acid binding proteins.

228 ity it may prove possible to better engineer nucleic acid binding proteins.

229 ing proteins such as U1A than other types of nucleic acid binding proteins.

230 ffective means of modulating the behavior of nucleic acid binding proteins.

231 iptional functions for these single stranded nucleic acid binding proteins.

232 gy (KH) motif is one of the major classes of nucleic acid binding proteins.

233 ncodes a novel member of the Y box family of nucleic acid binding proteins.

234 es affinity distributions of highly specific nucleic acid binding proteins.

235 entify human cDNAs that encode a spectrum of nucleic acid-binding proteins (NBPs).

236 ed strand-helix motif, which occurs in other nucleic acid-binding proteins and may represent a common

237 Many nucleic acid-binding proteins and the AAA+ family form h

238 Nucleic acid-binding proteins are involved in a great nu

239 ly, one of the most evolutionarily conserved nucleic acid-binding proteins currently known.

240 Predicting the affinity profiles of nucleic acid-binding proteins directly from the protein

241 -shock proteins (Csps) are a family of small nucleic acid-binding proteins found in 72% of sequenced

242 the most evolutionarily conserved family of nucleic acid-binding proteins known among bacteria, plan

243 or belonging to a family of highly conserved nucleic acid-binding proteins related by their ability t

244 ding proteins (PCBPs) constitute a family of nucleic acid-binding proteins that play important roles

245 roteins, such as human YB-1, are a family of nucleic acid-binding proteins that share a region of hig

246 ctures of human Puf-A that reveal a class of nucleic acid-binding proteins with 11 PUM repeats arrang

247 parallel with the separation that delineates nucleic acid-binding proteins, although most of the inso

248 protein, a model for single-strand specific nucleic acid-binding proteins, consists of three structu

249 structural abnormalities and the presence of nucleic acid-binding proteins, including the TAR DNA bin

250 ators of posttranslational modification, and nucleic acid-binding proteins.

251 uses these mobility differences to identify nucleic acid-binding proteins.

252 e acting protein was in the hnRNPA family of nucleic acid-binding proteins.

253 for affinity microcapture of site-specific, nucleic acid-binding proteins.

254 ivates Rho signifies that the specificity of nucleic-acid binding proteins is defined not only by the

255 the sequence-specificity of single-stranded nucleic-acid-binding proteins (SNABPs).

256 Nucleic-acid-binding proteins are generally viewed as ei

257 o acid residues, are present in a variety of nucleic-acid-binding proteins.

258 Furthermore, nucleic acid binding provides an elegant and simple mech

259 The nucleic acid binding region of TTP is comprised of two C

260 N- and C-terminal ends, respectively, of the nucleic acid binding region were required for activity.

261 1071 to 1178 within the previously annotated nucleic acid-binding region (NAB) of severe acute respir

262 The C-terminal, nucleic acid-binding region enhanced the ribonuclease ac

263 ying article, three short sequence segments (nucleic acid binding sequences (NBS)) important for RNas

264 ntified to have perturbed pK(a)s in both the nucleic acid binding site and in the distant ATP-binding

265 mutants further demonstrate that the primary nucleic acid binding site corresponds to a surface of th

266 ne, which reveals a novel positively charged nucleic acid binding site distal to the active center th

267 We conclude that the nucleic acid binding site in plant POT1 proteins is evol

268 fferent heterodimer was formed involving the nucleic acid binding site of BolA and the C-terminal tai

269 The results of this study indicate that the nucleic acid binding site of HCV helicase is allosterica

270 studies determine the location of a defined nucleic acid binding site on a large, native, multi-subu

271 fragment has been modeled into the RNase H2 nucleic acid binding site providing insight into the rec

272 al of the C-terminal domain of gp32 from its nucleic acid binding site that is in pre-equilibrium to

273 these residues are part of the HCV helicase nucleic acid binding site, and their roles were analyzed

274 he helicase dictates the conformation of its nucleic acid binding site.

275 clude that RNA or DNA binding to the primary nucleic acid binding sites causes conformational changes

276 s with dsDNA due to the presence of multiple nucleic acid binding sites identified both in the isolat

277 is a result of RNA contacting the secondary nucleic acid binding sites in the central channel of the

278 of displacing natural polyamines from their nucleic acid binding sites, and of inhibiting cell divis

279 d allosteric cross-talk between the ATP- and nucleic acid-binding sites achieved by the overall stabi

280 These findings provide proof of concept that nucleic acid binding small molecules, such as TMPyP4, ca

281 0 and possessed a modular organization, four nucleic acid-binding SN domains, a tudor domain and a co

282 acids, it has proven possible to adapt other nucleic acid binding species (aptamers) to function in a

283 Brg1 helicase has dual nucleic-acid-binding specificities: it is capable of bin

284 ic acids by intercalation, but the trends in nucleic acid binding specificity are highly diverse.

285 As a consequence, nucleic acid binding stimulates the rate at which a heli

286 common alpha/beta fold but exhibit different nucleic acid binding surfaces and distinct functional ro

287 of Molecular Cell reported that the typical nucleic acid binding surfaces of the RRM and winged-heli

288 an additional role for the p51 C terminus in nucleic acid binding that is compromised by inhibitor bi

289 By uncovering the molecular mechanisms of nucleic-acid binding, this study contributes to understa

290 that exploits the use of aqueous buffers for nucleic acid binding to and release from a solid phase i

291 The pH-controlled approach, which promotes nucleic acid binding to and release to the chitosan phas

292 We now propose that nucleic acid binding to the fingers domain may play a ro

293 We apply the method to the case of nucleic acids binding to silver, discovering that multip

294 c93b1 3d mutation that selectively abolishes nucleic acid-binding Toll-like receptor (TLR) (TLR3, -7,

295 Many studies of specific protein-nucleic acid binding use short oligonucleotides or restr

296 ty and/or the specificity of single-stranded nucleic acid binding were altered for each IMPDH1 mutant

297 ing domain are required for processivity and nucleic acid binding, which leads to dimerization of the

298 s have been implicated in structure-specific nucleic acid binding with roles in targeting RecQ protei

299 he hallmark GxxG loop (GxxG-to-GDDG) impairs nucleic acid binding without compromising the stability

300 protein, E3, which contains an N-terminal Z-nucleic acid binding (Zalpha) domain that is critical fo