ライフサイエンスコーパス: nucleophosmin

1 sting that avrainvillamide targets cys275 of nucleophosmin.

2 chaperone phosphoproteins, nucleoplasmin and nucleophosmin.

3 bility of genes, such as GAP43, p27(Kip) and nucleophosmin.

4 by somatic mutations in NPM1, which encodes nucleophosmin.

5 of phenotypes observed in the absence of B23/nucleophosmin.

6 a subnucleolar compartment that contains B23/nucleophosmin.

7 Nucleophosmin 1 (NPM1) acts in ribosome biogenesis, cent

8 Conversely, when we focused on nucleophosmin 1 (NPM1) associated networks, NPM1 establi

9 Mutations in the nucleophosmin 1 (NPM1) gene are considered a founder eve

10 ding to aberrant cytoplasmic localization of Nucleophosmin 1 (NPM1) have been recently identified as

11 Nucleophosmin 1 (NPM1) is a nucleolar protein involved i

12 Nucleophosmin 1 (NPM1) is an oligomeric, nucleolar phosp

13 bset analyses revealed that AML with mutated Nucleophosmin 1 (NPM1) may particularly benefit from VPA

14 of mutant level, size, and interaction with nucleophosmin 1 (NPM1) mutations remains controversial.

15 scribe how peptides derived from the mutated nucleophosmin 1 gene (NPM1(mut)) can elicit in vitro CD4

16 NPM1 (nucleophosmin 1) is a nucleolar phosphoprotein that regu

17 eosomal CENP-A is complexed with histone H4, nucleophosmin 1, and HJURP.

18 tion of the nucleolar proteins nucleolin and nucleophosmin 1.

19 in were increased, nm23/H1, peroxiredoxin 2, nucleophosmin 1/B23, and inorganic pyrophosphatase were

20 Nucleophosmin-1 (NPM1) is the most frequently mutated ge

21 nditions, hematopoietic precursors harboring nucleophosmin-1 (NPM1) mutation generated myeloid cells

22 and El Hajj et al independently report that nucleophosmin-1 (NPM1)-mutant leukemia is particularly v

23 cilitates chromatin transcription (FACT) and nucleophosmin-1 (previously implicated in transcriptiona

24 The presence of a mutated nucleophosmin-1 gene (NPM1(mut)) in acute myeloid leukem

25 terogeneous nuclear ribonucleoprotein F, and nucleophosmin-1) as major proteins exposed after injury.

26 ation factor 2, protein disulfide isomerase, nucleophosmin-1, chaperonin, actin, protein tyrosine pho

27 involved in subnuclear architecture, notably nucleophosmin, a 38-kDa nucleolar phosphoprotein that is

28 induced a decrease in the phosphorylation of nucleophosmin, a major nuclear phosphoprotein, and that

29 SBDS forms a protein complex with nucleophosmin, a multifunctional protein implicated in r

30 (ALK) under the control of the promoter for nucleophosmin, a nucleolar phosphoprotein.

31 eosarcoma cells, nucleostemin interacts with nucleophosmin, a nucleolar protein believed to possess o

32 tive effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is over

33 e the anaplastic lymphoma kinase (ALK), with nucleophosmin-ALK (NPM-ALK) fusions being the most commo

34 astic lymphoma kinase (ALK) fusion proteins (nucleophosmin-ALK [NPM-ALK] and other variants) are expr

35 utes a part of the oncogenic fusion proteins nucleophosmin-ALK and echinoderm microtubule-associated

36 The nucleophosmin-ALK fusion induces constitutive, ligand-in

37 Previously, nucleophosmin-ALK has been shown to activate phosphatidy

38 However, nucleolar accumulation of nucleophosmin-ALK may not be necessary for its oncogenic

39 irst discovered as the constitutively active nucleophosmin-ALK oncoprotein in anaplastic large cell l

40 resulting in aberrant expression of chimeric nucleophosmin-ALK.

41 suggest that the mTOR pathway contributes to nucleophosmin-ALK/PI3K/AKT-mediated tumorigenesis and th

42 tion t(2;5) and the resulting fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) are d

43 of the constitutively active tyrosine kinase nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expre

44 Constitutive overexpression of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is a

45 Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is an

46 s in the production of the nucleolar protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) prote

47 nduces the formation of the chimeric protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), whic

48 23;q35), resulting in aberrant expression of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK).

49 ults in the generation of the fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK).

50 the t(2;5)(p23;q35) and aberrantly expresses nucleophosmin-anaplastic lymphoma kinase (NPM-ALK).

51 generating an oncogenic fusion protein: the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK).

52 ults in the generation of the fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK).

53 The nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)/phosp

54 5) that produces the fusion protein NPM-ALK (nucleophosmin-anaplastic lymphoma kinase).

55 ormation mediated by the oncogenic, chimeric nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) tyros

56 NPM1c, result in cytoplasmic dislocation of nucleophosmin and are associated with distinctive transc

57 t CTCF copurifies with the nucleolar protein nucleophosmin and both are present at insulator sites in

58 cell-based experiments by knocking down p53, nucleophosmin and DNA methyltransferase 1.

59 o known CRM1 substrates: mutated cytoplasmic nucleophosmin and HIV-1 Rev.

60 EXIM1 interacts with two key p53 regulators, nucleophosmin and human double minute-2 protein (HDM2),

61 ic ligands binding to cell surface nucleolin/nucleophosmin and known as HB 19 for the lead compound a

62 hen evaluated whether nucleolar proteins B23/nucleophosmin and nucleolin, previously shown to interac

63 ch stabilizes its target transcripts such as nucleophosmin and p53 mRNAs.

64 emonstrate that GRK5 phosphorylates Ser-4 in nucleophosmin and regulates the sensitivity of cells to

65 ian cells; within nucleoli it interacts with nucleophosmin and rRNA through N-terminal Lys residues,

66 ocalizes with nucleolar markers such as B23 (nucleophosmin) and fibrillarin.

67 athway involving AKT, ROCK and CDK2/Cyclin E-nucleophosmin) and in mouse tissues, and increased in vi

68 action of ARF with the nucleolar protein B23(nucleophosmin) and promotes a transient p53-independent

69 ive and stain positively with nucleolar (B23/nucleophosmin) and stem/progenitor cell markers (SPRR1A

70 de NFkappaB, interferon regulatory factor-1, nucleophosmin, and the X-box binding protein-1.

71 nes, including those for REST/NRSF, Groucho, nucleophosmin, and Ubc4/5E2.

72 In addition, B23/nucleophosmin, another nucleolar protein, did not intera

73 of protamine-DNA complexes: NAP-1, NLP, and nucleophosmin are previously characterized histone chape

74 Mutations affecting NPM1 (nucleophosmin) are the most common genetic lesions found

75 stem which identified nucleolar protein B23 (nucleophosmin) as being associated with C23.

76 such as heat shock proteins, prohibitin, or nucleophosmin, as well as to the up-regulation of NF-kap

77 Nucleophosmin B23 is a nucleolar and centrosome-associat

78 two-dimensional gels showed that the form of nucleophosmin B23 that is up-regulated in melanoma repre

79 r, hepatoma-derived growth factor (HDGF) and nucleophosmin B23 were strongly correlated with melanoma

80 Nucleophosmin (B23) is a nucleolar phosphoprotein that h

81 he translocation of p53-stabilizing protein, nucleophosmin (B23), to the PNR.

82 It has been recently shown that the nucleophosmin/B23 (NPM) gene (5q35) and a novel anaplast

83 Nucleophosmin/B23 (NPM) is a pleiotropic nucleolar prote

84 nucleolar and ribosomal proteins, including nucleophosmin/B23 (NPM), a protein thought to foster the

85 tants that do not efficiently associate with nucleophosmin/B23 are unstable and functionally impaired

86 Nucleophosmin/B23 is a major multifunctional nucleolar p

87 Nucleophosmin/B23 is a multifunctional phosphoprotein th

88 The association of autoantibodies to nucleophosmin/B23 with pulmonary hypertension in sclerod

89 NPM (nucleophosmin/B23) is a major nucleolar protein which is

90 nd the hepatocellular carcinoma autoantigen, nucleophosmin/B23, as a model system to define the uniqu

91 In contrast, the nucleolar protein nucleophosmin/B23, which binds to p19Arf with high stoic

92 is identified altered expression of NEK2 and nucleophosmin/B23.

93 Moreover, we found that B23/nucleophosmin binds SENP3 and SENP5 in Xenopus laevis eg

94 ffinity-isolation of a protein identified as nucleophosmin by MS sequencing and Western-blotting.

95 f the three cysteine residues of a truncated nucleophosmin coexpressed with native nucleophosmin in C

96 Specific knockdown of nucleophosmin expression using RNAi attenuated apoptosis

97 are basic functions with, the nucleoplasmin/ nucleophosmin family of molecular chaperone proteins.

98 MO deconjugation may be a major facet of B23/nucleophosmin function in vivo.

99 e tyrosine kinase 3 gene (Flt3(ITD)) and the nucleophosmin gene (Npm1(c)) to induce AML in vivo, and

100 Mutations in the nucleophosmin gene (NPM1(mut)) are one of the most frequ

101 Frameshift mutations in exon 12 of the nucleophosmin gene (NPM1) result in aberrant cytoplasmic

102 ma kinase (ALK) receptor tyrosine kinase and nucleophosmin genes.

103 causing aberrant cytoplasmic localization of nucleophosmin have been demonstrated to be the most freq

104 idic, synthetic small molecules that bind to nucleophosmin have not been described, prior to this rep

105 ations, and that siRNA-promoted depletion of nucleophosmin in a population of HeLa S3 cells leads to

106 the similarity of Npm3 to nucleoplasmin and nucleophosmin in amino acid sequence, protein features,

107 ncated nucleophosmin coexpressed with native nucleophosmin in COS-7 cells revealed that the mutation

108 udy, we examined the underlying mechanism of nucleophosmin induction and showed that hyperproliferati

109 ctivation, as rapamycin completely prevented nucleophosmin induction.

110 In particular, nucleophosmin interacts with nucleolar components of new

111 Nucleophosmin is a classic mitogen-induced protein, with

112 Protein B23/nucleophosmin is a multifunctional protein that plays ro

113 B23/nucleophosmin is an abundant shuttling phosphoprotein, w

114 Among other effects, nucleophosmin is known to regulate the tumor suppressor

115 ereas its nucleolar phosphoprotein inhibitor nucleophosmin is up-regulated.

116 B23 (NPM/nucleophosmin) is a multifunctional nucleolar protein an

117 echanistic link between TSC1/mTOR signaling, nucleophosmin-mediated nuclear export of ribosome subuni

118 on through increased translation of existing nucleophosmin mRNAs.

119 However, the oncogenic potential of this nucleophosmin mutant (NPMc+) has never been established,

120 Nucleophosmin-mutated acute myeloid leukemia (NPM1mut-AM

121 FLT3 internal tandem duplication (ITD) and nucleophosmin mutations occurred at a similar frequency

122 y, involving interferon regulatory factor-1, nucleophosmin, NFkappaB, and CRE binding in cell surviva

123 Nucleophosmin (NPM) (B23) is an essential protein in mou

124 The resulting nucleophosmin (NPM) /ALK chimeric kinase is constitutive

125 Here we show that nucleophosmin (NPM) acts as a natural repressor of p53 b

126 We recently identified nucleophosmin (NPM) and anaplastic lymphoma kinase (ALK)

127 Moreover, nucleophosmin (NPM) and c-Myc, both of which are commonl

128 anslocation that forms a fusion gene between nucleophosmin (NPM) and MDS/myeloid leukemia factor 1 (M

129 A fusion gene between nucleophosmin (NPM) and myelodysplasia/myeloid leukemia

130 eport the purification and identification of nucleophosmin (NPM) and nucleolin as two genotoxic stres

131 s the center of ribosome synthesis, with the nucleophosmin (NPM) and p19(ARF) proteins antagonizing o

132 part, on their ability to keep low levels of nucleophosmin (NPM) and p53 mRNAs.

133 yelocytic leukemia (APL) fuses the genes for nucleophosmin (NPM) and the retinoic acid receptor alpha

134 ion of anaplastic lymphoma kinase (ALK) with nucleophosmin (NPM) and the subsequent expression of the

135 Recently, we identified nucleophosmin (NPM) as a key factor counteracting death

136 n-containing CCCTC binding factor (CTCF) and nucleophosmin (NPM) at the nucleolus.

137 le in p53-null cells by hyperphosphorylating nucleophosmin (NPM) at Thr199, as evidenced by observati

138 Nucleostemin (NS) and nucleophosmin (NPM) displayed an extremely high degree o

139 stic lymphoma kinase (ALK) gene fuses to the nucleophosmin (NPM) gene as a result of a (2;5) transloc

140 in the fusion of the ubiquitously expressed nucleophosmin (NPM) gene at 5q35 to the anaplastic lymph

141 35) chromosomal translocation that fuses the nucleophosmin (NPM) gene on chromosome 5q35 to a novel p

142 rming capability when truncated and fused to nucleophosmin (NPM) in the t(2;5) chromosomal rearrangem

143 Nucleophosmin (NPM) is a multifunctional protein frequen

144 Nucleophosmin (NPM) is a multifunctional protein that is

145 Nucleophosmin (NPM) is frequently overexpressed in leuke

146 Like c-Myc, multifunctional nucleophosmin (NPM) is tightly regulated during prolifer

147 inal portion of the nucleolar phosphoprotein nucleophosmin (NPM) joined to the entire cytoplasmic por

148 cid residues of the nucleolar phosphoprotein nucleophosmin (NPM) joined to the entire cytoplasmic por

149 ogenesis through increased expression of the nucleophosmin (NPM) nuclear-cytoplasmic shuttling protei

150 consensus sequence were abolished, with the nucleophosmin (NPM) reporter gene and used them for in v

151 recruiting Rac1 and its downstream effector nucleophosmin (NPM) to rDNA.

152 es the gene for the nucleolar phosphoprotein nucleophosmin (NPM) to the retinoic acid receptor alpha

153 NS interacts with nucleophosmin (NPM), a marker of nucleolar stress with c

154 Nucleophosmin (NPM), a multifunctional nucleolar phospho

155 We hypothesized that nucleophosmin (NPM), a nucleolar phosphoprotein, is crit

156 Nucleophosmin (NPM), a nucleolar phosphoprotein, is the

157 Nucleophosmin (NPM), a predominantly nucleolar protein,

158 Nucleophosmin (NPM), a previously characterized nucleola

159 PKR-modulating proteins we report here that nucleophosmin (NPM), a protein frequently overexpressed

160 Here we show that nucleophosmin (NPM), a RNA-binding protein, binds to an

161 Nucleophosmin (NPM), an oligomeric phosphoprotein and nu

162 We also identified nucleophosmin (NPM), an RNA-binding protein, as an impor

163 the most frequently mutated genes in AML is nucleophosmin (NPM), and this is associated with low CD3

164 F inhibited the interaction between DDX5 and nucleophosmin (NPM), preventing association of DDX5 with

165 ed here indicate that the nucleolar protein, nucleophosmin (NPM), redistributes from the nucleolus fo

166 nalysis of CXCR4 immune complexes identified nucleophosmin (NPM), which was confirmed by reciprocal c

167 ptase polymerase chain reaction (RT-PCR) for Nucleophosmin (NPM)-ALK during treatment identifies pati

168 This approach accurately identified the nucleophosmin (NPM)-ALK fusion protein in an anaplastic

169 ority of which harbor the well-characterized nucleophosmin (NPM)-ALK fusion protein.

170 ylation is accurately recapitulated in a new nucleophosmin (NPM)-ALK transgenic mouse model of lympho

171 human cell lines, primary human tumours and nucleophosmin (NPM)-ALK-induced murine tumours demonstra

172 n the nucleolus share the ability to bind to nucleophosmin (NPM).

173 t compartment by a nucleolar phosphoprotein, nucleophosmin (NPM).

174 in interacts with a 40 kDa shuttling protein nucleophosmin (NPM).

175 action partner of the anti-apoptotic protein nucleophosmin (NPM).

176 of the anaplastic lymphoma kinase (ALK) with nucleophosmin (NPM).

177 ng the expression of the cell cycle promoter nucleophosmin (NPM).

178 In this study, we report that activity of nucleophosmin (NPM)/ALK chimeric protein, the dominant f

179 hat T-cell lymphoma (TCL) cells carrying the nucleophosmin (NPM)/ALK fusion protein (ALK+ TCL) strong

180 sformation caused by the oncogenic, chimeric nucleophosmin (NPM)/anaplastic lymphoma kinase (ALK) rem

181 nisms of cell transformation mediated by the nucleophosmin (NPM)/anaplastic lymphoma kinase (ALK) tyr

182 Nucleophosmin (NPM)/B23 has been implicated in the regul

183 e describe a nuclear PI(3,4,5)P(3) receptor, nucleophosmin (NPM)/B23, that mediates the antiapoptotic

184 ns of p19(Arf) with Mdm2, or separately with nucleophosmin (NPM, B23) that localizes and stabilizes p

185 ain of the multifunctional nucleolar protein nucleophosmin (Npm-N) are central to its function, with

186 We identified nucleophosmin (NPM/B23) as a substrate of CDK2/cyclin E

187 Nucleophosmin (NPM/B23) is a key regulator in the regula

188 Nucleophosmin (NPM/B23) is a multifunctional oncoprotein

189 yclin E triggers centrosome duplication, and nucleophosmin (NPM/B23) is found to be one of its target

190 Nucleophosmin (NPM/B23) is one of the phosphorylation ta

191 leus as a physical and functional partner of nucleophosmin (NPM/B23), a major nucleolar phosphoprotei

192 We have recently found that nucleophosmin (NPM/B23), a phosphoprotein primarily foun

193 of p53-independent ARF targets, we isolated nucleophosmin (NPM/B23), a protein we show is required f

194 omal biogenesis through its interaction with nucleophosmin (NPM/B23), RNA helicase DDX5 and RNA polym

195 f many cellular proteins, including Mdm2 and nucleophosmin (NPM/B23), with which p19(Arf) physically

196 inal portion of the nucleolar phosphoprotein nucleophosmin(NPM) joined to the entire cytoplasmic port

197 or fusions (18% of cases), the gene encoding nucleophosmin (NPM1) (27%), tumor-suppressor genes (16%)

198 Furthermore, the nucleolar phosphoprotein nucleophosmin (NPM1) acts as a scaffold for PIDD and is

199 ts were the same in all 3 cases, between the nucleophosmin (NPM1) and fms-related tyrosine kinase 4 (

200 5 is able to interact with and phosphorylate nucleophosmin (NPM1) both in vitro and in intact cells.

201 Mutations in the human nucleophosmin (NPM1) gene are the most frequent genetic

202 Nucleophosmin (NPM1) gene has been heavily implicated in

203 Here, we show that nucleophosmin (NPM1) integrates within the nucleolus via

204 Nucleophosmin (NPM1) is a multifunctional phospho-protei

205 Nucleophosmin (NPM1) is a multifunctional protein that c

206 Nucleophosmin (NPM1) is a nucleocytoplasmic shuttling pr

207 Nucleophosmin (NPM1) is a nucleocytoplasmic shuttling pr

208 olyadenylation, the multi-functional protein nucleophosmin (NPM1) is deposited onto all cellular mRNA

209 Nucleophosmin (NPM1) mutations represent an attractive t

210 ed in CN-AML patients harboring mutations in nucleophosmin (NPM1) that are associated with favorable

211 rosine kinase 3 gene (FLT3-ITD), a wild-type nucleophosmin (NPM1), or both.

212 Nucleophosmin (NPM1/B23) and the activating transcriptio

213 arker (e.g., a mutation in the gene encoding nucleophosmin [NPM1]) could improve prognostication by i

214 eading to aberrant cytoplasmic expression of nucleophosmin (NPMc(+)) are the most frequent genetic le

215 a cytoplasmic FA subcomplex and the leukemic nucleophosmin (NPMc).

216 AML) carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ AML) accounts for about one-third o

217 on, all of which were dependent on efficient nucleophosmin nuclear export.

218 ia gene, promyelocytic leukemia zinc finger, nucleophosmin, nuclear matrix protein, and signal transd

219 We propose that nucleophosmin/nucleoplasmin complexes serve as chaperone

220 nactive, unphosphorylated CPC interacts with nucleophosmin/nucleoplasmin proteins, which are known to

221 tion of the CPC causes it to dissociate from nucleophosmin/nucleoplasmin.

222 Protein B23/nucleophosmin/numatrin (B23) is a key nucleolar/nuclear

223 rotein-protein interaction and verified that nucleophosmin only bound to activated conformationally a

224 not occur with two other nucleolar proteins, nucleophosmin or nucleolin.

225 some inhibition, siRNA-mediated knockdown of nucleophosmin potentiated nucleolar accumulation and inc

226 Nucleophosmin protein accumulation in the absence of Tsc

227 Nucleophosmin protein accumulation was dependent on mamm

228 Increases in nucleophosmin protein accumulation were suppressed by re

229 nic H-Ras(V12) cause tremendous increases in nucleophosmin protein expression.

230 ajor upstream inhibitor of mTOR, resulted in nucleophosmin protein induction through increased transl

231 ation and proximity assays confirmed the Bax-nucleophosmin protein-protein interaction and verified t

232 We show that NPM1 (nucleophosmin) regulates TLS via interaction with the ca

233 , we demonstrate that overexpression of NPM (nucleophosmin) significantly suppresses 12-O-tetradecano

234 Induction of nucleophosmin through Tsc1 loss resulted in a greater po

235 ence of p53, ARF can be stabilized by NS and nucleophosmin to serve as an alternative tumor-suppresso

236 ecognized including topoisomerases I and II, nucleophosmin, Translin, EGR1, dek, pim-1, TFG, and MLL.

237 ell-based apoptosis model, demonstrated that nucleophosmin translocation from nucleolus to cytosol pr

238 cellular fractionation studies verified that nucleophosmin translocation occurred within 3 h, at a ti

239 The molecular chaperone nucleophosmin was identified as a novel Bax-binding prot

240 Affinity-isolation of nucleophosmin was inhibited in the presence of iodoaceta

241 etion of SENP3 and SENP5 or depletion of B23/nucleophosmin, we observed accumulation of SUMO proteins

242 ied including FMS-like tyrosine kinase-3 and nucleophosmin, which will enhance our ability to more ac

243 ransport of tumor suppressors (e.g., p53 and nucleophosmin) whose function is altered in cancer becau

244 n that juxtaposes the dimerization domain of nucleophosmin with anaplastic lymphoma kinase (ALK).