ライフサイエンスコーパス: nucleosome

1 e nucleosome, illuminating the origin of the nucleosome.

2 TD) on the Tudor domain interaction with the nucleosome.

3 ve cleft on the histone H2A-H2B dimer in the nucleosome.

4 am re-positioning of RNAPII further into the nucleosome.

5 gnize CENP-A in the context of a rare CENP-A nucleosome.

6 and without irreversibly disrupting the host nucleosome.

7 with both histone and DNA components of the nucleosome.

8 tails to more interior positions within the nucleosome.

9 alized with a single SWR1 complex bound to a nucleosome.

10 o the 5-side of that found in mixed-sequence nucleosomes.

11 e insights into the transition to eukaryotic nucleosomes.

12 estion and association with H3K4me3-modified nucleosomes.

13 complexes, with little evidence for fragile nucleosomes.

14 sitioned nucleosomes and/or H2A.Z-containing nucleosomes.

15 k between immunogenicity and specificity for nucleosomes.

16 sensitivity and discriminate between DNA and nucleosomes.

17 l centromeric chromatin structures from bulk nucleosomes.

18 n site-specific recognition of ubiquitylated nucleosomes.

19 ucleosomes are digested faster than G/C-rich nucleosomes.

20 ng nucleosomal DNA at the H3-H4 interface of nucleosomes.

21 ents, act as coactivators, and interact with nucleosomes.

22 and Suv39h2 exclusively associate with poly-nucleosomes.

23 d gene expression without incorporation into nucleosomes.

24 pied by easily digested, unstable, "fragile" nucleosomes.

25 etylation of peptide substrates and complete nucleosomes.

26 d the histone H4 N-terminal tail to mobilize nucleosomes.

27 ically defined activity of bridging adjacent nucleosomes.

28 ndamental repeating unit of chromatin is the nucleosome: 147bp of DNA wrapped about an octamer of his

29 henium compounds that selectively target the nucleosome acidic patch, generating intra-nucleosomal H2

30 ation of strongly positioned, hypoacetylated nucleosomes across gene promoters.

31 The yeast Chd1 protein acts to position nucleosomes across genomes.

32 recognition motifs, which are located within nucleosomes across the genome.

33 life is visible in the intrinsically encoded nucleosome affinity.

34 ke ATPase motor to reposition and reorganize nucleosomes along genomic DNA.

35 n arrangement spans the two DNA gyres of the nucleosome and bridges both ends of a wrapped, approxima

36 tudies of the interaction between the CENP-A nucleosome and CENP-N.

37 heir lengths, include many genes involved in nucleosome and chromatin formation, and are extensively

38 Simultaneous binding of SWR to both H2A nucleosome and free H2A.Z induces SWR ATPase activity an

39 The details of DNA positioning on the nucleosome and the DNA conformation can provide key regu

40 se activities, the Fpr4 FKBP domain binds to nucleosomes and nucleosome arrays in vitro.

41 ocates along DNA at the H2A-H2B interface of nucleosomes and persistently displaces DNA from the surf

42 elective exchange of H2A.Z-H2B dimers out of nucleosomes and replacement by H2A-H2B dimers without an

43 s by INO80 promotes both the mobilization of nucleosomes and the selective exchange of H2A.Z-H2B dime

44 es, and it advances our understanding of how nucleosomes and their epigenetic information are maintai

45 ties of chromatin in terms of the spacing of nucleosomes and to make a direct connection between the

46 d crystal structures of unbound and H1-bound nucleosomes and validated these structures by site-direc

47 h 6mA are usually flanked by well-positioned nucleosomes and/or H2A.Z-containing nucleosomes.

48 l beta is not processive in the context of a nucleosome, and its single-turnover activity is reduced

49 4-RING ubiquitin E3 ligase-4 (CRL4) complex, nucleosomes, and chromatin remodelers.

50 e assembly system requires Sir2, Sir3, Sir4, nucleosomes, and O-acetyl-ADP-ribose.

51 DNA repair, binds ssNucs preferentially over nucleosomes, and ssNucs are effective at activating Fun3

52 ed by accessible chromatin, H3K4me3-modified nucleosomes, and the presence of Stowaway transposons.

53 at ligase IIIalpha-XRCC1 forms with the host nucleosome; and that the ligase IIIalpha-XRCC1-nucleosom

54 e also demonstrate that all Sir proteins and nucleosomes are components of these filaments to prove t

55 f MNase for A/T-rich DNA, such that A/T-rich nucleosomes are digested faster than G/C-rich nucleosome

56 Nucleosomes are disrupted during transcription and other

57 H2A.Z nucleosomes are enriched at temperature-responsive genes

58 We reveal that humanized nucleosomes are positioned according to endogenous yeast

59 Nucleosomes are stable enough to organize the genome yet

60 indicate that in the absence of remodeling, nucleosomes are strong barriers to DNA methyltransferase

61 ream region of OsBZ8 gene has highly dynamic nucleosome arrangement in Nonabokra, compared to IR64.

62 ral protein, LANA1, to bind viral genomes to nucleosomes arrayed on both cellular and viral DNA.

63 In contrast, AT-OUT nucleosome arrays formed less compact structures with de

64 he Fpr4 FKBP domain binds to nucleosomes and nucleosome arrays in vitro.

65 th recombinant chromatin complexes condenses nucleosome arrays independently of its catalytic activit

66 es but do not alter the intrinsic ability of nucleosome arrays to undergo salt-induced compaction and

67 Here, we tested this hypothesis by designing nucleosome arrays with A-tracts at specific locations in

68 nucleosome interactions similar to wild-type nucleosome arrays.

69 roteins that are central to the processes of nucleosome assembly and disassembly and thus the fluidit

70 Nucleosome assembly in the wake of DNA replication is a

71 ective in H3-H4 binding exhibited attenuated nucleosome assembly on nascent chromatin.

72 ote the entry of histones H3 and H4 into the nucleosome assembly pathway.

73 replication fork, through which RPA couples nucleosome assembly with ongoing DNA replication.

74 required for efficient DNA synthesis-coupled nucleosome assembly.

75 interphase centromeres to promote new CENP-A nucleosome assembly.

76 leosomal loop of DNA, suggesting a means for nucleosome assembly.

77 amic packaging of the genome by carrying out nucleosome assembly/disassembly, histone exchange, and n

78 and for the positioning of Pol V-stabilized nucleosomes at several tested loci, indicating that RNA

79 PARP-1 stabilizes Sox2 binding to nucleosomes at suboptimal sites through cooperative inte

80 cause a rapid and dynamic eviction of H2A.Z nucleosomes at target genes.

81 We investigated the structure of a 197 bp nucleosome bearing symmetric 25 bp linker DNA arms in co

82 f H2A.Z and identify PWWP2A as a novel H2A.Z-nucleosome binder.

83 that CENP-C competes with M18BP1 for CENP-A nucleosome binding at centromeres.

84 Our study revealed a cenH3 nucleosome binding CENPC-k motif at the C terminus of Ar

85 The M18BP1 motif resembles a CENP-A nucleosome binding motif in CENP-C, and we show that CEN

86 An interplay between the nucleosome binding proteins H1 and HMGN is known to affe

87 utions of each of the three candidate CENP-A nucleosome-binding domains (two on CENP-C and one on CEN

88 Sir2, the scaffolding protein Sir4, and the nucleosome-binding protein Sir3.

89 ion with a newly identified binding motif on nucleosome-bound CENP-C.

90 1 shifts the conformational landscape of the nucleosome by drawing the two linkers together and reduc

91 histone H3 variant CENP-A in the centromeric nucleosome by the kinetochore protein CENP-N.

92 sional strain created near the entry site of nucleosomes by INO80 promotes both the mobilization of n

93 ins that are well separated along the linear nucleosome chain can form long-range interactions in thr

94 we found that, although CHD7 and CHD8 slide nucleosomes, CHD6 disrupts nucleosomes in a distinct non

95 cient for long-range promoter-Ebeta looping, nucleosome clearance, and robust transcription throughou

96 how MRN promotes homologous recombination on nucleosome-coated DNA.

97 the majority of the heterotypic H3K27M-K27ac nucleosomes colocalize with bromodomain proteins at the

98 cleosome; and that the ligase IIIalpha-XRCC1-nucleosome complex decays when ligation is complete, all

99 n at centromeres requires a core centromeric nucleosome complex where CENP-C clamps down a stable nuc

100 ion is essential for the rhythmic changes of nucleosome composition at the frq promoter.

101 hanism for the action of proteins that alter nucleosome configurations such as histone chaperones and

102 me complex where CENP-C clamps down a stable nucleosome conformation and CENP-N fastens CENP-A to the

103 mmnolocalization results indicate most CENH3 nucleosomes contain phosphorylated H2AThr133 in centrome

104 A unique nucleosome containing the histone H3-specific variant CE

105 Using in vitro assembled nucleosomes containing discretely positioned DNA nicks,

106 e epigenetically specified and propagated by nucleosomes containing the centromere-specific H3 varian

107 ntromere is distinguished by the presence of nucleosomes containing the histone H3 variant, CENP-A.

108 illustrates how Chd1 senses DNA outside the nucleosome core and provides a basis for nucleosome spac

109 Packaging of DNA into the nucleosome core particle (NCP) is considered to exert co

110 The nucleosome core particle (NCP) is the basic structural u

111 d but independent readers bind to the intact nucleosome core particle (NCP).

112 lication of our processive search assay into nucleosome core particles revealed that Pol beta is not

113 tional modifications of histones forming the nucleosome core that are often regulated in cell-type-sp

114 pproximately 50 residues protruding from the nucleosome core.

115 cides with genome activation does not affect nucleosome density on DNA, but allows transcription fact

116 The lowest nucleosome density was found in the region of -900 bp re

117 However, HMGNs do alter the nucleosome-dependent condensation of the linker histone

118 In yeast, significant nucleosome-depleted regions are found, which facilitate

119 SMAD2 can bind pre-acetylated nucleosome-depleted sites.

120 This in turn facilitates CENP-A(Cse4) nucleosome deposition and kinetochore assembly.

121 In humans, CENP-A nucleosome deposition occurs in early G1 just after mito

122 distinguish between differentially modified nucleosomes, directing remodelling activity towards spec

123 Spt6 coordinates nucleosome dis- and re-assembly, transcriptional elongat

124 amics (constitutively active, synthetic with nucleosome-disfavoring sequences, and in the absence of

125 ndently of pioneer factors, where it induces nucleosome displacement and histone acetylation.

126 ses, but the structural intermediates during nucleosome disruption in vivo are unknown.

127 We have used this system to show that the nucleosome dramatically modulates CPD formation in a T11

128 length simultaneously on either side of the nucleosome during sliding.

129 r, while the H1 globular domain contacts the nucleosome dyad and both linkers, associating more close

130 Mif2 contacts one side of the nucleosome dyad, engaging with both Cse4 residues and AT

131 y Transfer (smFRET) to examine the real time nucleosome dynamics in the presence of the HsRAD51 NPF.

132 leosome, transcription factor binding at the nucleosome edge, and the presence of the histone H2A/H2B

133 We do detect MNase-sensitive nucleosomes elsewhere in the genome, including at transc

134 er, the molecular mechanisms by which CENP-A nucleosomes engage with kinetochore proteins are not wel

135 tone modifications, accompanied by decreased nucleosome enrichment and DNA demethylation mediated by

136 lization patterns of Sir proteins on the SIR-nucleosome filament reflect those patterns on telomeres

137 f these filaments to prove that they are SIR-nucleosome filaments.

138 g CENP-A assembly factors to existing CENP-A nucleosomes for the epigenetic inheritance of centromere

139 We demonstrated that nucleosomes form compact domains with a peak diameter of

140 dynamic competition for DNA binding between nucleosome-forming histones and transcription factors re

141 Nucleosome fragility was strongly and positively correla

142 n proposed that many yeast promoters are not nucleosome-free but instead occupied by easily digested,

143 DNA bound to the nucleosome, suggesting that nucleosome-free DNA is the preferred substrate of eukary

144 that nucleosome spacing and the presence of nucleosome-free DNA regions can modulate chromatin struc

145 The presence of longer nucleosome-free DNA regions can positively or negatively

146 BAF60 binds nucleosome-free regions of multiple G box-containing gen

147 teraction with chromatin, we purified native nucleosomes from mouse ES cells and detect that Suv39h1

148 Removing nucleosomes from regulatory sequences has been proposed

149 eam but impedes transcription through the +1 nucleosome genome-wide.

150 cal nuclease (MNase) is commonly used to map nucleosomes genome-wide, but nucleosome maps are affecte

151 e II (RNAPII) stalls at this well positioned nucleosome, GnRH-induced H3S28p, possibly in association

152 However, human nucleosomes have higher DNA occupancy, globally reduce R

153 Nucleosomes have structural and regulatory functions in

154 a T11-tract that covers one full turn of the nucleosome helix at seven different SHLs, and that the p

155 finger of CHD4 initiates recruitment to the nucleosome, however both PHDs are required to alter the

156 sed mechanism of DNA compaction predates the nucleosome, illuminating the origin of the nucleosome.

157 Previous studies have revealed that nucleosomes impede elongation of RNA polymerase II (RNAP

158 NA polymerase II (RNAPII) passes through the nucleosome in a coordinated manner, generating several i

159 for alpha-amino trimethylation of the CENP-A nucleosome in maintaining centromere function and faithf

160 D7 and CHD8 slide nucleosomes, CHD6 disrupts nucleosomes in a distinct non-sliding manner.

161 chaperone complex deposits histone H3.3 into nucleosomes in a DNA replication- and sequence-independe

162 association within DNA, the arrangements of nucleosomes in chromatin modulate the properties of long

163 odomain proteins by heterotypic H3K27M-K27ac nucleosomes in DIPG cells, we performed treatments in vi

164 Here, we "reset" yeast to use core human nucleosomes in lieu of their own (a rare event taking 20

165 nsights each has uncovered about the role of nucleosomes in shaping transcriptional processes.

166 into the functional properties of particular nucleosomes in their native molecular environment.

167 Genes with fragile nucleosomes in their promoters tended to be lowly expres

168 The ability to generate asymmetric nucleosomes in vivo and in vitro provides a powerful and

169 accessibility within the H3K36me3-containing nucleosome, instigated by the Tudor binding to H3K36me3,

170 ests that H4K16Ac directly reduces the inter-nucleosome interaction mediated by the H4 tail, which mi

171 This nucleosome interaction module enables KDM2A to decode nu

172 Using biochemical approaches we identify a nucleosome interaction module within KDM2A consisting of

173 rotein regions mediate H2A.Z-specificity and nucleosome interaction, whereas the PWWP domain exhibits

174 teristic of alternating rather than adjacent nucleosome interactions in tri-nucleosome units, particu

175 ormed less compact structures with decreased nucleosome interactions similar to wild-type nucleosome

176 l studies have defined transcription-induced nucleosome intermediates using only RNA Polymerase.

177 xt of chromatin, our understanding of how TF-nucleosome interplay affects gene expression is highly l

178 As a result, CHD8 slides nucleosomes into positions with more flanking linker DNA

179 findings indicate that the histone core of a nucleosome is more plastic than previously imagined and

180 ssive effect on transcription, whereas in +1 nucleosomes, it is important for maintaining the activit

181 diHMM not only accurately captures nucleosome-level information, but identifies domain-leve

182 identifies domain-level states that vary in nucleosome-level state composition, spatial distribution

183 that Sir2/4 stimulates Ubp10 DUB activity on nucleosomes, likely through a combination of targeting a

184 on originating from a focused PIC, and broad nucleosome-linked initiation.

185 s with A-tracts at specific locations in the nucleosome linkers to induce inward (AT-IN) and outward

186 Current nucleosome-mapping strategies involve digesting chromati

187 nly used to map nucleosomes genome-wide, but nucleosome maps are affected by the degree of digestion.

188 II promoter subtypes, suggesting that the +1 nucleosome may be involved in the transcriptional regula

189 ays in which dynamic properties intrinsic to nucleosomes may contribute to the discovery and efficien

190 different regulatory sequences give rise to nucleosome-mediated TF collaborations that quantitativel

191 Nucleosomes modulate CPD formation, favoring outside fac

192 The features of the CENP-A nucleosome necessary to distinguish centromeric chromati

193 We infer differences in the likelihood of nucleosome-nucleosome contacts among open chromatin, H3K

194 cture at the length scale encompassing local nucleosome-nucleosome interactions is thought to play a

195 ombination of factors, including cohesin and nucleosome-nucleosome interactions.

196 c regions of the genome with relatively high nucleosome occupancy and low co-occupancy by other trans

197 -Bisulfite Genome Sequencing (MAPit-BGS) and nucleosome occupancy and methylome sequencing (NOMe-seq)

198 tantly, the diminished cell-cycle changes in nucleosome occupancy around origins in the orc1-161 muta

199 ile, suggesting that proper establishment of nucleosome occupancy around origins is a critical step f

200 origins across the S. cerevisiae genome, and nucleosome occupancy around origins significantly correl

201 Our work thus establishes nucleosome occupancy as a novel and key chromatin parame

202 whole-genome bisulfite sequencing data, and nucleosome occupancy from NOMe-seq data.

203 by inferring allele-specific methylation and nucleosome occupancy in cell lines, and colon and tumor

204 We found that nucleosome occupancy in G1 varies greatly around origins

205 ng knowledge from oligonucleotide design and nucleosome occupancy models, we systematically evaluated

206 We tested whether changes in nucleosome occupancy occurred on the set of genes that i

207 emely stable in each cell cycle phase, while nucleosome occupancy showed notable phase dependent fluc

208 We conclude that encoding for high nucleosome occupancy, as in the human genome, is in fact

209 tercalator and salt induced release from the nucleosomes of different histones.

210 With knowledge of the positions of nucleosomes on a given genome, methods are now at hand t

211 ese features also determine the positions of nucleosomes on DNA and the lengths of the interspersed D

212 IIIalpha-XRCC1 complex binds to DNA nicks in nucleosomes only when they are exposed by periodic, spon

213 Interestingly, either origin-flanking nucleosomes or roadblocks resulted in helicase loading b

214 ct NETs, reconstituted chromatin, individual nucleosome particles, nor octameric core histones reprod

215 Nucleosome placement and repositioning can direct transc

216 t that association of the BRG1/hBRM BRD with nucleosomes plays a regulatory rather than targeting rol

217 hierarchical model is that 11-nanometer DNA-nucleosome polymers fold into 30- and subsequently into

218 Wrapping of genomic DNA into nucleosomes poses thermodynamic and kinetic barriers to

219 At the first nucleosome position downstream of the transcription star

220 subfamily of SWI2/SNF2 proteins that control nucleosome positioning and are associated with several c

221 investigate the in vivo relationship between nucleosome positioning and gene expression during develo

222 and reveal the detailed relationship between nucleosome positioning and gene regulation, as cells tra

223 Here, we use genome-wide analysis of nucleosome positioning and transcription profiling to in

224 ential gene expression analysis for RNA-seq, nucleosome positioning for MNase-seq, DNase hypersensiti

225 h comprehensive analysis DNA methylation and nucleosome positioning patterns of HepG2 cells in G0/G1,

226 Furthermore, the strength of the nucleosome positioning signals correlates with the compl

227 focal changes in chromatin accessibility and nucleosome positioning that render cells susceptible to

228 histone-modifying enzymes, and regulators of nucleosome positioning.

229 sibility by altering chromatin compaction or nucleosome positioning.

230 , we explored the functional implications of nucleosome properties on gene expression and development

231 or nucleosome remodeling is unknown, unlike nucleosome reassembly which is shown to be required for

232 -cycle-regulated binding of M18BP1 to CENP-A nucleosomes recruits the Mis18 complex to interphase cen

233 tic inactivation of a single DDM1/Lsh family nucleosome remodeler biases methylation toward inter-nuc

234 methylated DNA and recruiting the associated nucleosome remodeling and deacetylase (NuRD) complex.

235 s of FOG1 to dCas9 to recruit the endogenous nucleosome remodeling and deacetylase complex, were both

236 Here we show that the Mbd3/nucleosome remodeling and deacetylation (NuRD) chromatin

237 ve simply by breaking the connection between nucleosome remodeling and DNA methylation.

238 Nuclear localization and nucleosome remodeling and histone deacetylase (NuRD) com

239 mplexes, including HDAC1/2-containing Sin3B, nucleosome remodeling and histone deacetylase (NuRD), an

240 of the bromodomain protein ZMYND8 and NuRD (nucleosome remodeling and histone deacetylation) complex

241 BET inhibition induced marked nucleosome remodeling at the latent HIV-1 promoter, whic

242 Additionally, we demonstrate that nucleosome remodeling by CSB consists of three distinct

243 This interaction was required for nucleosome remodeling by keeping the ATPase function of

244 duced upon T cell activation by recruiting a nucleosome remodeling deacetylase (NuRD) complex to Pdcd

245 anti-inflammatory drugs or components of the nucleosome remodeling deacetylase (NuRD) complex, which

246 ISWI-family nucleosome remodeling enzymes need the histone H4 N-term

247 tion factor (BPTF) is the largest subunit of nucleosome remodeling factor (NURF), a member of the ISW

248 damaged base requires histone deposition or nucleosome remodeling is unknown, unlike nucleosome reas

249 Here, we show that a mitochondrial SWI/SNF (nucleosome remodeling) complex B protein, SWIB5, is capa

250 g complexes contribute to DNA damage-induced nucleosome remodeling, but the mechanism by which it con

251 Here we studied CSB's DNA-binding and nucleosome-remodeling activities at the single molecule

252 igated the role of the SWI/SNF ATP-dependent nucleosome-remodeling complex in the repair of a defined

253 Targeted inactivation of SWI/SNF nucleosome-remodeling complex members Smarca4 (Brg1) or

254 g genes regulated by pluripotency factor and nucleosome remodelling deacetylase (NuRD), we illustrate

255 ndary structure of chromatin, we confirmed a nucleosome repeat length (NRL)-dependent folding.

256 emodeling network, as judged by a yeast-like nucleosome repeat length.

257 These analyses demonstrate active nucleosome repositioning during Dictyostelium multicellu

258 y surfaces and the corresponding dynamics of nucleosome repositioning.

259 assembly/disassembly, histone exchange, and nucleosome repositioning.

260 CENP-A nucleosome retention at centromeres requires a core cent

261 ry and complement factors while upregulating nucleosome, ribosome, and chromatin-modifying genes.

262 nce features, such as the high GC content in nucleosome-rich regions.

263 case DNA-binding protein 1 (Chd1) remodeler, nucleosome sliding has been shown to depend on the DNA f

264 We demonstrate that nucleosome sliding is tightly controlled by two regulato

265 ated, instead gradually becomes uncoupled as nucleosome sliding reaches an end point and this is cont

266 Instead nucleosome sliding requires cooperativity between two IN

267 the nucleosome core and provides a basis for nucleosome spacing and directional sliding away from tra

268 oss of chdC caused an increase of intragenic nucleosome spacing and misregulation of gene expression,

269 Here we show that nucleosome spacing and the presence of nucleosome-free D

270 serve examples of strict association between nucleosome stability and PTMs across cell types, differe

271 findings imply that chromatin compaction by nucleosome stacking protects nucleosomal DNA from extern

272 is now overwhelming that partially assembled nucleosome states (PANS) are as important as the canonic

273 tes (PANS) are as important as the canonical nucleosome structure for the understanding of how access

274 ecting remodelling activity towards specific nucleosome substrates according to their modification st

275 h remodellers discriminate between different nucleosome substrates is poorly understood.

276 DDM1 enables methylation of DNA bound to the nucleosome, suggesting that nucleosome-free DNA is the p

277 e correlated with a delay in the eviction of nucleosomes surrounding the DSB.

278 ctivity does not contribute substantially to nucleosome targeting in vitro.

279 r the association of paired readers with the nucleosome that provides an intricate balance between co

280 eler a unique organization of domains on the nucleosome that reveals direct domain-domain communicati

281 lesions in DNA, both between and within the nucleosomes that package DNA in chromatin.

282 The structure of the nucleosome, the basic building block of the chromatin fi

283 Since NuRD physically rearranges nucleosomes, the dynamic mobility of this complex is dir

284 itment and the ability to traverse the first nucleosome, thereby promoting transcription of most gene

285 via conformational or positional changes of nucleosomes, thereby altering the access of transcriptio

286 ecode and stabilize the non-canonical CENP-A nucleosome to enforce epigenetic centromere specificatio

287 when ligation is complete, allowing the host nucleosome to return to its native configuration.

288 ISWI family of chromatin remodelers mobilize nucleosomes to control DNA accessibility and, in some ca

289 been shown to depend on the DNA flanking the nucleosome, transcription factor binding at the nucleoso

290 These CHDs can mediate nucleosome translocation in vitro, but their in vivo mec

291 Moreover, Fft3 also precludes nucleosome turnover at several euchromatic loci to preve

292 escribes a mechanism in which suppression of nucleosome turnover prevents formation of structural bar

293 than adjacent nucleosome interactions in tri-nucleosome units, particularly in H3K9me3-marked heteroc

294 revealed that a single methylated H3K36 per nucleosome was sufficient to silence cryptic transcripti

295 Fragile nucleosomes were defined by nucleosomal DNA fragments th

296 Histone proteins wrap around DNA to form nucleosomes, which further compact into the higher-order

297 DNA-binding domain contacts the edge of the nucleosome while in the presence of the non-hydrolyzable

298 he mechanical movement of RNAPII through the nucleosome with co-transcriptional chromatin modificatio

299 entered on 133 bp, consistent with octameric nucleosomes with DNA unwrapping at entry and exit.

300 to be assembled with histone H3.1-containing nucleosomes with wrapped DNA termini.

301 three steps in BER can act at many sites in nucleosomes without the aid of chromatin-remodeling agen