ライフサイエンスコーパス: null allele

1 null alleles) and LCA (four missense and one null allele).

2 1g(js) or Pcdh15(av-3J) alleles, or an Ush1c null allele.

3 ous deletion in Ddr2 to produce an effective null allele.

4 y to self-associate cannot complement an lfy null allele.

5 retention of beta1B, generating a functional null allele.

6 not be forced to segregate to a homokaryotic null allele.

7 cts indistinguishable from those caused by a null allele.

8 as well as the partial lethality of the p38b null allele.

9 nd rescued the male lethality of the Bpa(1H) null allele.

10 trap represents a hypomorphic rather than a null allele.

11 nthesis in sorghum, and the bmr6 mutant is a null allele.

12 , we generated mice with a conditional Hdac3 null allele.

13 o, we generated mice with a conditional PKD1-null allele.

14 ypomorphic allele of Rad51c in addition to a null allele.

15 cognition target (FRT)-dependent conditional null allele.

16 ease observed for each of two distinct fog-3 null alleles.

17 nse mutations than in those heterozygous for null alleles.

18 LacZ reporter allele, resulted in functional null alleles.

19 atio was highest among heterozygotes for VWF null alleles.

20 cngc16-1 and 16-2 were both loss-of-function null alleles.

21 causality is commonly tested with homozygous null alleles.

22 ltures harboring either two wild-type or two null alleles.

23 ess demyelination/dysmyelination than in the null alleles.

24 he function of yar was defined by generating null alleles.

25 mited by genetic redundancy and/or a lack of null alleles.

26 iate between MYMK wild type, hypomorphic and null alleles.

27 TPA suppression, indicating they function as null alleles.

28 among loci, a pattern usually suggestive of null alleles.

29 n tumors and are thought to give rise to p53-null alleles.

30 ving loci with potentially high frequency of null alleles.

31 causing CASQ2 missense mutations function as null alleles.

32 3 patients with no VWFpp were homozygous for null alleles.

33 llagen V, and is most often caused by COL5A1 null alleles.

34 erosis, nor do his relatives who carry APOL1 null alleles.

35 s often results in the generation of mutant (null) alleles.

36 Neither the missense nor the null allele affected TLR-induced secretion of IL-6.

37 premature termination mutations resulting in null alleles among ELN point mutations.

38 trast to our previous studies using the Hip1 null allele, an inhibition of tumorigenesis was not obse

39 In addition, using the Gli1 null allele and a Gli3 repressor allele, we reveal a spe

40 le CRE recombinase strain, a conditional p53-null allele and a loxP-stop-loxP activatable oncogenic K

41 we engineered a novel conditional p16(INK4a)-null allele and combined this allele with a melanocyte-s

42 We utilized mice heterozygous for a Snap25 null allele and deficient in SNAP-25 expression to model

43 variant (T596A) of Sting that functions as a null allele and fails to produce detectable protein.

44 Here, we generated a Nek8-null allele and found that homozygous mutant mice die at

45 activity phenocopied the effects of an E2f8 null allele and led to HCC.

46 ecapitulated in knock-in mice that carry one null allele and one mutant allele of the p53 gene.

47 Compound inheritance of a rare null allele and one of two low-frequency SNPs in the reg

48 Transgenic mice heterozygous for a Trp53-null allele and overexpressing EGFR in Schwann cells had

49 We generated a nos-2 null allele and show that nos-2; xnd-1 double mutants di

50 nd cancer cell-enriched protein) conditional-null allele and showed that neural-specific knockout of

51 Mature plants of the regenerated null allele and the weak allele display remarkable flora

52 on, we tested specific Trbl antisera, a trbl null allele and Trbl transgenes bearing site-directed mu

53 Using unmarked Brn3-null alleles and Brn3 conditional alleles in which gene

54 nvestigated mago nashi and tsunagi/Y14 using null alleles and clonal analysis.

55 opods (e.g., [5, 6]) and often segregate for null alleles and gene deletions [3, 4, 7, 8].

56 opportunity to test causality between APOL1 null alleles and glomerulosclerosis.

57 Overall, given the null alleles and phenotypic assays used, we did not find

58 and takes into account of allelic dropouts, null alleles and prior knowledge of inbreeding.

59 nsistent with synergism between recG and ruv null alleles and reinforced when the protein was shown t

60 in patients with RP (three missense and two null alleles) and LCA (four missense and one null allele

61 nterpreted as technical issues (for example, null alleles), and that it is important to take such fac

62 isely delete foraging, generating the for(0) null allele, and used recombineering to reintegrate a fu

63 ed these results using genetic deficiencies, null alleles, and inducible RNAi transgenes.

64 ome case has yet been associated with COL5A2 null alleles, and phenotypes that might result from such

65 ce we previously showed that CLPR2 and CLPR4 null alleles are always sterile and die on soil.

66 allele of the autonomous pathway gene fy (fy null alleles are embryo lethal) displayed background-spe

67 clv1 alleles are dominant negative, and clv1 null alleles are weak in phenotype, suggesting additiona

68 ngly, the hypersensitivity phenotype of ARP5 null allele arp5-1 is stronger than the severe knockdown

69 the common R555W mis-sense allele and a DYSF-null allele, as well as control human myoblast cultures

70 1g/L, respectively, whereas N variant was a 'null' allele associated with the absence of alphas1-case

71 re originally thought to be homozygous for a null allele at the glu1 gene and thus devoid of enzyme.

72 ted mice that have one mutant allele and one null allele at the Tgfb1 locus, reasoning that these mic

73 4.2-fold increased risk for MI; carriers of null alleles at LDLR were at even higher risk (13-fold d

74 Drosophila apoptosis, we produced authentic null alleles at this locus.

75 we demonstrate that introduction of a Trp53-null allele attenuates the vertebral defects found in Pd

76 mutations, which act as the equivalent of a null allele because they result in the generation of sma

77 mline heterozygosity of mouse Sdhb/Sdhc/Sdhd null alleles blunts chronic hypoxia-induced increases in

78 on the I1 inner arm dynein (dynein f) and a null allele, bop5-2, defective in the gene encoding the

79 gon-2 loss-of-function mutants (including a null allele) can be suppressed by gain-of-function mutat

80 The null alleles cannot heat-acclimate as light-grown plants

81 CDH23 null alleles cause deaf-blindness (Usher syndrome type 1

82 nse mutation FIG4(I41T) combined with a FIG4 null allele causes Charcot-Marie-Tooth 4J disease, a sev

83 The mouse Hinfp(LacZ) null allele causes early embryonic lethality due to a bl

84 mosaic eye imaginal discs, while ph(del), a null allele, causes only non-autonomous overgrowth, ph(5

85 with Ift172(avc1) and Ift172(wim), an Ift172 null allele: cilia were present on 42% of avc1 mouse emb

86 o-severe AD in European populations have FLG-null alleles compared with a general population frequenc

87 heterozygous for the patient mutation and a null allele (Copb2R254C/Zfn) show a severe perinatal phe

88 omparative leaf proteome analyses of a CLPR4 null allele demonstrate a central role of Clp protease i

89 ecp2 heterozygotes, which are mosaic for the null allele, demonstrated that electrical hyperexcitabil

90 tides, bib mutants phenocopy parachute (pac) null alleles, demonstrating that bib is a gain-of-functi

91 These null alleles, designated as y1-ww1 and y1-ww4, do not ac

92 mutations, and mice heterozygous for an Snf5-null allele develop MRTs with partial penetrance.

93 vo setting, mice heterozygous for an MT1-MMP-null allele display a distinct survival advantage and re

94 Mice heterozygous for either Pcbp1 or Pcbp2 null alleles display a mild and nondisruptive defect in

95 otype, mice heterozygous for a Ccm1- or Ccm2-null allele do not develop CCM lesions.

96 protein lacking the catalytic domain, or the null allele du1-R4059.

97 The null allele e resulted from an insertional disruption in

98 Embryos bearing null alleles exhibited laminin deficiency prior to mesen

99 Interestingly, three independent oshkt2;1-null alleles exhibited significantly reduced growth comp

100 stases were primarily negative for the fgfr1 null allele, exhibited high FGFR1 expression, and a neur

101 Although statistical support for null alleles existed, their presence would also be expec

102 Plants with NRB4 null alleles express profound insensitivity to SA, even

103 A targeted Zfp318 null allele extinguished IgD expression on mature B cell

104 ing seed development the effect of the cac1a null allele first becomes apparent at 3-d after flowerin

105 mained untested in the mouse, we generated a null allele for Cv2 which was crossed to Tsg and Chd mut

106 A mouse line with a null allele for Glut3 has been developed.

107 We isolated a zebrafish opa3 null allele for which homozygous mutants display increas

108 ccharomyces cerevisiae led us to reconstruct null alleles for both genes and prove that yrdC is essen

109 By contrast, null alleles for CLPP5 were embryo lethal.

110 Null alleles for CLPR2 and CLPR4 showed delayed embryoge

111 generated animals containing combinations of null alleles for each receptor, especially animals expre

112 unction during retinal development, multiple null alleles for optix have been generated.

113 elopment, we used mice harboring conditional null alleles for Sox4 and a Cre transgene.

114 Null alleles for the COL5A1 gene and missense mutations

115 We describe mice with null alleles for the Col5a2.

116 Mice homozygous for the null allele had a defect in spermatogenesis that resulte

117 nd the glutathione-S-transferase-mu1 (GSTM1) null allele have been shown separately to associate with

118 to other tasiR-ARF biogenesis mutants, dcl4 null alleles have an uncharacteristically mild phenotype

119 However, COL5A2 null alleles have yet to be associated with cEDS or othe

120 lusive since Crb1 mouse mutants, including a null allele, have failed to mimic the early-onset of LCA

121 e presence of technical issues (for example, null alleles), hierarchical structure (for example, host

122 Mdh1 null allele homozygotes show reductions in tolerance.

123 In ry506 (null allele) homozygotes or hemizygotes, JH III or pyrip

124 Screening of the ATM gene revealed a null allele in 2 of 23 (8.7%) patients of European ances

125 Plants homozygous for a null allele in AAO4 showed a reduction of 30% to 45% in

126 vivo model, we used mice heterozygous for a null allele in Bmpr2 (Bmpr2(+/-)) and wild-type litterma

127 to the y locus and showed the same recessive null allele in homozygosis: Deltay A set of molecular an

128 activity to levels comparable to the fad2-1 null allele in nearly all transgenic events.

129 Furthermore, a phyB null allele in the abp1-5 background is likely causative

130 ion J (orJ) mouse, which harbors a recessive null allele in the Vsx2 gene.

131 amed Aoba, represents the first functionally null allele in this species.

132 is to develop a screening method to generate null alleles in a human cell line haploid for all chromo

133 but the early embryonic lethality of Dicer1 null alleles in mice has limited our ability to address

134 (dysb), in isolation or in combination with null alleles in the dysb network component Blos1.

135 Null alleles in the genes encoding each enzyme were cons

136 Since null alleles in the heterozygous state lead to suppressi

137 inducible Cre transgene and Sox9 conditional null alleles in the mouse, we show that Sox9 is required

138 c differences between drosha and pasha/dgcr8 null alleles in two postembryonic lineages in the Drosop

139 Here, we identify QIL1 null alleles in two siblings displaying multiple clinica

140 utant animals by simplifying the creation of null alleles in virtually any organism.

141 proaches for synthetic genetic analysis with null-alleles in metazoans have not been feasible.

142 s, while HA-1(R) has been suggested to be a "null allele" in terms of T cell reactivity.

143 nscription factor Cdx2, alone or with a Cdx1 null allele, in the adult gastrointestinal tract.

144 These null alleles include copy-number variants (12 instances

145 Surprisingly, our characterization of a seh1 null allele indicates that, although required in the fem

146 GN results in the same phenotypes as the pgn null allele, indicating that a tight regulation of the P

147 rgeting this pathway, we introduced the Fn14 null allele into the MRL-lpr/lpr lupus mouse strain.

148 A mpk6, but not a mpk3, null allele is able to suppress the effects of this domi

149 ciliopathy Joubert syndrome, while the mouse null allele is embryonic lethal.

150 If an essential gene is deleted, the null allele is maintained in spontaneously generated het

151 nd the heat sensitivity of both missense and null alleles is associated with increased NO species.

152 hat the weak nature of the phenotype of clv1 null alleles is dependent on BAM activity, with bam clv

153 ss-of-function from enhanced inactivation or null alleles is rare and has been associated with myasth

154 The seed-specific phenotype of bcat2 null alleles, its strong transcription induction during

155 wnregulated in reproductive meristems of the null allele kn1-e1.

156 Importantly, mice heterozygous for the K9-null allele (Krt9(+/-)) show neither an overt nor histol

157 P2 knockout mice and human patients with RP2 null alleles leads to XLRP resembling recessive rod-cone

158 ventional gene targeting of Jak2, creating a null allele, leads to a block in definitive erythropoies

159 We isolated a null allele (lre-5) of LORELEI, which encodes a putative

160 ontrast to waltzer mice, which carry a CDH23 null allele mimicking USH1D, hair cell development is un

161 n this study, we generated an inducible Drd2 null-allele mouse strain that circumvented developmental

162 Mice homozygous for a MTAP null allele (Mtap(lacZ)) have an embryonic lethal phenot

163 hile, we regenerated a mature plant from the null allele mtnam-1.

164 r, differences between the phenotypes of the null allele mutants suggest that they play different rol

165 geneity and gene dosage effects in the mouse null alleles muted (Bloc1s5(mu/mu)) and dysbindin (Bloc1

166 ice homozygous for the Prkdc(scid) and Il2rg(null) alleles (NSG mice) permit engraftment of a wide-ra

167 is issue is similar to the high frequency of null alleles observed for microsatellite markers in Paci

168 the WAK2 dominant allele is suppressed by a null allele of a pectin methyl esterase (PME3) whose act

169 The hnn mutation is a null allele of Arl13b, a small GTPase of the Arf/Arl fam

170 ermline phenotypes of flies homozygous for a null allele of asun (asun(d93)).

171 ith this prediction, mice heterozygous for a null allele of Bicc1 had low BMD.

172 hronotoxicity of APAP, we used a conditional null allele of brain and muscle Arnt-like 1 (Bmal1, aka

173 We generated a null allele of car to test its requirement for trafficki

174 0 (Cep290(rd16/+)) but not of a heterozygous null allele of Cep290 (Cep290(null/+)) or of other cilio

175 Mice harboring a null allele of Csnk1e showed an increase in locomotor ac

176 We generated a null allele of Drosophila pasha, which encodes a double-

177 ting to generate a knock-in mouse carrying a null allele of enamelin (Enam) that has a lacZ reporter

178 To understand this further, we introduced a null allele of Fancc (Fancc-), encoding a member of the

179 The toku phenotype was attributed to a null allele of Gk5, encoding glycerol kinase 5 (GK5), a

180 a systematic reverse genetic screen using a null allele of HMT1 and the synthetic genetic array (SGA

181 We developed a conditional-null allele of Ifnar1 and used tissue-specific induction

182 Complementation testing with an engineered null allele of Il2ra, however, showed that jal is a muta

183 The phenotype is due to a null allele of Kcnj8, encoding Kir6.1, a protein that co

184 tic cell line that expresses a conditionally null allele of Ku86.

185 ic and respiratory phenotypes of mice with a null allele of Mecp2 to mice with Mecp2 removed from the

186 ve identified sister of open brain (sopb), a null allele of mouse Intraflagellar transport protein 12

187 Here we report that a null allele of mouse nucleoporin Nup133, a structural su

188 We identified a null allele of mouse Ttbk2 based on loss of Sonic hedgeh

189 ut class genes, small RNA populations from a null allele of mut-16 as well as a regulatory mut-16(mg4

190 Furthermore, mice heterozygous for a null allele of Nrip1 showed a CAKUT-spectrum phenotype.

191 ution of Ntn1 to development, we generated a null allele of Ntn1 and re-examined tissues exhibiting p

192 We then produced a viable null allele of oga (oga(del.1)) in Drosophila allowing v

193 n double heterozygous embryos also carried a null allele of p53.

194 Embryos that are homozygous for Splotch, a null allele of Pax3, have a severe neural crest cell (NC

195 Mice heterozygous for a null allele of prkar1a (Prkar1a(+/-)), the primary recep

196 present the identification of an unreported null allele of Pun1 from a non-pungent accession of Caps

197 ogical approaches indicate that tvrm148 is a null allele of Rpe65.

198 A genetic null allele of rpk confirms its critical role in touch r

199 To explore these issues, we created a null allele of Set7/9 in mice.

200 rthermore, germ-line clones homozygous for a null allele of shaggy (Drosophila GSK-3beta) both fail t

201 ALB/c background, or when heterozygous for a null allele of superoxide dismutase 2 (Sod2(+/-)).

202 V) collagen chains by generating mice with a null allele of the alpha3(V) gene Col5a3 (Col5a3-/- mice

203 In contrast, transfer DNA insertional null allele of the CAC1A gene is embryo lethal and delet

204 orn1)) mice are homozygous for a spontaneous null allele of the destrin (Dstn) gene, which is also kn

205 is of additional alleles show that lulu is a null allele of the FERM-domain gene erythrocyte protein

206 In plants homozygous for a null allele of the Gbeta gene, Galpha is associated with

207 nur7/nur7) mice that were heterozygous for a null allele of the gene that encodes the enzyme UDP-gala

208 f type 2 diabetes in mice heterozygous for a null allele of the insulin receptor and an N-ethyl-N-nit

209 In the yeast Saccharomyces cerevisiae, a null allele of the RAD27 gene, which encodes a structure

210 ease iRhom2, which was not complemented by a null allele of the same gene.

211 ) and was mimicked by a CRISPR/Cas9-targeted null allele of the same gene.

212 Here, we have generated a definitive null allele of the Skt/Etl4 gene and analysed homozygous

213 ccurs in the context of heterozygosity for a null allele of the tumor suppressor gene Pten, there is

214 oelectrics of neonatal mice homozygous for a null allele of Tmem16a (Tmem16a(-/-)) to investigate the

215 to develop by birth in mice homozygous for a null allele of Tmem16a (Tmem16a(tm1Bdh)(/tm1Bdh)) and di

216 We report that all mice homozygous for a null allele of Tmem16a died within one month of birth an

217 ked Klein-Zschocher (KLZ) mutation created a null allele of Yipf6, a member of a gene family believed

218 We generated mice with a conditional null allele of Zfp148 (ZBP-89(FL/FL)) using homologous r

219 z1Delta is synthetic sick or lethal with the null alleles of about 200 nonessential genes.

220 We performed mutant analysis with the null alleles of ABP1, abp1-c1 and abp1-TD1, and the TILL

221 nic Kras allele (Kras(mut) ) and conditional null alleles of Apc and Trp53 (iKAP).

222 We utilized point mutations and null alleles of BBS proteins to disrupt assembly of the

223 of emerin and LEM2 in somatic cells, we used null alleles of both genes to generate C. elegans animal

224 s severely affected in male embryos carrying null alleles of both Spry1 and Spry2.

225 between male C57BL/6J mice heterozygous for null alleles of Cacna1c and Tcf7l2 and wild-type females

226 itional mutant crd1Deltapsd1Delta containing null alleles of CRD1 (CL synthase) and PSD1 (mitochondri

227 We use hypomorphic and null alleles of Foxc1 to study the effect of meningeal d

228 Next, we produced conditional null alleles of Glutamic acid decarboxylase 1 (Gad1) and

229 d between mice and humans carrying biallelic null alleles of JAK3, TYK2, STAT1, or STAT5B.

230 animals were crossed to mice homozygous for null alleles of MMP-2, MMP-7, or MMP-9 genes.

231 Two null alleles of ns3, and RNAi, demonstrate the necessity

232 eye and ear is similar to that reported for null alleles of Pax2.

233 unctional interaction between RIP1 and FADD, null alleles of RIP1 were crossed into Fadd(-/-) mice.

234 Null alleles of SIEL are embryonic lethal.

235 rity between hypomorphic alleles of AGO1 and null alleles of SQN and by the genetic interaction betwe

236 We have exploited viable null alleles of the enzymes of O-GlcNAc cycling to exami

237 Null alleles of the gene encoding NEMO (NF-kappaB essent

238 The mutations generated null alleles of the saiR gene and resulted in elevated s

239 It was unclear why two null alleles of the same gene would give different pheno

240 We generated null alleles of the single Drosophila ZO protein Polycha

241 titatively assessed their ability to produce null alleles of their target gene by antibody staining a

242 nses to dilute octanol in animals containing null alleles of these 5-HT receptors.

243 both ATR and ATM orthologs, and plants with null alleles of these genes are viable.

244 generated using conditional hypomorphic and null alleles of Tsc2 combined with the neuron-specific s

245 Two null alleles of TUP5 caused a reduced viability of gamet

246 By generating a conditional null allele, one study proposed that the dpp stripe is c

247 d that introduction of the gamma-sarcoglycan-null allele onto the DBA/2J background confers a more se

248 sion is eliminated or diminished in an hlh-8 null allele or in hlh-2 (CeE/DA) RNAi, respectively.

249 is in mice homozygous for either the Tyrc-2J null allele or the Tyrc-h allele, which model OCA-1A and

250 Previous animal models carrying either a null allele or transgenic manipulation of Ngf or Trka ha

251 al explants from embryos with different Sfrp-null alleles or explants overexpressing ADAM10 extend ax

252 in cells with missense alleles, but not with null alleles, or by over-expressing calnexin, a calcium-

253 and ethylene, resembling the sunn-4 presumed null allele phenotype.

254 plementation testing between jal and a Gata3 null allele produced doubly heterozygous, phenotypically

255 A null allele recq4(19) causes a failure in cell prolifera

256 Two independent null alleles revealed that Copb2 is essential for early

257 n addition, phenotypic analysis of a mett-10 null allele reveals that METT-10 enables mitotic cell cy

258 b(+/W)) with mice heterozygous for the Scn1b-null allele (Scn1b(+/-)) to determine whether the C121W

259 Null alleles (sgb11/esk1-7) of ESK1 restore to wild-type

260 The hot5 null alleles show increased nitrate and nitroso species

261 le heterozygotes carrying both Pten and Tsc2-null alleles showed no increase relative to Pten(+/-) he

262 mutations, but 12Gso is clearly not a global null allele since homozygotes survive into adulthood.

263 Mouse embryos heterozygous for the null allele, Sox2(EGFP), appear normal.

264 A screen of the viable S. cerevisiae haploid null allele strain collection for resistance to SeMet wa

265 bstitution and the presence of low-frequency null alleles suggest a postduplication relaxation of pur

266 with the frequency of a phenocopy of the Ahr-null allele supports the conclusion that the ARA9 protei

267 th these phenotypes, mice carrying the fgfr1 null allele survived significantly longer than those wit

268 plementation of the phenotype of the diploid null allele, tam-2 2C by a genomic fragment containing t

269 Null-allele test on cDNA from patients' fibroblasts of b

270 We generated a genetic null allele that reveals Socs36E is required in the ante

271 The Prpf31-knockout mice mimic the null alleles that result from the majority of mutations

272 In addition, we find several "null" alleles that have mutations on the derived Dox bac

273 ice were crossed with mice carrying the Jag1 null allele, the adult progeny exhibited striking bile d

274 Unlike a perR null allele, the perR991 allele (F51S) derepresses KatA,

275 p.W253X) in the first exon is likely to be a null allele; the second, a missense mutation (p.I201F) w

276 Here we used mice with a conditional null allele to establish the timing and cell type that u

277 nd cooperates with heterozygosity for a Pten null allele to promote hyperactive PI3K/AKT signaling.

278 We then produced Rp2-null allele using transgenic mice that expressed Cre-rec

279 To explore FLRT3 function we generated a null allele via gene targeting.

280 enotypes exhibited by an aarA mutant, a tatC-null allele was constructed.

281 A Dmap1-null allele was generated to study the role of DMAP1 in

282 Similar circumstances existed when the CMAH null allele was polymorphic in ancestral hominins, just

283 Using a conditional Hrt2 null allele, we show that cardiomyocyte-specific deletio

284 tase-dead PTEN mutant (C124S) and maintain 1 null allele, we show that PTEN phosphatase activity is r

285 Using newly generated null alleles, we demonstrate that polychaetoid (pyd), th

286 Here, using null alleles, we demonstrate that the regulation of Axin

287 omozygous or heterozygous for the Tau (Mapt) null allele were found to exhibit increasing levels of a

288 animals heterozygous for the germline Stat5 null allele were subjected to CHS.

289 ing one fII(lox) allele and one constitutive-null allele were viable.

290 nse alleles and two T-DNA insertion, protein null alleles were characterized.

291 Sprn null alleles were produced that delete all protein codin

292 bop5-3, bop5-4, and bop5-5 are null alleles, whereas bop5-6 is an intron mutation that

293 To test this hypothesis, we bred an Xpa null allele, which eliminates NER, into the TNR mouse mo

294 ions in RanGAP levels by combining a RanGAP1 null allele with different RanGAP2 alleles.

295 Combining the rad27 null allele with rad3-102 dramatically stimulated interh

296 se mouse is required for the generation of a null allele with the IKMC cassette.

297 ve adhesion phenotype in embryos bearing the null allele with those carrying the 'traditional' knocko

298 Null alleles with ACC2 nonsense mutations, frameshift mu

299 We compare the phenotypes of Mmp1 null alleles with alleles that have specific hemopexin d

300 The correlation of null alleles with human phenotypes can provide insight i