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   1 f factor IX is already a reality for a small number of patients.                                     
     2 ng remission of this refractory disease in a number of patients.                                     
     3 ill be key to meeting the needs of a growing number of patients.                                     
     4 ue of PET tracers with the smallest possible number of patients.                                     
     5 ilar pathogens were detected but in a larger number of patients.                                     
     6 estimating the treatment effect in a smaller number of patients.                                     
     7  renal-replacement therapy in an appreciable number of patients.                                     
     8 e a time lag and are ineffective for a large number of patients.                                     
     9 cterizing behavioral deficits across a large number of patients.                                     
    10 nhibition is being observed in an increasing number of patients.                                     
    11  genetic diagnosis is achieved for a greater number of patients.                                     
    12 ial approach was successful in a significant number of patients.                                     
    13 osis, cirrhosis, and cancer in a significant number of patients.                                     
    14  one of these alone would miss a significant number of patients.                                     
    15 sed in the future for the treatment of large numbers of patients.                                    
    16 pies to provide survival benefit for greater numbers of patients.                                    
    17 astic leukemia (ALL), often comprising small numbers of patients.                                    
    18 idely explored, but often only benefit small numbers of patients.                                    
    19 e following original research, cohort study, number of patients 10 or more, and reported change in ma
  
  
  
    23  to immunohistochemistry, identifies a small number of patients (5 cases) with high residual tumor bu
  
  
    26 ear study period (2012-2014), we tracked the number of patients affected by MDRPa (colonized and/or i
    27  that uses both variation in performance and number of patients affected by the QM to set priorities 
  
  
    30 ide get more damaged in RA since the limited number of patients analyzed in the previous study had ma
    31 nown as inhibitors, develop in a significant number of patients and actively block FVIII activity, ma
  
    33    Nevertheless, PSD occurs in a significant number of patients and constitutes an important complica
  
  
  
  
    38 care CRAG testing simplifies screening large numbers of patients and enables physicians to prioritize
  
    40 t treatment can be detected in a substantial number of patients, and that this may be associated with
  
  
    43 sphagia from late-stage tumors; only a small number of patients are identified by screening and surve
  
    45 ith early-stage breast cancer, an increasing number of patients are pursuing mastectomy, which may be
  
    47 2 million deaths annually, and an increasing number of patients are resistant to existing therapies. 
  
    49 a number of recent audits suggest that large numbers of patients are failing to be assessed properly 
  
  
  
  
    54  are important for determining the potential number of patients available for cohort studies and anti
  
  
  
    58 million [13.2 million to 70.9 million]), the number of patients blind because of cataract is anticipa
  
  
  
    62 repeat tests performed increased, as did the number of patient cases categorized as ISH equivocal.   
    63 ained reasonably complete data for a limited number of patient characteristics, namely age, sex, and 
    64 int was the difference between groups in the number of patients classified as treatment failure durin
  
  
    67 as the total number of events divided by the number of patient-days of follow-up in each interval ass
  
    69  of mammographic screening will increase the number of patients diagnosed with DCIS, making a precise
  
    71 y transplantation; however, a non-negligible number of patients did not benefit from transplantation 
  
  
  
    75 tric hospitals to provide treatment to large numbers of patients during a large-scale disaster remain
  
    77 ous observational study in terms of both the number of patients enrolled and the standardization of l
    78 gression was used to study the effect of the number of patients enrolled at each institution on the m
  
  
  
  
  
  
  
    86 dy treatment (17 [28%] vs 16 [26%]), and the number of patients experiencing severe adverse events (t
  
    88 ng could complicate retreatment of the small number of patients failing regimens containing an NS5A i
  
    90 dia's private sector is treating an enormous number of patients for tuberculosis, appreciably higher 
  
    92 SA and Europe have substantially reduced the number of patients for whom antibiotic prophylaxis is re
  
  
  
    96 (BCVA) from baseline in the study eye and/or number of patients gaining at least 10 letters from base
  
    98  procedural revascularization in significant numbers of patients has led to attempts to develop alter
    99  virus (HIV) infection in Africa, increasing numbers of patients have pretreatment drug resistance.  
   100 ) have conflicting results, comprise a small number of patients, have short follow-up periods, and la
  
   102 sensitivity following SC challenge, over the number of patients having tested negative for both the S
  
  
  
   106 HIV disease progression by analyzing a large number of patients in 3 cohorts with different HIV disea
  
  
   109 ng to surgical adjustments in a considerable number of patients in all malignancies studied but espec
   110 epeat expansion exceeds that of the combined number of patients in all other microsatellite expansion
   111 , even though it assumes a large and similar number of patients in both risk groups, which is violate
   112 ), 107 patients were included, with the same number of patients in each clinical stage subgroup (12 s
   113 l relevant data, including outcome, P value, number of patients in each group, number of events in ea
   114  The availability of donor organs limits the number of patients in need who are offered liver transpl
   115 re, we enrolled 334 RA patients, the biggest number of patients in studies to address this issue and 
  
   117 suggestive of IBD considerably decreased the number of patients in the group in whom challenges in cl
  
  
  
   121 have emerged because of the relatively small number of patients included in some stroke studies.     
  
   123  limitations are the heterogeneity and small number of patients included in this study, the need for 
  
   125 ssen or dissipate with time, study on larger numbers of patients is necessary to elucidate factors th
   126  each group, number of events in each group, number of patients lost to follow-up, and trial characte
   127 x, and type of rhythm disorder with an equal number of patients managed with uninterrupted vitamin K 
  
   129 as to determine the impact of increasing the number of patients monitored on response time to simulat
   130 AF and regular AT occurred in a considerable number of patients; most of them initially presented wit
  
   132 ex (E) was defined as a function of adjusted number of patients (N(a)), total practice adjusted costs
   133 tratification could substantially reduce the number of patients necessary, when compared with no stra
   134 eduction for MV with HFNC was 29.8%, and the number of patients needed to treat to prevent one intuba
  
  
  
   138 sion development long term, regarding either number of patients (odds ratio 2.43; P = 0.03) or number
  
   140 vascular disease (CVD) were limited by small numbers of patients or a narrow range of endpoints.     
  
  
  
  
   145  One was the perception that, given the high number of patients presenting simultaneously and the ver
  
  
   148 nderwent one of 12 major operations, and the number of patients readmitted or transferred back to the
   149 ference between the randomised groups in the numbers of patients readmitted (100 [61%] of 165 CTOs vs
   150 Antimicrobial use prevalence, defined as the number of patients receiving antimicrobial drugs at the 
   151 icans, which will significantly increase the number of patients recommended for outcome-related benef
   152 egory 3 classification; however, the overall number of patients recommended for short-interval follow
   153 different data domains (data diversity), the number of patient records in the training data set (data
  
   155 ucing promyelocyte maturation, a significant number of patients relapse due to the development of ATR
  
  
  
   159 n in power, with a 67% mean reduction in the number of patients required in a drug trial for severe e
  
   161 rus infection have reduced mortality and the number of patients requiring liver transplantation, but 
   162 ing volatility indices measured from a small number of patient samples, we accurately predict the pop
  
  
  
   166 noids were associated with a greater average number of patients showing a complete nausea and vomitin
  
   168 ention the mean change in dystonia severity, number of patients studied, and evidence of efficacy bas
  
   170 nges in drug development because of the high number of patients suffering from neural diseases and th
   171 h pioneering treatment trials based on small numbers of patients suggest progression-free and overall
  
   173 ain injury, ESA therapy did not increase the number of patients surviving with moderate disability or
   174 delines or studies regarding the appropriate number of patients that a single watcher may safely and 
  
  
  
  
   179 ease necessitating the transfer of a growing number of patients to the adult healthcare service.     
  
   181 has been slow, largely due to the very small number of patients treated and the heterogeneity of trea
  
   183 ns or losses of patients (difference between number of patients treated in a centre and number expect
   184 case' clinical benefit of new therapies, the number of patients treated was increased by a total of 1
   185 dy to quantify the reduction in sample size, number of patients treated with the standard of care, an
  
   187  from China, short onset-to-door time, lower numbers of patients treated per center, higher diastolic
  
   189 50,116 procedures with a 55% increase in the number of patients undergoing pPCI at these facilities o
   190 ome recognition and smaller decreases in the number of patients' visits to federally qualified health
  
   192  At 3, 6, and 12 months after treatment, the number of patients was 40, 31, and 31, respectively, and
  
  
   195 ons for benign lesions in a relatively small number of patients was responsible for positively skewed
  
  
   198 ved within some disease subsets as increased numbers of patients were identified, recruited, followed
  
   200  expression measurements on relatively small numbers of patients while also uncovering gene-gene rela
  
   202     The primary objective was to compare the number of patients who achieved a pathological complete 
   203 device treatment to potentially increase the number of patients who can be treated despite long trans
   204 iratory distress syndrome as an outcome, the number of patients who developed acute respiratory distr
   205 risk (RR) was calculated on the basis of the number of patients who had been compulsorily admitted.  
  
   207 (3.8) versus 6.8 days (3.2; p=0.84), and the number of patients who had unscheduled hospital admissio
   208 0.0-2.0] vs 1.0 [1.0-2.0]; P = .39), and the number of patients who missed at least 1 dose was also s
   209    The primary objective was identifying the number of patients who present with sepsis and progress 
   210 ty with the revised versus the prior policy (number of patients who received increased priority for t
   211    The authors have shown that a substantial number of patients who recovered sufficiently to allow e
   212 f epilepsy surgery; this may help reduce the number of patients who refuse surgery after comprehensiv
  
  
  
   216 formance (using interquartile range) and the number of patients who were affected; then the two ranki
   217 proof-of-concept study is limited to a small number of patients who were selected based on several cr
  
  
   220 versus most recent follow-up outcomes (i.e., number of patients with >/=1 GR and number of sites with
   221 d, from 634 070 to 723 172 (+14.0%), and the number of patients with 1 or both eyes undergoing catara
  
  
  
  
   226 afety-net hospitals treat a disproportionate number of patients with advanced appendicitis while fall
  
   228 EER-Medicare data to create estimates of the number of patients with an HCV diagnosis, used an invers
   229 ab plus gemcitabine and cisplatin group, the number of patients with at least one grade 3 or worse ad
  
  
   232 ion therapy is administered to a significant number of patients with cancer, and radiation reactions 
  
  
   235 inson's disease has been reported in a small number of patients with chromosome 22q11.2 deletion synd
  
   237 get oncogenic WNT signaling in a significant number of patients with colorectal and other intestinal 
  
   239 d with the hepatitis C virus (HCV) ages, the number of patients with decompensated cirrhosis is expec
  
   241 netic risk score could also identify a small number of patients with discrepant genetic risk profiles
   242 xperience ischemic events, and a significant number of patients with dissection or aneurysm underwent
   243 outcome-opioid oversupply-was defined as the number of patients with either filled but unused opioid 
  
  
   246     In conclusion, we demonstrate a relevant number of patients with FDG-PET false-negative MM and a 
  
  
   249  patient adherence documented that a sizable number of patients with glaucoma do not take their medic
  
   251 selective beta-blocker therapy for the large number of patients with heart and respiratory or periphe
  
  
   254 ean difference 1.31 [0.37 to 2.25]), and the number of patients with impaired glucose tolerance (odds
  
   256  CHD pretest likelihood, 49.5% [SD, 23.8%]), number of patients with invasive coronary angiography af
   257 linical and genetic details of a substantial number of patients with IWC in order to define major and
  
  
   260 mechanisms of action to treat the increasing number of patients with life-threatening systemic fungal
   261 nt regimes, however probably due to the high number of patients with liver cirrhosis and prior treatm
  
   263 ose To determine the association between the number of patients with multiple myeloma (MM) treated an
  
   265  FKSI-DRS questionnaires completed using the number of patients with non-missing data at baseline and
  
  
   268 mance and prevent mobility loss in the large number of patients with PAD, including in those who are 
   269 in C5 cause eculizumab-resistance in a small number of patients with paroxysmal nocturnal hemoglobinu
  
  
  
   273 ents with complications divided by the total number of patients with postoperative complications.    
  
  
  
   277  would permit transplantation to the highest number of patients with similar outcomes in recipients o
  
  
   280 t-acting antivirals (DAAs), due to the small number of patients with treatment failure in approval st
  
  
  
   284 highly dependent on weekday/weekend pattern, number of patients with various abnormal complete blood 
  
  
  
  
   289 ithout patient navigation, in increasing the numbers of patients with cirrhosis undergoing surveillan
   290 ology community is increasingly facing small numbers of patients with each cancer subtype, requiring 
  
  
   293 ilable for clinical evaluation; however, the numbers of patients with FL and the resources to conduct
  
   295 pre-treatment loss to follow-up) between the numbers of patients with laboratory-confirmed RR-TB and 
  
   297 and should be determined, because increasing numbers of patients with SCD take this drug to improve r
   298 use of unrelated donors has led to increased numbers of patients with this painful complication.     
  
   300 tive care facilities are scarce, substantial numbers of patients with XDR tuberculosis who have faile
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