ライフサイエンスコーパス: nucleoplasmin

1 C causes it to dissociate from nucleophosmin/nucleoplasmin.

2 d with storage chaperone proteins, including nucleoplasmin.

3 0) are removed from erythrocyte chromatin by nucleoplasmin.

4 osome remains intact even in the presence of nucleoplasmin.

5 e T antigen or the standard bipartite NLS of nucleoplasmin.

6 chromatin, a process that can be mediated by nucleoplasmin.

7 oocyte extracts or hypophosphorylated oocyte nucleoplasmin.

8 hts into the mechanism of histone binding by nucleoplasmins.

9 In Xenopus laevis, nucleoplasmin 2 (NPM2) decondenses sperm DNA in vitro.

10 Here, oocytes obtained from nucleoplasmin 2 knockout (Npm2-/-) mice were used to inv

11 mplementary DNA for a highly acidic protein, nucleoplasmin 3 (NPM3), was found in multiple positive c

12 nced homology to the histone binding site of nucleoplasmin, a chromatin remodeling protein found in X

13 blocks nuclear import of RPA but not that of nucleoplasmin, a classical import substrate.

14 for this reaction, and have shown that it is nucleoplasmin, a previously known chromatin remodelling

15 On the basis of the similarity of Npm3 to nucleoplasmin and nucleophosmin in amino acid sequence,

16 ed to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin.

17 the nuclear localization sequences (NLSs) of nucleoplasmin and the tumor suppressor p53 in human cell

18 This protein resembles Xenopus laevis nucleoplasmin, and it has therefore been termed dNLP, fo

19 depletion of importin alpha blocks import of nucleoplasmin but not that of RPA.

20 luster downstream of the bipartite signal of nucleoplasmin can be directed to the nucleus by flanking

21 We propose that nucleophosmin/nucleoplasmin complexes serve as chaperones that negativ

22 extracts or purified hyperphosphorylated egg nucleoplasmin decondense sperm chromatin and remove sper

23 Nucleoplasmin decondenses the sperm chromatin by removin

24 We also find that Drosophila Nucleoplasmin (dNlp) is present in regions of active tra

25 The nucleoplasmin family of histone chaperones is identified

26 re with a central pore, is only found in the nucleoplasmin family.

27 s of loop mutations support the premise that nucleoplasmins form decamers when they bind H2A-H2B dime

28 RanGTP caused accumulation of nucleoplasmin-gold along the length of extended cytoplas

29 Nucleoplasmin is a histone chaperone that consists of a

30 Nucleoplasmin is able to partially relieve this repressi

31 re shown in bold; [4,5]), whereas the NLS of nucleoplasmin is bipartite.

32 We conclude that hyperphosphorylation of nucleoplasmin is used to modulate the rapid changes in c

33 ly discovered that consists of an N-terminal nucleoplasmin-like (NPL) domain and a C-terminal FKBP pe

34 Here, we report the first structure of a nucleoplasmin-like domain (NPL) from the unrelated Droso

35 family of proteins that share the pentameric nucleoplasmin-like NPL domain and are found in protists,

36 tin assembly system comprises the Drosophila nucleoplasmin-like protein (dNLP) histone chaperone, the

37 l transcription regulator, which resembles a nucleoplasmin-like protein (NLP) with an AT-hook motif.

38 Surprisingly, one of these is nucleoplasmin-like protein (NLP), which we had previousl

39 s therefore been termed dNLP, for Drosophila nucleoplasmin-like protein.

40 Addition of the histone binding protein, nucleoplasmin, mediated the displacement of the core his

41 We show that H2A and nucleoplasmin methylation appears late in oogenesis and

42 ure, and sequence analysis revealed that the nucleoplasmin NLS coding sequence was deleted from the g

43 Gag proteins bearing the nucleoplasmin NLS insertion displayed an assembly defect

44 The nucleoplasmin NLS requires two essential clusters of bas

45 Human Npm2 is an ortholog of Xenopus nucleoplasmin (Np), a chaperone that binds histones.

46 ent the structure of an N-terminal domain of nucleoplasmin (Np-core) at 2.3 A resolution.

47 Nucleoplasmin (Npm) is a highly conserved histone chaper

48 We demonstrate that nucleoplasmin (Npm), an exceedingly abundant maternally

49 ts with egg-type histones by the egg protein nucleoplasmin (Npm).

50 of, and may share basic functions with, the nucleoplasmin/ nucleophosmin family of molecular chapero

51 H2A/H2A.X-F and H4 and the histone chaperone nucleoplasmin on a conserved motif (GRGXK).

52 udies showed that the nuclear phosphoprotein nucleoplasmin performs the first stage of chromatin deco

53 r localization signal (NLS) derived from the nucleoplasmin protein was inserted into the Myr1E Gag se

54 sphorylated CPC interacts with nucleophosmin/nucleoplasmin proteins, which are known to oligomerize i

55 m nuclei can be licensed by a combination of nucleoplasmin, RLF-M and a partially purified fraction t

56 hether the nuclear targeting activity of the nucleoplasmin sequence was responsible for the infectivi

57 Furthermore, dephosphorylation of egg nucleoplasmin slows sperm decondensation and prevents ba

58 activity, SW1-SNF, or the histone chaperone, nucleoplasmin, suggesting that the binding of these fact

59 tional nucleolar protein and a member of the nucleoplasmin superfamily of acidic histone chaperones.

60 nds upon the massive hyperphosphorylation of nucleoplasmin that occurs when oocytes mature into eggs.

61 A bipartite NLS derived from nucleoplasmin was inserted into a region of the MA domai

62 ls an increased association of the chaperone nucleoplasmin with ribonucleoprotein particles dependent