ライフサイエンスコーパス: nucleocytoplasmic transport

1 zation and aggregation of NUPs and defective nucleocytoplasmic transport.

2 Nuclear pore complexes (NPCs) facilitate nucleocytoplasmic transport.

3 of integral membrane proteins and/or during nucleocytoplasmic transport.

4 mplexes in the two extracts, consistent with nucleocytoplasmic transport.

5 vergence may represent a unique mechanism of nucleocytoplasmic transport.

6 o be involved in signal transduction through nucleocytoplasmic transport.

7 esting an important role of the nucleolus in nucleocytoplasmic transport.

8 in is necessary and sufficient for mediating nucleocytoplasmic transport.

9 rotein assemblies that are the sole sites of nucleocytoplasmic transport.

10 acids 47-229, is also sufficient to inhibit nucleocytoplasmic transport.

11 The Ran GTPase plays a central role in nucleocytoplasmic transport.

12 hting the importance of the shape effects in nucleocytoplasmic transport.

13 on between the SUMO modification pathway and nucleocytoplasmic transport.

14 within the nucleus to inhibit bi-directional nucleocytoplasmic transport.

15 0 nucleoporins that cooperatively facilitate nucleocytoplasmic transport.

16 ellular function is the proper regulation of nucleocytoplasmic transport.

17 a small signaling GTPase that is involved in nucleocytoplasmic transport.

18 tion between the import and export phases of nucleocytoplasmic transport.

19 ction may require regulated, CRM1-dependent, nucleocytoplasmic transport.

20 n NPC-associated factor that participates in nucleocytoplasmic transport.

21 for a Brownian affinity gating mechanism for nucleocytoplasmic transport.

22 ects a more global process for regulation of nucleocytoplasmic transport.

23 mplex (NPC) are fundamental to understanding nucleocytoplasmic transport.

24 critical for understanding the mechanism of nucleocytoplasmic transport.

25 small ras-like GTPase involved in regulating nucleocytoplasmic transport.

26 ndergo degradation in the nucleus instead of nucleocytoplasmic transport.

27 d RNA sequences under conditions of impaired nucleocytoplasmic transport.

28 ulation of unspliced BDV transcripts through nucleocytoplasmic transport.

29 TPase Ran/Gsp1p, which is essential for most nucleocytoplasmic transport.

30 AN, a region that is supposed to function in nucleocytoplasmic transport.

31 125 MDa multiprotein assembly that mediates nucleocytoplasmic transport.

32 ted terminal differentiation and/or aberrant nucleocytoplasmic transport.

33 ) are 110-megadalton assemblies that mediate nucleocytoplasmic transport.

34 lex (NPC) filaments and is a docking site in nucleocytoplasmic transport.

35 nstitutes the sole gateway for bidirectional nucleocytoplasmic transport.

36 oncentration in the nucleus is important for nucleocytoplasmic transport.

37 Nups in the nuclear pore, and mechanisms of nucleocytoplasmic transport.

38 ptors (Karyopherins (Kaps)) that orchestrate nucleocytoplasmic transport.

39 mbers (karyopherins) mediate the majority of nucleocytoplasmic transport.

40 t, consistent with its essential function in nucleocytoplasmic transport.

41 ility of Cic by controlling the rates of its nucleocytoplasmic transport.

42 TPase Ran and the importin proteins regulate nucleocytoplasmic transport.

43 G domain nucleoporins, which are crucial for nucleocytoplasmic transport.

44 nonsense-mediated mRNA decay pathway, and to nucleocytoplasmic transport.

45 sphorylation site which is essential for its nucleocytoplasmic transport.

46 TG (RAN) translation proteins also disrupted nucleocytoplasmic transport.

47 e activity of Ran-GTPase, a key regulator of nucleocytoplasmic transport.

48 ndant GTPase responsible for the majority of nucleocytoplasmic transport.

49 was originally identified as a regulator of nucleocytoplasmic transport [1] and subsequently found t

50 The nucleocytoplasmic transport activity was not dependent o

51 studies offered clues that mHTT may disrupt nucleocytoplasmic transport and a mutation of an NUP can

52 occupancy of multiple RPEL motifs regulates nucleocytoplasmic transport and activity of MAL.

53 entify polyglutamine-dependent inhibition of nucleocytoplasmic transport and alteration of nuclear in

54 In addition, LKB1 nucleocytoplasmic transport and AMPK activation in respo

55 utant that is used extensively in studies of nucleocytoplasmic transport and cell-cycle progression.

56 nuclear pore complex (NPC) has dual roles in nucleocytoplasmic transport and chromatin organization.

57 uclear pore complex (NPC) is responsible for nucleocytoplasmic transport and constitutes a hub for co

58 lts confirm that CAN plays a crucial role in nucleocytoplasmic transport and imply an essential role

59 MO E3 ligase activity that functions in both nucleocytoplasmic transport and mitosis.

60 oughout the cell cycle, including interphase nucleocytoplasmic transport and mitotic spindle assembly

61 Arginine methylation can affect both nucleocytoplasmic transport and protein-protein interact

62 To further explore the role of Kap123p in nucleocytoplasmic transport and ribosome biogenesis, we

63 ntial for many cellular processes, including nucleocytoplasmic transport and spindle assembly.

64 ranslational regulation of p53 comprises its nucleocytoplasmic transport and subsequent proteasomal d

65 lays a cell type-specific role in regulating nucleocytoplasmic transport and that this function is es

66 like U1 and U5 RNAs in their bi-directional nucleocytoplasmic transport and their 5'-cap hypermethyl

67 infection, E1B-55K is required for efficient nucleocytoplasmic transport and translation of late vira

68 te phase, E1B-55K modulates the preferential nucleocytoplasmic transport and translation of the late

69 Ran, which provides spatial information for nucleocytoplasmic transport and various mitotic processe

70 p62 at the nuclear envelope (probably during nucleocytoplasmic transport) and also in nucleoli, clear

71 romised nuclear envelope integrity, impaired nucleocytoplasmic transport, and accumulation of DNA dou

72 tion of host gene expression, disablement of nucleocytoplasmic transport, and disruption of the host

73 ical for cellular processes such as mitosis, nucleocytoplasmic transport, and nuclear envelope format

74 ct role of the disorder within FG repeats in nucleocytoplasmic transport, and resolves the apparent c

75 he nuclear pore complexes (NPCs) that enable nucleocytoplasmic transport, and the spindle pole bodies

76 latory elements (INS) that impair stability, nucleocytoplasmic transport, and translation by unknown

77 c nuclear permeability barrier and selective nucleocytoplasmic transport are maintained by nuclear po

78 ycine (FG) repeats play an important role in nucleocytoplasmic transport as they bind to transport re

79 Here we demonstrate that nucleocytoplasmic transport at the membrane domain surro

80 The RanGTPase acts as a master regulator of nucleocytoplasmic transport by controlling assembly and

81 n et al. provide evidence for the control of nucleocytoplasmic transport by protein kinase signaling

82 We have examined whether signal-mediated nucleocytoplasmic transport can be regulated by phosphor

83 Thus, to overcome the limited capacity for nucleocytoplasmic transport, cells requiring increased n

84 dependent on a tRNA structure necessary for nucleocytoplasmic transport, consistent with primer sele

85 tain this conformation throughout the entire nucleocytoplasmic transport cycle.

86 zymes in ubiquitination, carrier proteins in nucleocytoplasmic transport, cyclin-dependent kinase in

87 ce in the eye have specific requirements for nucleocytoplasmic transport, despite involving processes

88 ion, whereas inhibitors of transcription and nucleocytoplasmic transport did not.

89 -FTD spectrum disorder, including autophagy, nucleocytoplasmic transport, DNA damage repair, pre-mRNA

90 We propose that L inhibits nucleocytoplasmic transport during infection by disrupti

91 To study nucleocytoplasmic transport during multicellular develop

92 ever little is known about the regulation of nucleocytoplasmic transport during the formation of myof

93 ta and ste5ts), indicating that reduction in nucleocytoplasmic transport enhances mating proficiency.

94 ll GTPase Ran is essential for virtually all nucleocytoplasmic transport events.

95 uction of securin by APC is regulated by the nucleocytoplasmic transport factors Rae1 and Nup98.

96 ave been proposed to mediate the movement of nucleocytoplasmic transport factors.

97 of numerous biological processes, including nucleocytoplasmic transport, genomic stability, and gene

98 rtial sequestration of factors essential for nucleocytoplasmic transport (Gle1 and RanGAP1), and intr

99 The separate components of nucleocytoplasmic transport have been well characterized

100 may lead to unique insights into the role of nucleocytoplasmic transport in adrenal function and neur

101 and serves as the sole conduit to facilitate nucleocytoplasmic transport in eukaryotes.

102 s) are key cellular transporter that control nucleocytoplasmic transport in eukaryotic cells, but its

103 cts in the nuclear pore complex and impaired nucleocytoplasmic transport in Huntington's disease (HD)

104 Therefore, we evaluated the NPC and nucleocytoplasmic transport in multiple models of HD, in

105 s provide evidence for an important role for nucleocytoplasmic transport in the pathogenic mechanism

106 Virtually nothing is known about nucleocytoplasmic transport in these parasites (phylum A

107 th mutations in many other genes involved in nucleocytoplasmic transport, including SRP1 (alpha-impor

108 (Phe) mutants that retained the capacity for nucleocytoplasmic transport, indicative of overall intac

109 sses of mRNA metabolism, including splicing, nucleocytoplasmic transport,initiation of translation, a

110 Nucleocytoplasmic transport involves assembly and moveme

111 Interference with nucleocytoplasmic transport is a strategy employed by ce

112 Dysfunction in nucleocytoplasmic transport is also an emerging theme in

113 permeability, selectivity, and the speed of nucleocytoplasmic transport is an assembly of natively u

114 p53 nucleocytoplasmic transport is carried out by a bipartit

115 Receptor-mediated nucleocytoplasmic transport is dependent on the GTPase R

116 We conclude that the directionality of nucleocytoplasmic transport is determined mainly by the

117 stablished general background information on nucleocytoplasmic transport is discussed.

118 Nucleocytoplasmic transport is facilitated by nuclear po

119 Nucleocytoplasmic transport is mediated by nuclear pore

120 Nucleocytoplasmic transport is mediated by nuclear pore

121 Nucleocytoplasmic transport is mediated by the interacti

122 Nucleocytoplasmic transport is mediated by the interplay

123 Nucleocytoplasmic transport is sustained by karyopherins

124 asm, it may mediate a connection between the nucleocytoplasmic transport machinery and the endosomal

125 To further our understanding of how the nucleocytoplasmic transport machinery interfaces with it

126 As RCC1 is an important component of the nucleocytoplasmic transport machinery, we find that dRCC

127 concomitantly can interact with the soluble nucleocytoplasmic transport machinery.

128 exportins represent an essential part of the nucleocytoplasmic transport machinery.

129 rovides several binding sites for the mobile nucleocytoplasmic transport machinery.

130 rovides a multitude of binding sites for the nucleocytoplasmic transport machinery.

131 common mechanism for SUMOylation to regulate nucleocytoplasmic transport may lie in the interplay bet

132 e propose that RB inactivation, via aberrant nucleocytoplasmic transport, may disrupt normal cell dif

133 the NPC, taking a central role in the vital nucleocytoplasmic transport mechanism.

134 gradient of RanGTP on chromatin that directs nucleocytoplasmic transport, mitotic spindle assembly an

135 ifunctional small GTPase that is involved in nucleocytoplasmic transport, mitotic spindle assembly, a

136 ll GTPase Ran is best known for its roles in nucleocytoplasmic transport, mitotic spindle assembly, a

137 y of GTPases, is best known for its roles in nucleocytoplasmic transport, mitotic spindle fiber assem

138 n guanosine triphosphatase (GTPase) controls nucleocytoplasmic transport, mitotic spindle formation,

139 The NUP107 complex is important for nucleocytoplasmic transport, nuclear envelope assembly,

140 Nucleocytoplasmic transport occurs exclusively through n

141 Nucleocytoplasmic transport occurs through gigantic prot

142 Nucleocytoplasmic transport occurs through nuclear pore

143 To understand how the vital process of nucleocytoplasmic transport occurs, the contribution of

144 ite mutant TA accumulation in NE structures, nucleocytoplasmic transport of a reporter protein was un

145 Nuclear eIF4E functions in nucleocytoplasmic transport of a subset of transcripts i

146 the canonical Wnt pathway by regulating the nucleocytoplasmic transport of beta-catenin rather than

147 ant function of small GTPases in the cell is nucleocytoplasmic transport of both proteins and RNA.

148 Retroviral replication requires the nucleocytoplasmic transport of both spliced and unsplice

149 Therefore, we characterized the nucleocytoplasmic transport of each of the heterogeneous

150 te the structural features that underlie the nucleocytoplasmic transport of FABP4.

151 gs define a possible mechanism for regulated nucleocytoplasmic transport of Gln3p by phosphorylation

152 roductive infection, including the selective nucleocytoplasmic transport of late viral mRNA.

153 1 phosphorylation at S307, which directs the nucleocytoplasmic transport of LKB1 and consequent AMPK

154 We investigated the mechanism of nucleocytoplasmic transport of LKB1 in response to its c

155 role that can be considered dependent on the nucleocytoplasmic transport of macromolecules (i.e. is t

156 The nuclear pore complex mediates nucleocytoplasmic transport of macromolecules in eukaryo

157 In eukaryotes, the nucleocytoplasmic transport of macromolecules is mainly

158 Nucleocytoplasmic transport of macromolecules is regulat

159 The NPC regulates nucleocytoplasmic transport of macromolecules, utilizing

160 Ran GTPase is required for nucleocytoplasmic transport of many types of cargo.

161 Moreover, the role of nucleocytoplasmic transport of mature mRNA during liver

162 enetic information is regulated by selective nucleocytoplasmic transport of messenger RNA:protein com

163 ype suggests that this protein regulates the nucleocytoplasmic transport of molecules involved in sev

164 est that polyadenylation is required for the nucleocytoplasmic transport of mRNA and that Rev interac

165 Saccharomyces cerevisiae and facilitates the nucleocytoplasmic transport of mRNA-binding proteins thr

166 TAP and NxT1, both of which are involved in nucleocytoplasmic transport of mRNA.

167 recombination and the proper processing and nucleocytoplasmic transport of mRNA.

168 rus has been used as a model system to study nucleocytoplasmic transport of mRNA.

169 hat Arabidopsis AtNUP160 is critical for the nucleocytoplasmic transport of mRNAs and that it plays i

170 roteins may occur at NPCs and facilitate the nucleocytoplasmic transport of mRNAs.

171 We therefore investigated the nucleocytoplasmic transport of NP from influenza virus A

172 indings suggest a role of phosphorylation in nucleocytoplasmic transport of NP.

173 In addition these mutations affect nucleocytoplasmic transport of Npl3p.

174 rt receptors (karyopherins) that mediate the nucleocytoplasmic transport of protein and RNA cargoes.

175 Active nucleocytoplasmic transport of protein and RNA in eukary

176 investigated possible roles of xNup98 in the nucleocytoplasmic transport of proteins and RNAs by anal

177 Regulated nucleocytoplasmic transport of proteins is central to ce

178 distribution, vaults may be involved in the nucleocytoplasmic transport of ribosomes and/or mRNA.

179 The general molecular mechanisms involved in nucleocytoplasmic transport of RNA are only beginning to

180 inson-Gilford progeria syndrome inhibits the nucleocytoplasmic transport of several factors with key

181 eIF-4E is involved in nucleocytoplasmic transport of specific mRNAs including

182 bodies may participate in the regulation of nucleocytoplasmic transport of specific mRNAs.

183 ated with PML nuclear bodies, eIF4E mediates nucleocytoplasmic transport of specific transcripts, and

184 key translation factor and as a promoter of nucleocytoplasmic transport of specific transcripts.

185 Possible functions for this complex in nucleocytoplasmic transport of spliced mRNA, as well as

186 JAK/STAT signaling through their control of nucleocytoplasmic transport of STAT92E.

187 tly how these interactions contribute to the nucleocytoplasmic transport of substrates remains unclea

188 etition between autocatalytic processing and nucleocytoplasmic transport of the initial TRz transcrip

189 This impairs the nucleocytoplasmic transport of the tumor necrosis factor

190 cy virus type 1 (HIV-1) is essential for the nucleocytoplasmic transport of unspliced and partially s

191 protein export pathway in order to allow the nucleocytoplasmic transport of unspliced viral RNA.

192 Nucleocytoplasmic transport of viral ribonucleoproteins

193 This is not due to a general decline in nucleocytoplasmic transport or to occlusion or loss of n

194 with recent reports showing that DPRs affect nucleocytoplasmic transport, our results point to an imp

195 t factors underlie the efficiency of certain nucleocytoplasmic transport pathways.

196 we recently established its crucial role in nucleocytoplasmic transport processes and cell cycle pro

197 with the Ran-GTPase support also its role in nucleocytoplasmic transport processes.

198 Here we analyzed the nucleocytoplasmic transport properties of both Gag prote

199 e divided into two groups according to their nucleocytoplasmic transport properties.

200 Rev is a nucleocytoplasmic transport protein that directly binds

201 show that importin beta, a well established nucleocytoplasmic transport protein, interacts with comp

202 irst time revealed a novel role that MOG1, a nucleocytoplasmic transport protein, plays in cardiac ph

203 1 have been shown to regulate transcription, nucleocytoplasmic transport, protein stability, and prot

204 estration and impairment of nuclear HR23 and nucleocytoplasmic transport proteins is an outcome of, a

205 g karyopherins and effectors of Ran-mediated nucleocytoplasmic transport, providing insight into pote

206 s will continue to be applied to outstanding nucleocytoplasmic transport questions, and that the appr

207 defective mutants, a nonsense allele of the nucleocytoplasmic transport receptor, Kap104, was identi

208 rm1 is a member of the karyopherin family of nucleocytoplasmic transport receptors and mediates the e

209 abidopsis ortholog of the importin beta-like nucleocytoplasmic transport receptors exportin 5 in mamm

210 e RanGTPase cycle provides directionality to nucleocytoplasmic transport, regulating interactions bet

211 Continuous cycles of nucleocytoplasmic transport require disassembly of trans

212 answer by other means, yet the complexity of nucleocytoplasmic transport requires that interpretation

213 included 1) mRNAs within the nucleolus when nucleocytoplasmic transport, rRNA biogenesis, or RNA pro

214 3, where a cluster of consensus sites near a nucleocytoplasmic transport signal is confined to a spec

215 ant ZIC3 proteins identified the presence of nucleocytoplasmic transport signals.

216 ntrols multiple cellular processes including nucleocytoplasmic transport, spindle assembly, and nucle

217 es in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and post

218 The small GTPase Ran is involved in nucleocytoplasmic transport, spindle formation, nuclear

219 P) is important to Ran signaling involved in nucleocytoplasmic transport, spindle organization, and p

220 The Ran GTPase drives nucleocytoplasmic transport, stabilizes mitotic spindles

221 The fundamental process of nucleocytoplasmic transport takes place through the nucl

222 is blocked by an inhibitor of Ran-dependent nucleocytoplasmic transport, the Matrix protein of vesic

223 the role of nuclear pore complexes (NPCs) in nucleocytoplasmic transport, the mechanism of NPC assemb

224 As the sole site of nucleocytoplasmic transport, the nuclear pore complex (N

225 Nucleocytoplasmic transport, the trafficking of macromol

226 The nuclear pore complex gates nucleocytoplasmic transport through a massive, eight-fol

227 Cardioviruses disrupt nucleocytoplasmic transport through the activity of thei

228 The nuclear pore complex (NPC) mediates nucleocytoplasmic transport through the nuclear envelope

229 f G4C2 repeat expansion is the compromise of nucleocytoplasmic transport through the nuclear pore, re

230 There is significant evidence linking nucleocytoplasmic transport to cell cycle control.

231 ights into how these nucleoporins coordinate nucleocytoplasmic transport to mount a robust immune res

232 These results demonstrate that maximum nucleocytoplasmic transport velocities can be modulated

233 unidentified cellular molecules that undergo nucleocytoplasmic transport via a pathway that is not as

234 Nuclear transport receptors (NTRs) mediate nucleocytoplasmic transport via their affinity for unstr

235 Although global nucleocytoplasmic transport was not significantly altere

236 Consistent with a potential role in nucleocytoplasmic transport, we found that HST interacts

237 easomal degradation and proteins involved in nucleocytoplasmic transport were sequestered by poly(GA)

238 s detected by FRET methods; the kinetics for nucleocytoplasmic transport were unaffected by mutations

239 echanics is essential for characterizing the nucleocytoplasmic transport, which has a central importa

240 pore complex encloses a central channel for nucleocytoplasmic transport, which is thought to consist

241 This mechanism may coordinate nucleocytoplasmic transport with other mitogenic effects

242 model of an intact NPC structure to examine nucleocytoplasmic transport with refined spatial and tem

243 The nuclear pore complex (NPC) mediates all nucleocytoplasmic transport, yet its structure and bioge