ライフサイエンスコーパス: nullizygous

1 and gene expression in vivo in 11 beta-HSD-1 nullizygous (11 beta-HSD-1(-/-)) mice.

2 Here we show that both p27 nullizygous and p27 heterozygous mice are predisposed to

3 d COX-2 expression was similar in C/EBP beta nullizygous and wild-type mice.

4 In Pms2 nullizygous animals, the mutation frequency in the supFG

5 The nullizygous anx7 (-/-) phenotype is lethal at embryonic

6 matopoietic progenitor cells (HPC) from mice nullizygous at the Fanconi anemia (FA) group C locus (FA

7 matopoietic progenitor cells (HPC) from mice nullizygous at the Fanconi anemia (FA) group C locus and

8 Mice nullizygous at the Neu1 locus develop clinical abnormali

9 Furthermore, we find that msh5 nullizygous B cells undergo CSR normally, have unaltered

10 ces apoptosis induced by DNA damage in a p53 nullizygous background, acting downstream of mitochondri

11 Galphao nullizygous beta-cells contain an increased number of in

12 from related mice, the Pms2-, Mlh1-, or Msh2-nullizygous cell lines were found to exhibit higher leve

13 In contrast, mSin3A nullizygous cells show normal chromosome dynamics and cy

14 Using p21 nullizygous cells, we demonstrate that p21 is nonessenti

15 RhoB deletion increased the proliferation of nullizygous cells, whereas restoring RhoB in null cells

16 Nullizygous (-/-) cells were susceptible to cotransforma

17 titive growth advantage for KITD816V in Tet2-nullizygous compared with wild-type cells.

18 All nullizygous control animals receiving MMC exhibited panc

19 ice closely resembled the phenotype of CSF-1-nullizygous (Csf1(op)/Csf1(op)) mice, including the oste

20 We have now established nullizygous embryo fibroblast lines from APE1(-/-) mouse

21 e causes embryonic lethality in mice, and no nullizygous embryo fibroblasts have been isolated.

22 , but erythropoiesis is not evident in Plcg1 nullizygous embryos at the same stage.

23 ificantly diminished vasculogenesis in Plcg1 nullizygous embryos based on the lack of expression of t

24 pensable roles during embryogenesis, because nullizygous embryos become developmentally retarded and

25 In addition, Plcg1 nullizygous embryos express a greatly reduced level of v

26 cular patterning defects analogous to Notch1 nullizygous embryos.

27 the tumors arising in ARF hemizygous or ARF nullizygous Emu-myc transgenic mice also overexpressed M

28 mera consisting of wild-type hosts and Trp53 nullizygous epithelium, which undergoes a high rate of n

29 tical for mammalian development because mice nullizygous for a targeted disruption of the DNMT1 DNA m

30 ike fibroblasts generated from mouse embryos nullizygous for a targeted disruption of the genes encod

31 Mouse embryos nullizygous for a targeted disruption of the Huntington'

32 nalysis of bone marrow hematopoiesis in mice nullizygous for APE2 and find an inhibition of the pro-B

33 Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop multiple tumo

34 /- and Atm-/- mice were radioresistant, mice nullizygous for both Bax and Atm showed additional reduc

35 heir genetic interactions, we generated mice nullizygous for both genes.

36 e insulin receptor (IR), we examined embryos nullizygous for both Igf1r and Insr.

37 Mice nullizygous for both mdr1a and mdr1b-type Pgps and kept

38 We now report that mice nullizygous for both PPARalpha and AOX (PPARalpha-/- AOX

39 mice that were homozygous, heterozygous, or nullizygous for cdk4.

40 ic fibroblasts with those expressed in cells nullizygous for chop.

41 umber in animals genetically heterozygous or nullizygous for cyclin D1.

42 ed with myostatin (mstn-/-) deletion in mice nullizygous for delta-sarcoglycan (scgd-/-), a model of

43 in mouse embryonic fibroblasts conditionally nullizygous for HIF-1 alpha.

44 sent study, we used mouse embryo fibroblasts nullizygous for HIF-1alpha or AMPK expression to show th

45 We have isolated two cell lines nullizygous for HIF-1alpha, one from embryos genetically

46 fibroblasts (MEFs), wild-type (MTF-1+/+), or nullizygous for MTF-1 (MTF-1-/-) were used to develop fi

47 Animals nullizygous for p300 died between days 9 and 11.5 of ges

48 However, mice nullizygous for p45 express nearly normal levels of beta

49 s as readily, however, in the hearts of mice nullizygous for p53 as in wild-type littermates.

50 that K5 E2F1 transgenic mice heterozygous or nullizygous for p53 develop spontaneous skin carcinomas,

51 weeks of age in the transgenic mice that are nullizygous for p53, they are still monoclonal, indicati

52 ed in wild-type or murine embryo fibroblasts nullizygous for p53or p21(CIP1).

53 Mice nullizygous for Plcg1 cease growing at early to mid-gest

54 the absence of any mutagenic treatment, mice nullizygous for Pms2 showed a 100-fold elevation in muta

55 formation was significantly greater in mice nullizygous for PPAR-delta.

56 Mice nullizygous for PRIP died between embryonic day 11.5 and

57 Murine embryos nullizygous for Rb die midgestation with defects in cell

58 ild-type murine embryo fibroblasts and those nullizygous for regulators of the G1/S checkpoint, we ob

59 Mice that are nullizygous for Sbf1 exhibit male infertility characteri

60 Here we show that mice nullizygous for SCD1 and PPARalpha are still protected a

61 mouse embryonic fibroblasts (MEFs) that were nullizygous for the catalytic alpha subunit of AMP-activ

62 in vivo role of CP2, we have generated mice nullizygous for the CP2 allele.

63 e we report that murine embryonic stem cells nullizygous for the major DNA methyltransferase (Dnmt1)

64 We utilized transformed cells nullizygous for VEGF to specifically express each of the

65 nd mice homozygous for this allele resembled nullizygous HDH: mutants and died after embryonic day 8.

66 f 16 and 19.5 months, respectively, but Cdk2 nullizygous littermates did not display tumors through 2

67 c studies demonstrate that in neurofibromas, nullizygous loss of Nf1 in Schwann cells and haploinsuff

68 rossed, and F1 animals bred to obtain doubly nullizygous mice (T(-)GR(-)).

69 53BP1 overcomes embryonic lethality in Brca1-nullizygous mice and rescues HR deficiency, as measured

70 4 was substantially increased in the FXR/BAR nullizygous mice and was further elevated by cholic acid

71 ound that the HRR events that occur in Parp1 nullizygous mice are associated with a significant incre

72 We report here that C/EBPbeta-nullizygous mice are completely refractory to skin tumor

73 In the CSF-1 nullizygous mice compared to wild-type mice, there was a

74 ort, we show that p21(Cip1) heterozygous and nullizygous mice develop more tumors than do wild-type m

75 ganglion cells in retinal grafts from c-jun nullizygous mice developed axons that projected into the

76 S-folinic acid (SFA; 40 mg/kg)-treated PCFT-nullizygous mice exhibited increased P-glycoprotein tran

77 RNA and protein analysis confirmed that the nullizygous mice expressed no full-length or truncated v

78 ameliorated, and the lethality of Bard1; p53-nullizygous mice is delayed until E9.5.

79 were within normal ranges, erythrocytes from nullizygous mice lacked CXC and CC chemokine-binding act

80 rated RANK (receptor activator of NF-kappaB) nullizygous mice to determine the molecular genetic inte

81 sed as a reporter, the mutation frequency in nullizygous mice was increased from 16.3 x 10(-5) to 42.

82 Treatment of sod2 nullizygous mice with EUK189 proportionately increased t

83 We show that treatment of sod2 nullizygous mice with synthetic superoxide dismutase (SO

84 Mice with inactivated SOD2 (sod2 nullizygous mice) die prematurely, exhibiting several me

85 eted disruption of the FANCC gene (fancc -/- nullizygous mice) exhibit many of the characteristic fea

86 ycoprotein transport was blocked in the PCFT-nullizygous mice, indicating that multiple neuroprotecti

87 In contrast to Lmo4 nullizygous mice, nonexencephalic Deaf-1 mutants remaine

88 gulation of BSEP/SPGP-mediated efflux in FXR nullizygous mice, result in an alternate but apparent co

89 Using Id2 nullizygous mice, we assessed in vivo the requirement fo

90 A subset of DJ-1-nullizygous mice, when fully backcrossed to a C57BL/6 [c

91 In FXR/BAR nullizygous mice, which have dramatically reduced BSEP/S

92 en hampered by the prenatal death of Rb; E2f nullizygous mice.

93 keletal muscle declines significantly in p53 nullizygous mice.

94 rmed and characterized kidney failure in xor-nullizygous mice.

95 nflammatory infiltrates in lung and liver of nullizygous mice.

96 Mice that are wild type (WT) or MMP-9 nullizygous (MMP-9(-/-)) were used for in vivo studies a

97 obtained by using wild-type and HIF-1 alpha nullizygous mouse embryonic fibroblasts (mEFs) that the

98 sformed mouse cells and fibroblasts from Rh1-nullizygous mouse embryos contain normal levels of cycli

99 Examination of various tissues from RB1-nullizygous mouse embryos showed problems in differentia

100 The FIX nullizygous (-/-) mouse was devoid of factor IX antigen

101 lucagon and other alpha cell markers in Ngn3 nullizygous mutant animals.

102 etinas from embryonic day 12.5 (E12.5) c-jun nullizygous or wild-type mice were transplanted onto the

103 s from various organs of 4 to 6-week old p53-nullizygous (p53-/-) mice display aneuploidy and frequen

104 The nullizygous phenotype in conjunction with high-level exp

105 Here we demonstrate that nullizygous PKCbeta (PKCbetaKO) mice are highly resistan

106 In this study, we demonstrate that RanBP10-nullizygous platelets show normal adhesion on collagen a

107 with folinic acid reversed this phenotype in nullizygous pups.

108 ed PCa tissues from PKCepsilon wild-type and nullizygous TRAMP mice.