ライフサイエンスコーパス: nucleotide excision repair

1 oside and camptothecin, suggesting a role in nucleotide excision repair.

2 fficient substrate for transcription-coupled nucleotide excision repair.

3 Mutational burden increased with impaired nucleotide excision repair.

4 f about 500 kDa, TFIIH is also essential for nucleotide excision repair.

5 pair proteins that reduced the efficiency of nucleotide excision repair.

6 known for its role in transcription-coupled nucleotide excision repair.

7 ysis suggests may result from less-effective nucleotide excision repair.

8 on of genes encoding molecules important for nucleotide excision repair.

9 compromises DNA break rejoining and base and nucleotide excision repair.

10 volved in the initial steps of global genome nucleotide excision repair.

11 nylation but were nevertheless inhibitory to nucleotide excision repair.

12 are the primary initiators of global genome nucleotide excision repair.

13 on in addition to its well-known function in nucleotide excision repair.

14 DE-dG), which are removed from the genome by nucleotide excision repair.

15 Rad14p is a DNA damage recognition factor in nucleotide excision repair.

16 the unwinding of a damaged DNA duplex during nucleotide excision repair.

17 tial fate of excised oligonucleotides during nucleotide excision repair.

18 ted the importance of the targeted genes for nucleotide excision repair.

19 ucleotide oligonucleotides by the process of nucleotide excision repair.

20 st contractions, but through BER rather than nucleotide excision repair.

21 s lesion and its ability to be recognized by nucleotide excision repair.

22 e (Pol) II and trigger transcription-coupled nucleotide excision repair.

23 excision repair, but they are substrates for nucleotide excision repair.

24 mcitabine or cisplatin reflected inefficient nucleotide excision repair.

25 to essentially all DNA damages processed by nucleotide excision repair.

26 hesis of up to 30 nucleotides during base or nucleotide excision repair.

27 or required for transcription initiation and nucleotide excision repair.

28 air pathways of homologous recombination and nucleotide excision repair.

29 with the drug by removal of the damages with nucleotide excision repair.

30 ranscription-coupled repair, a subpathway of nucleotide excision repair.

31 bulky lesions more commonly associated with nucleotide excision repair.

32 adducts which could influence the ability of nucleotide excision repair.

33 d plays essential roles in transcription and nucleotide excision repair.

34 ation of intermediates in mismatch repair or nucleotide-excision repair.

35 compromised arises via transcription-coupled nucleotide excision repair, a previously identified cont

36 rs the DNA unwinding activity of XPD and the nucleotide excision repair activity of TFIIH.

37 UvrD helicase is required for nucleotide excision repair, although its role in this pr

38 ingly, we find that the loss of p21 restores nucleotide excision repair and apoptosis in Ddb2(-/-) mi

39 ated an antagonistic role of DDB2 and p21 in nucleotide excision repair and apoptosis.

40 of the CRL4-CSN complex, thereby regulating nucleotide excision repair and cell death.

41 duced a protein that had full capacities for nucleotide excision repair and cisplatin resistance.

42 oint, and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link r

43 a way that depends on transcription-coupled nucleotide excision repair and mismatch repair.

44 B2), a nuclear protein, participates in both nucleotide excision repair and mRNA transcription.

45 bservation that aRPA supports early steps of nucleotide excision repair and recombination indicates t

46 -peptide conjugates, which can be subject to nucleotide excision repair and replication bypass.

47 ol kappa), which has been implicated in both nucleotide excision repair and trans-lesion synthesis, r

48 tains a [4Fe-4S] cluster and is critical for nucleotide excision repair and transcription.

49 mplex is a versatile factor involved in both nucleotide excision repair and transcriptional coactivat

50 ch a scenario reflects a natural step during nucleotide excision repair, and given that the germline

51 unctions in methyl-directed mismatch repair, nucleotide excision repair, and homologous recombination

52 structure-specific endonuclease required for nucleotide excision repair, and incision-defective XPG m

53 cated in DNA replication, DNA recombination, nucleotide excision repair, and methyl-directed mismatch

54 regulation in DNA repair pathways, e.g. BER, nucleotide excision repair, and mismatch repair, and dec

55 lays a key role in recognizing DNA damage in nucleotide excision repair, and patients with XPC defici

56 to global genome repair-specific elements of nucleotide excision repair, and suggests that TCR is a m

57 Mitochondria lack nucleotide excision repair, and therefore, it is importa

58 mologous recombination, DNA mismatch repair, nucleotide excision repair, and translesion DNA synthesi

59 recognition of such DNA lesions by the human nucleotide excision repair apparatus, are discussed.

60 scription-coupled DNA repair (TCR) branch of nucleotide excision repair, are hypersensitive to cispla

61 Consequently, nucleotide excision repair at an actively transcribed ge

62 These lesions are removed through nucleotide excision repair because humans lack a DNA gly

63 nd recruits the enzymes involved in base and nucleotide excision repair (BER and NER).

64 DNA repair, presumably because p21 inhibits nucleotide excision repair by blocking proliferating cel

65 V600E) and ARF deletion synergize to inhibit nucleotide excision repair by epigenetically repressing

66 oderma pigmentosum C (XPC) complex initiates nucleotide excision repair by recognizing DNA lesions be

67 r essential for initiating the global genome nucleotide excision repair by recognizing the DNA lesion

68 ssage of the RNA polymerase complex and that nucleotide excision repair can remove the block and rest

69 ty is modulated by the transcription-coupled nucleotide excision repair capacity.

70 e absence of DNA damage the yeast Rad4-Rad23 nucleotide excision repair complex binds to the promoter

71 aled this coactivator to be the trimeric XPC-nucleotide excision repair complex.

72 ognized by the xeroderma pigmentosum C (XPC) nucleotide excision repair complex.

73 XPD, a 5'-3' helicase involved in nucleotide excision repair, contains a [4Fe-4S] cluster

74 portant for genomic stability including XPD (nucleotide excision repair), DDX11 (sister chromatid coh

75 XP patients have a nucleotide excision repair defect and a 10,000-fold incr

76 n on UV-damaged DNA, which is independent of nucleotide excision repair, demonstrating a clear requir

77 The absence of Endo VIII or nucleotide excision repair did not significantly affect

78 essive diseases that belong to the family of nucleotide excision repair disorders.

79 into DNA double-strand breaks (DSBs) by the nucleotide excision repair endonucleases XPF and XPG.

80 air by promoting backtracking and recruiting nucleotide excision repair enzymes to exposed lesions.

81 shielded by blocked RNA polymerase, allowing nucleotide excision repair enzymes to gain access to sit

82 ential role in repair of cisplatin damage by nucleotide excision repair, exhibits circadian oscillati

83 a suggest that the key transcription-coupled nucleotide excision repair factor (TC-NER) Cockayne synd

84 se activity but independent of the essential nucleotide excision repair factor XPA.

85 Here we have used purified core nucleotide excision repair factors (RPA, XPA, XPC, TFIIH

86 Among these, nucleotide excision repair factors promote CDT1 destruct

87 corporation during replication, or incorrect nucleotide excision repair following oxidative damage.

88 a critical DNA damage recognition factor in nucleotide excision repair for which genetic deficiency

89 In contrast, even though nucleotide excision repair gene homologs have been found

90 Human nucleotide excision repair generates two incisions surro

91 single-nucleotide polymorphisms of selected nucleotide excision repair genes and arterial stiffness

92 mic instability resulting from the defective nucleotide excision repair genes ERCC1 and XPD (Ercc1(d/

93 a mechanism for its anticancer activity, the nucleotide excision repair genes were studied in bone ma

94 n initiates the global genomic subpathway of nucleotide excision repair (GG-NER) for removal of UV-in

95 modeled at lesion sites in the global genome nucleotide excision repair (GG-NER) pathway.

96 tion impaired the capacity of global genomic nucleotide excision repair (GG-NER), a critical mechanis

97 for by selective resistance to global-genome nucleotide excision repair (GG-NER).

98 sruption of Xpc, essential for global-genome nucleotide excision repair (ggNER) of helix-distorting n

99 have been found in plants, the mechanism of nucleotide excision repair has not been investigated.

100 4 (D4) revealed no particular sensitivity to nucleotide excision repair, homologous recombination rep

101 In this study, we measured nucleotide excision repair in both normal melanocytes an

102 Nucleotide excision repair in Escherichia coli is stimul

103 at the G*[C8-N3]T* lesions are substrates of nucleotide excision repair in human cell extracts.

104 ficient substrates for transcription-coupled nucleotide excision repair in human cells.

105 e congruence of in vivo and in vitro data on nucleotide excision repair in humans.

106 leotide excision repair system in E. coli by nucleotide excision repair in humans.

107 at the 8-MOP photoadducts are substrates for nucleotide excision repair in mammalian cells.

108 nd (6-4)PP photolyases, as well as genes for nucleotide excision repair in plants, such as Arabidopsi

109 , we examined a potential role for canonical nucleotide excision repair in the removal of ribonucleot

110 approach for studying the mechanism of human nucleotide excision repair in vivo.

111 Nucleotide excision repair is a major DNA repair mechani

112 Nucleotide excision repair is an important and highly co

113 or that mediates both ATR-CHK1 signaling and nucleotide excision repair is replication protein A, and

114 leotide single-stranded DNA gap generated by nucleotide excision repair is the signal that activates

115 Nucleotide excision repair is the sole mechanism for rem

116 These results suggest that nucleotide excision repair is unlikely to play a major r

117 y DNA adducts from the transcribed genes via nucleotide excision repair is well characterized in mamm

118 If the nucleotide excision repair machinery does not promptly r

119 zyme from the DNA, and recruits the Uvr(A)BC nucleotide excision repair machinery via UvrA binding.

120 ts normally recognized by Fanconi anemia and nucleotide excision repair machinery, although the mecha

121 epair by recruiting UvrA, a component of the nucleotide excision repair machinery, to the site.

122 teness of the DNA damage to be mended by the nucleotide excision repair machinery.

123 lly mutagenic if not properly removed by the nucleotide excision repair machinery.

124 tandem duplications suggests that errors in nucleotide excision repair may be resolved via a similar

125 Mitochondria lack a functional nucleotide excision repair mechanism to repair DNA adduc

126 acity in any four of the following pathways: nucleotide excision repair, mismatch repair, base excisi

127 d cisplatin-induced gap-filling synthesis in nucleotide excision repair (NER) and a reduced dATP leve

128 oup A (XPA) is a crucial factor in mammalian nucleotide excision repair (NER) and nuclear import of X

129 at INO80 acts in the same genetic pathway as nucleotide excision repair (NER) and that the Ino80-C co

130 Global nucleotide excision repair (NER) and transcription-coupl

131 sions, cdG and cdA are repaired by the human nucleotide excision repair (NER) apparatus.

132 Given the use of nucleotide excision repair (NER) as a backup pathway for

133 35 (ATR-pS435), a modification that enhances nucleotide excision repair (NER) by facilitating recruit

134 Mutations in nucleotide excision repair (NER) components (e.g. XPA-1

135 -coupled DNA repair (TCR) is a subpathway of nucleotide excision repair (NER) dedicated to rapid remo

136 s affecting TFIIH has been attributed to the nucleotide excision repair (NER) defect as well as to im

137 Nucleotide excision repair (NER) defects are associated

138 N(2)-dG (G*), manifests large differences in nucleotide excision repair (NER) efficiencies in DNA dup

139 formation and resulted in 2- to 3-fold lower nucleotide excision repair (NER) efficiencies in Escheri

140 Nucleotide excision repair (NER) efficiencies of DNA les

141 Chl are efficiently repaired by a dedicated Nucleotide Excision Repair (NER) enzyme.

142 Nucleotide excision repair (NER) excises bulky DNA lesio

143 We have performed nucleotide excision repair (NER) experiments in human He

144 , a central DNA damage recognition factor in nucleotide excision repair (NER) extensively regulated b

145 the MSH2 mismatch repair protein and the XPA nucleotide excision repair (NER) factor are among the pr

146 eroderma pigmentosum group A (XPA) is a core nucleotide excision repair (NER) factor essential for NE

147 n NSs is similar to OmegaXaV motifs found in nucleotide excision repair (NER) factors and transcripti

148 does not appear to affect the expression of nucleotide excision repair (NER) factors, such as XPC an

149 o significant impact on the transcription of nucleotide excision repair (NER) factors.

150 The transcription of ERCC1 and other nucleotide excision repair (NER) genes is strongly influ

151 Nucleotide excision repair (NER) has long been known to

152 acologically-induced cAMP signaling promotes nucleotide excision repair (NER) in a cAMP-dependent pro

153 A prominent role for nucleotide excision repair (NER) in disease caused by My

154 des flanking a DNA lesion on either side, on nucleotide excision repair (NER) in extracts from human

155 an tissues and whether it is a substrate for nucleotide excision repair (NER) in vivo.

156 Nucleotide excision repair (NER) is a conserved and vers

157 Nucleotide excision repair (NER) is a highly conserved p

158 Nucleotide excision repair (NER) is a major repair pathw

159 Nucleotide excision repair (NER) is a very important def

160 Nucleotide excision repair (NER) is an evolutionarily co

161 Nucleotide excision repair (NER) is critical for maintai

162 Nucleotide excision repair (NER) is critical for the rep

163 Nucleotide excision repair (NER) is responsible for prot

164 Nucleotide excision repair (NER) is responsible for the

165 Nucleotide excision repair (NER) is shown to not play a

166 Nucleotide excision repair (NER) is the key DNA repair s

167 Nucleotide excision repair (NER) is the principal pathwa

168 Nucleotide excision repair (NER) is the sole mechanism i

169 How the nucleotide excision repair (NER) machinery gains access

170 tial scaffolding protein in the multiprotein nucleotide excision repair (NER) machinery.

171 The molecular basis of resistance to nucleotide excision repair (NER) of certain bulky DNA le

172 Disruption of the nucleotide excision repair (NER) pathway by mutations ca

173 Strains with mutations in the nucleotide excision repair (NER) pathway genes uvrC or u

174 G adducts can be efficiently repaired by the nucleotide excision repair (NER) pathway in normal human

175 Effective repair of such lesions by the nucleotide excision repair (NER) pathway is required to

176 XPA is an essential protein in the nucleotide excision repair (NER) pathway, in charge of r

177 terations in another DNA repair pathway, the nucleotide excision repair (NER) pathway, which may exhi

178 hotosensitive diseases with mutations in the nucleotide excision repair (NER) pathway, which repairs

179 4)-POBdT could be subjected to repair by the nucleotide excision repair (NER) pathway.

180 cal role in the repair of DNA damage via the nucleotide excision repair (NER) pathway.

181 fic DNA lesions, which are the substrates of nucleotide excision repair (NER) pathway.

182 sed skin cancer, is caused by defects in the nucleotide excision repair (NER) pathway.

183 uplex DNA, these lesions are repaired in the nucleotide excision repair (NER) pathway.

184 ances the repair of DNA photoproducts by the nucleotide excision repair (NER) pathway.

185 DNA-binding protein that participates in the nucleotide excision repair (NER) pathway.

186 lease, is best known for its function in the nucleotide excision repair (NER) pathway.

187 response to UV light-induced DNA damage, the nucleotide excision repair (NER) pathways are activated

188 Nucleotide excision repair (NER) plays a vital role in p

189 Nucleotide excision repair (NER) protects against sunlig

190 Nucleotide excision repair (NER) proteins have been foun

191 We find that the nucleotide excision repair (NER) proteins UvrA, UvrB, an

192 eIF3a negatively regulates the synthesis of nucleotide excision repair (NER) proteins, and, in turn,

193 study this, we measured the distribution of nucleotide excision repair (NER) rates for UV-induced le

194 Nucleotide excision repair (NER) removes chemically dive

195 Nucleotide excision repair (NER) removes these photoprod

196 that can yield mechanistic information about nucleotide excision repair (NER) stimulated by cAMP-depe

197 ion coupled repair (TCR) are two pathways of nucleotide excision repair (NER) that differ in the dama

198 -coupled DNA repair (TCR) is a subpathway of nucleotide excision repair (NER) that is triggered when

199 red the stability of 26 proteins involved in nucleotide excision repair (NER) under normal growth con

200 Here we report that USP7 regulates nucleotide excision repair (NER) via deubiquitinating xe

201 ity, small changes in mismatch repair (MMR), nucleotide excision repair (NER), and homologous recombi

202 ch two-strand mutations depend on functional nucleotide excision repair (NER), but the molecular mech

203 In nucleotide excision repair (NER), damage recognition by

204 Nucleotide excision repair (NER), interstrand cross-link

205 uble-stranded DNA junctions and has roles in nucleotide excision repair (NER), interstrand crosslink

206 to DNA repair by base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR),

207 Strikingly, nucleotide excision repair (NER), the most versatile DNA

208 ajor endpoints for assessing the activity of nucleotide excision repair (NER), the most versatile DNA

209 re hypersensitive to KP1019, suggesting that nucleotide excision repair (NER), translesion synthesis

210 Using repair-defective nucleotide excision repair (NER)-, mismatch repair-, and

211 We report here that a nucleotide excision repair (NER)-associated-factor is re

212 nalysis suggests that NusA participates in a nucleotide excision repair (NER)-dependent process to pr

213 ged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner.

214 human cell extracts yields a characteristic nucleotide excision repair (NER)-induced ladder of short

215 ly mutagenic UVB-induced DNA photolesions by nucleotide excision repair (NER).

216 cisplatin-modified DNA in the nucleus by the nucleotide excision repair (NER).

217 ct of the initial damage recognition step in nucleotide excision repair (NER).

218 NA lesions caused by exposure to UV light is nucleotide excision repair (NER).

219 tial for RNA polymerase II transcription and nucleotide excision repair (NER).

220 d be expected to be more readily repaired by nucleotide excision repair (NER).

221 ge by flagging O(6)-alkylguanine lesions for nucleotide excision repair (NER).

222 l of ultraviolet (UV)-induced DNA lesions by nucleotide excision repair (NER).

223 bal genomic repair (GGR) are two pathways of nucleotide excision repair (NER).

224 nown to be involved in transcription-coupled nucleotide excision repair (NER).

225 evidence that these lesions are repaired by nucleotide excision repair (NER).

226 udies suggest that repair also can occur via nucleotide excision repair (NER).

227 is responsible for recognizing DNA damage in nucleotide excision repair (NER).

228 ion group A (XPA) mice that are deficient in nucleotide excision repair (NER).

229 anslational event required for cAMP-enhanced nucleotide excision repair (NER).

230 r for skin cancers, is primarily repaired by nucleotide excision repair (NER).

231 IIH) is essential for both transcription and nucleotide excision repair (NER).

232 e associated with somatic alterations in the nucleotide- excision repair (NER) pathway has not yet be

233 toproducts are recognized and removed by the nucleotide-excision repair (NER) pathway.

234 or total DNA polymerase-blocking lesions and nucleotide excision repair of (6-4) photoproducts in vit

235 Hrq1 supports the nucleotide excision repair of DNA damage caused by the c

236 ys essential roles in both transcription and nucleotide excision repair of nuclear DNA, however, whet

237 n damage-recognition protein responsible for nucleotide excision repair of UVB damage to DNA, is lost

238 licative DNA polymerases and are repaired by nucleotide excision repair or bypassed by translesion po

239 DNA damage requires upstream involvement of nucleotide excision repair or UVDE repair enzymes.

240 AG repeats does not involve mismatch repair, nucleotide excision repair, or transcription, processes

241 -RAD23B complex is one of the key factors of nucleotide excision repair participating in the primary

242 ways, here we show its role in the versatile nucleotide excision repair pathway (NER) that removes a

243 have defects in seven of the proteins of the nucleotide excision repair pathway and in DNA polymerase

244 f UvrA and UvrD1, thought to be parts of the nucleotide excision repair pathway of M. tuberculosis.

245 The nucleotide excision repair pathway removes ultraviolet (

246 lates repair by recruiting components of the nucleotide excision repair pathway to the site.

247 ERCC2 is indispensable for nucleotide excision repair pathway, and its functional p

248 onent of the protein homeostasis network and nucleotide excision repair pathway, as a modifier of the

249 ires a specific sub-branch of the DNA damage nucleotide excision repair pathway, termed transcription

250 DNA after the lesion has been excised by the nucleotide excision repair pathway, while others partici

251 and XPF involves two major components of the nucleotide excision repair pathway.

252 ssential for the repair of DNA damage by the nucleotide excision repair pathway.

253 lated DNA and shunt the damaged DNA into the nucleotide excision repair pathway.

254 plays an essential role in DNA repair in the nucleotide excision repair pathway.

255 known to function in the mismatch repair and nucleotide excision repair pathways and has also been su

256 aryotes, DNA double-strand break repair, and nucleotide excision repair pathways.

257 into global genome or transcription-coupled nucleotide excision repair pathways.

258 We determined that nucleotide excision repair plays a key role in the remov

259 repair, the process of transcription-coupled nucleotide excision repair plays a role in the removal o

260 The nucleotide excision repair protein complex ERCC1-XPF is

261 Here, we reveal a novel function of the nucleotide excision repair protein DDB2 in the accumulat

262 uctural features and interactions with other nucleotide excision repair protein factors of the two en

263 Here, we show that the mammalian nucleotide excision repair protein homolog MMS19 can sim

264 o psoralen crosslinks was independent of the nucleotide excision repair recognition factor, XPC.

265 es implicated in diverse processes including nucleotide excision repair, regulating gene expression a

266 ction exhibit essentially normal activity in nucleotide excision repair, revealing RPA separation of

267 cation of XPA, a critical factor controlling nucleotide excision repair signaling pathways.

268 ovided a 60 bp duplex, which is suitable for nucleotide excision repair studies.

269 leic acid (DNA) lesions by the global genome nucleotide excision repair subpathway is performed by th

270 factor II H (TFIIH) is a major actor of both nucleotide excision repair subpathways of which transcri

271 and results obtained in cells defective for nucleotide excision repair suggest that breakage of DNA

272 his damage is repaired by photolyase and the nucleotide excision repair system in E. coli by nucleoti

273 es are not efficiently targeted by the human nucleotide excision repair system in vitro or in culture

274 ggest that M. genitalium possesses an active nucleotide excision repair system, possibly representing

275 that possess mutations in components of the nucleotide excision repair system.

276 humans and mice, UV damage is removed by the nucleotide excision repair system.

277 is one of the six core factors of the human nucleotide excision repair system.

278 ing cells with either competent or deficient nucleotide excision repair systems, we demonstrate that

279 ubgroups with impaired transcription coupled nucleotide excision repair (TC-NER) (category 1: XP-A, B

280 Transcription-coupled nucleotide excision repair (TC-NER) allows RNA polymeras

281 formation requires the transcription-coupled nucleotide excision repair (TC-NER) factor Cockayne synd

282 in cells deficient in transcription-coupled nucleotide excision repair (TC-NER) or global genomic NE

283 primarily involves the transcription-coupled nucleotide excision repair (TC-NER) pathway.

284 Transcription-coupled nucleotide excision repair (TC-NER) requires the coordin

285 known for its role in transcription-coupled nucleotide excision repair (TC-NER), contains a ubiquiti

286 Transcription-coupled nucleotide excision repair (TCR) accelerates the removal

287 In eukaryotic cells, transcription coupled nucleotide excision repair (TCR) is believed to be initi

288 important and well-conserved sub-pathway of nucleotide excision repair that preferentially removes D

289 ual incisions, and repair resynthesis during nucleotide excision repair, the fate of the dual incisio

290 uded that melanoma cells retain capacity for nucleotide excision repair, the loss of which probably d

291 Here we show that E-cadherin promotes nucleotide excision repair through positively regulating

292 cells, however, disruption of Nrf1 impaired nucleotide excision repair through suppressing the trans

293 Although human cells possess a mechanism (nucleotide excision repair) to repair UV-induced DNA dam

294 tes activate a specific repair pathway, i.e. nucleotide excision repair, to remove UVB-induced DNA le

295 en involves multiple repair pathways such as nucleotide-excision repair, translesion DNA synthesis (T

296 es involved in removal of photo-damage (e.g. nucleotide excision repair uvrABC, recombinases recBCD a

297 ontrast, a deletion mutant for the predicted nucleotide excision repair uvrC gene showed growth defec

298 Previous reports have shown that both nucleotide excision repair, which is the sole pathway in

299 The lesions can only be repaired by nucleotide excision repair with a low efficiency.

300 N1 5' nuclease superfamily members acting in nucleotide excision repair (XPG), mismatch repair (EXO1)