ライフサイエンスコーパス: nucleolar

1 s into rRNA structural rearrangements during nucleolar 60S assembly.

2 rs belonging to the importin-alpha family in nucleolar accumulation of the PMTV TGB1 protein and, sub

3 An increase in the nucleolar activity of FGFR2 in BBDS elevates levels of r

4 36) has been implicated in the regulation of nucleolar activity.

5 exclusively cytoplasmic, the CPEB4 LCD forms nucleolar aggregates and CPEB4 LCD-expressing animals ha

6 effective thermodynamic parameters governing nucleolar and END assembly, but do not appear to fundame

7 Thus, anti-nucleolar and pro-apoptotic effects of protein C are fla

8 Nucleolar and ribosomal proteins showed short half-lives

9 The nucleolar and spindle-associated protein NUSAP1 is a mic

10 by global chromosome architecture, provides nucleolar and/or nuclear peripheral anchoring points con

11 C1q binding and C1r/C1s degradation of nucleolar antigens during cell apoptosis potentially red

12 cation of a novel RNA binding sequence for a nucleolar Arabidopsis PUF protein that contains an atypi

13 argeting and meiosis and impacts nuclear and nucleolar architecture when deleted or overexpressed.

14 Gle1 targeting and modulation of nuclear and nucleolar architecture.

15 at nuclear Fascin plays an important role in nucleolar architecture.

16 promotes the localization of specific loci (nucleolar-associated domains [NADs]) and proteins to the

17 l DNA (rDNA) genes leads to the formation of nucleolar-associated gammaH2AX signals, which persist ow

18 ated function of TDP-43 in the processing of nucleolar-associated RNA.

19 en Ki-67, whose depletion also decreases the nucleolar association of NADs.

20 n of multiple nucleolar proteins and reduces nucleolar association with several repetitive element-co

21 h serotype-specific differential patterns of nucleolar association; AAPs and assembled capsids do not

22 nteracting motif (SIM) within p150 abolishes nucleolar associations, whereas PCNA or HP1 interaction

23 The extent of nucleolar autoantigen degradation upon C1 treatment was

24 cells, nucleoli were targeted by C1q and two nucleolar autoantigens were degraded by C1r/C1s protease

25 PE1 suggest a role for the redistribution of nucleolar BER factors in determining cisplatin toxicity.

26 trate that CMV pUL31 functions in regulating nucleolar biology and contributes to the reorganization

27 UL31 is necessary and sufficient to regulate nucleolar biology involving the reorganization of nucleo

28 tion of nucleoli during infection.IMPORTANCE Nucleolar biology is important during CMV infection with

29 er, the extent of CMV-mediated regulation of nucleolar biology is not well established.

30 oes not strongly affect the Raman spectra of nucleolar biomolecular components, but may significantly

31 UBF trimethylation leads to nucleolar chromatin condensation and decreased rDNA tran

32 However, the role of NPM1 in nucleolar chromatin dynamics and ribosome biogenesis rem

33 is linked to impaired rDNA transcription and nucleolar chromatin remodeling, which may play key roles

34 1 binding proteins with functions related to nucleolar chromatin structure and RNA polymerase I trans

35 thylated by ESET modulates the plasticity of nucleolar chromatin.

36 CAF-1 subunits is sufficient for maintaining nucleolar chromosome and protein associations.

37 manipulating C. elegans cell size, we change nucleolar component concentration and confirm several ke

38 ired for phase separation of NPM1 with other nucleolar components in vitro and for localization withi

39 number rather than a fixed concentration of nucleolar components, which condense into nucleoli only

40 ), Piwi-interacting (piRNAs), small nuclear, nucleolar, cytoplasmic (sn-, sno-, scRNAs, respectively)

41 nome stability via a mechanism that involves nucleolar-cytoplasmic shuttling.

42 which associates with chromosomes only after nucleolar disassembly later in prophase.

43 ic rDNA induced by the BBDS mutations direct nucleolar disorganization, alter ribosome biogenesis, an

44 t a putative link exists between NSs-induced nucleolar disruption and its inhibitory function on cell

45 m redistribution, evocative of virus-induced nucleolar disruption.

46 silencing of 35S rRNA genes (rDNA), known as nucleolar dominance (ND), is common in interspecific hyb

47 18S, 5.8S and 26S ribosomal RNA) silencing (nucleolar dominance) and rRNA gene dosage, we studied a

48 9orf72 transcripts or RAN dipeptides promote nucleolar dysfunction.

49 The anti-nucleolar effects were most pronounced in postmitotic ne

50 luded from the nucleolus, in contrast to the nucleolar enrichment of assembled AAV2 capsids; and, sur

51 theless, ribotoxic drugs rapidly promote its nucleolar exit.

52 in A expression are each sufficient to drive nucleolar expansion.

53 etry identified 175 proteins in human T cell nucleolar extracts that bound to Sepharose-immobilized H

54 Da) macromolecular complexes in human T cell nucleolar extracts.

55 The nucleolar factor, digestive organ expansion factor (DEF)

56 Nucleolar FGFR2 activates rDNA transcription via interac

57 tially associating with its hRRP6-containing nucleolar form.

58 of CARF increased the amount of XRN2 in the nucleolar fraction as determined by cell fractionation a

59 of Caenorhabditis elegans in the absence of nucleolar fragmentation.

60 Yet, the precise link between NuMA and nucleolar function remains undetermined.

61 in RNA splicing, editing, nuclear export and nucleolar function.

62 o our knowledge, this is the first report of nucleolar functions for NSs within the Bunyaviridae fami

63 The nucleolar functions of p150 are separable from its inter

64 Persistent nucleolar gammaH2AX also acts as a histone modification

65 Nucleolar GTP-binding protein (NGP-1) is overexpressed i

66 we report the newly identified small GTPase, Nucleolar GTP-binding protein 1 (NOG1), functions for pl

67 Upregulated expression of nucleolar GTPase nucleostemin (NS) has been associated w

68 ly overlapped with those of the human T cell nucleolar H1 binding proteins.

69 sheds light on a sophisticated mechanism of nucleolar homeostasis surveillance during stress.

70 uman NF-kappaB repressing factor (NKRF) as a nucleolar HSP essential for nucleolus homeostasis and ce

71 In the presence of DSBs, TLC1 RNA remains nucleolar in most G2/M cells but accumulates in the nucl

72 reduced ribosome content without disrupting nucleolar integrity, cell survival, and signaling respon

73 single cell cycle is associated with loss of nucleolar integrity, demonstrating that the defects at t

74 II and facilitates their maturation, while a nucleolar isoform has been implicated in rRNA biogenesis

75 , we found that Nop4 is a hub protein in the nucleolar large subunit (LSU) processome interactome.

76 icking, controlling 5'-to-3' exoribonuclease nucleolar levels and regulating rRNA processing.

77 However, in either case they regulated the nucleolar levels of the PAFs.

78 localizes to mitochondria in addition to its nucleolar localization and inhibits the mitochondrial ap

79 We propose that one mechanism of nucleolar localization involves phase separation of prot

80 elomeres at a time in S-phase HeLa cells; no nucleolar localization is detected.

81 tion by the 20 S proteasome, suggesting that nucleolar localization is indispensable for the stress-i

82 within p150N, which is also required for the nucleolar localization of NADs and Ki-67 during interpha

83 ng total BER capacity, and 3) modulating the nucleolar localization of several BER enzymes.

84 he RNAi-mediated depletion of UBF diminishes nucleolar localization of SmgGDS and promotes proteasome

85 The distinct nucleolar localization of the mitotic flare indicates th

86 nd that SET7/9 monomethylation in a putative nucleolar localization region of LIN28A increases its nu

87 Here, we show that NSs contains a nucleolar localization signal (NoLS) and induces disorga

88 ly appears to target the nucleolus through a nucleolar localization signal (NoLS) localized between r

89 inal sequence that is predicted to contain a nucleolar localization signal (NoLS), only p8 is found i

90 The interaction was mediated by two nucleolar localization signals identified by bioinformat

91 antly, these R-motifs are found in canonical nucleolar localization signals.

92 s to the growing body of work on nuclear and nucleolar localization signals.

93 AV serotype 2 (AAV2) that act as nuclear and nucleolar localization signals.

94 Mammalian WDR12 displays prominent nucleolar localization that is dependent upon active rib

95 ion upon EGF, VEGF and Insulin treatment and nucleolar localization with Insulin treatment.

96 he GW motif in p37 that concurrently affects nucleolar localization, efficient interaction with AGO1,

97 f 22 C-terminal residues of ZIKV-C prevented nucleolar localization, ribosomal stress and apoptosis.

98 ctivity on gene expression is related to its nucleolar localization.

99 escence microscopy shows nuclear and intense nucleolar localization.

100 y-activating protein (AAP), a nonstructural, nucleolar-localizing AAV protein essential for viral cap

101 deno-associated virus serotype 2 (AAV2) is a nucleolar-localizing protein that plays a critical role

102 ole for the human p150 subunit in regulating nucleolar macromolecular interactions.

103 NSs colocalizes with nucleolar markers such as B23 (nucleophosmin) and fibril

104 biogenesis in tumors and a new mechanism of nucleolar modulation of p53.

105 n nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cu

106 Nucleolar morphology is controlled by chromatin structur

107 a loss of nucleolar RNA content and altered nucleolar morphology resulting from in vivo H1 depletion

108 , and RRF; however, the resulting changes in nucleolar morphology suggest a similar cellular response

109 depletion of SmgGDS in cancer cells disrupts nucleolar morphology, signifying nucleolar stress.

110 component of the small subunit processome, a nucleolar multi-protein complex whose only known functio

111 aracterize AAV2 AAP (AAP2) nuclear (NLS) and nucleolar (NoLS) localization signals near the carboxy-t

112 espite reducing canonical signaling, enhance nucleolar occupancy of FGFR2 at the ribosomal DNA (rDNA)

113 both proteins altered pUL31 localization and nucleolar organization.

114 d Gr359 occurred in both the centromeres and nucleolar organizer regions (NORs) in D- and AD-genome s

115 at MAS2 colocalizes with the 45S rDNA at the nucleolar organizer regions (NORs).

116 M1 presented with altered silver staining of nucleolar organizer regions, coupled to a modest decreas

117 hat assemble at the transcriptionally active nucleolar organizing regions, we observe dozens of "extr

118 Recently, it has become evident that nucleolar passage of movement proteins occurs commonly i

119 In contrast, the nucleolar pattern of B23 was unchanged upon infection wi

120 Furthermore, the nucleolar phosphoprotein nucleophosmin (NPM1) acts as a

121 NPM1 (nucleophosmin 1) is a nucleolar phosphoprotein that regulates many cellular pr

122 partner of nucleophosmin (NPM/B23), a major nucleolar phosphoprotein with diverse cellular activitie

123 rowth, demonstrating that the NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2

124 RAIDD dependent but PIDD independent, and a nucleolar platform that requires both PIDD and RAIDD.

125 eolus to the nucleoplasm during heat stress; nucleolar pools are replenished during recovery upon HSF

126 duced nucleolar stress and apoptosis disrupt nucleolar PPAN localization and induce its accumulation

127 Midasin's role in assembling Nsa1 particles, nucleolar precursors of the 60S subunit.

128 Moreover, in the latter system, nucleolar presence of ZIKV capsid protein (ZIKV-C) was a

129 67 interactors included proteins involved in nucleolar processes and chromatin regulators.

130 Here, we report that deletion of Nol3 (Nucleolar protein 3) in mice leads to an MPN resembling

131 ear antigen (MINA53; also known as MINA) and nucleolar protein 66 (NO66) catalyse histidine hydroxyla

132 Previous studies showed that nucleolar protein 66 (NO66), the Jumonji C-domain-contai

133 tion in an RNA recognition motif of RBM28, a nucleolar protein conserved to yeast (Nop4).

134 pitation experiments revealed that the major nucleolar protein fibrillarin is coprecipitated in the P

135 ression of rRNA, ribosomal proteins, and the nucleolar protein fibrillarin, dependent on NCL-1.

136 C1, an abundant and evolutionarily conserved nucleolar protein in eukaryotic organisms, is required f

137 Nucleolar protein interacting with the FHA domain of pKi

138 We found that nucleolin, a nucleolar protein involved in ribosomal maturation, boun

139 Nucleophosmin 1 (NPM1) is a nucleolar protein involved in ribosome biogenesis, stres

140 dc14 by counteracting phosphorylation of the nucleolar protein Net1 by Cdk.

141 n of UL84FLAG also colocalized with the host nucleolar protein nucleolin at the peripheries of both r

142 viral proteins, viral DNA, and the cellular nucleolar protein nucleolin in the subnuclear replicatio

143 ligomerization domain of the multifunctional nucleolar protein nucleophosmin (Npm-N) are central to i

144 The nucleolar protein PICT1 regulates tumor suppressor p53 b

145 Nucleostemin (NS) is a nucleolar protein regulating stem cell proliferation and

146 NPM1 is a nucleolar protein required for the maintenance of genome

147 ion between the DDR factor NBS1 and TCOF1, a nucleolar protein that regulates ribosomal DNA (rDNA) tr

148 Furthermore, we show that FGF13 1A is a nucleolar protein that represses ribosomal RNA transcrip

149 Specifically, nucleolin, an essential nucleolar protein, preferentially binds the HRE G-quadru

150 y is important during CMV infection with the nucleolar protein, with nucleolin playing a role in main

151 lacked significant autoproteolysis, but many nucleolar proteins and autoantigens were degraded by C1

152 on of p150 causes redistribution of multiple nucleolar proteins and reduces nucleolar association wit

153 al increase (up to 40%) in concentrations of nucleolar proteins and RNA, most likely due to cell shri

154 quantitative dynamics by which six different nucleolar proteins assemble into the nucleoli of Drosoph

155 included members of the cohesin complex and nucleolar proteins associated with rDNA biology.

156 smic concentration and distribution of these nucleolar proteins in the wild-type embryos is consisten

157 factors RBM8A, SRSF9, and PSF as well as the nucleolar proteins NPM1 and PHF6, and recombinant GSK-3b

158 f nucleoli with C1 caused degradation of the nucleolar proteins nucleolin and nucleophosmin 1.

159 protease activation and the cleavage of many nucleolar proteins or autoantigens.

160 ntinuclear autoimmunity by broadly degrading nucleolar proteins or autoantigens.

161 t with their in vivo immiscibility, purified nucleolar proteins phase separate into droplets containi

162 In the absence of rDNA, the nucleolar proteins studied are able to form high-concent

163 oantigens were degraded by C1 proteases; >20 nucleolar proteins were identified as C1 cleavable.

164 After C1 treatment, cleaved nucleolar proteins were identified by proteomic two-dime

165 l counting analysis quantitated 135 specific nucleolar proteins whose levels were significantly alter

166 gation has identified NuMA among hundreds of nucleolar proteins.

167 olar biology involving the reorganization of nucleolar proteins.

168 that MLN4924 changes the composition of the nucleolar proteome but does not inhibit RNA Pol I transc

169 It also indicates that targeting the nucleolar proteome without affecting nucleolar transcrip

170 tion also triggers changes in composition of nucleolar proteome, as indicated by an overall reduction

171 th camptothecin which transiently stabilized nucleolar R-loops recruited RNase H1 to the nucleoli.

172 e intranuclear position of the gene, but the nucleolar recruitment of Pol III-transcribed genes requi

173 PP2A(Cdc55) prevents nucleolar release of the Cdk (Cyclin-dependent kinase)-a

174 itute the central scaffolding protein of the nucleolar remodeling complex (NoRC) that regulates the e

175 d RNA, which prevents the recruitment of the nucleolar remodeling complex to the ribosomal DNA promot

176 BEND3 associates with the nucleolar-remodeling complex (NoRC), and SUMOylated BEND

177 dition to drastic accumulation of sumoylated nucleolar RENT and inner kinetochore complexes.

178 r machineries such as RNA polymerases, small nucleolar ribonucleoparticles and phosphatidylinositol 3

179 lence, including SpoU methylase and U3 small nucleolar ribonucleoprotein IMP3.

180 d in transcriptional regulation and in small nucleolar ribonucleoprotein particle assembly and thus p

181 NAs and fibrillarin (FBL, an enzymatic small nucleolar ribonucleoprotein, snoRNP) are frequently over

182 In vitro, assembly of box C/D small nucleolar ribonucleoproteins (snoRNPs) involves the sequ

183 complexes, such as RNA polymerase II, small nucleolar ribonucleoproteins and mammalian target of rap

184 Box C/D small (nucleolar) ribonucleoproteins [s(no)RNPs] catalyze 2'-O-

185 The interaction of the IE62 SRT with nucleolar-ribosomal protein EAP resulted in the formatio

186 The SRT of IE62 interacted with the nucleolar-ribosomal protein EAP, which resulted in the f

187 pressed histone genes and U small nuclear or nucleolar RNA (sn/snoRNA) loci that form intra- and inte

188 In eukaryotes, the highly conserved U3 small nucleolar RNA (snoRNA) base-pairs to multiple sites in t

189 RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) genes.

190 transcription termination at noncoding small nucleolar RNA (snoRNA) genes.

191 actions of the pre-rRNA and causes U14 small nucleolar RNA (snoRNA) to remain associated with pre-rRN

192 DGCR8 controls the stability of mature small nucleolar RNA (snoRNA) transcripts independently of Dros

193 variants of the 333-nucleotide-long U3 small nucleolar RNA (snoRNA).

194 ression (which is influenced by miRNA, small nucleolar RNA and lncRNA), activation of K-Ras (mutation

195 rons can be degraded or processed into small nucleolar RNA and microRNA derived from intronic RNA.

196 mponents, but may significantly decrease the nucleolar RNA concentration.

197 H1DeltaTKO mESC demonstrated both a loss of nucleolar RNA content and altered nucleolar morphology r

198 5' external transcribed spacer and U3 small nucleolar RNA in providing an intertwined RNA-protein as

199 ultiple protein complexes, such as the small nucleolar RNA protein complex.

200 Here we report that the nucleolar RNA proteins Rpp29, fibrillarin, and RPL23a ar

201 However, this small nucleolar RNA was not a useful normalizer for cancer ste

202 32 sncRNAs (26 miRNAs, 5 piRNAs, and 1 small nucleolar RNA).

203 ich contains an orphan box H/ACA class small nucleolar RNA, ACA11, in an intron, is associated with s

204 cluding microRNA, long intergenic RNA, small nucleolar RNA, natural antisense transcript, small nucle

205 drial mt-Nd2, and Snora75, a noncoding small nucleolar RNA.

206 C/D box small nucleolar RNAs (SNORDs) are small noncoding RNAs, and th

207 sis on rRNA, which are guided by H/ACA small nucleolar RNAs (snoRNA).

208 in complexes, including ribosomal RNA, small nucleolar RNAs (snoRNAs) and 7SK RNA.

209 all mRNAs, and non-coding RNAs such as small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRN

210 Small nucleolar RNAs (snoRNAs) are a class of non-coding RNAs

211 RNAs, small nuclear RNAs (snRNAs), and small nucleolar RNAs (snoRNAs) are all enriched in virions.

212 nexpectedly, we found that a subset of small nucleolar RNAs (snoRNAs) are associated with the mammali

213 Small nucleolar RNAs (snoRNAs) are conserved noncoding RNAs be

214 Box C/D small nucleolar RNAs (snoRNAs) are evolutionarily conserved no

215 Small nucleolar RNAs (snoRNAs) are non-coding RNAs that form r

216 in human and mouse mRNA and identified small nucleolar RNAs (snoRNAs) as a new class of m6A-containin

217 For the case of small nucleolar RNAs (snoRNAs) encoded within introns of mRNA

218 Small nucleolar RNAs (snoRNAs) guide chemical modifications of

219 Small nucleolar RNAs (snoRNAs) guide nucleotide modifications

220 Profiling the expression patterns of small nucleolar RNAs (snoRNAs) in joint ageing and OA may prov

221 s of 16 tumors identified a cluster of small nucleolar RNAs (snoRNAs) that are highly up-regulated in

222 Surprisingly, several hundred small nucleolar RNAs (snoRNAs) were identified as coilin inter

223 However, whether small nucleolar RNAs (snoRNAs), a class of non-coding RNAs cru

224 es detection of NAD(+)-capped intronic small nucleolar RNAs (snoRNAs), suggesting NAD(+) caps can be

225 old, false discovery rate </= 5%) were small nucleolar RNAs (snoRNAs).

226 he elevated expression of a cluster of small nucleolar RNAs (snoRNAs).

227 be modulated by a subset of associated small nucleolar RNAs (snoRNAs).

228 regulatory ncRNAs such as small nuclear and nucleolar RNAs (snRNAs and snoRNAs).

229 In addition, nineteen small nucleolar RNAs also revealed differential expression in

230 omal stress, evidenced by depletion of small nucleolar RNAs and nuclear dispersal of ribosomal protei

231 res in the ribosome, box C/D and H/ACA small nucleolar RNAs and U4 small nuclear RNA.

232 and found that small nuclear RNAs and small nucleolar RNAs contributed the most abundant capped lead

233 hallmarked by increased expression of small nucleolar RNAs, long noncoding RNAs, microRNAs (miRNAs),

234 ely map RNase-protected regions within small nucleolar RNAs, spliceosomal RNAs, microRNAs, tRNAs, lon

235 is to identify the two main classes of small nucleolar RNAs, the box H/ACA snoRNAs and the box C/D sn

236 cripts including microRNAs, piRNAs and small nucleolar RNAs.

237 NAs, piwi-interacting RNA (piRNA), and small nucleolar RNAs.

238 lls-ribosomal RNAs, transfer RNAs, and small nucleolar RNAs.

239 noma transcript 1 (Malat1) and several small nucleolar RNAs.

240 lator of rDNA in bone unexpectedly reveals a nucleolar route for FGF signaling that allows for indepe

241 brosis of explanted hearts and gene-specific nucleolar segregation defects in cardiomyocytes, indicat

242 Rather, nucleolar sequestration of RELA was observed.

243 iated degradation of SmgGDS, indicating that nucleolar sequestration of SmgGDS by UBF stabilizes SmgG

244 tment of Pol II repressor RENT (regulator of nucleolar silencing and telophase exit) complex at the r

245 oduction increases with age, indicating that nucleolar size and activity can serve as aging biomarker

246 Knockdown of fibrillarin also reduces nucleolar size and extends lifespan.

247 We further show that nucleolar size correlates with donor age in primary fibr

248 We find that nucleolar size directly scales with cell size in early C

249 umour suppressor extends lifespan and limits nucleolar size in the major C. elegans longevity pathway

250 size is altered, we observe inverse scaling: nucleolar size increases in small cells and decreases in

251 Among wildtype C. elegans, individual nucleolar size varies, but is highly predictive for long

252 size was associated with decreased neuronal nucleolar size.

253 We show that nucleolar SmgGDS interacts with the RNA polymerase I tra

254 yadenylation, whereas transcription of small nucleolar (sno)/small nuclear (sn)RNA genes is terminate

255 Eukaryotic box C/D small nucleolar (sno)RNPs catalyse the site-specific 2-O-methy

256 ifications that are mostly mediated by small nucleolar (sno)RNPs during ribosome production.

257 on of both RPS6 and AtHD2B to one or several nucleolar spots.

258 number and contributes to the maintenance of nucleolar stability.

259 Trm112 binds precursor ribosomes at an early nucleolar stage, m(7)G methylation occurs at a late step

260 easure changes in RNA flexibility during the nucleolar stages of 60S assembly in yeast.

261 with a role of the NF45/NF90 heterodimer in nucleolar steps of 60S subunit biogenesis, downregulatio

262 Staurosporine-induced nucleolar stress and apoptosis disrupt nucleolar PPAN lo

263 tructure-activity relationships in assays of nucleolar stress and cell viability demonstrate key phar

264 As a consequence, circANRIL induces nucleolar stress and p53 activation, resulting in the in

265 Failure of this process results in nucleolar stress and p53-mediated apoptosis.

266 Treatment of H1299 cells with nucleolar stress inducers, such as actinomycin D, 5-fluo

267 Here, we demonstrate that nucleolar stress induces proteasome-mediated degradation

268 Physiologically relevant nucleolar stress induction with reactive oxygen species

269 The p53-mediated nucleolar stress response associated with inhibition of

270 So far, the role of PPAN in nucleolar stress response has remained elusive.

271 AS40 negatively regulates the RPL11-HDM2-p53 nucleolar stress response pathway and suppresses inducti

272 biogenesis, and activate the Rpl11-Mdm2-p53 nucleolar stress response pathway.

273 MA in rDNA transcription and p53-independent nucleolar stress response supports a central role for th

274 ribosome biogenesis, tumor suppression, and nucleolar stress response.

275 ugh which ribosomal proteins (RPs) transduce nucleolar stress signals via MDM2 to p53 has been descri

276 some-mediated degradation machinery to sense nucleolar stress within the nucleolus.

277 Downregulation of NuMA expression triggers nucleolar stress, as shown by decreased nascent pre-rRNA

278 or SmgGDS in protecting malignant cells from nucleolar stress, thus promoting cell cycle progression

279 g nucleoplasmic localization did not undergo nucleolar stress-induced degradation, although the same

280 In summary, we provide evidence for a novel nucleolar stress-response pathway involving PPAN, NPM, a

281 1/RPL5-Mdm2 pathway, with characteristics of nucleolar stress.

282 ribosomal biogenesis can initiate so-called nucleolar stress.

283 adruplex, and patient cells show evidence of nucleolar stress.

284 ls disrupts nucleolar morphology, signifying nucleolar stress.

285 MA upon actinomycin D or doxorubicin-induced nucleolar stress.

286 action network in the nucleolus required for nucleolar structure and integrity.

287 rphology of the nucleoli exposed an abnormal nucleolar structure in Pf1-deficient cells.

288 s the link between Myc-induced regulation of nucleolar target genes, which are rate limiting for cell

289 that FGFR2 mutations in BBDS, which amplify nucleolar targeting of FGFR2, activate ribosomal DNA (rD

290 ll-to-cell movement, importin-alpha-mediated nucleolar targeting of TGB1 is an essential step in esta

291 ed for importin-alpha interaction in plants, nucleolar targeting, and long-distance movement.

292 e stained with a tyrosine hydroxylase-silver nucleolar (TH-AgNOR) stain.

293 with potentiated Stat5 signaling and altered nucleolar topology.

294 uence insertion in HEV bestows novel nuclear/nucleolar trafficking capabilities to the ORF1 protein o

295 Ect2 activates rRNA synthesis by binding the nucleolar transcription factor upstream binding factor 1

296 ing the nucleolar proteome without affecting nucleolar transcription initiates the required signallin

297 amoxifen, and fulvestrant induce nuclear and nucleolar translocation of HE4 and that HE4 overexpressi

298 Indeed, the nucleolar volume almost entirely accounts for the extra

299 n model of PD on the number, morphology, and nucleolar volume of dopaminergic cells in the substantia

300 The lesion also resulted in a decrease in nucleolar volume that was similar in all three regions (