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1 bic regions, including the ventral striatum (nucleus accumbens).
2 (but not with structural differences in the Nucleus Accumbens).
3 n thalamus), and limbic system (amygdala and nucleus accumbens).
4 trength at prefrontal cortex synapses in the nucleus accumbens.
5 ng the D1 dopamine receptor (D1-MSNs) in the nucleus accumbens.
6 e respective change of the RPE signal in the nucleus accumbens.
7 D1DR/PKA-dependent AMPA transmission in the nucleus accumbens.
8 inhibition of DA clearance in slices of the nucleus accumbens.
9 llial regions, particularly the striatum and nucleus accumbens.
10 gions of the CNS such as the hippocampus and nucleus accumbens.
11 e measuring phasic dopamine signaling in rat nucleus accumbens.
12 rter assays and in vivo microdialysis in rat nucleus accumbens.
13 ntration in the medial prefrontal cortex and nucleus accumbens.
14 d cocaine-induced release of dopamine in the nucleus accumbens.
15 g food picture evaluation in the caudate and nucleus accumbens.
16 ntials in direct-pathway MSNs (dMSNs) in the nucleus accumbens.
17 s cocaine-induced changes of dopamine in the nucleus accumbens.
18 rexcitability of medium spiny neurons of the nucleus accumbens.
19 al response to anticipation of reward in the nucleus accumbens.
20 mic oxytocin were mediated by actions in the nucleus accumbens.
21 age and was modulated by D1 availability in nucleus accumbens.
22 utamen and higher D1-receptor density in the nucleus accumbens.
23 e of the brain's reward regions, such as the nucleus accumbens.
24 and cocaine-enhanced extracellular DA in the nucleus accumbens.
25 effects depend on oxytocin signaling in the nucleus accumbens.
26 thylation at the Auts-Caln1 loop base in the nucleus accumbens.
27 in striatal projection neurons (SPNs) of the nucleus accumbens.
28 nal networks and their connectivity with the nucleus accumbens.
29 repressor of gene expression, acting in the nucleus accumbens, a brain reward region, is capable of
33 el-free analyses convergently indicated that nucleus accumbens activity can support aggregate forecas
34 re observed in striatum, olfactory tubercle, nucleus accumbens, amygdala, and neocortex, whereas in s
35 in reward processing, including the caudate, nucleus accumbens, amygdala, anterior insula, and orbito
36 seven bilateral subcortical structures: the nucleus accumbens, amygdala, caudate, hippocampus, palli
37 the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, palli
38 th these conditions (i.e. prefrontal cortex, nucleus accumbens, amygdala, ventral tegmental area) is
39 rain sites on the mesolimbic reward pathway (nucleus accumbens; amygdala) that receive OT projections
41 cally in D2-type medium spiny neurons in the nucleus accumbens, an effect seen in male but not female
43 gene promoter regions, was evaluated in the nucleus accumbens and dorsal striatum of rats using west
44 s (MSNs), the main projection neurons in the nucleus accumbens and dorsal striatum, and their functio
45 so increased the expression of Zif268 in the nucleus accumbens and dorsolateral striatum of LgA rats.
46 vulnerability, we focused on the core of the nucleus accumbens and examined expression and epigenetic
47 s in excitability of medium spiny neurons in nucleus accumbens and gating the compositional plasticit
48 ture mechanistic studies of gene networks in nucleus accumbens and gene regulatory mechanisms across
49 thic care was preferentially associated with nucleus accumbens and medial orbitofrontal cortex activi
51 similarities between the ventral striatum's nucleus accumbens and olfactory tubercle (OT) suggests t
52 , which is crucial for processing of affect; nucleus accumbens and orbitofrontal cortex of the reward
53 ed opposite effects on TrkB signaling in the nucleus accumbens and prefrontal cortex, tat-cyclotraxin
54 twork and increased connectivity between the nucleus accumbens and the cingulo-opercular network.
55 ated with decreased connectivity between the nucleus accumbens and the default mode network and incre
57 striatal functional connectivity between the nucleus accumbens and the midcingulate cortex in respons
58 city at synapses between specific neurons in nucleus accumbens and ventral pallidum, and how these ch
60 ium spiny neurons (D1-/D2-MSNs) comprise the nucleus accumbens, and activity in D1-MSNs promotes, whe
61 gression within the caudate, ventral caudate/nucleus accumbens, and anterior and posterior insula, 2)
62 er brain regions, including the hippocampus, nucleus accumbens, and anterior cingulate cortex, in ind
64 on levels were increased in the amygdala and nucleus accumbens, and decreased in the hippocampus, but
66 wo regions studied, orbitofrontal cortex and nucleus accumbens, are not sequentially dependent during
67 criptional and epigenetic alterations in the nucleus accumbens, are thought to contribute to this lif
68 findings identify a functional role for the nucleus accumbens as a critical brain region whereby CBD
69 bility to induce long-term depression in the nucleus accumbens, as well as increased potentiation at
70 zygous c.892C>T (p.Arg298Trp) variant in the nucleus accumbens associated 1 (NACC1) gene in seven aff
72 l lateral core or caudal medial shell of the nucleus accumbens attenuated cocaine priming-induced rei
73 oding RNA RP1-269M15.3 in frontal cortex and nucleus accumbens basal ganglia, respectively, were sign
75 opamine neurotransmission in the core of the nucleus accumbens (but not the dorsolateral striatum).
76 d activation in brain reward regions such as nucleus accumbens, but could not address gene expression
77 e recruited a more excitable ensemble in the nucleus accumbens, but not orbitofrontal cortex, compare
83 napses on medium spiny neurons (MSNs) in the nucleus accumbens core (NAcore) and requires spillover o
84 ver from cortical terminals synapsing in the nucleus accumbens core (NAcore) to stimulate metabotropi
85 th response factor 1 immunoreactivity in the nucleus accumbens core and anteromedial BNST in female m
86 echanism for use-dependent inhibition in the nucleus accumbens core and dorsal striatum, is also mini
87 e strategy to knock down GLT-1 or xCT in the nucleus accumbens core and examined the behavioral and m
88 he excitability of neuronal ensembles in the nucleus accumbens core and shell (NAc(core) and NAc(shel
90 prolonged mode of dopamine signaling in the nucleus accumbens core and that such signaling relates t
91 vior, as well as synaptic impairments in the nucleus accumbens core considered hallmarks of addiction
92 8,899 into the anteromedial BNST but not the nucleus accumbens core increased social approach and dec
93 rom the dorsomedial prefrontal cortex to the nucleus accumbens core makes it difficult to selectively
94 (t-SP) of cortical glutamatergic synapses on nucleus accumbens core medium spiny neurons, but it is u
95 itored dopamine concentration changes in the nucleus accumbens core of rats throughout acquisition an
96 immobilization stress, and 3 weeks later the nucleus accumbens core was examined for changes in gluta
97 ly, local administration of OSU6162 into the nucleus accumbens core, but not dorsolateral striatum, s
98 dings suggest that low D2 mRNA levels in the nucleus accumbens core, likely mediated via epigenetic m
99 sporter-inhibiting effects of cocaine in the nucleus accumbens core, which was normalized following a
102 nset, long-lasting increase in extracellular nucleus accumbens DA, locomotion, and brain-stimulation
103 l (locus coeruleus) and preference/aversion (nucleus accumbens) demonstrate the unique capabilities o
106 lative activation of glutamatergic inputs to nucleus accumbens during cued reinstatement of cocaine s
107 ed genome-wide RNA expression in post-mortem nucleus accumbens from donors (N=26) with known loneline
109 regions studied (thalamus, caudate, putamen, nucleus accumbens, globus pallidus, and substantia nigra
111 ), striatum (Hedge's g=0.57, P<0.05) and the nucleus accumbens (Hedge's g=1.30, P<0.05) compared to c
113 trics of the caudate, putamen, pallidum, and nucleus accumbens in 53 depressed patients (mean age: 44
114 classes of dopaminergic neurons in the mouse nucleus accumbens in a sensitized locomotor response to
115 subiculum and potentially its projections to nucleus accumbens in context-induced relapse after punis
116 e addition of the orbitofrontal cortices and nucleus accumbens in patients with semantic dementia.
117 naling across the rostral-caudal axis of the nucleus accumbens in the control of drug-induced negativ
118 , who explored the role of astrocytes in the nucleus accumbens in the neural mechanisms underlying co
119 hese results emphasize the centrality of the nucleus accumbens in the pathophysiology of reward defic
121 in both medial prefrontal cortex (mPFC) and nucleus accumbens, increased anxiety-like behavior, and
122 orking model that synaptic plasticity in the nucleus accumbens is central to age-related changes in v
123 circuit from the medial prefrontal cortex to nucleus accumbens is dynamically modulated to enhance fe
125 ymptoms motivate continued drug use, and the nucleus accumbens is important for orchestrating both pr
126 The SIIPS1 includes patterns of activity in nucleus accumbens, lateral prefrontal and parahippocampa
127 of the thalamus as a prominent input to the nucleus accumbens mediating the expression of opiate-wit
128 our current understanding about the role of nucleus accumbens MSN subtypes in stress-related depress
129 aimed to assess molecular differences in the nucleus accumbens (NAc) (a specific brain nucleus postul
130 hippocampus (male/female) and upregulated in nucleus accumbens (NAc) (male) in depressed human subjec
131 dorsal raphe nucleus (DRN) afferents to the nucleus accumbens (NAc) abolishes cocaine reward and pro
132 ls of the histone dimethyltransferase G9a in nucleus accumbens (NAc) after chronic cocaine administra
133 rp1), the mitochondrial fission mediator, in nucleus accumbens (NAc) after repeated cocaine exposure
134 day after the second extinction test and the nucleus accumbens (NAc) and dorsal striatum were collect
135 with the addiction cycle: the dopamine-dense nucleus accumbens (NAc) and norepinephrine-rich ventral
136 ned functional and structural changes in the nucleus accumbens (NAc) and prefrontal cortex (PFC) asso
137 la (BLA) sends excitatory projections to the nucleus accumbens (NAc) and regulates motivated behavior
138 as employed on tissue from subregions of the nucleus accumbens (NAc) and the amygdala to examine both
139 ated dopamine receptor (DRD)-1 and -2 in the nucleus accumbens (NAc) and with down-regulated Lepr in
140 atory glutamatergic neurotransmission in the nucleus accumbens (NAc) appear to drive this drug-induce
142 tic activation of cholinergic neurons in the nucleus accumbens (NAc) are inhibited by CB1 agonists an
143 ions in global DNA hydroxymethylation in the nucleus accumbens (NAc) because neuroplastic changes in
144 ) in medium spiny neurons (MSNs) of the core nucleus accumbens (NAc) by combining patch-clamp recordi
146 y measured real-time dopamine release in the nucleus accumbens (NAc) core or shell while rats receive
147 cocaine craving depends on strengthening of nucleus accumbens (NAc) core synapses through incorporat
150 napses on medium spiny neurons (MSNs) of the nucleus accumbens (NAc) drives behavioral adaptations in
151 from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) fire in response to unpredicted
154 sed in C57BL/6J mice to confirm the role for nucleus accumbens (NAC) glutamate/Homer2 expression in M
155 that the medial prefrontal cortex (mPFC)-to-nucleus accumbens (NAc) glutamatergic transmission is se
157 lc6a15, a neutral amino acid transporter, in nucleus accumbens (NAc) in depression and stress suscept
158 nvestigated the role of AMPK activity in the nucleus accumbens (NAc) in relapse to cocaine seeking.
159 PV) expressing GABAergic interneurons of the nucleus accumbens (NAc) in the behavioral adaptations in
161 given growing evidence of Cdk5 expression in nucleus accumbens (NAc) influencing reward-related behav
163 Excitatory synaptic transmission in the nucleus accumbens (NAc) is a key biological substrate un
164 We previously showed that DeltaFosB in the nucleus accumbens (NAc) is a key mediator of this cross-
168 ed long-term potentiation (theta-LTP) in the nucleus accumbens (NAc) is significantly impaired in sli
170 ch plays a dynamic role in cocaine action in nucleus accumbens (NAc) medium spiny neuron (MSN) subtyp
171 ked to alterations of synaptic strength onto nucleus accumbens (NAc) medium spiny neurons (MSN).
174 uperficial mPFC projections to a subfield of nucleus accumbens (NAc) neurons naturally encodes the de
177 ptic protein expression are increased in the nucleus accumbens (NAc) of mice excessively consuming al
178 e task, we measured phasic DA release in the nucleus accumbens (NAc) of rats during presentation of c
180 dn5) and abnormal blood vessel morphology in nucleus accumbens (NAc) of stress-susceptible but not re
182 ses within the basolateral amygdala (BLA) to nucleus accumbens (NAc) projection, and maturation of th
184 nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context a
186 ctive excitatory glutamatergic inputs to the nucleus accumbens (NAc) shell and core, respectively.
188 observed increased beta-gal staining in the nucleus accumbens (NAC) shell and dorsal raphe nucleus,
189 ptor-expressing neurons (D1+ neurons) in the nucleus accumbens (NAc) shell but not the core in mice,
190 nd depressive-like behavior through a common nucleus accumbens (NAc) shell calcium-permeable alpha-am
191 cue-activated orbitofrontal cortex (OFC) and nucleus accumbens (NAc) shell ensembles using wild-type
192 Here, we studied the role of projections to nucleus accumbens (NAc) shell from ventral subiculum (vS
193 neurons of a mouse and their projections to nucleus accumbens (NAc) shell play a necessary and suffi
195 creased dopamine release and reuptake in the nucleus accumbens (NAc) shell, a major target region.
196 antagonist Ro25 was infused into IL-mPFC or nucleus accumbens (NAc) shell, another structure implica
197 ress regulates the expression of Fosb in the nucleus accumbens (NAc) to promote the cell-type-specifi
198 nent, increases dopamine (DA) release in the nucleus accumbens (NAc) via inhibition of local VTA GABA
199 c increases in dopamine concentration in the nucleus accumbens (NAc) while discrete aversive stimuli
200 subunits of AMPA glutamate receptors in the nucleus accumbens (NAc), a brain region critical for mod
201 sed whether impaired dopamine release in the nucleus accumbens (NAc), a brain region critical to goal
203 spines on medium spiny neurons (MSNs) in the nucleus accumbens (NAc), a critical brain region for coc
205 nxiety- and depression-like behaviors in the nucleus accumbens (NAc), a key brain reward region.
206 ssion in mice, increases SIRT1 levels in the nucleus accumbens (NAc), a key brain reward region.
207 ors, and examined Tet1 expression changes in nucleus accumbens (NAc), a key brain reward region.
208 ding RNA is also highly expressed within the nucleus accumbens (NAc), a pivotal brain region underlyi
209 ls exhibited preferential D2R changes in the nucleus accumbens (NAc), a striatal region that critical
210 have been implicated in social behavior: the nucleus accumbens (NAc), amygdala, and ventral tegmental
211 2) selective knockdown of Tlr4 mRNA in mouse nucleus accumbens (NAc), and (3) injection of the TLR4 a
212 mediated by the basolateral amygdala (BLA), nucleus accumbens (NAc), and medial prefrontal cortex (m
213 of reward-related brain regions, such as the nucleus accumbens (NAc), are linked to the pathophysiolo
214 , such as the basolateral amygdala (BLA) and nucleus accumbens (NAc), as important to valence encodin
215 xpression in brain reward regions, including nucleus accumbens (NAc), contribute to persistent functi
216 icity in the reward system, particularly the nucleus accumbens (NAc), drives drug-adaptive behavior.
217 f abuse, increases levels of dopamine in the nucleus accumbens (nAc), facilitating behavioural reinfo
218 ally specific changes in activity within the nucleus accumbens (NAc), which occur during anticipatory
219 to cocaine generates silent synapses in the nucleus accumbens (NAc), whose eventual unsilencing/matu
220 te a role for increased H3.3 dynamics in the nucleus accumbens (NAc)-a key limbic brain reward region
234 ject to the ventral tegmental area (VTA) and nucleus accumbens (NAc); however, direct neuroanatomical
237 usion of varenicline (0.3 mul/side) into the nucleus accumbens (NAc; 0 or 3.5 mug), but not the ventr
238 PFC) and subcortical reward-related regions (nucleus accumbens, NAC) mediates the selection of approp
239 , we examined functional connectivity of the nucleus accumbens (NAcc) - a hub of the reward network -
240 ctional neuroimaging research indicates that nucleus accumbens (NAcc) and anterior insula (AIns) acti
242 ammetry recordings of dopamine levels in the nucleus accumbens (NAcc) core and shell in rats working
243 subjective value-related activity within the nucleus accumbens (NAcc) during inter-temporal choice an
244 Abnormal reward-related responses in the nucleus accumbens (NAcc) have been reported for major de
245 g via the kappa-opioid receptor (KOR) in the nucleus accumbens (NAcc) powerfully mediates negative af
246 tronger responses to food commercials in the nucleus accumbens (NAcc) than children not at risk.
248 arch, and in MDD more generally, include the nucleus accumbens (NAcc), lateral prefrontal cortex (LPF
249 eir infants and the connectivity between the nucleus accumbens (NAcc), the amygdala, and the medial p
251 he ortholog Kmt2b, in adult ventral striatum/nucleus accumbens neurons markedly increased anxiety sco
253 dback) and an alternate neurofeedback group (nucleus accumbens), none sustained activation in target
254 either altered extracellular dopamine in the nucleus accumbens nor maintained self-administration.
256 ing of dopamine signaling in the core of the nucleus accumbens of rats to determine the relationship
257 hether this function is localized within the nucleus accumbens or distributed also within the OT.
259 erior insula activity, but no differences in nucleus accumbens or orbitofrontal activation, compared
261 e paraventricular nucleus of the thalamus to nucleus accumbens pathway is necessary and sufficient to
262 experience-induced neural adaptations in the nucleus accumbens, prefrontal cortex, and ventral tegmen
263 cordings reveal that spontaneous activity of nucleus accumbens-projecting VTA (VTA-NAc) neurons is se
265 d miR-181b in human brain and blood, greater nucleus accumbens reactivity to positive emotional stimu
268 nt of chromatin remodeling complexes, in the nucleus accumbens regulates reward-related behaviors in
271 ex formation with SMAD3 are increased in the nucleus accumbens, resulting in increased binding of BRG
272 nt component of this network is the anterior nucleus accumbens shell (aNAcSh), which sends GABAergic
273 d had elevated mRNA expression in the medial nucleus accumbens shell (NAcSh) and caudate nucleus in p
274 ated with prominent morphological changes in nucleus accumbens shell (NACsh) neurons, including incre
275 in U (NMU) is a neuropeptide enriched in the nucleus accumbens shell (NAcSh), a brain region associat
276 ADD to vmPFC and/or vmPFC projections to the nucleus accumbens shell allows the chemogenetic exploita
277 prefrontal cortex (vmPFC) projection to the nucleus accumbens shell is important for extinction of c
278 ubstantia nigra, entopeduncular nucleus, and nucleus accumbens shell measured using brain mapping ana
279 that blockade of PKA binding to AKAPs in the nucleus accumbens shell of Sprague-Dawley rats attenuate
280 of D1-like dopamine receptors (D1DRs) in the nucleus accumbens shell promoted cocaine seeking through
281 are formed only in neuronal ensembles of the nucleus accumbens shell that are related to associative
282 f nicotine to induce dopamine release in the nucleus accumbens shell, a brain area believed to underl
283 oject abundantly to cingulate cortex and the nucleus accumbens shell, and moderately to medial amygda
284 to vmPFC neurons that project to the medial nucleus accumbens shell, confirming that these neurons a
285 ed in stress-induced relapse, comprising the nucleus accumbens shell, the dorsal raphe nucleus and th
291 gions (cortex, hippocampus, caudate-putamen, nucleus accumbens, thalamus, and hypothalamus) of BAC al
293 of cocaine to elevate dopamine levels in the nucleus accumbens, the ability of cocaine to establish a
294 y associated with reward responsivity in the nucleus accumbens, the default mode network, and the cin
295 trast, within the striatum, the shell of the nucleus accumbens, the hippocampal projection zone, and
296 axons continue to grow ectopically from the nucleus accumbens to the PFC and profoundly change PFC s
297 First, in cross-sectional analyses, right nucleus accumbens volume was inversely related to anhedo
298 y in particular brain regions, including the nucleus accumbens, where oxytocin receptor signaling fac
299 le to induce stable synaptic rewiring in the nucleus accumbens, which will likely influence responses
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