ライフサイエンスコーパス: numbering

1 idues 184A, 185, 221A, and 224 (chymotrypsin numbering).

2 esidues 148, 348, 404, and 504 (ovine PGHS-1 numbering).

3 is located at position 290 (Escherichia coli numbering).

4 ), 226(M1), and 254(M2) (using alpha subunit numbering).

5 e Ile16-Asp194 salt bridge (chymotrypsinogen numbering).

6 n the loop at position 159 (Escherichia coli numbering).

7 pped by MCPF-CoA as Cys-114 (mature sequence numbering).

8 , 699, 703, and 710 (chicken skeletal myosin numbering).

9 thylation of residue G2470 (Escherichia coli numbering).

10 ally conserved "perturbing" Lys-194 (E. coli numbering).

11 S(1) pocket (position 189, chymotrypsinogen numbering).

12 ine of the TrkA domain (Y785 in TrkA residue numbering).

13 288L/F290V (all mutants given T. californica numbering).

14 3 and by the residue at position 119 (CYP4A3 numbering).

15 enosine-1518 and -1519 (all Escherichia coli numbering).

16 he residue at position 192 (chymotrypsinogen numbering).

17 putative catalytic Glu-458 (Escherichia coli numbering).

18 been deleted (TolR(62-133), Escherichia coli numbering).

19 on the 39-loop of the protease (chymotrypsin numbering).

20 igosaccharide side chain at position 146 (N2 numbering).

21 s at positions 27, 31, and 34 (based on ChTX numbering).

22 mutated in silico to PVVV (P407V in the 2A79 numbering).

23 residues 81 to 83 and 117 to 122 of HA1 (H5 numbering).

24 with conserved Arg122 (PfDHFR-TS amino acid numbering).

25 d residue for ATP contact is Lys(6)(9) (P2X2 numbering).

26 (superscripts refer to Ballesteros-Weinstein numbering).

27 vative substitutions (N291G and P294K; human numbering).

28 contributions at positions 37 and 69 (pcDHFR numbering).

29 the non-hydrogen-bonded Val 38 (eubacterial numbering).

30 F(2495), NPLY(2519), and DPF(2534) (315-HARE numbering).

31 serine protease domain (G216 in chymotrypsin numbering).

32 STVs are associated with anomalous vertebral numbering.

33 om a population of citizens aged >/=50 years numbering 1.71 million in 2000 and 1.87 million in 2010

34 e AR gene and introduce CAG repeat mutations numbering 100 or more triplets.

35 from four subjects showed additional phyla (numbering 2), genera (numbering 28), and SLOTUs (numberi

36 epeat number) within the two large kindreds, numbering 22 and 23 repeat units.

37 rRNA nucleotides 2618-2620 (Escherichia coli numbering 2583-2585) and 2541(2506), thereby reorienting

38 is positioned by nucleotides A2637 (E. coli numbering, 2602) and (methyl)U2619(2584).

39 owed additional phyla (numbering 2), genera (numbering 28), and SLOTUs (numbering 65).

40 of G protein-coupled receptors, the Tas2rs, numbering 3 to approximately 66, depending on the specie

41 ering 2), genera (numbering 28), and SLOTUs (numbering 65).

42 of saturable binding sites (KD = 1 microM), numbering 8.6 x 10(5) sites/cell.

43 and the number of black USMD GY1 residents, numbering 859, declined from the previous year.

44 We identified 66Y (N1 numbering), a highly conserved amino acid that was criti

45 terotrimer crystal structure, Glu153 (B'beta numbering) abuts the catalytic site on the C subunit, an

46 A single-site mutation of Pro(101) in EPSPS (numbering according to the enzyme from Escherichia coli)

47 ly identical, with the exception of Met-118 (numbering according to the mature BR sequence), which is

48 hose at positions 36 and 75 modulate fusion (numbering according to the Newcastle disease virus [NDV]

49 stal structures have suggested that Lys-110 (numbering according to the Sulfolobus solfataricus enzym

50 141 and Glu275 are in adenylosuccinate lyase numbering), acts as the general base in most fumarase cl

51 work reaches from betaL328 (Escherichia coli numbering) and betaQ441 via alphaQ399, betaR398, and alp

52 nhibitory phosphorylation at Ser287 (Xenopus numbering) and docking of 14-3-3.

53 r (15)-NH2 (1) (a somatostatin agonist, SRIF numbering) and H-Cpa (2)-c[DCys (3)-Tyr (7)-DTrp (8)-Lys

54 otein surface (D132, Rhodobacter sphaeroides numbering) and leads to another acidic residue near the

55 superscripts refer to Ballesteros-Weinstein numbering) and non-polar interactions with residues in H

56 modified at the DPhe(7) position (alpha-MSH numbering) and pharmacologically characterized for agoni

57 n modified at the Trp(9) position (alpha-MSH numbering) and pharmacologically characterized for agoni

58 n modified at the His(6) position (alpha-MSH numbering) and pharmacologically characterized for agoni

59 ified the electrophilic cysteine as C759 (B1 numbering) and prepared a mixed disulfide between E. col

60 of both the Weinreb amide at C3 (beta-lactam numbering) and the amino acid side chain at C4 are well-

61 in KD1 interacts with Asp-189 (chymotrypsin numbering) and with the carbonyl oxygens of Gly-219 and

62 ct cells started at amino acid 4 (cystatin C numbering), and displayed reversible inhibition of papai

63 Asp 63, Tyr 95, Tyr 188, and His 249 (N-lobe numbering), and to two oxygens from carbonate.

64 an intestine harbors a beneficial microbiota numbering approximately 10(12) organisms per gram of col

65 O-Alu is a representative of an Alu subclass numbering approximately 400,000 copies, suggesting many

66 , Asp114 (TM3), and Asp118 (TM3) (mouse MC4R numbering) are important for melanocortin-based peptide

67 amembrane residues, Lys-28 and Ser-26 (Abeta numbering), as the critical determinants for efficient i

68 )-Lys(9)-Thr(10)-Cys(11)]Thr(12)-NH(2) (SRIF numbering), at the five known human somatostatin recepto

69 cysteine of the channel (Cys-910, rat NaV1.2 numbering; at site 8).

70 erved serine residues, Ser(18) and Ser(20), (numbering based on isoform 1c) form at least one phospho

71 ked a threonine or arginine at position 319 (numbering based on the HXB2 genome) with AOP-RANTES resi

72 assignment of provisional subtypes, subtype numbering beyond "w," and the nomenclature of intergenot

73 drug-resistance (e.g., H275Y NA mutation [N1 numbering]) but revealed mutations outside the NA active

74 Armagh numbering ca. 140 mature trees.

75 itions 163, 288, 289, 444, and 454 (PsAMADHs numbering) can, directly or not, significantly modulate

76 amino acid position 275 (H274Y, universal N2 numbering), conferring resistance against oseltamivir (T

77 esence of a tyrosine at position 249 (PpNRH1 numbering) confers high hydrolase activity for purine ri

78 There is currently no universally accepted numbering convention for the antiviral drug-related resi

79 36, Trp62, Phe64, and Trp72 (kringle residue numbering convention) in ligand binding.

80 ifications, an automated tool for HA subtype numbering conversion, linkouts to disease event data and

81 Note that the numbering corresponds to full-length headpiece.

82 11 and alanine at positions 35 and 39 (hCRF numbering) decreases CRF1R activity and increases CRF2R

83 2, U2506, U2584, and A2602 (Escherichia coli numbering), demonstrating its potential for the analysis

84 utations at A2451, U2585, and C2063 (E. coli numbering) did not significantly affect either of the re

85 f the two conserved Met252 and Met428 (Kabat numbering) disrupted the interface interactions between

86 A new exon 1 has been found that changes the numbering established for the human VDR gene.

87 ues Asp-179(4.60) and Asp-275(6.58) (residue numbering follows the Ballesteros-Weinstein scheme), wit

88 APP that is phosphorylated at Thr668 (pAPP; numbering for APP695), we show that a phosphorylated, ca

89 Thus the sequence alignment and numbering for CH1 domains has been revised to be consist

90 1 in vitro at Ser-692, Ser-695, and Ser-852 (numbering for human isoform).

91 s 491 to 500 (Los Alamos National Laboratory numbering for the HXB2 strain).

92 The E337 and C550 residues (numbering from hChAT) were previously shown to dictate t

93 in this sequence (designated G6 and A7, with numbering from the promoter -10 region).

94 served Asn(633) of the PSI PsaB polypeptide (numbering from the Synechococcus elongatus crystal struc

95 ivation region (viz, A or C at position 1002 numbering from the translation start site of Ik-1) withi

96 residues 238-277 (58-97 in chymotrypsinogen numbering) from the protease domain of factor X bound on

97 Numbering GA733-2 cysteines sequentially from the N term

98 nd slave oscillators, with groups of candles numbering greater than two, creating a synchronised moti

99 ssociated with drug resistance, NA-R292K (N2 numbering), has been found in some H7N9 clinical isolate

100 involving Glu235 (Glu70 in chymotrypsinogen numbering; hereafter, the numbers in brackets refer to t

101 R157K in the gene encoding hemagglutinin (H3 numbering), I109T in the gene encoding nucleoprotein, an

102 catalytic site (R152W, A246T, and D293N, N2 numbering), (ii) subtype-independent substitutions (E119

103 regions (FIV numbering, with equivalent HIV numbering in superscript): I37(32)V in the active core r

104 nts in common eiders (Somateria mollissima), numbering in the hundreds to thousands of dead birds, ha

105 he7-d-Trp8-Lys9-Thr10-Phe11], L-363,301 (the numbering in the sequence refers to the position of the

106 ies are abundant in all human serum, usually numbering in the thousands.

107 or down-regulation is Thr(11)Gln(17)Thr(19) (numbering in TM).

108 rotein VP-1 region (positions 1740-1833, Dun numbering) in 49 biopsies obtained from 24 patients with

109 g the side chain of Tyr 71 (Tyr 75 in pepsin numbering) in a novel orientation.

110 for one residue at the 101st position (Kabat numbering) in CDR3 of the variable heavy chain (V(H)), h

111 ue 399 in the B loop of HA2 (residue 72, HA2 numbering) in different monomers of the trimeric A(H1N1)

112 Arg-15 (bovine pancreatic trypsin inhibitor numbering) in KD1 interacts with Asp-189 (chymotrypsin n

113 stitutions M19V, A232V, D248N, and I436V (N1 numbering) in pH1N1low-1 and pH1N1low-2.

114 Site-directed mutation of Lys-1374 (human numbering) in RBF to Arg or Ile residues almost complete

115 16S rRNA at residues 1540 and 1541 (E. coli numbering) in the anti-Shine-Dalgarno mRNA binding seque

116 Arg(74), Arg(75), and Lys(78) (chymotrypsin numbering) in the catalytic function of activated protei

117 eration of a free radical at Tyr-385 (PGHS-1 numbering) in the cyclooxygenase active site; the Tyr-38

118 ition 292 (using the convention of rhodopsin numbering) in the dolphin LWS cone pigment results in a

119 acing the gatekeeper residue (Thr-338; c-Src numbering) in the inhibitor-binding site with a bulkier

120 on, lysine to glutamine, at position 166 (H3 numbering) in the major antigenic site of HA was reporte

121 ed a cysteine residue at position 442 (EU/OU numbering) in the third constant domain (C(H)3) of the h

122 o acid substitutions at PrP codon 164 (mouse numbering), in the beta2-alpha2 loop region of the prion

123 ifically at amino-acid residue T668 (APP-695 numbering) increases during staurosporine-induced apopto

124 acids at position 100 and/or 107 (sequential numbering) into the unmutated Ab 36-65.

125 H257, Y260, H143, Y28, R80, and D91 (residue numbering is from RmL).

126 e polymorphisms at -1082, -819, and -592 bp (numbering is relative to the transcription start site).

127 e c oxidase, Asp407 (Rhodobacter sphaeroides numbering) is at the interface of subunit I and subunit

128 In serine proteases, Gly193 (chymotrypsin numbering) is conserved with rare exception.

129 The data suggest that E89II (E. coli numbering) is critical for the function of the heme copp

130 ) (superscripts denote Ballesteros-Weinstein numbering) is experimentally observed and appears to be

131 (nucleotides 2042 to 2628; Escherichia coli numbering) is implicated in peptidyltransferase activity

132 1081 of large subunit rRNA (Escherichia coli numbering) is part of a domain targeted by antibiotics a

133 the conserved Trp256 (murine ferrochelatase numbering) is partially responsible for the observed por

134 erved AKR catalytic tetrad, His(120) (AKR1D1 numbering), is substituted by a glutamate in AKR1D1.

135 A2451 in 23S ribosomal RNA (Escherichia coli numbering) led to the proposal of a mechanism of rRNA ca

136 residues 263-271 (using the DENV serotype 3 numbering) located between the two globular domains of N

137 MCADH, while that in LCADH is Glu255 (MCADH numbering), located over 100 residues away in its primar

138 Our calculations show that adding CP-AMPARs numbering <5% of existing synaptic AMPARs is sufficient

139 proteases (residues 143-154 in chymotrypsin numbering) may be responsible for their differential rea

140 Numbering microparticles, including LMPs, might be usefu

141 and Trp-107, Mycobacterium tuberculosis KatG numbering) (MYW).

142 additional heteroatom at position 4 (oxazole numbering, N > O > CH) substantially increases activity

143 a carboxylic acid, most likely E-242 (bovine numbering), occurred in P(M) and relaxed back in F.

144 (8)-Lys(9)-Thr(10)-Phe(11)-Cys(14)]-OH (SRIF numbering) (ODT-8) by one of the four conformationally b

145 (8)-Lys(9)-Thr(10)-Phe(11)-Cys(14)]-OH (SRIF numbering) (ODT-8) that is potent at all SRIF receptor s

146 the side chain of His -18 (see Figure 1 for numbering of amino acids) of the beta-polypeptide.

147 rvey the entire spine and provide definitive numbering of disks and vertebrae was compared with neuro

148 specially the Arg238-Glu459 salt bridge (the numbering of residues follows myosin II in Dictyostelium

149 ote: In the AOP version of this article, the numbering of the author affiliations was incorrect.

150 sidues, F47, F51, and F58 (denoted using the numbering of the larger headpiece protein).

151 ided with the original annotations and plate numbering of the paper atlas and enable viewing the mate

152 nd Arg134 constitute the catalytic site; the numbering of the residues includes the signal sequence.

153 ality was evaluated by using visual scoring, numbering of visible bronchi, and quantitative measureme

154 amino acids 326-336 (143-154 in chymotrypsin numbering) of factor X (fX) comprise a flexible surface

155 ent study indicated that Tyr99 (chymotrypsin numbering) of factor Xa and Thr99 of activated protein C

156 posed helix 330-338 (162-170 in chymotrypsin numbering) of IXa in its interaction with VIIIa.

157 loops (amino acids 143-154, chymotrypsinogen numbering) of plasma serine proteases play key roles in

158 to-uracil transition at position 70 (E. coli numbering) of RNase P.

159 mutation at position 2058 (Escherichia coli numbering) of the 23S rRNA gene.

160 mediated by the residue at position 374 (HA0 numbering) of the HA2 subdomain as critical for HA trime

161 structured portion (residues 7-29, glucagon numbering) of the micelle-bound 27-residue peptide is 1.

162 acids [aa] 61 to 87 using PB1-F2 amino acid numbering) of the PB1-F2-derived C-terminal peptides fro

163 le mutant (F86L/T93P/S118T; bovine rhodopsin numbering) of the tiger salamander UV cone pigment appea

164 vate the DRN with ON DRN-projecting RGCs out numbering OFF DRN-projecting RGCs.

165 -Phe-Trp(8)-Lys-Thr-Phe-Cys-OH (somatostatin numbering; OLT-8, 9) substituted by imBzl-l- or -d-His a

166 When attacking an Utetheisa egg cluster (numbering on average 20 eggs), the larva subjects it to

167 ve site of 23S rRNA, A2602 (Escherichia coli numbering), on the peptidyl transferase activity of the

168 ential RNA (RPR) and protein subunits (RPPs) numbering one in bacteria, and at least four in archaea

169 -I222T, rg-H274Y, rg-N294S, and rg-R371K, N2 numbering) or zanamivir (rg-E119A and rg-R371K) failed t

170 s loop (residues 143-154 in chymotrypsinogen numbering) plays a pivotal role in determining the macro

171 ates that amino acid residue 90 (B. fragilis numbering) plays an important role in conferring substra

172 n of APP, lysine 624, on the basis of APP695 numbering (position 28 relative to Abeta) that plays a c

173 An arginine (R481) (Rhodobacter sphaeroides numbering), positioned between the D-propionates of the

174 ution occurred at C(10) and C(9a) (mitomycin numbering) providing a CD(3) ether and a CD(3) hemiamina

175 4R, C725S, A728S, D730S, and C731S (Na(v)1.4 numbering) reduced block of Na(v)1.4 by 4-, 86-, 12-, 18

176 s3-Xxx7-DTrp8-Lys9-Thr10-Cys14]-Thr-NH2 (the numbering refers to the position in native SRIF), with X

177 y(8)-Lys(9)-Thr(10)-Zzz(11)-Cys(14)]-OH (the numbering refers to the position in native SRIF), with X

178 the flavin-(N3), has been included (residue numbering refers to the yeast sequence).

179 he other extends from positions -73 to -103 (numbering relative to the transcription start site of cf

180 ted at sites 1917 and 1951 (Escherichia coli numbering), respectively, in the 23S rRNA gene of C. bur

181 rt, and integrase), in which the amino acid numbering restarts at the first codon position of each d

182 yrosyl radical on R2 (Y122, Escherichia coli numbering) reversibly generates the transient thiyl radi

183 (The numbering scheme for gp41 (e.g., gp41(553-590) for 1) ad

184 utein sequence begins with Gly121 (using the numbering scheme for the wild-type protein) and terminat

185 a conserved cysteine residue at position 83 (numbering scheme of the 140-residue form of FGF-1).

186 2 (TM7) equivalent to Lys(7.45) (Ballesteros numbering scheme) involved in covalently attaching retin

187 Multiple different numbering schemes exist, they vary in the nomenclature t

188 The chromosome numbering schemes of the genetic linkage and physical ma

189 nnotate sequences with the five most popular numbering schemes: Kabat, Chothia, Enhanced Chothia, IMG

190 ressed by phosphorylation at Ser287 (Xenopus numbering; Ser216 of human Cdc25C) and subsequent bindin

191 Numbering sFRP-1 cysteines sequentially from the N termi

192 saturated acyl chains at the stereospecific numbering (sn)-1 position from PC and likely a channelin

193 st that plant CPS prefers the stereospecific numbering (sn)-1 position whereas E. coli CPS acts on sn

194 nogonids (sea spiders) are marine arthropods numbering some 1,160 extant species.

195 d to Cys-305 (Cys-331 in human type II IMPDH numbering), suggesting that Cys-305 functions as a nucle

196 achieved by the use of a computer encrypted numbering system at the National Cancer Institute) and b

197 A standardized numbering system for HBV polymerase is proposed.

198 ed on this information, we propose a uniform numbering system for the beta3 exons.

199 (residue -34 to -15 and -11 to +6, using the numbering system in which the conserved histidine residu

200 The new consensus rt domain numbering system is genotype independent and allows inve

201 In BPR, Glu142 (the GPR numbering system is used) is deprotonated and can act as

202 otrypsin numbering system; for the urokinase numbering system it is Ile(159)-Lys(404)) and two point

203 at involves, principally, Lys345 and Glu211 (numbering system of enolase 1 from yeast).

204 s to HVS and KSHV ORFs and used the HVS/KSHV numbering system to designate these ORFs.

205 at position +4 in the beta-polypeptide (the numbering system used assigns position 0 to the His whic

206 in lacking the N-terminal pyroglutamate (the numbering system used has Asp2 as the N-terminal residue

207 ds to Gly(193) in chymotrypsin, which is the numbering system used subsequently.

208 m label was located at positions (patchoulol numbering system) C5 (both isotopomers, ca. 100%) and C1

209 rg59+Asn108 mutants (using the P. falciparum numbering system) exhibit no significant fitness defects

210 H310A, H435Q, H435R, and H310A/H435Q, Kabat numbering system) expressed well in mammalian cell cultu

211 Residue 192 (chymotrypsin numbering system) in thrombin, activated protein C, and

212 group of His157 (His159 in the yeast enolase numbering system) is in van der Waals contact (4.5 A) wi

213 acidic residue at position 144 (chymotrypsin numbering system) is the primary determinant of the dist

214 Lysine 72 (using the vertebrate numbering system) is trimethylated in cytochromes c from

215 ations for the 3-residue region 237-240 (ABL numbering system) of TEM-1 beta-lactamase.

216 riants (I253A, H310A, and H310A/H435Q; Kabat numbering system) that exhibited differential serum pers

217 Lys65, His66, and Tyr71 (using the thrombin numbering system), that were resistant to HCII inhibitio

218 due that occupies position 192 (chymotrypsin numbering system), which plays a pivotal role in determi

219 man, were aligned, using the now-known Kabat numbering system, and a quantitative measure, variabilit

220 equences were also aligned using a different numbering system, since the locations of their CDRs (31-

221 eported at positions according to the E.coli numbering system.

222 d proteins for variant reporting and an exon numbering system.

223 sidues Ile(16)-Lys(243) (in the chymotrypsin numbering system; for the urokinase numbering system it

224 in the region and legacy exon and amino acid numbering systems.

225 mmon biological agents in the sea, typically numbering ten billion per litre.

226 erases of the exocyclic N6 of A2058 (E. coli numbering) that forms the macrolide binding site in the

227 e insertion loop at residue 60 (chymotrypsin numbering) that has been implicated in modeling studies

228 rm of the Abl tyrosine kinase (H396P; Abl-1a numbering) that is resistant to the Abl inhibitor imatin

229 fide bond (Cys(191)-Cys(220) in chymotrypsin numbering) that links two beta-loop structures that defi

230 g-73, Arg-75, and Arg-77 in chymotrypsinogen numbering) that play key roles in the function of thromb

231 ines, R481 and R482 (Rhodobacter sphaeroides numbering), that interact directly with heme a and the h

232 D132(I) (subunit I; Rhodobacter sphaeroides numbering), the entrance of the K-channel has not been c

233 1) at Thr(697) and/or Thr(855) (rat sequence numbering) to inhibit phosphatase activity and increase

234 dine residue (His-287, murine ferrochelatase numbering) to leucine and reduced over 2 orders of magni

235 and that the NPXY tyrosine (Tyr743 by APP751 numbering, Tyr682 in APP695) is required for APP endocyt

236 hour) could be obtained via parallelization (numbering up) by simply wrapping several membrane tubing

237 ing of the base at position 1492 (by E. coli numbering) upon binding to the E. coli rRNA A site, but

238 both residues 145-157 and 201-212 (human p53 numbering used throughout).

239 ted that aspartate 143 (Escherichia coli TGT numbering) was involved in heterocyclic substrate recogn

240 eophilicity at the delta10 double bond (GGPP numbering) was synthesized and incubated with taxadiene

241 nizes MYPT1 phosphorylated at Thr(654) (M130 numbering), we determined that this calcium-independent

242 Automated disk-vertebra detection and numbering were concordant with neuroradiologist assignme

243 esidues (Tyr(677) and Tyr(701), using hFGFR1 numbering) were essential for bioactivity, but the remai

244 Arg73, Arg75, and Arg77 in chymotrypsinogen numbering) were individually substituted with a Glu.

245 F linkage sites (using the original sequence numbering) were residue 39, which is at the beginning of

246 s(230), Arg(233), and Lys(239) (chymotrypsin numbering) were substituted with Ala in separate constru

247 teine at positions 3 and/or 14 (somatostatin numbering) were/was substituted with d-cysteine, norcyst

248 e chains of two residues, S353 and T354 (NIS numbering), were identified as the Na(+) ligands at Na2.

249 tion, two substitutions, H274Y and R292K (N2 numbering), were introduced into each NA gene for compar

250 , or dual sulfation at both positions (Kabat numbering where H designates heavy chain) leads to an in

251 s Ser236 (Dictyostelium discoideum myosin II numbering) which was proposed to be involved in a hydrog

252 ucleotide at position 1408 (Escherichia coli numbering), which is an adenosine in prokaryotic ribosom

253 This preference is linked to Phe902 (human numbering), which is responsible for low-affinity bindin

254 d, with the single exception of Glu-22 (IL-3 numbering), which is strictly conserved but nonetheless

255 ntains an aspartate residue [Asp157 (spinach numbering)], which is highly conserved in eukaryotic and

256 on, VRVIII (amino acids 586 to 591 [AAV8 VP1 numbering]), which lies on the surface of the protrusion

257 Arg-173, Lys-175, and Lys-179; chymotrypsin numbering) with Ala, using an expression system that all

258 0d, K60f, E217, and R221 in chymotrypsinogen numbering) with alanine altered the substrate specificit

259 ite Ser-581 (full-length fatty acid synthase numbering) with alanine completely eliminated catalytic

260 His42, His124, and Glu126 (Aquifex aeolicus numbering), with particular attention paid to the effect

261 combinations of three critical regions (FIV numbering, with equivalent HIV numbering in superscript)

262 itions 1345-1350/1372-1376 (Escherichia coli numbering), within the three-way junction loop, which bi

263 rporation of a quaternary center at C-6 (THP numbering) would restore the facial selectivity with mor