ライフサイエンスコーパス: nucleotide

1 monomer in solution, regardless of the bound nucleotide.

2 encies of correct and all possible incorrect nucleotides.

3 more stable than mRNAs that begin with other nucleotides.

4 of cell-signaling pathways involving cyclic nucleotides.

5 alone is enough for the modification of two nucleotides.

6 roximately 5 nucleotides to as little as 1-2 nucleotides.

7 s proteins scavenging the mutagenic oxidised nucleotide 8-oxo-dGTP.

8 00-nucleotide region of the genome (R0) from nucleotides 889 to 1289 encompassing the 3' end of the d

9 s, sequence-intrinsic SHM-targeting rates of nucleotides across substrates representing maturation st

10 Collectively, we conclude that nucleotides activate P2Y6 receptors to suppress GC growt

11 ions, as well as R1150Q/R1150W, augmented Mg-nucleotide activation.

12 ECs terminate from effects of the TL on the nucleotide addition rate that indirectly affect terminat

13 hance or decrease the anti-HIV-1 efficacy of nucleotide analogue reverse transcription inhibitors pre

14 Average nucleotide and amino acid identities revealed that the f

15 c hub in cells that enables the synthesis of nucleotides and amino acids and epigenetic modifications

16 of cDNA target regions of approximately 100 nucleotides and counting of individual molecules.

17 for the de novo synthesis of dTMP and purine nucleotides and for remethylation of homocysteine to met

18 trate-binding domain) in response to adenine nucleotides and substrates.

19 ring dry periods, mean that the synthesis of nucleotides and their polymerization into RNA occurred i

20 iently synthesize polymers composed of these nucleotides, and most interestingly, that SFM4-3 can als

21 e the interaction of myosin-5B with F-actin, nucleotides, and the pyrazolopyrimidine compound myoVin-

22 ilar to other Hsp70s, its activity relies on nucleotide- and substrate-controllable docking and undoc

23 ide strategy for intracellular delivery of a nucleotide antagonist of eIF4E in mantle cell lymphoma (

24 The European Nucleotide Archive offers a rich platform for data shari

25 1, asymmetric dimethylarginine, and adenine nucleotides are all products of hemolysis that promote v

26 It requires at least two unpaired nucleotides at the 5' end of its substrates and prefers

27 eaving the 5' strand DNA approximately 10-20 nucleotides away from the ends.

28 ty and by secondary interactions between the nucleotide bases and the metal.

29 thod to detect and correct position-specific nucleotide biases in HTS short read data.

30 site rearrangements that lead to a decreased nucleotide binding affinity and incorporation rate.

31 ve to 8-oxoG bypass is due to an alternative nucleotide binding conformation in the precatalytic tern

32 tion in the catalytic site of the C-terminal nucleotide binding domain restored proper protein traffi

33 the transmembrane domain and the C-terminal nucleotide binding domain.

34 s reveals how reversible dimerization of the nucleotide binding domains drives opening and closing of

35 Although cyclic nucleotide binding has been shown to promote CNG and HCN

36 hen the catalytic glutamate of the canonical nucleotide binding site 2 was mutated to glutamine.

37 ve site in the absence of PPi, suggests that nucleotide binding stimulates PPi dissociation and occur

38 ogy analysis all strongly support defects in nucleotide-binding activity.

39 n two well-structured domains: an N-terminal nucleotide-binding domain (NBD) and a C-terminal substra

40 te-controllable docking and undocking of its nucleotide-binding domain (NBD) and substrate-binding do

41 docked model predicted that a region in the nucleotide-binding domain (NBD) of DnaK interacted with

42 the nucleotide-binding domain and substrate-binding domain)

43 We show that TRIP8b binds the HCN cyclic nucleotide-binding domain through a 37-residue domain an

44 In mice, specific nucleotide-binding domain, leucine-rich repeat-containin

45 sis inhibitory proteins (NAIPs) activate the nucleotide-binding domain, leucine-rich repeat-containin

46 ress immunity; however, the plant can evolve nucleotide-binding domain-leucine-rich repeat domain-con

47 Plant nucleotide-binding leucine-rich repeat (NLR) proteins en

48 Nucleotide-binding oligomerization domain (Nod)-containi

49 yrin domain containing 1 (NLRP1), NLRP3, and nucleotide-binding oligomerization domain (NOD)-like rec

50 We demonstrate that both TNF-R and nucleotide-binding oligomerization domain stimulation pr

51 The inflammasome proteins nucleotide-binding oligomerization domain, leucine rich

52 f the Crohn's disease susceptibility protein nucleotide-binding oligomerization domain-containing 2 (

53 bial sensors, recent evidence indicates that nucleotide-binding oligomerization domains (NODs) can al

54 Thus, the NTRs affect the specific nucleotide-binding properties of MYO1C isoforms, adding

55 d that their interaction is sensitive to the nucleotide-bound state of the motor.

56 s/s) disassembly, which depends on F-actin's nucleotide-bound state.

57 in the presence of ATP and in the absence of nucleotide, but not in the presence of ADP.

58 s, pentose phosphate pathway, polyamines and nucleotides, but an increase in TCA and urea cycle inter

59 rporation kinetics of non-fluorescent native nucleotides by DNA polymerases.

60 the substitution of a cytosine for a thymine nucleotide (C64T) at codon 22, leading to a premature st

61 poson presence/absence patterns and flanking nucleotide changes suggest an important influence of mos

62 entified 3 amino acid changes, 16 synonymous nucleotide changes, and a 12-bp insertion strongly assoc

63 The nucleotide concentration dependence was measured at temp

64 top positions, in a length range of 16 to 22 nucleotides consistently present in the MalaEx.

65 elements, we developed a bisulfite-mediated nucleotide-conversion strategy for large-scale mutationa

66 ssical d mutation was found to be due to one nucleotide deletion that would truncate the deduced prod

67 o, which was detected only for the 7- and 21-nucleotide deletions.

68 We also probed the nucleotide dependence of this interaction, confirming th

69 ing ability of hGBP1F Furthermore, we report nucleotide-dependent polymerization of hGBP1F, which com

70 cantly altered 35 proteins mainly related to nucleotide-dependent processes and lipid metabolism.

71 inding of hGBP1F In addition, we demonstrate nucleotide-dependent tethering ability of hGBP1F Further

72 rtner [GPCRs, Gbetagamma, effectors, guanine nucleotide dissociation inhibitors (GDIs), GTPase-activa

73 ide site diversity (piN/piS), and synonymous nucleotide diversity (piS), avoiding the statistical non

74 lains the discrepancy between the rather low nucleotide diversity in herring and its huge census popu

75 cultivated G. hirsutum as compared with low nucleotide diversity on these chromosomes in landrace G.

76 ed by highly polymorphic loci with extensive nucleotide diversity, copy number variation of paralogou

77 document a northern-most population with low nucleotide diversity, divergent allele frequencies and t

78 umber of new alleles, representing increased nucleotide diversity, on chromosomes 1 and 2 in cultivat

79 The cleavage site is 11/9 nucleotides downstream of the A residue.

80 -GCCGC-3' site and cleaves the DNA 7 and 6/7 nucleotides downstream on the top and bottom DNA strands

81 ng frame and TRmD both by a approximately 60 nucleotide element that spans the initiating AUG and by

82 Cap-proximal nucleotides encircled by the tunnel provide affinity to

83 a small GTPase that functions as a guanosine nucleotide exchange factor (GEF) for ARL3-GDP.

84 LARG (leukemia-associated Rho guanine nucleotide exchange factor (GEF)), PDZ-RhoGEF, and p115R

85 Here, we demonstrate that the Hsp70 nucleotide exchange factor Bag1 promotes hERG degradatio

86 ity by recruiting its activator, the guanine nucleotide exchange factor GEF-H1.

87 tes the nuclear transport of the Ran guanine nucleotide exchange factor RCC1.

88 The Rac1 guanine nucleotide exchange factor Tiam1 mediates an OGD-induced

89 nositol 3-kinase (PI3K) and the Rac1 guanine nucleotide exchange factor Tiam1.

90 naturally explains how KaiA, by acting as a nucleotide exchange factor, can stimulate phosphorylatio

91 erning, we previously identified the guanine nucleotide exchange factor, RAPGEF5.

92 ologue of the SH3BP5 family of Rab11 guanine nucleotide exchange factors (GEFs).

93 RasGRPs are guanine nucleotide exchange factors that are specific for Ras or

94 vity that can be stimulated by two different nucleotide exchange factors, Sil1 and Lhs1.

95 Inhibition of Ras nucleotide exchange is a promising new approach but bett

96 tions at this position impaired GEF-mediated nucleotide exchange.

97 emodeler essential for transcription-coupled nucleotide excision DNA repair.

98 ubgroups with impaired transcription coupled nucleotide excision repair (TC-NER) (category 1: XP-A, B

99 ts normally recognized by Fanconi anemia and nucleotide excision repair machinery, although the mecha

100 lly mutagenic if not properly removed by the nucleotide excision repair machinery.

101 important and well-conserved sub-pathway of nucleotide excision repair that preferentially removes D

102 to essentially all DNA damages processed by nucleotide excision repair.

103 or required for transcription initiation and nucleotide excision repair.

104 bulky lesions more commonly associated with nucleotide excision repair.

105 ding ataxias, amyotrophic lateral sclerosis, nucleotide expansion disorders (Friedreich ataxia and fr

106 much faster than the lesion-recognition and nucleotide flipping steps that were independently determ

107 tes (rNMPs) are the most common non-standard nucleotides found in DNA of eukaryotic cells, with over

108 Comparison of ATP-bound and nucleotide-free states reveals how reversible dimerizati

109 the crystal structure of kinesin-6 Zen4 in a nucleotide-free, apo state, with the NL initial segment

110 A transient conformation of decoding-centre nucleotide G530 stabilizes the cognate codon-anticodon h

111 ng the response through the olfactory cyclic nucleotide-gated (CNG) channel and stimulates a depolari

112 We found that cAMP activates cyclic nucleotide-gated (CNG) channels and thereby induces a Ca

113 n through hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, and contributes to depo

114 Cyclic nucleotide-gated channel (CNGC) family members mediate C

115 cAMP opens cyclic nucleotide-gated channels allowing a Ca(2+) influx that

116 Cyclic-nucleotide-gated channels are essential for vision and o

117 Piwi-interacting RNAs (piRNAs) are 26-30-nucleotide germ line-specific small non-coding RNAs that

118 ient protein targeting to the INM depends on nucleotide hydrolysis.

119 hat the most stable dCn i-motifs possess one nucleotide in each of the three loops and a core built o

120 t to 0.056 and 0.065 adducts in 10(8) normal nucleotides in 50 mug of DNA.

121 show that while the hexameric HerA binds six nucleotides in an 'all-or-none' fashion, HerA-NurA harbo

122 A that forms a T-loop module and a subset of nucleotides in the cobalamin-binding pocket.

123 n the DNA helix, where it effectively blocks nucleotide incorporation across the adduct by Dpo4.

124 Polbeta mouse tissue and KO cells had lower nucleotide incorporation activity.

125 ultiple mismatches, abasic sites, and single nucleotide insertions.

126 ined that the ribosomal footprint extends 13 nucleotides into the N-terminal coding region and, when

127 oth extension contexts, wherein the incoming nucleotide is bound in either the canonical Watson-Crick

128 on of Structure-seq2 in which a biotinylated nucleotide is incorporated during reverse transcription,

129 that protein accessibility decreases as the nucleotide is located closer to the backbone.

130 ethylation measurements at the resolution of nucleotides, it is relatively costly and so several stud

131 However, addition of the second nucleotide (kobs2) is 700-fold faster for tCfTP than tCT

132 trafficking machinery, and increased adenine nucleotide levels.

133 ng noncoding RNAs (lncRNAs)-transcripts >200 nucleotides long that do not encode proteins.

134 The relative fluxes through glycolysis and nucleotide metabolism pathways were consistent across th

135 iminosugars as glycosyl phosphate and sugar nucleotide mimics.

136 avage in elongation complexes backtracked by nucleotide misincorporation.

137 ep, a complete discrimination against single nucleotide mismatched sequences under practical conditio

138 icantly increased its capacity to remove G/T nucleotide mismatches or 5-formylcytosine.

139 16 different HEV sequences with significant nucleotide mismatching in primer/probe binding regions,

140 ion of HCN4 by cAMP, i.e. the primary cyclic nucleotide modulator of HCN channels.

141 For type I and II CRISPR-Cas systems, single-nucleotide mutations in the seed or protospacer adjacent

142 stigate only a subset of all possible single nucleotide mutations.

143 ized short RNA corresponding to the first 19 nucleotides (nt) of the rabies virus genome, we demonstr

144 synthesis, which could restore the full 100 nucleotides of (T2AG3)n lost from replicated chromosome

145 siently forming loops and hairpins within 30 nucleotides of the break.

146 ogen bond interactions between the first two nucleotides of the codon and anticodon and then is stabi

147 f PALADIN against existing tools that employ nucleotide or protein alignment algorithms.

148 the TRBO-sgRNA constructs, which retained 5' nucleotide overhangs.

149 Amino acids, nucleotide pathways, and metabolites involved in redox r

150 The lead single-nucleotide polymorphism (rs12445022) was also associated

151 ificantly associated with a genotyped single-nucleotide polymorphism (rs12519770, P=2.98x10(-)(8)) in

152 A single nucleotide polymorphism (rs16260) linked to increased ca

153 AC4 CpG sites were tagged by a nearby single-nucleotide polymorphism (rs7570903), which also associat

154 Single nucleotide polymorphism (SNP) associations were stratifi

155 we present a genome-wide analysis of single-nucleotide polymorphism (SNP) data for Spanish teosinte,

156 TB-DzT combines a multiplex PCR with single nucleotide polymorphism (SNP) detection using highly sel

157 type-phenotype studies based first on single nucleotide polymorphism (SNP) genotyping and then with w

158 The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766)

159 ntified an atherosclerosis-associated single-nucleotide polymorphism (SNP) located in the intron of t

160 Our data show that a single-nucleotide polymorphism (SNP) mutation in the GL4 gene r

161 high-affinity AICE2 motif at a human single-nucleotide polymorphism (SNP) of the gene encoding the i

162 tion of a specific variant type (e.g. single nucleotide polymorphism (SNP) or indel) within a broader

163 show that ADABF is more powerful than single-nucleotide polymorphism (SNP)-set kernel association tes

164 otype for rs72820264, an intragenetic single-nucleotide polymorphism associated with LVOTDs (P=2.1x10

165 breeding coefficients based on 37 037 single-nucleotide polymorphism loci, and population density as

166 Exploration of the CRF1 receptor single nucleotide polymorphism rs110402 found that response to

167 e investigated whether the functional single nucleotide polymorphism rs4523957, which is an expressio

168 ion radioligands are sensitive to the single nucleotide polymorphism rs6971; however, this is probabl

169 inhibitors, those with the rs1898671 single-nucleotide polymorphism were more likely to have stopped

170 A widely prevalent single nucleotide polymorphism, rs13266634 in the SLC30A8 gene

171 We also demonstrate that the SRR single nucleotide polymorphism, rs4523957, is associated with p

172 This mutation- and single nucleotide polymorphism-independent method could be cruc

173 , or homozygous for the TSLPrs1898671 single-nucleotide polymorphism.

174 cus ( TSNAX-DISC1 noncoding RNA, lead single-nucleotide polymorphism: rs149133391, minor allele [C] f

175 he gene for complement factor H (lead single nucleotide polymorphism: rs800292; P=2.4x10(-35)).

176 e aim of the study was to investigate single nucleotide polymorphisms (SNP) located in genes encoding

177 quence diversity was high with a mean single nucleotide polymorphisms (SNP) rate of approximately 1 p

178 In total, 24,710 high-quality Single Nucleotide Polymorphisms (SNP) were identified.

179 Ten correlated single-nucleotide polymorphisms (SNPs) (r(2)>0.9) located in an

180 genome identified approximately 7.4 M single nucleotide polymorphisms (SNPs) and 1.9 M indels.

181 by incorporating prior information of single nucleotide polymorphisms (SNPs) and combining two releva

182 ons between published type 2 diabetes single nucleotide polymorphisms (SNPs) and genome-wide methylat

183 Europeans, we genotyped the 10 novel single nucleotide polymorphisms (SNPs) and performed an associa

184 cted a follow-up study to examine the single nucleotide polymorphisms (SNPs) associated with family h

185 mmary statistics for four independent single nucleotide polymorphisms (SNPs) associated with isoleuci

186 DNA (dd-cfDNA) by taking advantage of single-nucleotide polymorphisms (SNPs) distributed across the g

187 of 1284 AMD cases and controls for 93 single nucleotide polymorphisms (SNPs) from 7 genes.

188 using summary statistics obtained for single-nucleotide polymorphisms (SNPs) identified from a genome

189 sed the associations of 19,830 common single-nucleotide polymorphisms (SNPs) in 151 Wnt pathway autos

190 gle nucleotide variants (SNVs) due to single nucleotide polymorphisms (SNPs) in the genome, or RNA ed

191 Conditional analysis on known index single nucleotide polymorphisms (SNPs) indicated an additional

192 (2) Single nucleotide polymorphisms (SNPs) known to be involved in

193 By using the 2,271,584 single nucleotide polymorphisms (SNPs) on the panel from previo

194 fter removing potentially pleiotropic single nucleotide polymorphisms (SNPs) possibly acting via obes

195 cally significant association between single nucleotide polymorphisms (SNPs) rs1800544 ADRA2A (odds r

196 Single-nucleotide polymorphisms (SNPs) that surpassed a signifi

197 ssociation between IA development and single nucleotide polymorphisms (SNPs), but many SNPs have not

198 Single nucleotide polymorphisms (SNPs), the most common genetic

199 elect the most potentially associated single-nucleotide polymorphisms (SNPs), whereas the markers on

200 re simple sequence repeats (SSRs) and single nucleotide polymorphisms (SNPs).

201 differences among ST382 strains were single nucleotide polymorphisms (SNPs).

202 ian population (n = 769) yielded nine single-nucleotide polymorphisms (SNPs): G-1106A, A-1018T, T-101

203 METHOD: We genotyped nine IL13 "tag" single nucleotide polymorphisms (tag SNPs) in 367 challenge-pro

204 ' for typing Y-STRs and Y-chromosomal single nucleotide polymorphisms (Y-SNPs).

205 to previously reported CKD-associated single-nucleotide polymorphisms and provided evidence for inter

206 me-wide association study to identify single-nucleotide polymorphisms associated with genetic suscept

207 strumental variable analysis based on single nucleotide polymorphisms determining birth weight combin

208 ity-based transmission (five or fewer single nucleotide polymorphisms different and with identical re

209 n of variance explained by all common single-nucleotide polymorphisms for this tiredness question was

210 olygenic risk score (PRS) composed of single nucleotide polymorphisms from the pathway most consisten

211 on and validation of 234,452 putative single nucleotide polymorphisms in-silico, of which 8,967 high

212 in all three species, the density of single nucleotide polymorphisms increases as one approaches a m

213 of how specific genetic mutations or single nucleotide polymorphisms influence the onset of disease,

214 six candidate PSS1 genes by comparing single-nucleotide polymorphisms of (1) the bulked DNA sample of

215 o identify significant differences in single-nucleotide polymorphisms or copy number variants, respec

216 ubsequent imputation revealed 660,238 single nucleotide polymorphisms that are rare (<1%) or absent i

217 dy to assess the association of EFNB3 single nucleotide polymorphisms with human hypertension risks,

218 Single nucleotide polymorphisms within the prion protein gene h

219 ing population by using clustering of single nucleotide polymorphisms' trajectories and (ii) use quan

220 We tested a total of 3.8 million single nucleotide polymorphisms, as well as imputed HLA alleles

221 ompare allele read fractions at known single-nucleotide polymorphisms, considering depth-dependent be

222 n six clusters of strongly associated single nucleotide polymorphisms, selected on the basis of their

223 s-methylation quantitative trait loci single nucleotide polymorphisms.

224 with approximately 9 000 000 imputed single-nucleotide polymorphisms.

225 plasticity, using 45,608 high-quality single-nucleotide polymorphisms.

226 ments and genotyped with 2.5 million single-nucleotide polymorphisms.

227 typing with microsatellites and 9230 single-nucleotide polymorphisms.

228 The dCTP pyrophosphatase 1 (dCTPase) is a nucleotide pool "housekeeping" enzyme responsible for th

229 art procedure to identify quantitative trait nucleotides (QTNs) associated with complex traits.

230 generation by targeting proregenerative P2Y2 nucleotide receptor (P2Y2R) activated by extracellular A

231 Correlations between P2 nucleotide receptor expression and hCPC growth kinetics

232 radical (Fe(III)2-Y(*)) cofactor to initiate nucleotide reduction.

233 and extensive phylogenetic analyses of a 400-nucleotide region of the genome (R0) from nucleotides 88

234 Expansions of short nucleotide repeats produce several neurological and neur

235 in de novo gene "birth." TGA provided single-nucleotide resolution for each binding site and delineat

236 We explored the landscape of BCAs at nucleotide resolution in 273 subjects with a spectrum of

237 put RNA structure probing method, we provide nucleotide resolution insights into rRNA structural rear

238 hat can interrogate nascent RNA structure at nucleotide resolution.

239 mage and repair in these organisms at single-nucleotide resolution.

240 Single-nucleotide-resolution mapping of m(6)A coupled with ribo

241 3 +/- 0.92 and 1.05 +/- 0.99 in 10(8) normal nucleotides, respectively).

242 4 +/- 1.20 and 2.10 +/- 1.77 in 10(8) normal nucleotides, respectively, which were significantly high

243 fined by DNA binding site sizes of 30 and 60 nucleotides, respectively.

244 3.1 and 1.3 BPDE-N(2)-dG adducts per 10(11) nucleotides, respectively.

245 Addition of guanine nucleotides resulted in changes in the solvent accessibi

246 ll stages are abundant in heterogeneous 28-nucleotide RNAs.

247 anosine (ddI), and lamivudine (3TC), and the nucleotide RTI inhibitor tenofovir (TDF), show efficacy

248 es on the concerted action of DNA polymerase nucleotide selectivity, proofreading activity, and DNA m

249 associated type I (VAI) RNA in terms of both nucleotide sequence and secondary structure but differs

250 e with point mutations without chromosome or nucleotide sequence context bias would open the door to

251 The nucleotide sequence in this region has been determined f

252 Transfer RNA (tRNA) links messenger RNA nucleotide sequence with amino acid sequence during prot

253 Cpf1 requires a specific nucleotide sequence, called a protospacer adjacent motif

254 by genomic aberrations, including changes in nucleotide sequences.

255 yped in our reference laboratory by means of nucleotide sequencing and extensive phylogenetic analyse

256 4 rootstocks produced more DCL2-dependent 22-nucleotide siRNAs than the wild type and showed enhanced

257 the nonsynonymous relative to the synonymous nucleotide site diversity (piN/piS), and synonymous nucl

258 this is the first observation of non-cyclic-nucleotide small molecules with agonist properties towar

259 s of Abs, and achieved breadth with only 10% nucleotide somatic hypermutation and no insertions or de

260 tion response element (TAR) RNA, we achieved nucleotide-specific classification of two independent se

261 e 'G-loop' element that accounts for guanine nucleotide specificity.

262 K phosphorylation of Mcm2, binding to eighty-nucleotide ssDNA, and recruiting pol alpha to Mcm2-7 in

263 dmilling in filamentous actin (F-actin) in a nucleotide-state dependent manner.

264 actions between flavodoxin and the different nucleotide states of the Fe protein is critically import

265 D) using Cas9D10A nickase promotes efficient nucleotide substitution by gene editing.

266 s not sufficient to explain the variation of nucleotide substitution rates.

267 igh affinity and abundance of its endogenous nucleotide substrates.

268 olyases, but they retain the ability to bind nucleotides such as ATP.

269 Moreover, Coop-seq uncovers a nucleotide switch within the POU half-site when spacing

270 ular membranes and are essential for salvage nucleotide synthesis and purinergic signaling.

271 ells generates formate, and thereby promotes nucleotide synthesis.

272 h of the editing window from approximately 5 nucleotides to as little as 1-2 nucleotides.

273 ditors to knock out genes by changing single nucleotides to create stop codons.

274 Model studies using thymidine nucleotides to lock in i-motif loop lengths support the

275 Adenine nucleotide translocase (ANT) exchanges ADP/ATP through t

276 However, nucleotide transport across the additional plastid membr

277 fficient to partially populate the OF state, nucleotide trapping in the pre- or post-hydrolytic state

278 t, we further validate that the nonconsensus nucleotide triplet code constitutes a key signature prov

279 viously unseen drug-induced rearrangement of nucleotides U2506 and U2585 of the 23S rRNA resulting in

280 ertions and deletions (indels) and of single-nucleotide variant (SNV) mutations.

281 customize the classification of genome-wide nucleotide variant data most relevant to biological rese

282 Here we report de novo non-synonymous single-nucleotide variants (SNVs) by conducting whole exome seq

283 RNA sequences of a gene can have single nucleotide variants (SNVs) due to single nucleotide poly

284 evel analysis of rare (<1% frequency) single-nucleotide variants (SNVs) revealed that the gene encodi

285 tion (indels) accumulating as fast as single nucleotide variants (SNVs), and elevated amounts of dele

286 specific antigen analyses has been on single nucleotide variants (SNVs), with the contribution of sma

287 We identified 2719 single nucleotide variants (SNVs).

288 We found an average of 73.8 de novo single nucleotide variants and 12.6 de novo insertions and dele

289 ion of rare genic CNVs and regulatory single-nucleotide variants and found that reactivation of gene

290 of frequency, they are second only to single nucleotide variants as pathogenic mutations.

291 was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293, P=3.3

292 ly significant P-values also for GLRB single-nucleotide variants rs17035816 (P=3.8 x 10(-4)) and rs76

293 ctly call allele frequencies of known single nucleotide variants.

294 ts primarily recognize the PAM-complementary nucleotides via the substituted residues.

295 A rapid shift toward higher energy adenine nucleotides was observed following clinical reperfusion,

296 Here we demonstrate that activating nucleotides with 2-aminoimidazole results in superior re

297 entional DNA synthesizer, containing neutral nucleotides with a methylated phosphate group.

298 quantum point contact measurements on single nucleotides within DNA macromolecules, we demonstrate th

299 uld be R-tracts, contiguous runs of >/=4 RNA nucleotides within DNA strand and the only common substr

300 ere the OrzO antitoxin base pairs to the 174-nucleotide zorO 5 UTR.