ライフサイエンスコーパス: nucleoside hydrolase

1 ide hydrolase from Crithidia fasciculata (IU-nucleoside hydrolase).

2 the inosine-uridine nucleoside hydrolase (IU-nucleoside hydrolase).

3 tate analogue inhibitors for purine-specific nucleoside hydrolase.

4 novani nucleoside hydrolase as a nonspecific nucleoside hydrolase.

5 conserved among the characterized protozoan nucleoside hydrolases.

6 o nonspecific and uridine-inosine-preferring nucleoside hydrolases.

7 minoribitol inhibitors yet described for the nucleoside hydrolases.

8 olysis of the N-ribosidic bond using several nucleoside hydrolases.

9 njunction with a mass selective detector for nucleoside hydrolase, a purine-metabolizing enzyme.

10 ico studies suggest that HopQ1 might possess nucleoside hydrolase activity based on the presence of a

11 Although the conservation of the nucleoside hydrolases among protozoan parasites offers p

12 ng enzymes of therapeutic importance such as nucleoside hydrolases and purine nucleoside phosphorylas

13 tructure is similar to the C. fasciculata IU-nucleoside hydrolase apoenzyme.

14 Nucleoside hydrolases are involved in nucleoside salvage

15 e specificity data identify this L. donovani nucleoside hydrolase as a nonspecific nucleoside hydrola

16 rovide nanomolar inhibition constants for IU-nucleoside hydrolase exhibit micromolar inhibition const

17 IU-nucleoside hydrolase from C. fasciculata and the protein

18 structure of the nonspecific inosine-uridine nucleoside hydrolase from Crithidia fasciculata (IU-nucl

19 IU-nucleoside hydrolase from Crithidia fasciculata and the

20 The nonspecific nucleoside hydrolase from Crithidia fasciculata cocrysta

21 s 78% sequence identity with the nonspecific nucleoside hydrolase from Crithidia fasciculata.

22 itors are also described for the nonspecific nucleoside hydrolase from Crithidia fasciculata.

23 The full-length cDNA for nucleoside hydrolase from Leishmania major was cloned an

24 -nanomolar inhibitor for the purine-specific nucleoside hydrolase from Trypanosoma brucei brucei.

25 a purine-specific nucleoside hydrolase (IAG-nucleoside hydrolase) from Trypanosoma brucei brucei.

26 The mechanism of action of inosine-uridine nucleoside hydrolase has been investigated by long-term

27 The amino acid sequence for IU-nucleoside hydrolase has no close relatives among the kn

28 olysis of the N-ribosidic bond of inosine by nucleoside hydrolase has oxocarbenium character and a pr

29 e-specific and purine/pyrimidine-nonspecific nucleoside hydrolases have been reported.

30 , BxpC, CotY, and inosine-uridine-preferring nucleoside hydrolase; however, these spores retained hal

31 ism of action of inosine-adenosine-guanosine nucleoside hydrolase (IAG-NH) has been investigated by l

32 ed for this enzyme and for a purine-specific nucleoside hydrolase (IAG-nucleoside hydrolase) from Try

33 rugs, the existence of multiple and distinct nucleoside hydrolases in a single species demands specia

34 Nucleoside hydrolase is a central enzyme in the purine s

35 IU-nucleoside hydrolase is composed of a mixed eight-strand

36 The most abundant nucleoside hydrolase is relatively nonspecific but prefe

37 Several protozoan nucleoside hydrolase isozymes with distinct substrate sp

38 Inosine-uridine nucleoside hydrolase (IU-NH) catalyzes the hydrolysis of

39 dimensional structure of the inosine-uridine nucleoside hydrolase (IU-NH) from C. fasciculata determi

40 Crithidia fasciculata is the inosine-uridine nucleoside hydrolase (IU-nucleoside hydrolase).

41 ibitors are isozyme-specific, with (Km/Ki IU-nucleoside hydrolase)/(Km/Ki IAG-nucleoside hydrolase) v

42 Nucleoside hydrolases may play a crucial role in that sa

43 Like the nucleoside hydrolases NUCLEOSIDE HYDROLASE1 (NSH1) and N

44 Binding of these inhibitors to nonspecific nucleoside hydrolase occurs primarily via interaction wi

45 The crystal structure of the L. major nucleoside hydrolase revealed a bound Ca(2+) ion in the

46 sequence analysis revealed that the L. major nucleoside hydrolase shares 78% sequence identity with t

47 de hydrolase was identified as a nonspecific nucleoside hydrolase since it demonstrates the character

48 h (Km/Ki IU-nucleoside hydrolase)/(Km/Ki IAG-nucleoside hydrolase) values up to 39,000.

49 The L. major nucleoside hydrolase was identified as a nonspecific nuc

50 Further, the nucleoside hydrolase was localized to specific foci in L