ライフサイエンスコーパス: nucleoporin

1 th (PCD) in plants, is a novel transmembrane nucleoporin.

2 phobic phenylalanine-glycine (FG) domains on nucleoporins.

3 regulation via the phosphorylation status of nucleoporins.

4 ng that the CTD does not interact with other nucleoporins.

5 partners for the O-GlcNAc-modified FG-repeat nucleoporins.

6 ir cargoes, regulatory factors, and specific nucleoporins.

7 iple copies of ~30 different proteins called nucleoporins.

8 with nuclear import and export receptors and nucleoporins.

9 S, the Nup107/160 complex, Nup53, and the FG nucleoporins.

10 t channel via transient interactions with FG nucleoporins.

11 e that provides docking sites for additional nucleoporins.

12 old is generated by multiple copies of seven nucleoporins.

13 s restriction by transient binding to the FG-nucleoporins.

14 of proteins that do not specifically bind FG-nucleoporins.

15 ELYS and the nucleoporin 107-160 complex, components of mitotic kinet

16 ssive missense mutation in the gene encoding nucleoporin-107 (NUP107) that results in abnormal ovaria

17 identified a recessive missense mutation in nucleoporin-107 (NUP107, c.1339G>A, p.D447N).

18 We previously found that nucleoporin 153 (Nup 153) is required for timely progres

19 beta transportin-3 (TNPO3) and NPC component nucleoporin 153 (NUP153) as being important for infectio

20 s 1-24 and resembles region 1011-1035 of the nucleoporin 153 (Nup153).

21 ctly with the FxFG-rich C-terminal domain of nucleoporin 153 (NUP153C).

22 olyadenylation specific factor 6 (CPSF6) and nucleoporin 153 kDa (NUP153), bind to the CA hexamer wit

23 Nucleoporins 153 and 358, which bind HIV-1 capsid, play

24 We show that the nucleoporin 160kDa (Nup160) gene of the fruitfly Drosoph

25 es revealed that nucleoporin p62 (NUP62) and nucleoporin 214 (NUP214) are differentially distributed

26 import, including transportin 3 (TNPO3) and nucleoporin 358 (NUP358), in the targeting of gene-dense

27 Here, we show that nucleoporin 62 (Nup62) is a chromatin-bound protein and

28 Knockdown of nucleoporin 62 strongly inhibited viral morphogenesis, w

29 We determined the nucleoporin 85 (Nup85)*Seh1 structure, a module in the h

30 ution, chromosome-wide binding maps of human nucleoporin 93 (Nup93) in the presence and absence of a

31 mRNA export factor 1 (Rae1) and nucleoporin 98 (Nup98) are host cell targets for the mat

32 bip1 (bric a brac interacting protein 1) and Nucleoporin 98 (Nup98) as additional regulators of the e

33 emia (AML), a genetic fusion protein between nucleoporin 98 and the third plant homeodomain (PHD) fin

34 The nucleoporin 98 gene (NUP98) is fused to a variety of par

35 Structural chromosomal rearrangements of the Nucleoporin 98 gene (NUP98), primarily balanced transloc

36 encodes an Arabidopsis homolog of mammalian nucleoporin 98, a component of the nuclear pore complex

37 KDM5A or RBBP2), to a common fusion partner nucleoporin-98 (NUP98) as identified in human leukaemias

38 Recently we determined that the nucleoporin ALADIN participates in spindle assembly in s

39 Our data demonstrate a novel function of the nucleoporin Alm1 in proteasome localization required for

40 nsists of as many as 224 copies of the three nucleoporins, amounting to a molar mass of 12.3 MDa and

41 ese studies reveal that knockdown of certain nucleoporins and components of nucleocytoplasmic traffic

42 uit CRM1, export cargo proteins, and certain nucleoporins and concomitantly affect nuclear protein an

43 xperiments on the functional requirements of nucleoporins and nuclear lamins.

44 We observed crosslinking between FG-repeat nucleoporins and nuclear transport factors, suggesting t

45 res of the interacting domains between these nucleoporins and pieced together the molecular architect

46 NUP98, a nucleoporin, and its interaction partner Rae1, have been

47 sts cell-type-specific functions for certain nucleoporins, and gene expression profiling has revealed

48 FG-nucleoporins, the binding strength to FG-nucleoporins, and the antagonistic effect of transport f

49 ions with IBB domains, phenylalanine-glycine nucleoporins, and the GTPase Ran during transport.

50 e the interaction with transport substrates, nucleoporins, and the GTPase Ran.

51 built from multiple copies of ~30 different nucleoporins, and understanding how these nucleoporins a

52 and Kalverda et al. now reveal that certain nucleoporins are actively involved in transcription insi

53 t the nanoscale organization and function of nucleoporins are context dependent in a way that is requ

54 Nucleoporins are essential components of the nuclear por

55 Nucleoporins are linked with cell-type-specific gene reg

56 se 1 (SENP1) and SENP2, we observe that many nucleoporins are mislocalized and, in some cases, reduce

57 e complex is disassembled and, increasingly, nucleoporins are proving to have mitotic functions when

58 We further show several nucleoporins are required for the complete assembly of R

59 and a lining of transport-factor-binding FG-nucleoporins are sufficient for selective transport, we

60 es and support the proposal that the adaptor nucleoporins arose from ancestral karyopherins.

61 Using nucleoporins as a paradigm for long-term protein persist

62 nt nucleoporins, and understanding how these nucleoporins assemble into the NPC scaffold imposes a fo

63 In the prepore model, nucleoporins assemble on the chromatin as an intermediat

64 We show that the spatial organization of FG nucleoporin assemblies with the transport proteins can b

65 We found that nucleoporin-associated SEs localize preferentially to th

66 duced gene expression patterns and chromatin-nucleoporin association, suggesting that Nup155-mediated

67 gene expression through changes in chromatin-nucleoporin association.

68 A subset of nucleoporins bear a domain with multiple phenylalanine-g

69 oci, Sec13, Nup98, and a subset of FG-repeat nucleoporins bind to developmentally regulated genes und

70 , and Nup88, as well as a group of FG-repeat nucleoporins, bind to the Drosophila genome at functiona

71 Overexpression of importin-beta, or of the nucleoporin-binding region, inhibited RANGAP1 recruitmen

72 The central region (harboring nucleoporin-binding sites) regulates microtubule dynamic

73 rus type 1 (HSV-1) capsids interact with the nucleoporin CAN/Nup214 in infected cells and that RNA si

74 Strikingly, we found that nucleoporins can be released from nuclear bodies and rei

75 the growing body of evidence that structural nucleoporins can have novel tissue-specific roles.

76 (Exportin-1), MEX67/MTR2 (TAP/p15), and five nucleoporins cause accumulation of unspliced tRNA, a hal

77 Importantly, recruitment of the bulk of FG nucleoporins, characteristic of mature nuclear pores, wa

78 ture of a reconstituted ~400-kilodalton coat nucleoporin complex (CNC) from Saccharomyces cerevisiae

79 e that the structured domains in the adaptor nucleoporin complex are held together by peptide interac

80 The human Nup107-160 nucleoporin complex plays a major role in formation of t

81 which is a TREX-2 homolog that is part of a nucleoporin complex, functions as part of a cryptic aspe

82 he interactions between the approximately 30 nucleoporins comprising the modular structure of the nuc

83 better understand how a family of "adaptor" nucleoporins--concentrically surrounding this channel--m

84 ec13, Nup75, Nup93, and Nup205, are scaffold nucleoporins considered important for the overall integr

85 Both nucleoporins contain a stretch of distinct, Ran-binding

86 ough the nuclear pore complex (NPC) requires nucleoporins containing natively unfolded phenylalanine-

87 Nucleoporins containing phenylalanine glycine (FG) repea

88 The RanBP2 nucleoporin contains an internal repeat domain (IR1-M-IR

89 Notably, each of the three nucleoporins contains additional nuclear pore complex bi

90 vity associated with a kinetochore-localized nucleoporin contributes to two key events that occur dur

91 provides mechanistic insights into how these nucleoporins coordinate nucleocytoplasmic transport to m

92 how via RNAi-mediated knockdown that ELYS, a nucleoporin critical for the recruitment of the essentia

93 rred to as cytoplasmic assemblies of PML and nucleoporins (CyPNs), after cell division.

94 P107 in ovarian development and suggest that nucleoporin defects may play a role in milder and more c

95 Similar studies with antibodies specific for nucleoporins demonstrated attenuation by antibodies spec

96 Nucleoporin depletions suggest that translocation throug

97 The cohesive nature of a human nucleoporin did not necessarily correlate with that of i

98 Here, we demonstrate specific defects in nucleoporin distribution in strains lacking Heh1p and He

99 a tethered layer of intrinsically disordered nucleoporin domains containing Phe-Gly (FG)-rich repeats

100 molecular assembly of intrinsically unfolded nucleoporin domains rich in phenylalanine-glycine dipept

101 It consists of nucleoporin domains rich in phenylalanine-glycine motifs

102 ween Saccharomyces cerevisiae Nup159 and the nucleoporin, Dyn2.

103 These "channel" nucleoporins each contain an ordered region of approxima

104 ndidates with high confidence, including the nucleoporin ELYS, lamin B1, and four proteins (emerin, M

105 : recruitment of the critical pore-targeting nucleoporin ELYS/MEL-28 to chromatin.

106 nucleoporins, we have identified a specific nucleoporin essential for P granule integrity and functi

107 In particular, Nup159, a nucleoporin exclusively located on the cytoplasmic side

108 e and neuronal differentiation, but how this nucleoporin exerts its function and whether it modulates

109 Besides the lack of nucleoporin expression and NPC turnover, we discovered a

110 N-terminal half of Nup98, which contains the nucleoporin FG/GLFG repeat motifs.

111 Intrinsically disordered Phe-Gly nucleoporins (FG Nups) within nuclear pore complexes exe

112 ffinity of Kapbeta1 to phenylalanine-glycine nucleoporins (FG Nups), which is comparable with RanGTP.

113 surface is composed of phenylalanine-glycine nucleoporins (FG Nups)--intrinsically disordered protein

114 inding disordered phenylalanine-glycine-rich nucleoporins (FG-Nups).

115 t roles of terminal unstructured segments in nucleoporins for the architecture, function, and assembl

116 s and also substituted FG domains from other nucleoporins for the Nup98 domain to directly compare co

117 sis by locally removing NPP-3 and associated nucleoporins from the NE.

118 d their role at nuclear pore complexes, some nucleoporins function in the nucleoplasm.

119 unexpected mechanistic complexities based on nucleoporin functions and specialized import and export

120 The nucleoporin gene NUP98 is fused to several genes includi

121 gous nonsense or splice-site variants in the nucleoporin genes NUP37, NUP43, and NUP188, which have n

122 tants was suppressed by deletion of specific nucleoporin genes.

123 Previously, we identified the nucleoporin gp210/Nup210 as a critical regulator of musc

124 They also indicate that nucleoporins have an active role in plant signaling.

125 pUL25 interacts with CAN/Nup214 and another nucleoporin, hCG1, and binds to the pUL36 and pUL6 prote

126 The Nsp1*Nup49*Nup57 channel nucleoporin heterotrimer (CNT) attaches to the IRC solel

127 a new role for the pore-associated SENPs in nucleoporin homeostasis and in achieving proper configur

128 l structure of a protein complex between two nucleoporins, human Nup107 and Nup133.

129 h Nup98a/b, two phenylalanine-glycine repeat nucleoporins implicated in maintaining the selective nuc

130 er of the NPC and supporting a role for this nucleoporin in the permeability barrier.

131 to the reversible accumulation of newly made nucleoporins in cytoplasmic foci.

132 We demonstrate that the roles of these nucleoporins in supporting Smad nuclear import are separ

133 ks between HEH1 and HEH2, and genes encoding nucleoporins in the membrane, inner, and outer ring comp

134 We characterize the behavior of the FG nucleoporins in vivo using polarized fluorescence micros

135 Previous work has shown that several nucleoporins, including Nup62 are degraded in cells infe

136 Surprisingly, many of these nucleoporins, including Sec13, Nup75, Nup93, and Nup205,

137 nd centrin 2 to associate biochemically with nucleoporins, including the Xenopus laevis Nup107-160 co

138 various conformational transitions of the FG nucleoporins induced by the cargo-carrying transport pro

139 core a yet-uncharacterized function of these nucleoporins inside the nucleus, even in cells that cont

140 on, suggesting that Nup192 possesses another nucleoporin interaction partner.

141 he importance of finely adjusted karyopherin-nucleoporin interactions for efficient cargo translocati

142 ecture and the molecular details of the coat nucleoporin interactions forming the central "triskelion

143 NPC and validating their placement with our nucleoporin interactome, we built a composite structure

144 here it acts with Cdk1 to hyperphosphorylate nucleoporin interfaces to promote NPC disassembly and nu

145 P-5 is dispensable for incorporation of most nucleoporins into nuclear pores and for nuclear protein

146 ccelerated during aging and that a subset of nucleoporins is oxidatively damaged in old cells suggest

147 his maintenance is limited, however, as some nucleoporin levels decrease during aging, providing a ra

148 Nup50, are continuously exchanged, scaffold nucleoporins, like the Nup107/160 complex, are extremely

149 sically disordered polypeptides, known as FG nucleoporins, lining its passageway.

150 These effects on nucleoporin localization are likely of functional import

151 or Nup358, the two major Phe-Gly (FG) repeat nucleoporins localized on the cytoplasmic side of the NP

152 actions between the structured core scaffold nucleoporins, mediate the assembly of the inner ring com

153 velope, to uncover an intriguing role of the nucleoporin MEL-28 in mediating chromosome segregation v

154 how that the conserved kinetochore-localized nucleoporin MEL-28/ELYS docks the catalytic subunit of p

155 NE lumen is sufficient to suppress both the nucleoporin mislocalization and growth defects in heh1De

156 This is the first evidence for a nucleoporin modulating the import reaction by directly a

157 re reproducibly enriched with AAL, including nucleoporins, mRNA-processing enzymes, and cell-signalin

158 he defect in the yeast temperature-sensitive nucleoporin mutant nup159.

159 Finally, we used different anti-nucleoporin nanobodies to purify the major NPC building

160 eraction partners of the yeast transmembrane nucleoporin Ndc1.

161 LBR), MAN1, Lap2beta, and the trans-membrane nucleoporins Ndc1 and POM121 drive the spreading of ER m

162 taches to the IRC solely through the adaptor nucleoporin Nic96.

163 rest is suppressed in mutant embryos lacking nucleoporin NPP-16/NUP50 function, indicating that this

164 terest, this screen revealed that the Nup205 nucleoporin NPP-3 can negatively modulate the timing of

165 We identify the central channel nucleoporins NPP-1/Nup58, NPP-4/Nup54, and NPP-11/Nup62

166 s hindered by the phenylalanine-glycine (FG) nucleoporin (Nup) barrier unless molecules are chaperone

167 The ceNXF2 NTF2 domain bears at least two nucleoporin (Nup) binding pockets necessary for the colo

168 idely expressed variant of the transmembrane nucleoporin (Nup) Pom121 (named sPom121, for "soluble Po

169 , we provide evidence that the transmembrane nucleoporin (Nup), POM121, but not the Nup107-160 comple

170 ase and two Cdk phosphorylation sites in the nucleoporin Nup1 were required for peripheral targeting

171 promoted by the interaction of Drg1 with the nucleoporin Nup116.

172 Here we report that a null allele of mouse nucleoporin Nup133, a structural subunit of the NPC, dis

173 Here we show that the nucleoporin Nup153 interacts with Sox2 in adult NeuPCs,

174 We find the dynamics of nucleoporin Nup153 to be regulated so as to produce rapi

175 th its CID and MCM3AP domains, together with nucleoporin Nup153.

176 Although SNX9 does not bind nucleoporins Nup153 or Nup214 or some beta importins (Im

177 ermined the crystal structure of one adaptor nucleoporin, Nup157.

178 r pore assembly through its interaction with nucleoporin Nup159.

179 PCs) during interphase is facilitated by the nucleoporin Nup2 via its importin alpha- and Ran-binding

180 The transmembrane nucleoporin Nup210 is absent in proliferating myoblasts

181 proteins interacted with CRM1, Ran, and the nucleoporin NUP214 in a manner fundamentally different f

182 LNO1, a homolog of the nucleoporin NUP214 in human (Homo sapiens) and Nup159 in

183 indicate that a 137-amino-acid region of the nucleoporin Nup214 is a binding site for the major AdV c

184 filaments of the NPC that is mediated by the nucleoporin Nup214.

185 nism requires the phenylalanine-glycine (FG)-nucleoporin Nup35, which is consistent with use of the n

186 ore stable, higher affinity complex with the nucleoporin Nup358/RanBP2 that preferentially protects i

187 characterized the species-specific scaffold nucleoporin Nup37 and ELY5/ELYS.

188 tion proceeds through the acquisition of the nucleoporin Nup37.

189 Finally, we showed that mutation of the nucleoporin Nup50 increased the lifespan of TDP-43 trans

190 work, we have studied the interaction of the nucleoporin Nup50 with importin alpha5.

191 d two alternative complexes with the soluble nucleoporins Nup53 and Nup59, which in turn bind to Nup1

192 d domain in interaction with another channel nucleoporin (Nup54) and a transport factor (Kapbeta1).

193 We recently showed that the three "channel" nucleoporins, Nup54, Nup58, and Nup62, interact with eac

194 nsport, which is thought to consist of three nucleoporins, Nup54, Nup58, and Nup62.

195 ing between a structured domain of a channel nucleoporin (Nup58) and its neighboring disordered domai

196 ires the DNA sequence of the contacted gene, nucleoporins Nup60 and Nup2, and cohesin.

197 We find that the nucleoporin Nup62 and the C termini of the nephronophthi

198 , finding that ICP27 directly binds the core nucleoporin Nup62.

199 Three out of approximately 30 nucleoporins, Nup62, Nup54, and Nup58, line the nuclear

200 Here we show that the conserved nucleoporin Nup93 is essential for NPC assembly and conn

201 teraction between HCV capsid protein and the nucleoporin Nup98 at cytosolic lipid droplets that is im

202 ists of an N-terminal FG-rich portion of the nucleoporin NUP98 fused to the homeodomain region of the

203 ecule mRNA analyses, we demonstrate that the nucleoporin Nup98 is required for full expression of p21

204 In this issue, Singer et al. reveal that the nucleoporin Nup98 supports adaptation to genotoxic stres

205 We find a contribution of the nucleoporin Nup98 to mitotic spindle assembly through re

206 One such nucleoporin, Nup98, binds chromatin and regulates gene e

207 Nucleoporins (Nups) are a family of proteins best known

208 Recent studies have shown that a subset of nucleoporins (Nups) can detach from the nuclear pore com

209 addition to mediating transport, a subset of nucleoporins (Nups) engage in transcriptional activation

210 Intrinsically disordered nucleoporins (Nups) form a selective filter inside the N

211 tive studies have unveiled a full catalog of nucleoporins (Nups) that comprise the NPC, structural ar

212 NPCs lacking these nucleoporins (Nups) were blocked from entry into the dau

213 In ooc-5-mutant germ cell nuclei, nucleoporins (Nups) were mislocalized in large plaques b

214 The NPC channels are lined with nucleoporins (Nups) with extended FG (Phe-Gly) motif rep

215 Of approximately 30 nucleoporins (Nups), 15 are structured and form the Y an

216 embled from approximately 30 proteins termed nucleoporins (Nups), mediates selective nucleocytoplasmi

217 They are formed by about 30 nucleoporins (Nups), which can be roughly categorized in

218 ose of nuclear transport and is dependent on nucleoporins (NUPs), which comprise a ciliary pore compl

219 by nuclear pore complexes (NPCs) made up of nucleoporins (NUPs).

220 led from multiple copies of approximately 30 nucleoporins (Nups).

221 f approximately 30 different proteins called nucleoporins (Nups).

222 tures composed of approximately 30 proteins (nucleoporins [Nups]).

223 About 30 different proteins (nucleoporins, nups) arrange around a central eightfold r

224 The cytoplasmic filament nucleoporins of the nuclear pore complex (NPC) are criti

225 fragments of three cytoplasmically oriented nucleoporins of yeast: Nup82, Nup116, and Nup159.

226 perphosphorylation of nuclear pore proteins (nucleoporins or Nups), including Nup62, Nup153, and Nup2

227 one another and a subset of NPC components (nucleoporins or Nups).

228 m approximately 30 different proteins called nucleoporins or Nups.

229 ear envelope and composed of proteins termed nucleoporins (or "Nups"), and (2) nuclear transport fact

230 i from orthogonal perspectives revealed that nucleoporin p62 (NUP62) and nucleoporin 214 (NUP214) are

231 Herein, we show that partial knockdown of nucleoporin p62 (NUP62) by small-interfering RNA confers

232 gene expression profiling has revealed that nucleoporin p62 (NUP62) transcripts are decreased in the

233 alyses revealed the presence of fibrillarin, nucleoporin p62, and La in BIG1 and nucleolin immunoprec

234 ith dysplasia, but the immunoreactivities of nucleoporin p62, DEP-domain containing protein 5, clathr

235 its shape and dimensions to that of another nucleoporin pair, Sec13*Nup145C.

236 DRA2, together with other nucleoporins, participates positively in the control of

237 lls, showed reproducibly altered patterns of nucleoporin phosphorylation.

238 We conclude that nucleoporins play an unanticipated regulatory role in NE

239 NPP-16/NUP50 function, indicating that this nucleoporin plays an important role in prophase arrest i

240 Conversely, the transmembrane nucleoporin POM121 is critical for the incorporation of

241 cadherin-like lumenal domain of the membrane nucleoporin Pom152p.

242 yeast (Saccharomyces cerevisiae), encodes a nucleoporin protein containing phenylalanine-glycine rep

243 ular mRNA translation and cleavage of select nucleoporin proteins (Nups) within nuclear pore complexe

244 including the cleavage of Phe/Gly-containing nucleoporin proteins (Nups) within nuclear pore complexe

245 ring position of the unfolded domains of the nucleoporin proteins (the FG-Nups), which control select

246 lone, several regulatory factors (e.g., RNA, nucleoporin proteins, and the endogenous small molecule

247 raction of RanGAP1 stably interacts with the nucleoporin RanBP2 at a binding site that is flanked by

248 We show an unexpected function of a nucleoporin, RanBP2, in maintaining BA homoeostasis thro

249 nteraction and upstream or at the time of FG nucleoporin recruitment.

250 Thus, we have delineated the nucleoporin requirement of MAD nuclear import, reflectin

251 ently tagging specific domains of individual nucleoporins revealed both rigid and flexible domains: t

252 crystallographic analysis of these scaffold nucleoporins revealed the molecular details of their int

253 Here we show that the nucleoporins Sec13, Nup98, and Nup88, as well as a group

254 a novel interacting partner of the conserved nucleoporin Seh1 and add to the growing body of evidence

255 ssue-specific requirement for the structural nucleoporin Seh1 during Drosophila oogenesis.

256 FG domains from several human nucleoporins showed no interactions in this assay; howev

257 Nup192 is a major component of an adaptor nucleoporin subcomplex proposed to link the NPC coat wit

258 nt mediates interactions with the Nup107-160 nucleoporin subcomplex.

259 We further define the nucleoporin subunit targets for transportin and importin

260 C revealed an early pore intermediate where nucleoporin subunits POM121 and the Nup107-160 complex w

261 PC) during interphase and to require certain nucleoporins, such as Tpr in animal cells, to properly l

262 Using nucleoporins tagged with green fluorescent protein along

263 the sole E2 for SUMOylation, and of TPR, the nucleoporin that forms the basket on the nuclear side of

264 Nup214/CAN, a nucleoporin that is found at the cytoplasmic side of the

265 known interaction between Nek2 and Nup98, a nucleoporin that localizes to the ciliary base, is impor

266 Nup358 is a metazoan-specific nucleoporin that localizes to the cytoplasmic filaments

267 omal region is the gene coding for Nup214, a nucleoporin that localizes to the cytoplasmic side of th

268 NUP98 is a nucleoporin that plays complex roles in the nucleocytopl

269 Nup153 is the nucleoporin that provides this scaffold for Nup50.

270 enylalanine-glycine (GLFG) repeat-containing nucleoporin that, in addition to nuclear transport, cont

271 Furthermore, we discovered that NPP-3 and nucleoporins that are associated with it are lost from t

272 re related and evolutionary conserved, large nucleoporins that are part of the NPC scaffold.

273 rties of intrinsically disordered regions of nucleoporins that bind transport factors.

274 eaturing an octagonal symmetry involving the nucleoporins that constitute the NPC ring.

275 Here we identify a subset of nucleoporins that, in conjunction with Msk (Drosophila I

276 length of the nanopore region coated with FG-nucleoporins, the binding strength to FG-nucleoporins, a

277 Recent evidence indicates that structural nucleoporins, the building blocks of the NPC, have a var

278 te regions of GANP show local homology to FG nucleoporins, the yeast mRNA export factor Sac3p, and th

279 association of identified target genes with nucleoporins through interaction with Nup155.

280 s indirect tethering to FG-repeat-containing nucleoporins through karyopherins.

281 lates the affinity of the import complex for nucleoporins, thus dictating its persistence inside the

282 Here we show that the addition of the Nup210 nucleoporin to NPCs during myoblast differentiation resu

283 eractome, allowing assignment of trypanosome nucleoporins to discrete NPC substructures.

284 and the NTF2-like and UBA domains binding FG-nucleoporins to facilitate movement through nuclear pore

285 complex to the region that interacts with FG-nucleoporins to facilitate passage through nuclear pores

286 Cleaved p75(NTR) interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttlin

287 ed by cross-linking highly O-GlcNAc-modified nucleoporins to proteins involved in nuclear transport.

288 g is required to increase the trafficking of nucleoporins to the cell cortex in stressed or meiotical

289 ce relieved by heterogeneous dissociation of nucleoporins to yield NPC-denuded ER domains competent a

290 describe the link between the nuclear basket nucleoporins (Tpr and Nup153) and chromatin organization

291 blies formed from approximately 30 different nucleoporins, typically organized in subcomplexes.

292 In an RNAi screen against nucleoporins, we have identified a specific nucleoporin

293 Using recombinant nucleoporins, we show that Sp-Nup37 specifically binds t

294 Ubiquitin and nucleoporins were identified as distinctively localizing

295 s has particular relevance for the FG domain nucleoporins, which are crucial for nucleocytoplasmic tr

296 approximately 30 different proteins, termed nucleoporins, which assemble to form one of the largest

297 or-cargo complexes that specifically bind FG-nucleoporins, while significantly inhibiting the passage

298 RanBP2 is a nucleoporin with SUMO E3 ligase activity that functions

299 e by regulating the distribution of specific nucleoporins within the nuclear pores.

300 egments ("protomers") of the three "channel" nucleoporins yielded a model for how this channel is con