ライフサイエンスコーパス: nucleoplasmic

1 o chromatin and SCML2B that is predominantly nucleoplasmic.

2 n the NES exporter Xpo1/Crm1 also caused the nucleoplasmic accumulation of 5' ITS1.

3 Nucleoplasmic accumulation of TLC1 RNA depends on Cdc13

4 ate Clp1 to promote genotoxic stress-induced nucleoplasmic accumulation.

5 relocalized from the nuclear periphery into nucleoplasmic aggregates and produced no nuclear blebbin

6 localize lamin A/C from the nuclear rim into nucleoplasmic aggregates, (ii) overexpression of U(L)34

7 ns and the mutant lamin protein are found in nucleoplasmic aggregates.

8 obic cluster analysis also predicts that the nucleoplasmic amino-terminal portion of LBR contains two

9 R from four patients with PBC recognized the nucleoplasmic, amino-terminal domain but not the carboxy

10 Human LBR has a nucleoplasmic, amino-terminal domain of 208 amino acids

11 LBR has a nucleoplasmic, amino-terminal domain of approximately 20

12 hat is phosphorylated on serine 366 (pLa) is nucleoplasmic and associated with precursor tRNAs and ot

13 lls that incorporates a method for obtaining nucleoplasmic and chromatin fractions and removing cytop

14 Deletion of NUP60 renders Nup2p nucleoplasmic and compromises Nup2p-mediated recycling o

15 outer nuclear membranes, which separate the nucleoplasmic and cytoplasmic compartments.

16 om either side of the midplane ring and form nucleoplasmic and cytoplasmic entries.

17 nstitute a cell-cycle control device linking nucleoplasmic and cytoplasmic events.

18 nation iCLIP (Fr-iCLIP), in which chromatin, nucleoplasmic and cytoplasmic fractions are prepared fro

19 ed C2C12 skeletal muscle myoblasts, p204 was nucleoplasmic and its level was low.

20 ith NPCs is dependent on the synergy of both nucleoplasmic and lumenal domains.

21 CHD7 dually functions as a regulator of both nucleoplasmic and nucleolar genes and provide a novel av

22 in the nucleoplasm, RbS795 migrates between nucleoplasmic and speckle compartments.

23 sites in the nuclear envelope from both the nucleoplasmic and the cytoplasmic sides.

24 apping subcellular distribution of cytosolic/nucleoplasmic and topogenic signal-encoding mRNAs, with

25 al subunit in eukaryotes involves nucleolar, nucleoplasmic, and cytoplasmic steps.

26 -seq with fractionated chromatin-associated, nucleoplasmic, and cytoplasmic transcripts.

27 s the CB marker protein, coilin is primarily nucleoplasmic, and the function of this fraction is not

28 that was sufficient for association with the nucleoplasmic aspect of the NPC.

29 lamins comprise the lamina and a variety of nucleoplasmic assemblies that together are major structu

30 s and Rac GTPases mediate the recruitment of nucleoplasmic Aux/IAAs into proteolytically active nucle

31 ve, eight-fold symmetric channel capped by a nucleoplasmic basket and structurally unique, cytoplasmi

32 3, indicating that SENP2 associates with the nucleoplasmic basket of the NPC.

33 ucleoplasmic side of the NPC, at or near the nucleoplasmic basket.

34 ne patient showed increased micronucleus and nucleoplasmic bridge formation, delayed recovery of DNA

35 -) cells is associated with the formation of nucleoplasmic bridges and increased chromosomal instabil

36 of cases (and no controls) had >or=6 induced nucleoplasmic bridges, and 23% of cases (versus 2% of co

37 ases (and no controls) had >or=4 spontaneous nucleoplasmic bridges, and 25% of cases (versus 5% of co

38 er risk based on the numbers of micronuclei, nucleoplasmic bridges, and nuclear buds defined by perce

39 a continuous scale, spontaneous micronuclei, nucleoplasmic bridges, and nuclear buds were associated

40 d chromosomal damage endpoints (micronuclei, nucleoplasmic bridges, and nuclear buds) per 1,000 binuc

41 of spontaneous and NNK-induced micronuclei, nucleoplasmic bridges, and nuclear buds, respectively.

42 missible induction of dicentric chromosomes, nucleoplasmic bridges, micronuclei and aneuploidy.

43 HuR appears predominantly nucleoplasmic but has been shown to shuttle between the

44 In normal cells, BIN1 was predominantly nucleoplasmic but was also present in a subnuclear compa

45 We show that the nucleoplasmic, C-terminal domain of human MAN1 binds to

46 independently in raising levels of cytosolic/nucleoplasmic Ca(2+) as a source of Ca(2+) for Ca(2+)-de

47 channels) induces NE-derived Ca(2+) release, nucleoplasmic Ca(2+) elevation and cyclic AMP response e

48 These changes were associated with altered nucleoplasmic Ca(2+) handling in cardiomyocytes from hyp

49 Altered nucleoplasmic Ca(2+) levels were translated to higher ac

50 al and potential pathophysiological role for nucleoplasmic Ca(2+) signals and suggest that this infor

51 to GM1 ganglioside that mediates transfer of nucleoplasmic Ca(2+) to the NE lumen and constitutes a c

52 , mGluR5 is perfectly positioned to regulate nucleoplasmic Ca(2+)in situ.

53 was associated with a transient rise in the nucleoplasmic Ca2+ concentration.

54 ard the center is a prominent feature of the nucleoplasmic Ca2+ transient.

55 temporal and spatial characteristics of the nucleoplasmic [Ca2+] transient is considered.

56 d Mre11 in fractionated lysates (cytoplasmic/nucleoplasmic, chromatin-bound, and nuclear matrix fract

57 eolus-associated filaments; and (iii) dense, nucleoplasmic clusters.

58 oes rapid exchange between chromatin and the nucleoplasmic compartment in living cells.

59 oes rapid exchange between chromatin and the nucleoplasmic compartment.

60 odies and nucleoli, in addition to a diffuse nucleoplasmic compartment.

61 also novel roles for dynamic Nups within the nucleoplasmic compartment.

62 sociated with it to asymmetrically segregate nucleoplasmic components.

63 on, quantitative study of the changes in the nucleoplasmic concentration and distribution of these nu

64 est a dynamic interaction, controlled by the nucleoplasmic concentration of Gsp1p-GTP, between Nup60p

65 leus is dynamically regulated, and may alter nucleoplasmic concentrations and/or assembly of multimol

66 hromosomes, its deletion subtly affected the nucleoplasmic distribution of the protein during interph

67 ates from these stress granules to a diffuse nucleoplasmic distribution, typical of unstressed cells.

68 romatin immunoprecipitation reveal a diffuse nucleoplasmic distribution, weak association with chroma

69 expression, Alt-ATXN1 displays a homogenous nucleoplasmic distribution.

70 tion to being present in a low-level diffuse nucleoplasmic distribution.

71 Here we show that acidic nucleoplasmic DNA-binding protein (And-1, a high mobilit

72 Here we identify acidic nucleoplasmic DNA-binding protein 1 (And-1) as a new fac

73 Here, we show that acidic nucleoplasmic DNA-binding protein 1 (And-1) forms comple

74 ed a functional link between Gcn5 and acidic nucleoplasmic DNA-binding protein 1 (And-1) that is elev

75 t residues 72-98 adjacent to the membrane in nucleoplasmic domain are important for the interaction w

76 uses with large deletions in the cytoplasmic-nucleoplasmic domain of ADP retain much of their ability

77 iruses with mutations within the cytoplasmic-nucleoplasmic domain of ADP showed normal glycosylation

78 In a yeast two-hybrid screen, the nucleoplasmic domain of lamin B receptor (LBR), an integ

79 of a recombinant polypeptide comprising the nucleoplasmic domain of rat LAP2 (residues 1-398) into m

80 hanges and HIV inhibition both mapped to the nucleoplasmic domain of SUN2 that interacts with the nuc

81 for nuclear migration and interacts with the nucleoplasmic domain of the SUN protein UNC-84.

82 by at least two discrete regions within its nucleoplasmic domain.

83 Nucleoplasmic domains of XENOPUS: LAP2 isoforms varied 9

84 istributed in their previously characterized nucleoplasmic domains.

85 d at the nuclear periphery during G1, became nucleoplasmic during S-phase, and then returned to the n

86 TP was elevated in the extracts to mimic the nucleoplasmic environment, the patterns of interacting p

87 P53 by inhibiting MDM2 or BRCA1 restored the nucleoplasmic expression of DeltaNp63.

88 Using nucleoplasmic extract (NPE) from Xenopus laevis eggs and

89 We find that cdc7 is greatly enriched in nucleoplasmic extract and that this high concentration i

90 to form prereplication complexes and then in nucleoplasmic extract to initiate DNA synthesis.

91 Using nucleoplasmic extracts (NPE) derived from the eggs of Xe

92 gy-dependent DSB repair using Xenopus laevis nucleoplasmic extracts as a model system.

93 pproach to investigate DNA end processing in nucleoplasmic extracts derived from the unfertilized egg

94 his activity can be provided by cytosolic or nucleoplasmic extracts in a subsequent export step.

95 cleus, with import cargo accumulating at the nucleoplasmic face of nuclear pore complexes, as when Ra

96 onent of the basket structure located on the nucleoplasmic face of nuclear pore complexes.

97 lear lamina is a protein meshwork lining the nucleoplasmic face of the inner nuclear membrane and rep

98 o filamentous structures stretching from the nucleoplasmic face of the NE into the nucleoplasm, simil

99 SUMO-3 protein conjugates, localizes to the nucleoplasmic face of the NPC.

100 K cells, it accumulates appropriately at the nucleoplasmic face of the nuclear envelope.

101 Nup153 is located at the nucleoplasmic face of the nuclear pore complex (NPC), in

102 n protein suggest that Ulp1 localizes to the nucleoplasmic face of the nuclear pore complex.

103 p153, a nucleoporin that is localized to the nucleoplasmic face of the pore.

104 On the nucleoplasmic face, where the Ran--GTP levels are predic

105 etween opposing sheets of NE such that their nucleoplasmic faces are in contact.

106 hown to localize to both the cytoplasmic and nucleoplasmic faces of the NPC core.

107 NPC is observed on both the cytoplasmic and nucleoplasmic faces of the nuclear envelope.

108 mutations in human cells and found that the nucleoplasmic Fbw7alpha isoform accounts for almost all

109 t occupy distinct compartments: Fbw7alpha is nucleoplasmic, Fbw7beta is cytoplasmic, and Fbw7gamma is

110 that Nup50 is specifically localized in the nucleoplasmic fibrils of the pore complex.

111 c9 localizes to both the cytoplasmic and the nucleoplasmic filaments of the NPC.

112 three characteristic morphologies: (i) long, nucleoplasmic filaments; (ii) short, nucleolus-associate

113 g showed colocalization in both nucleoli and nucleoplasmic foci in breast tumor cells and asynchronou

114 s, BRCA1 protein dispersed from nucleoli and nucleoplasmic foci to other nucleoplasmic sites, which d

115 vealed BRCA1 expression in both nucleoli and nucleoplasmic foci.

116 PML tumor suppressor protein into a diffuse nucleoplasmic form and its association with metaphase ch

117 tle effect on the location or stability of a nucleoplasmic form of ARF.

118 was preferentially localized to the soluble, nucleoplasmic fraction.

119 These results bear on the structure of the nucleoplasmic ground substance-an extremely controversia

120 lyzed non-snoRNP factors associated with the nucleoplasmic human U3 snoRNA.

121 This reactivated geminin provides the major nucleoplasmic inhibitor of origin relicensing during lat

122 d movements of certain other RNAs from their nucleoplasmic injection sites to the nucleoli.

123 It is known that the nucleoplasmic ionised calcium concentration (Can) contro

124 trans-autophosphorylation of its cytoplasmic-nucleoplasmic kinase domain.

125 the lamina meshwork size and the mobility of nucleoplasmic lamin A (LA).

126 we show here leads to loss of LAP2alpha and nucleoplasmic lamins A/C, impaired proliferation, and do

127 ular matrix expression but not the levels of nucleoplasmic lamins A/C.

128 1 transcriptional memory is lost, leading to nucleoplasmic localization after repression and slower r

129 croscopy confirmed mrnp 41's cytoplasmic and nucleoplasmic localization and revealed a striking label

130 We also found a PICT1 mutant showing nucleoplasmic localization did not undergo nucleolar str

131 All three proteins contain a nucleoplasmic localization signal (NpLS) that prevents t

132 s and megakaryocytes, in addition to diffuse nucleoplasmic localization.

133 -GFP predicted to ablate N-acetylation cause nucleoplasmic location, whereas a variant with an N-term

134 speculate that SNIP is part of an organized nucleoplasmic machinery responsible for processing of SL

135 Unlike the nucleoplasmic MDM2 and p53, ARF localizes in the nucleol

136 We previously reported that nucleoplasmic mobilization of NS stabilizes MDM2 (mouse

137 Predominately nucleoplasmic molecules visualized by immunofluorescence

138 d/or III retards both the nuclear export and nucleoplasmic movement of PTB.

139 rom those in the newly synthesized CA-RNA or nucleoplasmic mRNA.

140 Our data demonstrate that the nucleoplasmic N-terminal acidic domain of Mps3 is not es

141 phy and demonstrated for the first time that nucleoplasmic NF7 exists primarily as free homotrimers.

142 mutants that disrupt silencing abrogate this nucleoplasmic-nucleolar partitioning.

143 p interact at the cytoplasmic NPC face, with nucleoplasmic Nup116p localization utilizing novel bindi

144 tead, sPom121 colocalizes and interacts with nucleoplasmic Nup98, a previously identified transcripti

145 of the cytoplasm, nuclear invaginations, and nucleoplasmic opacity, as well as aggregations of juncti

146 Here we use selective buffers of nucleoplasmic or cytoplasmic Ca(2+) to determine that ce

147 -231 cells with adenoviral RXR alpha induced nucleoplasmic overexpression of RXR alpha and resulted i

148 a substantial increase in both nucleolar and nucleoplasmic p19(ARF), Mdm2 did not relocalize to the n

149 ramatically altered, from its normal diffuse nucleoplasmic pattern to accumulation in dense nuclease-

150 s nuclear speckled distribution to a diffuse nucleoplasmic pattern.

151 a cells without affecting migration and with nucleoplasmic patterns of damage similar to constricted

152 ctories exchange components with the soluble nucleoplasmic pool over time as gene expression programs

153 PS bodies), which were set against a diffuse nucleoplasmic population excluding nucleoli.

154 e obtained direct physical evidence that the nucleoplasmic PRC1 is monomeric, whereas PRC2 can dimeri

155 copy to characterize the structures of yeast nucleoplasmic pre-60S particles affinity-purified using

156 g2 binds the inter-subunit face of maturing, nucleoplasmic pre-60S particles, and the location clashe

157 Matrin-3 binds RNA and DNA and is a nucleoplasmic protein originally identified from the ins

158 Here we show that piwi encodes a novel nucleoplasmic protein present in both somatic and germli

159 The Dictyostelium cudA gene encodes a nucleoplasmic protein that is essential for normal culmi

160 nsists of nuclear membrane protein UL50, and nucleoplasmic protein UL53, which is recruited to the nu

161 In situ fractionation removes most nucleoplasmic protein, permitting immunofluorescent loca

162 Since a number of nucleoplasmic proteins also relocate upon heat shock, th

163 y binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes,

164 mentalized; little exchange was observed for nucleoplasmic proteins between mother and bud.

165 Recently, two nucleoplasmic proteins from mice were observed to bind t

166 d reversibly relocate multiple nucleolar and nucleoplasmic proteins to the cytoplasm.

167 In support, sequestration of nucleoplasmic proteins to the periphery impacts cell ste

168 NA export involves association of mRNAs with nucleoplasmic proteins, delivery to the nuclear pore com

169 the LEM family of inner nuclear membrane and nucleoplasmic proteins.

170 an be found inside the nucleolus and diffuse nucleoplasmic punctates.

171 questering or mobilizing a small fraction of nucleoplasmic Rad51 and suggest a mechanism for the dyna

172 hydroxyurea reduces the immobile fraction of nucleoplasmic Rad51.

173 Nuclear retention of nucleoplasmic Rb during G(1) phase but not of speckle-as

174 this protein, we have examined in detail its nucleoplasmic region, which is predicted to harbor a Tud

175 , which are in the cytoplasmic, central, and nucleoplasmic regions of the NPC, respectively.

176 erous punctate foci dispersed throughout the nucleoplasmic regions of the nucleus and was also presen

177 Eukaryotic cells begin to assemble discrete, nucleoplasmic repair foci within seconds after the onset

178 1 expression is necessary and sufficient for nucleoplasmic retention of L22.

179 des may be taking place, particularly at the nucleoplasmic reticula that reach deep within the nucleo

180 ng tubular invaginations that form a dynamic nucleoplasmic reticulum (NR).

181 e presence of nuclear LDs attached to type I nucleoplasmic reticulum in triple seipin mutant embryos,

182 -like invaginations of the nuclear envelope (nucleoplasmic reticulum).

183 ing supports the existence of an ITPR1-lined nucleoplasmic reticulum.

184 Cytoplasmic and nucleoplasmic Rpb1 was phosphorylated exclusively on Tyr

185 This suggests that nucleoplasmic RXR alpha restores retinoid sensitivity.

186 plasmic sequences, 0.80% for randomly chosen nucleoplasmic sequences and 12% for nuclear localization

187 Nucleostemin (NS) is a nucleolar-nucleoplasmic shuttle protein that regulates cell prolif

188 P3-gated Ca(2+) as a key regulator of TDP-43 nucleoplasmic shuttling and proteostasis and suggest pha

189 Here we took advantage of the nucleoplasmic shuttling of free arrestins and used a "nu

190 primarily interact with the periphery on the nucleoplasmic side and in the centre of the NPC, without

191 AFM images further show polyplexes on the nucleoplasmic side of the envelope, presumably indicatin

192 ar lamina, a filamentous meshwork lining the nucleoplasmic side of the inner nuclear membrane.

193 t substrate is released from Kapbeta2 at the nucleoplasmic side of the NPC by competition with the Nu

194 ect targeting of both Nup96 and Nup98 to the nucleoplasmic side of the NPC was found to be dependent

195 alpha/cargo complexes are dissociated on the nucleoplasmic side of the NPC, and this dissociation req

196 ctron microscopy, Nup96 was localized to the nucleoplasmic side of the NPC, at or near the nucleoplas

197 Nup214 on the cytoplasmic, and Nup153 on the nucleoplasmic side of the NPC, failed to assemble into N

198 Cytological labeling located otefin on the nucleoplasmic side of the nuclear envelope.

199 lamina, a filamentous network underlying the nucleoplasmic side of the nuclear membrane, whereas lami

200 lp1 and Mlp2) form filaments attached to the nucleoplasmic side of the nuclear pore complexes via int

201 Tpr is a coiled-coil protein found near the nucleoplasmic side of the pore complex.

202 te of movement away from either a speckle or nucleoplasmic site was monitored using digital imaging m

203 Mobilization from the nucleolus to nucleoplasmic sites likely permits uncoating and subsequ

204 splicing, suggesting that they function near nucleoplasmic sites of transcription.

205 he nucleoplasm, largely to specific discrete nucleoplasmic sites or speckles; this pattern was stable

206 rom nucleoli and nucleoplasmic foci to other nucleoplasmic sites, which did not colocalize with nucle

207 lly identical in both speckles and at random nucleoplasmic sites.

208 ays at both the nucleolar Sm-independent and nucleoplasmic Sm-dependent stages of SL RNA maturation c

209 ion/dissociation of its 'residents' with the nucleoplasmic space.

210 SmD1b resides in nucleoli and nucleoplasmic speckles, colocalizing with the splicing-r

211 o-localize with splicing factors and diffuse nucleoplasmic staining.

212 nt assembly of membrane-less cytoplasmic and nucleoplasmic structures, including ribonucleoprotein (R

213 of the presenilins with kinetochores on the nucleoplasmic surface of the inner nuclear membrane, tog

214 GCL's subcellular distribution on the nucleoplasmic surface of the nuclear envelope and its ef

215 Recent data suggest that after nucleoplasmic synthesis, snoRNAs transiently localize to

216 be caused by inappropriate desumoylation of nucleoplasmic targets that are normally spatially protec

217 Once nucleoplasmic, the subunits moved in the same random man

218 RNA, and lipids were determined in nucleoli, nucleoplasmic transcription sites, nuclear speckles, con

219 a (TNFalpha) induced rapid and complete sNix nucleoplasmic translocation concomitant with nuclear tra

220 ow that both the precursor and mature length nucleoplasmic U3 snoRNAs are present in larger multiprot

221 isphosphate receptor channel isoforms in the nucleoplasmic versus the endoplasmic reticulum.

222 Anaphase kinetochore force and nucleoplasmic viscosity were comparable with previous es

223 in the rapid (within minutes) recruitment of nucleoplasmic YFP-SRC-1, while antagonist additions dimi