ライフサイエンスコーパス: nucleoside transporter

1 ucleoside kinase as well as an equilibrative nucleoside transporter.

2 database may function as a broadly selective nucleoside transporter.

3 d dipyridamole-sensitive human equilibrative nucleoside transporter.

4 boside (NBMPR), a potent inhibitor of the es nucleoside transporter.

5 was taken up inefficiently through a P1-type nucleoside transporter.

6 ties from previously characterized mammalian nucleoside transporters.

7 emichannels, ABC protein family members, and nucleoside transporters.

8 nd formation over 3'-OH is essential for all nucleoside transporters.

9 lated in sequence to mammalian equilibrative nucleoside transporters.

10 genes encode functional adenosine/pyrimidine nucleoside transporters.

11 of a substrate-binding site in Na+-dependent nucleoside transporters.

12 diated by both facilitated and Na+-dependent nucleoside transporters.

13 confirmed that AICAr enters cells via purine nucleoside transporters.

14 lyzed the expression and activity of various nucleoside transporters.

15 equilibrative (ENT) and concentrative (CNT) nucleoside transporters.

16 purines from their hosts via nucleobase and nucleoside transporters.

17 ansporter 1 (SGLT1) and of the concentrative nucleoside transporter 1 (CNT1) in the plasma membrane b

18 Erythrocyte equilibrative nucleoside transporter 1 (eENT1) levels are reduced in h

19 They import purines via equilibrative nucleoside transporter 1 (ENT1) homologs.

20 e of ticagrelor inhibiting the equilibrative nucleoside transporter 1 (ENT1) on platelets, leading to

21 Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleos

22 iant of adenosine transporter, equilibrative nucleoside transporter 1 (ENT1), was associated with the

23 y preventing the expression of equilibrative nucleoside transporter 1 (ENT1).

24 last extracellular loop of the equilibrative nucleoside transporter 1 (ENT1; also called SLC29a1) is

25 nd substrate interactions with equilibrative nucleoside transporter 1 (ENT1; SLC29A1) are known to be

26 transporter 1 (hENT1) or human concentrative nucleoside transporter 1 (hCNT1), when stably expressed

27 We identified the human equilibrative nucleoside transporter 1 (hENT1) as the most abundant nu

28 The human equilibrative nucleoside transporter 1 (hENT1) is an important modulat

29 reviously shown that the human equilibrative nucleoside transporter 1 (hENT1) is expressed and functi

30 nucleoside transporters, human equilibrative nucleoside transporter 1 (hENT1) or human concentrative

31 trations specifically to human equilibrative nucleoside transporter 1 (hENT1) produced in recombinant

32 ansport was dominated by human equilibrative nucleoside transporter 1 (hENT1) under both growth condi

33 de the activities of the human equilibrative nucleoside transporter 1 (hENT1), deoxycytidine kinase (

34 The expression of human equilibrative nucleoside transporter 1 (hENT1), thymidine kinase 1 (TK

35 ing thymidine kinase and human equilibrative nucleoside transporter 1 (hENT1).

36 The Plasmodium falciparum Equilibrative Nucleoside Transporter 1 (PfENT1) is a member of the equ

37 inhibited adenosine uptake via equilibrative nucleoside transporter 1 and synergistically enhanced ad

38 confirm that CBD binds to the equilibrative nucleoside transporter 1 with a Ki < 250 nM.

39 ing the PPM transporter PfNT1 (P. falciparum nucleoside transporter 1) are auxotrophic for hypoxanthi

40 xogenous apical protein, CNT1 (concentrative nucleoside transporter 1), and found no increase in CNT1

41 xin43, connexin37, pannexin-1, equilibrative nucleoside transporter 1, CD39, CD73, ecto-nucleotide py

42 f vesicles containing SGLT1 or concentrative nucleoside transporter 1.

43 mputational model of the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1) that captured this

44 smembrane domains of the Leishmania donovani nucleoside transporter 1.1, LdNT1.1, which transports ad

45 inically used vasodilator with equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2) inhibito

46 y transfected the cloned human equilibrative nucleoside transporters 1 and 2 (hENT1 and hENT2) into n

47 side transporter family member equilibrative nucleoside transporter-1 (ENT1) in the regulation of car

48 ly and directly inhibiting the equilibrative nucleoside transporter-1 (ENT1).

49 iscovered a role for the human concentrative nucleoside transporter-1 (hCNT1; SLC28A1), a high-affini

50 Low expression of human equilibrative nucleoside transporter-1 (hENT1) may result in gemcitabi

51 hat are deficient in the human equilibrative nucleoside transporter-1, the IC(50) of GemC18-NPs was o

52 ine-guanosine-specific Crithidia fasciculata nucleoside transporter 2 (CfNT2) that had gained the abi

53 ansport was dominated by human equilibrative nucleoside transporter 2.

54 eoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in

55 we found that mice lacking the equilibrative nucleoside transporter 3 (ENT3) developed a spontaneous

56 lationship (QSAR) of the human concentrative nucleoside transporter 3 (hCNT3) expressed in Xenopus la

57 We tested the hypothesis that endothelial nucleoside transporter acts as a barrier impeding the de

58 ve epithelial differentiation, expression of nucleoside transporters affecting gemcitabine response,

59 ptake depends predominantly on equilibrative nucleoside transporters after conversion of AMP to adeno

60 Significantly, PfNT1, unlike the mammalian nucleoside transporters, also has the capacity to transp

61 tance is reduced uptake into tumor cells via nucleoside transporters, although precise mechanisms are

62 oped through reduced RBV uptake via the ENT1 nucleoside transporter and antiviral efficacy was reduce

63 s are regulated by a close interplay between nucleoside transporters and adenosine kinase.

64 tion and isolation of DNAs encoding parasite nucleoside transporters and the functional characterizat

65 f inosine did not require cellular uptake by nucleoside transporters and was partially reversed by bl

66 omorphic consequences of dysfunction of this nucleoside transporter, and importantly suggests a new m

67 ess dependent on deoxycytidine kinase and on nucleoside transporters, and it was resistant to cytidin

68 Equilibrative nucleoside transporters are a unique family of proteins

69 data provide the first direct evidence that nucleoside transporters are able to critically modulate

70 Nucleoside transporters are likely to play a central rol

71 trate that the NBMPR-sensitive equilibrative nucleoside transporters are novel and unexpected targets

72 (TMD 5), using a GFP-tagged hENT1 in a yeast nucleoside transporter assay system.

73 at this can be overcome with dipyridamole, a nucleoside transporter blocker.

74 nal fluid (CSF) containing inhibitors of the nucleoside transporter but not with this solution plus a

75 Inhibition of nucleoside transporters by a series of uridine and adeno

76 tor agonists and inhibition of equilibrative nucleoside transporters by dipyridamole may have therape

77 tivity (LdNT1) to clone genes encoding these nucleoside transporters by functional rescue.

78 ndent and was inhibited by the concentrative nucleoside transporter (CNT) blocker phloridzin but not

79 transporter (ENT) ENT1 or the concentrative nucleoside transporter (CNT) CNT3.

80 Members of the concentrative nucleoside transporter (CNT) family (SLC28) mediate the

81 The human SLC28 family of concentrative nucleoside transporter (CNT) proteins has three members:

82 ne transporter proteins, human concentrative nucleoside transporter (CNT)1, CNT2, and CNT3, all of wh

83 em L and system y+L amino acid carriers; the nucleoside transporters cNT1 and 2, eNT1 and 2, and the

84 how differential expression of concentrative nucleoside transporters (CNT1 and CNT2) prompted us to s

85 The concentrative nucleoside transporter, CNT1 (SLC28A1), mediates the cel

86 Concentrative nucleoside transporters (CNTs) and equilibrative nucleos

87 Concentrative nucleoside transporters (CNTs) are responsible for cellu

88 transporters 1 and 2 (hENT1 and hENT2) into nucleoside transporter-deficient PK15NTD cells.

89 , purine nucleoside selective, concentrative nucleoside transporter (designated mCNT2).

90 The N1, N2, and N3 Na+-nucleoside transporters differ in substrate selectivity.

91 The N1, N2, and N3 Na+-dependent nucleoside transporters differ in terms of their transpo

92 riboside (NBMPR)-insensitive, equilibrative nucleoside transporter ei by functional complementation

93 Equilibrative nucleoside transporters encompass two conserved, charged

94 cker phloridzin but not by the equilibrative nucleoside transporter (ENT) blocker dipyridamole.

95 g intracellular uptake via the equilibrative nucleoside transporter (ENT) ENT1 or the concentrative n

96 ed transporter assigned to the equilibrative nucleoside transporter (ENT) family (SLC29).

97 Transporters of the equilibrative nucleoside transporter (ENT) family promote the uptake o

98 er (PMAT) that belongs to the equillibrative nucleoside transporter (ENT) family.

99 1 (PfENT1) is a member of the equilibrative nucleoside transporter (ENT) gene family.

100 cloned human NBMPR-sensitive, equilibrative nucleoside transporter ENT1 and thus was designated ENT2

101 ed the positive correlation between SLC29A1 (nucleoside transporter ENT1) expression and potency of n

102 uptake, because of reduced expression of the nucleoside transporters ENT1 and CNT1.

103 adenosine transporter, type 1 equilibrative nucleoside transporter (ENT1), drink more ethanol compar

104 lthioinosine (NBMPR)-sensitive equilibrative nucleoside transporter (ENT1), incubation with SB203580

105 aling by inhibiting the type 1 equilibrative nucleoside transporter (ENT1), whereas chronic ethanol e

106 isoform of the NBMPR-sensitive equilibrative nucleoside transporter (ENT1).

107 o the function of 6BT as an inhibitor of the nucleoside transporter, ent1, which is thought to preven

108 te into cells deficient in the equilibrative nucleoside transporter ENT2, and reconstitution of ENT2

109 by increasing the activity of an alternative nucleoside transporter, ENT2.

110 eoside transporters (CNTs) and equilibrative nucleoside transporters (ENTs) are important in physiolo

111 Equilibrative nucleoside transporters (ENTs) are polytopic integral me

112 onsistent with the notion that equilibrative nucleoside transporters (ENTs) terminate adenosine signa

113 Equilibrative nucleoside transporters (ENTs) translocate hydrophilic n

114 cellular compartment by way of equilibrative nucleoside transporters (ENTs), we hypothesized a functi

115 rminated by its uptake through equilibrative nucleoside transporters (ENTs).

116 translocation of adenosine via equilibrative nucleoside transporters (ENTs).

117 show that Slc29a1 (ENT-1) is the predominant nucleoside transporter expressed in the mouse testis.

118 ee transport mechanisms of the equilibrative nucleoside transporter family by which nucleosides and n

119 onstration that members of the equilibrative nucleoside transporter family can be electrogenic and es

120 Permeases of the equilibrative nucleoside transporter family mediate the uptake of nucl

121 us studies have implicated the equilibrative nucleoside transporter family member equilibrative nucle

122 Permeases belonging to the equilibrative nucleoside transporter family promote uptake of nucleosi

123 irst mammalian examples of the equilibrative nucleoside transporter family to be characterized, hENT1

124 LdNT2 is a member of the equilibrative nucleoside transporter family, which possesses several c

125 low homology to members of the equilibrative nucleoside transporter family.

126 logous to other members of the equilibrative nucleoside transporter family.

127 mology to other members of the equilibrative nucleoside transporter family.

128 ar to members of the mammalian equilibrative nucleoside transporter family.

129 erates in other members of the equilibrative nucleoside transporter family.

130 s, like PfNT1, a member of the equilibrative nucleoside transporter family.

131 ani express two members of the equilibrative nucleoside transporter family; LdNT1 encoded by two clos

132 t required adenosine uptake by equilibrative nucleoside transporters followed by its (intracellular)

133 ion of a proton-dependent, broadly selective nucleoside transporter from Caenorhabditis elegans.

134 Previous genetic studies on the LdNT1.1 nucleoside transporter from Leishmania donovani defined

135 Asp389 and Arg393 residues within the LdNT2 nucleoside transporter from Leishmania donovani were mut

136 and outward-facing states of a concentrative nucleoside transporter from Neisseria wadsworthii.

137 We have identified a gene encoding a nucleoside transporter from P. falciparum, PfNT1, and an

138 ent the crystal structure of a concentrative nucleoside transporter from Vibrio cholerae in complex w

139 rent M, 55,000 is immunologically related to nucleoside transporters from several other species and t

140 fui1Delta cells lacking the plasma membrane nucleoside transporter Fui1 confers sensitivity to the t

141 d residue of hENT1 that is important in both nucleoside transporter function and sensitivity to inhib

142 ase transporter gene or both NT3 and the NT2 nucleoside transporter gene resulted in pronounced upreg

143 TbNT2, implying the existence of a family of nucleoside transporter genes in these parasites.

144 The canalicular Na+-dependent purine nucleoside transporter has been cloned from rat liver.

145 Furthermore, nucleoside transporters have been implicated in the upta

146 s that human concentrative and equilibrative nucleoside transporters (hCNT1 and hENT1) are present on

147 sequence identity to the human facilitative nucleoside transporter hENT1.

148 relating its uptake with human equilibrative nucleoside transporter (hENT1) levels, stromal reaction,

149 The human equilibrative nucleoside transporter (hENT1) protein transports gemcit

150 nase gene (hsv-tk) and a human equilibrative nucleoside transporter (hENT1).

151 A knockdown experiments demonstrate that the nucleoside transporter, hENT1, plays a key role in the c

152 The human equilibrative nucleoside transporter, hENT1, which is sensitive to inh

153 Human nucleoside transporters (hNTs) mediate cellular influx o

154 sis, we have sought to determine whether the nucleoside transporters, human equilibrative nucleoside

155 e transporter 1 (hENT1) as the most abundant nucleoside transporter in leukemia cell lines and in AML

156 l inhibits uptake of adenosine by a specific nucleoside transporter in NG108-15 neuroblastoma x gliom

157 To investigate the putative role of nucleoside transporters in the regulation of excitatory

158 (hCNT1; SLC28A1), a high-affinity pyrimidine nucleoside transporter, in determining the chemosensitiv

159 ative 5-azacytidine-5'-elaidate (CP-4200), a nucleoside transporter-independent drug, persisted after

160 treating CD56(bright)CD16(-) NK cells with a nucleoside transporter inhibitor, which increase extrace

161 OV-3 cells to dipyridamole, an equilibrative nucleoside transporter inhibitor; APCP, a CD73 (ecto-5'-

162 ls should assist the design of high-affinity nucleoside transporter inhibitors and substrates for bot

163 icantly enhanced in the presence of the ENT1 nucleoside transporter inhibitors dipyridamole and NBTI

164 ighly sensitive to inhibition by the classic nucleoside transporter inhibitors dipyridamole and nitro

165 oupled nucleoside transport by concentrative nucleoside transporters is unknown.

166 cate that this phenomenon is mediated by the nucleoside transporters LdNT1 and LdNT2, as well as by t

167 at encode high affinity adenosine-pyrimidine nucleoside transporters LdNT1.1 and LdNT1.2 and that tra

168 nally constrained analogues of the potent es nucleoside transporter ligand, nitrobenzylmercaptopurine

169 Fun26, a homolog of human ENT (equilibrative nucleoside transporter), localizes to the vacuolar membr

170 , adenosine deaminase, and the equilibrative nucleoside transporter: mature receptors with complex gl

171 Na+-dependent nucleoside transporters mediate the intracellular uptake

172 Concentrative nucleoside transporters, members of the solute carrier t

173 Recent publications suggest that nucleoside transporters might influence uptake and there

174 This gene encodes a nucleoside transporter, mutations in which cause histioc

175 us uridine and the specific inhibitor of the nucleoside transporter, nitrobenzylthioinosine, did not

176 5 as well as Nitrobenzylthioinosine (NBMPR - nucleoside transporter (NT) inhibitor).

177 lass of integral membrane proteins, known as nucleoside transporters (NTs), for specific transport ac

178 Equilibrative nucleoside transporters of the SLC29 family play importa

179 lar cloning has isolated two subtypes of Na+-nucleoside transporters; one is pyrimidine-selective (N2

180 laevis oocytes expressing the P. falciparum nucleoside transporter PfNT1 established that this trans

181 Equilibrative nucleoside transporters play essential roles in nutrient

182 transport of adenosine through equilibrative nucleoside transporter, raised the measured extracellula

183 entity to each other and to TbNT2, a P1 type nucleoside transporter recently identified in our labora

184 The rat equilibrative nucleoside transporter (rENT1) was revealed by antibody

185 dium-dependent, purine nucleoside selective, nucleoside transporters, respectively.

186 neurons, the expression profile of specific nucleoside transporter subtypes such as ENT1 is not esta

187 We have cloned the gene for a T. brucei nucleoside transporter, TbNT2, and shown that this perme

188 oved to be a broad selectivity, low affinity nucleoside transporter that could also transport adenine

189 ENT1 is an equilibrative nucleoside transporter that enables trans-membrane bi-di

190 nsported into hepatocytes by a Na+-dependent nucleoside transporter that is present in the canalicula

191 has the substrate specificity of the P1 type nucleoside transporters that have been previously charac

192 se models with dipyridamole, an inhibitor of nucleoside transporters that potentiates extracellular a

193 To determine the location of the PfNT1 nucleoside transporter, the first component of the nucle

194 ify hENT3 as a mitochondrial and a lysosomal nucleoside transporter, the precise connections between

195 table to the direct release of adenosine via nucleoside transporters; the release of adenine nucleoti

196 que pharmacophore models for each respective nucleoside transporter were generated.

197 scherichia coli mutant that lacked all known nucleoside transporters, whereas a phtD(+) allele did no

198 Recently, we constructed a broadly selective nucleoside transporter which accepts both purine and pyr

199 osine transporter ENT1 (type 1 equilibrative nucleoside transporter), which provides protection for a

200 PfNT1 encodes a functional purine/pyrimidine nucleoside transporter whose expression is strongly deve

201 selective, hENT2 is a generally low affinity nucleoside transporter with 2.6-, 2.8-, 7.7-, and 19.3-f

202 ally and biochemically that LdNT2 is a novel nucleoside transporter with an unusual and strict specif

203 This can be overcome by blocking the nucleoside transporter with dipyridamole.