ライフサイエンスコーパス: nucleolus

1 iors indicative of active recruitment to the nucleolus.

2 ation signal (NoLS), only p8 is found in the nucleolus.

3 E-2 fragments of pre-rRNA transcript in the nucleolus.

4 Dxz4 and Ds-TR appear to be anchored to the nucleolus.

5 accompanied by their translocation into the nucleolus.

6 extension, or "flare," that encompasses the nucleolus.

7 s critical for formation and function of the nucleolus.

8 rochromatin at the external periphery of the nucleolus.

9 8S rRNAs and assembled into ribosomes in the nucleolus.

10 ne, regulates bone formation from within the nucleolus.

11 gulating protein and DNA interactions at the nucleolus.

12 egulating pluripotency in the oft-overlooked nucleolus.

13 RPS6 and AtHD2B were localized to the nucleolus.

14 nd1 chromosomal segments localized next to a nucleolus.

15 chinery to sense nucleolar stress within the nucleolus.

16 mine methylation of H2A is restricted to the nucleolus.

17 on is confined to the region adjacent to the nucleolus.

18 opulation showing intense E2 staining of the nucleolus.

19 ylation of rDNA and NOR association with the nucleolus.

20 are tandemly repeated and give origin to the nucleolus.

21 argeted to the ribosome assembly site in the nucleolus.

22 hering of HP1gamma-enriched chromatin to the nucleolus.

23 nd most steps in SRP biogenesis occur in the nucleolus.

24 vely, fluorescent spots were observed in the nucleolus.

25 5 associates with tRNA gene complexes in the nucleolus.

26 al (NoLS) and induces disorganization of the nucleolus.

27 e-pole body to the immediate vicinity of the nucleolus.

28 hat a split rDNA locus indeed forms a single nucleolus.

29 f the H1.0-binding proteins are found in the nucleolus.

30 RPs) from the cytoplasm into the nucleus and nucleolus.

31 regulates the structure and function of the nucleolus.

32 uclear clustering of the tRNA genes near the nucleolus.

33 with CtBP and localize predominantly to the nucleolus.

34 ately in line with the Shapley value and the nucleolus.

35 , CAL1 localizes to both centromeres and the nucleolus.

36 s with but is nevertheless distinct from the nucleolus.

37 components and tTAFs within the spermatocyte nucleolus.

38 being regulated by activities present in the nucleolus.

39 s system appears critically dependent on the nucleolus.

40 calization in the granular components of the nucleolus.

41 which causes full release of Cdc14 from the nucleolus.

42 from the cytokeratin filament network to the nucleolus.

43 mplex with the PIDDosome and NPM1 within the nucleolus.

44 he nucleus, whereas OGT is excluded from the nucleolus.

45 transcription and processing of rRNA in the nucleolus.

46 uires robust manufacture of ribosomes in the nucleolus.

47 t, closely apposed to or embedded within the nucleolus.

48 ncing of ribosomal DNA (rDNA) repeats in the nucleolus.

49 he discovery of nonribosomal proteins in the nucleolus.

50 established activities occurring within the nucleolus.

51 entry induces a brief Cdc14 release from the nucleolus.

52 ed calpain, we localized this protein to the nucleolus.

53 n of core, leading to an accumulation in the nucleolus.

54 Rad52 is normally excluded from the nucleolus.

55 rect a GFP fusion protein to the nucleus and nucleolus.

56 the nucleus, they were also found within the nucleolus.

57 ucleus of yeast cells but is enriched in the nucleolus.

58 ughter nuclei (containing the NORs), and the nucleolus.

59 th the increased optical density in the lens nucleolus.

60 haracterized by structural disruption of the nucleolus.

61 art of a convergent mechanism focused on the nucleolus.

62 of unknown function that can localize to the nucleolus.

63 nslocates with other splicing factors to the nucleolus.

64 tion, morphology and self-interaction of the nucleolus.

65 a centromere prevented its association with nucleolus.

66 lves phase separation of proteins within the nucleolus.

67 ation resulting from NE expansion around the nucleolus.

68 ng a structure reminiscent of the eukaryotic nucleolus.

69 buting the protein within the nucleus to the nucleolus.

70 ghts into the structural organization of the nucleolus.

71 and Loc1 are localized predominantly in the nucleolus.

72 cence complementation in the nucleoplasm and nucleolus.

73 , a number of whose products localize to the nucleolus.

74 specific nuclear compartment adjacent to the nucleolus.

75 , which recruit Pc and form Pc bodies in the nucleolus.

76 nd is preferentially located adjacent to the nucleolus.

77 ribution of XRN2 between the nucleoplasm and nucleolus.

78 The nucleolus, a dynamic nuclear compartment long regarded a

79 Although most snoRNAs reside in the nucleolus, a growing body of evidence indicates that sno

80 es the ribosomal DNA (rDNA) that defines the nucleolus, a major hallmark of nuclear organization.

81 , we investigate the initial assembly of the nucleolus, a membrane-less organelle involved in differe

82 Here, we show that the size of the nucleolus, a membraneless organelle important for cell-s

83 identically to rAAV2 and accumulated in the nucleolus, a step recently described by our laboratory t

84 A transient enlargement of the nucleolus accompanied cell division in the Second Mitoti

85 d is essential for PIDDosome assembly in the nucleolus after DNA damage.

86 Conversely, the nucleolus also acts as a first-responder to growth-relat

87 tic marks as well as heterochromatin and the nucleolus also appeared around the 8-cell stage.

88 at 25 Kb resolution, revealing a structured nucleolus, an absence of chromosome territories, and con

89 gest and most well-known nuclear body is the nucleolus, an organelle whose primary function in riboso

90 , we now show that AROS localizes to (i) the nucleolus and (ii) cytoplasmic ribosomes.

91 ely held beliefs about the importance of the nucleolus and AAP in AAV assembly and show the heterogen

92 tion, Cdc14 is transiently released from the nucleolus and activated.

93 i are uniquely clustered together within the nucleolus and all major rRNA gene variants, including th

94 how these "infraribosomal" links between the nucleolus and cell cycle progression operate in both for

95 ne the relationship of this structure to the nucleolus and cell division apparatus.

96 e propose that a functional link between the nucleolus and centromere assembly exists in Drosophila,

97 through ordered events that initiate in the nucleolus and culminate in the cytoplasm.

98 0/LIN-9 by inducing its translocation to the nucleolus and decreasing the expression of the Mip130/LI

99 TbMTase37 localizes to the nucleolus and depletion of the protein results in accumu

100 tween RRP1B and E2F1 can be found inside the nucleolus and diffuse nucleoplasmic punctates.

101 ll-length RGH3alpha isoform localizes to the nucleolus and displays a speckled pattern within the nuc

102 NA (TLC1 RNA) is spatially segregated to the nucleolus and excluded from sites of DNA repair in a cel

103 CHP1 attenuates the abundance of UBF in the nucleolus and inhibits RNA synthesis when quiescent cell

104 AV2) showed that assembly takes place in the nucleolus and is dependent on AAP and that capsids coloc

105 C-rich rDNA-like substrates that form in the nucleolus and normally inhibit progression of the RNA po

106 The frequency of association with nucleolus and nuclear periphery depends on linear genomi

107 nt kinetics in the two compartments studied (nucleolus and nucleoplasm), suggesting a direct transcri

108 erexpressed GFP-NS1 localized throughout the nucleolus and nucleoplasm, and to several transcriptiona

109 ressed from a plasmid can be detected in the nucleolus and nucleoplasm, but it largely fails to assem

110 ion of histone H3 and NSP in the nucleus and nucleolus and of histone H3 and MP in the cell periphery

111 The nucleolus and other nuclear bodies behave like liquid-ph

112 The nucleolus and other ribonucleoprotein (RNP) bodies are m

113 f FLCN, dFLCN (a.k.a. dBHD) localizes to the nucleolus and physically interacts with the 19S proteaso

114 n yeast (eco1-W216G) exhibits a disorganized nucleolus and reduced looping at the rDNA.

115 We confirm that NuMA is present in the nucleolus and reveal redistribution of NuMA upon actinom

116 essed and exogenous coilin accumulate in the nucleolus and suppress rRNA synthesis.

117 a protein that localizes to the nucleus and nucleolus and that interacts with the human enhancer of

118 we focus on how two nuclear organelles, the nucleolus and the Cajal body, respond to stress.

119 The relationship between the nucleolus and the centromere, although documented, remai

120 ently tagged CITFA-7 was concentrated in the nucleolus and the ESB.

121 bosomal DNA promoters and is abundant in the nucleolus and the expression site body subnuclear compar

122 rganizer regions responsible for forming the nucleolus and the genes for the 28S, 18S, and 5.8S/2S RN

123 The protein shuttles between the nucleolus and the nucleus in a GTP-dependent fashion.

124 two distinct phenotypes, those with a single nucleolus and those with multiple nucleoli; (2) the perc

125 position the inactive X chromosome near the nucleolus and to preserve one of its main epigenetic fea

126 ts that the genes congregate together at the nucleolus and/or centromeres.

127 ity of c-Myc to induce rRNA synthesis in the nucleolus, and constitutive NPM overexpression stimulate

128 Plk5 protein localizes predominantly to the nucleolus, and deletion of a putative nucleolus localiza

129 rtial redistribution of Pkp-1 protein to the nucleolus, and depletion of Pkp-1 resulted in increased

130 zes TIF-IA, induces its translocation to the nucleolus, and enhances its interaction with Pol I.

131 hology, most dramatically in the nucleus and nucleolus, and in the number, size, and location of lipi

132 radation, immobilizes the protein within the nucleolus, and results in detergent-insoluble NS.

133 teins that function in RNA metabolism in the nucleolus, and suggest that a new paradigm for linker hi

134 nstrated that Gag and L9 interact within the nucleolus, and the CA domain was the major site of inter

135 ster of meiotic centromeres localizes to the nucleolus, and this association requires centromere func

136 ase complex components localize to the yeast nucleolus, and this localization is essential for mRNA m

137 somal DNA repeats localizing within a single nucleolus, and transfer RNA (tRNA) genes present in an a

138 After migrating to the nucleolus, ANG cleaves promoter-associated RNA, which pr

139 genesis and morphological alterations in the nucleolus are presently coming into focus.

140 a striking conformation that implicates the nucleolus as a formidable barrier to interaction between

141 Thus we have identified the nucleolus as a novel site for caspase-2 activation and f

142 The study identifies the nucleolus as a target of inhibitors of NEDDylation and p

143 v's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal

144 We have found H1.0 to be enriched at nucleolus-associated DNA repeats and chromatin domains,

145 ) long, nucleoplasmic filaments; (ii) short, nucleolus-associated filaments; and (iii) dense, nucleop

146 ction of NPM1 in the spatial organization of nucleolus-associated heterochromatin.

147 ription results in Rad52 localization to the nucleolus, association with rDNA and subsequent formatio

148 cerevisiae, Cdc14 is sequestered within the nucleolus before anaphase entry through its association

149 y cotranscriptionally and passes through the nucleolus before its nuclear export.

150 h, binding concentrated in the nuclei to the nucleolus but not the chromatins.

151 ry for the export of rDNA breaks outside the nucleolus but required for timely repair of meiotic DSBs

152 Rex-2 localized predominantly to the nucleus/nucleolus, but in contrast to the detection of phosphory

153 mutation not only delocalizes NPM1 from the nucleolus, but it also disorganizes promyelocytic leukem

154 hout interphase, Cdc14 is sequestered in the nucleolus, but successful anaphase activates the mitotic

155 ing maturation of the 90S preribosome in the nucleolus, but that translocation of L13a into the nucle

156 nto ribosomes and is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality contr

157 Specifically, in the nucleolus, c-Myc has been shown to be recruited to ribos

158 tase Cdc14 was released prematurely from the nucleolus concomitant with hyperphosphorylation of its n

159 In addition, the nucleolus contributes to neuronal stress responses, incl

160 ises the fundamental question of whether the nucleolus controls p53 directly, i.e., as a site where p

161 In the nucleolus, DDX21 occupies the transcribed rDNA locus, di

162 ized in the dense fibrillar component of the nucleolus dependently on active RNA polymerase I transcr

163 and -11, and AAP, assembled capsids, and the nucleolus do not colocalize for all the serotypes.

164 it network (MEN) component, Cdc14p, from the nucleolus during anaphase is delayed in mdm10Delta cells

165 rk (MEN) releases Cdc14 phosphatase from the nucleolus during anaphase, leading to the inactivation o

166 Cdc55 maintains Cdc14 sequestration in the nucleolus during early meiosis, and this is essential fo

167 dc14B, a mammalian orthologue, also exit the nucleolus during interphase upon DNA replication stress

168 sociated domains [NADs]) and proteins to the nucleolus during interphase.

169 3 preferentially localize to the nucleus and nucleolus during interphase.

170 and that capsids colocalize with AAP in the nucleolus during the assembly process.

171 P1 is tightly regulated and expressed in the nucleolus during the G1/S phases.

172 h, and its product is nuclear localized with nucleolus enrichment.

173 nucleophosmin (NPM), redistributes from the nucleolus following hyperthermia, increases its associat

174 sporting the viral capsid VP3 protein to the nucleolus for assembly.

175 It is sequestered in the nucleolus for most of the cell cycle by the nucleolar pr

176 ow a desumoylation enzyme is targeted to the nucleolus for removing SUMO from specific substrates and

177 hromatin to release bulk rRNA genes into the nucleolus for ribosome production, which fuels single nu

178 We demonstrate that the nucleolus formation is precisely timed in D. melanogaste

179 sistent with the role of rRNA in seeding the nucleolus formation.

180 Although, the nucleolus has been observed for almost 200 years in neur

181 The nucleolus has emerged as a platform for the organization

182 The life of the nucleolus has proven to be more colorful and multifacete

183 ctor (NKRF) as a nucleolar HSP essential for nucleolus homeostasis and cell survival under proteotoxi

184 h HSV-2 ICP34.5 proteins are detected in the nucleolus, ICP34.5alpha is predominantly located in cyto

185 urrent notions about the role of AAP and the nucleolus in capsid assembly.

186 tivity promotes TLC1 RNA localization in the nucleolus in G2/M.

187 hology and increases the surface size of the nucleolus in human and germline cells of Caenorhabditis

188 t contains the IWRXY motif, localizes to the nucleolus in human cells and interacts with both mammali

189 (b) specific delivery of an antibody to the nucleolus in monolayer cancer cells and in an in vitro 3

190 (K0) localizes in both the cytoplasm and the nucleolus in neuronal SH-SY5Y cells.

191 dent p53 activation, implying a role for the nucleolus in p53 activation by ribosomal biogenesis stre

192 d noncoding RNAs immobilizes proteins in the nucleolus in response to a specific stimulus.

193 al repeat transcripts that accumulate at the nucleolus in RNAi-deficient cells and in initiating the

194 that deltaAg localizes predominantly to the nucleolus in the absence of HDV genome replication while

195 V5, -8, and -9 capsids are excluded from the nucleolus, in contrast to the nucleolar enrichment of as

196 ing for chromatin components that target the nucleolus, including CTCF and HP1beta.

197 s that multiple rDNA loci will form a single nucleolus independent of their location within the genom

198 or "factories," analogous to the eukaryotic nucleolus, indicating that transcription and RNA polymer

199 iculum, mitochondria, granules, nucleus, and nucleolus inside a yeast spore cell.

200 Both RECQL5 and WRN re-localize from the nucleolus into the nucleus after replicative stress and

201 Both RECQL5 and WRN re-localize from the nucleolus into the nucleus after replicative stress and

202 The synthesis of ribosomal subunits in the nucleolus is a conserved, essential process that results

203 The nucleolus is a membrane-less organelle formed through li

204 The nucleolus is a plurifunctional organelle in which struct

205 Accumulation of ARF in the nucleolus is associated with poor outcome and attenuated

206 own as the center of ribosome synthesis, the nucleolus is connected to cell cycle regulation in more

207 Ribosomal subunit assembly in the nucleolus is dependent on efficient targeting of ribosom

208 GDS to interact with UBF and localize in the nucleolus is diminished by expressing DiRas1 or DiRas2,

209 Subsequently, the cytoplasmic nucleolus is disassembled and rebuilt at a new site arou

210 Consequently, the nucleolus is displaced.

211 cellular center of ribosome biogenesis, the nucleolus is essential for the growth of developing neur

212 The nucleolus is formed around repeats of a transcriptional

213 The remodeling of chromatin in the nucleolus is important for the control of ribosomal DNA

214 Since the nucleolus is known to play a key role in cell growth, th

215 The p8 location in the nucleolus is linked to a bipartite NoLS.

216 lus, but that translocation of L13a into the nucleolus is not sufficient for its incorporation into r

217 Our model demonstrates the nucleolus is phase separated from other chromatin in the

218 How the nucleolus is segregated during mitosis is poorly underst

219 The nucleolus is the cellular organelle in which the formati

220 The nucleolus is the subnuclear organelle responsible for rR

221 to the nucleolus, and deletion of a putative nucleolus localization signal (NoLS) within its N-termin

222 shoot apical meristems and FEN1-GFP shows a nucleolus-localized signal in tobacco cells.

223 Although disruption of the nucleolus may trigger the p53-dependent neuronal death,

224 nuclear envelope, nuclear pore complexes and nucleolus must also be segregated.

225 and ribosomal RNA remodelling events in the nucleolus, nucleoplasm and cytoplasm.

226 bosome biogenesis occurs successively in the nucleolus, nucleoplasm, and cytoplasm.

227 Under stress conditions, NKRF directs XRN2 nucleolus/nucleoplasm trafficking, controlling 5'-to-3'

228 SIM physical separation of the NOR from the nucleolus occurs, and NE modifications promote expulsion

229 the 3' end of scR1, which accumulates in the nucleolus of cells lacking the activities of these compl

230 anner, and translocated into the nucleus and nucleolus of infected cells.

231 for megagametogenesis and is enriched in the nucleolus of meiotic and mitotic cells.

232 In addition, SMN can also be detected in the nucleolus of neurons.

233 yelocytic leukemia protein bodies and to the nucleolus of the cell, the site of RNA polymerase I-medi

234 ll silenced rRNA gene subtypes mapped to the nucleolus organizer region (NOR) on chromosome 2 (NOR2).

235 Mutations or alterations that affect the nucleolus organizer region have pleiotropic effects on g

236 Nucleolus organizer regions (NORs) are chromosomal loci

237 housands of 45S rRNA gene copies localize in Nucleolus Organizer Regions (NORs), and the activation o

238 arrays in Drosophila contain the cis-acting nucleolus organizer regions responsible for forming the

239 raises new possibilities for the nucleoplasm-nucleolus pathways of these proteins and their functiona

240 to the nuclear envelope associated with the nucleolus, possibly to avoid disruption of intranuclear

241 a small NE expansion occurs adjacent to the nucleolus prior to anaphase in a Cdc5-dependent manner.

242 The accumulation of MtgA around the nucleolus promotes a similar accumulation of the endopla

243 cleoplasm in interphase nuclei, whereas, the nucleolus region exhibited a more prominent immuno-posit

244 thin the ribosome synthetic machinery of the nucleolus remain largely unexploited.

245 ing, to show that subcompartments within the nucleolus represent distinct, coexisting liquid phases.

246 localizes and stabilizes p19(Arf) within the nucleolus, require p19(Arf) N-terminal amino acids that

247 e protein-protein interaction network in the nucleolus required for nucleolar structure and integrity

248 ere initially localized in the cytoplasm and nucleolus, respectively, at 18 h postinfection.

249 it is unable to localize in the nucleus and nucleolus, respectively.

250 ropose that nuclear sub-domains, such as the nucleolus, result from phase separations within the nucl

251 S6(Rpt1)] to the nucleoplasm (but not to the nucleolus) resulted in complete reversal of inhibition o

252 and the formation of a single, peri-nuclear nucleolus results in the clustering of rDNA.

253 Here, we demonstrate that PHF6 is a nucleolus, ribosomal RNA promoter-associated protein.

254 As the major function of the nucleolus, ribosome biogenesis demands a considerable am

255 In the nucleolus, RNA polymerase-1 (Pol1)-mediated transcriptio

256 The nucleolus senses stress and is a central hub for coordin

257 The nucleolus serves as a principal site of ribosome biogene

258 y repetitive DNA, such as those found in the nucleolus, show a self-organization that is marked by sp

259 y of the Drosophila Y chromosome that affect nucleolus size and morphology, but do not limit steady-s

260 Nucleolus size is an indicator of ribosome biogenesis an

261 This reduction in nucleolus size required Dpp and Hh signaling.

262 In this study, nucleolus size was monitored during cell fate specificat

263 Further experiments revealed that this nucleolus stress-induced cell cycle arrest involves the

264 NPM1 was mainly expressed in nucleus and nucleolus subcellular compartments.

265 e isolated NC domain of Gag localized to the nucleolus, suggesting that it contains a nucleolar local

266 erein, we describe CX-3543, a small molecule nucleolus-targeting agent that selectively disrupts nucl

267 CHD7 is also constitutively localized to the nucleolus, the site of rRNA transcription.

268 nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and in

269 However, unlike the nucleolus, these assemblies are highly variable in numbe

270 cells and specifically appears to target the nucleolus through a nucleolar localization signal (NoLS)

271 stic nucleation step in the formation of the nucleolus, through a seeding mechanism.

272 y tethering ribosomal protein L11 within the nucleolus to repress the binding of L11 to the E3 ligase

273 he creation of this structure and allows the nucleolus to retain its tripartite organization and tran

274 d by a complex pathway that extends from the nucleolus to the cytoplasm and is powered by many energy

275 ors that propel ribosome maturation from the nucleolus to the cytoplasm.

276 nd NE modifications promote expulsion of the nucleolus to the cytoplasm.

277 re-60S ribosomes, accompanying them from the nucleolus to the nuclear periphery, and provide evidence

278 cts as a thermosensor translocating from the nucleolus to the nucleoplasm during heat stress; nucleol

279 nslocation of de-phosphorylated NPM from the nucleolus to the nucleoplasm.

280 orms, causing their re-localization from the nucleolus to the nucleoplasm.

281 ion induced a translocation of AATF from the nucleolus to the nucleus, thereby enabling its physical

282 that in SBV-infected cells, B23 undergoes a nucleolus-to-nucleoplasm redistribution, evocative of vi

283 in vitro, and regulates Maf1 nucleoplasm-to-nucleolus translocation.

284 dicating that TORC1 regulates nucleoplasm-to-nucleolus transport of Maf1.

285 structural and functional adaptation of the nucleolus, triggered by heat shock or physiological acid

286 In G1, this parental cytoplasmic nucleolus undergoes sequential disassembly releasing nuc

287 t, all of which are under the control of the nucleolus upon stress.

288 tein content and structural integrity of the nucleolus using the H1 triple isoform knockout (H1DeltaT

289 t nucleophosmin (NPM1) integrates within the nucleolus via a multi-modal mechanism involving multival

290 Localization within the nucleolus was regulated by the N terminus of the protein

291 nucleolin, a major protein component of the nucleolus, was identified among these proteins by mass s

292 e H1 and protein-protein interactions in the nucleolus, we used biochemical and proteomics approaches

293 nucleus, which included 1) mRNAs within the nucleolus when nucleocytoplasmic transport, rRNA biogene

294 iation of Pol III-transcribed genes with the nucleolus, when permitted by global chromosome architect

295 s reflecting a structure like the eukaryotic nucleolus where many different ribosomal RNA operons are

296 uction of Dicer altered the structure of the nucleolus, where pre-rRNA processing occurs.

297 ves excessive ribosome biogenesis within the nucleolus, which elicits unbridled cell growth and proli

298 dence for translation in the nucleoplasm and nucleolus, which is regulated by infectious and chemical

299 associated with the asymmetrically localized nucleolus, which suggests that the site of membrane expa

300 nuclear extension always coincided with the nucleolus, while the morphology of the DNA mass remained