ライフサイエンスコーパス: nurse cell

1 rs the endocycle and develops as a polyploid nurse cell.

2 um, and the cell exits meiosis and becomes a nurse cell.

3 n whether to differentiate as an oocyte or a nurse cell.

4 cause the presumptive oocyte to develop as a nurse cell.

5 ases during its maturation into a functional nurse cell.

6 pod classes, gametogenesis functions without nurse cells.

7 enter the endocycle and develop as polyploid nurse cells.

8 in the squamous stretch cells overlying the nurse cells.

9 e polyploid in preparation for their role as nurse cells.

10 e structures and the formation of binucleate nurse cells.

11 to the oocyte depends upon apoptosis of the nurse cells.

12 d the structural integrity of the oocyte and nurse cells.

13 the oocyte and exhibit variation within the nurse cells.

14 in the formation of egg chambers with extra nurse cells.

15 n the regulation of actin-bundle assembly in nurse cells.

16 ted in response to increased constriction by nurse cells.

17 chanical pressure imposed by the surrounding nurse cells.

18 is region are not necessary for apoptosis in nurse cells.

19 nterconnect the oocyte and its 15 associated nurse cells.

20 n the majority of cytoplasm is lost from the nurse cells.

21 by taking up materials transported from the nurse cells.

22 be inappropriately present in morula mutant nurse cells.

23 oid cell cycles to prepare for their role as nurse cells.

24 es the amount of satellite DNA propagated in nurse cells.

25 hile the remaining 15 cells differentiate as nurse cells.

26 ay participate in membrane biogenesis in the nurse cells.

27 study F-actin dynamics within the Drosophila nurse cells.

28 ation often resulting in the formation of 16 nurse cells.

29 ll cluster to resist compressive forces from nurse cells.

30 tain the meiotic cycle and develop as pseudo-nurse cells.

31 thway, and the remaining 15 differentiate as nurse cells.

32 the endoreplication defects in Elg1-depleted nurse cells.

33 ors Bicaudal D (BicD) and Egalitarian in the nurse cells.

34 operly or undergo DNA fragmentation in dying nurse cells.

35 tene cells appear to function transiently as nurse cells.

36 the remaining fifteen cells become polyploid nurse cells.

37 en the oocyte is removed from the egg field, nurse cells abort their differentiation program, undergo

38 ex accumulated in large processing bodies in nurse cells, accompanied by MT reorganization.

39 ocalizes mRNAs and proteins deposited by the nurse cells across the oocyte.

40 ing, Enabled localizes to barbed ends of the nurse cell actin filaments, suggesting its mechanism of

41 In vivo, the assembly of nurse-cell actin bundles is accompanied by extensive per

42 Both nurse cell and oocyte chromosomes require cup to attain

43 lop to form a germline cyst consisting of 15 nurse cells and an oocyte.

44 hile nanos RNA is synthesized by the ovarian nurse cells and appears at the posterior pole of the ooc

45 s functional and localizes to nuclei of both nurse cells and follicle cells during oogenesis.

46 that both EcR-A and EcR-B1 are expressed in nurse cells and follicle cells throughout oogenesis.

47 an exaggerated inflammatory response around nurse cells and in the pleural cavity.

48 ly assembles actin filaments into bundles in nurse cells and maintains their stability under fluctuat

49 ransport through the ring canals linking the nurse cells and oocyte appears to be independent of both

50 Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded duri

51 i may regulate chromosome compaction in both nurse cells and oocyte.

52 n cystocytes for maturation into specialized nurse cells and oocyte.

53 eurons, the cardia (proventriculus), and the nurse cells and oocytes of the ovary.

54 nd mitotic clonal analysis reveals that both nurse cells and oocytes require SMN to maintain normal o

55 e reactivated, and DNA damage accumulates in nurse cells and oocytes.

56 n smn cause abnormal nuclear organization in nurse cells and oocytes.

57 protein is made but excluded from nuclei of nurse cells and oocytes; upon egg activation, YA acquire

58 he oocyte then comes to lie posterior to the nurse cells and signals through the Gurken/Egfr pathway

59 egg chambers that are supported by germline nurse cells and surrounded by somatic follicle cells.

60 lex involved in localizing mRNAs both within nurse cells and the developing oocyte.

61 transport of cytoplasmic components between nurse cells and the oocyte during previtellogenic stages

62 unctate distribution in the cytoplasm of the nurse cells and the oocyte until the protein disappears

63 e defective in osk mRNA localization in both nurse cells and the oocyte.

64 that yl RNA is synthesized by the germ line nurse cells and then transported to the oocyte.

65 chanism of movement of gurken RNA within the nurse cells and towards and through ring canals connecti

66 Drosophila bicoid mRNA is synthesized in the nurse cells and transported to the oocyte where microtub

67 ale hawaiensis, a species whose ovaries lack nurse cells and whose eggs lack obvious polarity.

68 s in the cytoplasm and perinuclear region of nurse cells and, like Otu, moves to the periphery of the

69 ells have endoreplicated DNA (as observed in nurse cells), and (4) oocyte-specific cytoplasmic marker

70 ithelium, detach from it, invade neighboring nurse cells, and migrate as a coherent cluster.

71 f its cell types-the somatic epithelial, the nurse cells, and the oocyte.

72 n of the actin cytoskeleton and a failure of nurse cell apoptosis, each of which are required for nor

73 oth of these phenomena are manifestations of nurse-cell apoptosis.

74 We have determined that nurse cells are cleared from the Drosophila egg chamber

75 rmeabilization, and DNA fragmentation of the nurse cells are impaired when phagocytosis is inhibited.

76 itude and prolonged nature of this response, nurse cells are rarely destroyed by infiltrating cells.

77 mic bridges, and determinants synthesized in nurse cells are transported through these bridges to the

78 ng oogenesis, Hsp70 inducibility was lost in nurse cells around stage 10, in a posterior-to-anterior

79 e cells: the centripetally migrating and the nurse cell-associated follicle cells.

80 DNA fragmentation begins in nurse cells at stage 12, following the completion of cyt

81 endently regulating chromosome compaction in nurse cells at the end of the unique endoreplication cyc

82 During oogenesis in wild-type Drosophila, nurse cells become polyploid and do not contain cyclin B

83 is disrupted, membranes separating adjacent nurse cells break down and the structural integrity of t

84 es in the follicular epithelium that uncover nurse cells but not the oocyte.

85 These mRNAs originate in the nurse cells, but how they move into the oocyte remains p

86 proteins are expressed in both follicle and nurse cells, but they do not accumulate at detectable le

87 In Drosophila, each oocyte is connected to nurse cells by cytoplasmic bridges, and determinants syn

88 nein-mediated processes such as migration of nurse cell centrosomes into the oocyte during the early

89 chromosomes, neither protein is required for nurse cell chromosome development or oocyte production.

90 d plays a role both in mRNA localization and nurse cell chromosome organization, probably by regulati

91 Thus, loss-of-function mutations arrest nurse cell chromosome reorganization at the five-blob st

92 uired in germ-line cells for cyst formation, nurse cell chromosome structure and egg maturation.

93 ough loss of Su(Hw) causes global defects in nurse cell chromosome structure, we demonstrate that the

94 ell cycle, by studying changes in Drosophila nurse cell chromosomes throughout the 10 to 12 endocycle

95 CP190 extensively co-localize with Su(Hw) on nurse cell chromosomes, neither protein is required for

96 share another phenotype, persistent polytene nurse cell chromosomes.

97 e show in live egg chambers that, within the nurse cell compartment, dynein actively transports green

98 by guided migration and invasion through the nurse cell complex toward the oocyte.

99 cell sheet involution between the oocyte and nurse cell complex which patterns the operculum structur

100 ion of the structural organization of oocyte-nurse cell complexes to generate multinucleate germline-

101 tethering of nurse cell nuclei, "dumping" of nurse cell contents into the oocyte, establishment of oo

102 egeneration and a failure of the transfer of nurse cell contents to the oocyte, indicating that TGF-b

103 We provide evidence that in nurse cells, continuous filopodia-like actin cables, gro

104 positioning is crucial during dumping, when nurse cells contract and expel their contents into the o

105 When nurse cells contract, actin cables associate laterally w

106 led important roles in oocyte determination, nurse cell cortical integrity and nurse cell dumping, an

107 thin the oocyte, and proper execution of the nurse cell cycle (endoreplication of DNA) and the oocyte

108 erantia-bicoid mRNA complex formation in the nurse cell cytoplasm allows anterior-specific transport

109 r the formation of parallel actin bundles in nurse cell cytoplasm and bristle shaft cells.

110 reaming begins during stage 10B, just before nurse cell cytoplasm is dumped into the oocyte.

111 vities were necessary for normal transfer of nurse cell cytoplasm to the oocyte.

112 utation of dDP in the germline also prevents nurse cell cytoplasm transfer to the oocyte, resulting i

113 f follicle cell migration, and completion of nurse cell cytoplasm transport (dumping).

114 es and are sterile due to a severe defect in nurse cell cytoplasm transport caused by the absence of

115 kinked bristles and are fertile with a mild nurse cell cytoplasm transport defect.

116 Subsequently, to mix incoming nurse cell cytoplasm with ooplasm, a subcortical layer o

117 Nonetheless, bicoid mRNA injected into the nurse cell cytoplasm, withdrawn, and injected into a sec

118 tions indicate a rise in free calcium in the nurse-cell cytoplasm coincident with the permeabilizatio

119 g currents and thorough mixing of oocyte and nurse-cell cytoplasm.

120 n tumor is required for the formation of the nurse cell cytoplasmic actin array that is essential for

121 cytoplasm transport caused by the absence of nurse cell cytoplasmic actin bundles.

122 g nurse cells may prevent destruction of the nurse cell cytoskeleton and the connected oocyte.

123 of a small subset of follicle cells prevents nurse cell death and cytoplasmic dumping.

124 ant, in which egg chambers undergo premature nurse cell death and degeneration.

125 and show dumpless egg chambers and premature nurse cell death in germline clones.

126 dcp-1 mutants are viable and nurse cell death in late oogenesis occurs normally.

127 ne, pita, leading to lethality and defective nurse cell death in late oogenesis.

128 ive Drice formed localized aggregates during nurse cell death in late oogenesis; however, active Dric

129 Early nurse cell death is not observed in the dcp-1/pita doubl

130 tage 13, indicating a block in developmental nurse cell death.

131 As oogenesis proceeds, 15 nurse cells die for every oocyte that is produced.

132 However, in the presence of the oocyte, nurse cells differentiate and enter an unusual apoptosis

133 Progression through the nurse cell differentiation program requires the presence

134 ail to complete cytoplasm transport from the nurse cells, DNA fragmentation is markedly delayed and b

135 go multiple rounds of endoreplication as the nurse cells do in a normal egg chamber.

136 increased Puc activity result in incomplete nurse cell dumping and aberrant dorsal appendages.

137 nsfer into the oocyte, events reminiscent of nurse cell dumping in Drosophila We propose that cytopla

138 ssion in the follicle cells and a failure of nurse cell dumping to coordinate with dorsal appendage e

139 ilaments in late nurse cells that facilitate nurse cell dumping, and migration of somatic border cell

140 rmination, nurse cell cortical integrity and nurse cell dumping, and support the idea that Capping pr

141 ablished Drosophila oogenesis, in particular nurse cell dumping, as a new model to determine how PGs

142 During nurse cell dumping, Enabled localizes to barbed ends of

143 anos localization initiates immediately upon nurse cell dumping, whereby diffusion, enhanced by micro

144 rd mitochondrial transport until the time of nurse cell dumping.

145 ia intracellular bridges by a process called nurse cell dumping.

146 red to coordinate centripetal migration with nurse cell dumping.

147 events occurring within the germline-derived nurse cells during Drosophila mid-oogenesis or follicle

148 r the death and removal of germ-line-derived nurse cells during late oogenesis.

149 transcripts, which are initially detected in nurse cells during mid-oogenesis, become localized to th

150 r cytoplasmic actin filament assembly in the nurse cells during oogenesis, although it may facilitate

151 cin is in the nuclei of the germline-derived nurse cells during stages 10B-12 (S10B-12) and at the nu

152 actin breakdown resulting in multi-nucleate nurse cells, early F-actin filament and aggregate format

153 for how actin structures position nuclei in nurse cells, employing evolutionary conserved machinery.

154 sophila, where a small number of specialized nurse cells expel their contents into the enlarging oocy

155 ally decreases as they adopt the alternative nurse cell fate.

156 ubcortical actin breakdown and disruption of nurse cell-follicle cell contacts, followed by germ cell

157 s an important role in cortical integrity of nurse cells, formation of robust bundled actin filaments

158 The syncytium is a nurse cell formed within the roots of Glycine max by the

159 etween border cells and their substrate, the nurse cells, functions in a positive feedback loop with

160 show that knockdown of Hop in the germ line nurse cells (GLKD) of Drosophila ovaries leads to activa

161 y other polyploid and polytene cells, during nurse cell growth the major satellite DNAs become highly

162 Unexpectedly, nurse cells in Akap200 mutant ovaries also had enlarged,

163 1 (EMS1) in forming the monolayer of tapetal nurse cells in Arabidopsis.

164 lution of sedentary endoparasitism and plant nurse cells in cyst and root-knot nematodes.

165 ox genes are expressed in Sertoli cells, the nurse cells in direct contact with developing male germ

166 Nurse cells in female-sterile alleles of morula begin to

167 ramming in germline companion cells, such as nurse cells in insects and vegetative nuclei in plants,

168 is stress-induced, whereas the cell death of nurse cells in late oogenesis is developmentally regulat

169 The death of nurse cells in late oogenesis is developmentally regulat

170 ive migration of the border cells in-between nurse cells in the Drosophila egg chamber.

171 ic mice reduces that protein specifically in nurse cells in the testis.

172 s cause a metaphase arrest, and endo cycling nurse cells inappropriately reenter mitosis in mr mutant

173 During stage 13, nurse cells increasingly contain highly fragmented DNA a

174 sues, produces a very different phenotype in nurse cells, inducing formation of highly enlarged lipid

175 esis its RNA is rapidly transported from the nurse cells into the oocyte where it accumulates specifi

176 ted with apoptosis and that apoptosis of the nurse cells is a necessary event for oocyte development.

177 responses occur at the site of infection, a nurse cell known as the syncytium.

178 Ichinohe occurs at the site of infection, a nurse cell known as the syncytium.

179 ppear in the germarium, suggesting that some nurse cells lack affinity for invading prefollicular cel

180 In mutant but not wild-type endomitotic nurse cells, "late S" patterns of bromodeoxyuridine inco

181 was highly expressed in SCID thymus and in a nurse cell line, but not in other thymic epithelial cell

182 t the cytoskeletal and nuclear events in the nurse cells make use of the machinery normally associate

183 This limited caspase activation in dying nurse cells may prevent destruction of the nurse cell cy

184 es show defects in actin filament formation, nurse cell membrane stability and border cell migration.

185 marium, but it is predominantly localized to nurse cell membranes.

186 Loss-of-function mutations block nurse cell nuclear transitions at the five-blob stage an

187 accompanied by extensive perforation of the nurse-cell nuclear envelopes, and both of these phenomen

188 In Drosophila nurse cells, nuclear positioning is crucial during dumpi

189 the germline causes F-actin formation in the nurse cell nuclei and germinal vesicle during mid-oogene

190 ng oocyte maturation, is required for timely nurse cell nuclei clearing from mature egg chambers.

191 eggshell and embryonic patterning and arrest nurse cell nuclei during a stage-specific reorganization

192 show a high percentage of egg chambers with nurse cell nuclei persisting past stage 13, indicating a

193 56 is required for bulk mRNA export from the nurse cell nuclei that supply most of the material to th

194 e oocyte cortex, actin-mediated tethering of nurse cell nuclei, "dumping" of nurse cell contents into

195 teins do bind to the polytene chromosomes in nurse-cell nuclei and enter the oocyte nucleus.

196 embryos, third instar larvae, and late stage nurse cells of adult females.

197 laments and aggregates, within the posterior nurse cells of S9 follicles; wild-type follicles exhibit

198 colocalizes with Exu in both the oocyte and nurse cells of the Drosophila egg chamber.

199 Here, we use the nutrient-storing nurse cells of the fly ovary to study the cellular effec

200 with this, dp53 RNA levels were high in the nurse cells of the ovary.

201 anterior pole of the egg chamber towards the nurse cell-oocyte boundary.

202 t the time follicle cells first surround the nurse cell-oocyte complex.

203 duce ovarian follicles with multiple sets of nurse cell-oocyte complexes.

204 he follicular epithelium that surrounds each nurse cell/oocyte cluster to form an egg chamber.

205 ins to condense during late S phase and that nurse cell polytene chromosome structure is controlled b

206 The cytogenetic locations on the nurse cell polytene chromosomes have been determined for

207 ytogenetic map of An. funestus using ovarian nurse cell polytene chromosomes.

208 At a late stage in Drosophila oogenesis, nurse cells rapidly expel their cytoplasm into the oocyt

209 Nurse cells require microtubules and Exuperantia to supp

210 trong allele of cappuccino has multinucleate nurse cells, similar to those previously described in ch

211 ression of constitutively active RhoL led to nurse cell subcortical actin breakdown and disruption of

212 Mice depleted of WT1 in Sertoli nurse cells suffered from increased germ cell apoptosis,

213 sues supporting early development and single nurse cells supporting gametogenesis.

214 ogenesis, RCs connect the maturing oocyte to nurse cells supporting its growth.

215 terminally differentiated pollen vegetative nurse cell surrounding the sperm cells undergoes a progr

216 on of robust bundled actin filaments in late nurse cells that facilitate nurse cell dumping, and migr

217 e this unusual apoptosis program in immature nurse cells that have not completed differentiation.

218 ggest the presence of cytoplasmic factors in nurse cells that inhibit the initiation of DNA fragmenta

219 ocalization is limited to chromosomes within nurse cells, the specialized cells that support oocyte g

220 in transfer of cytoplasm from the accessory nurse cells through the ring canals into the oocyte.

221 hoL transgene in the Drosophila ovary caused nurse cells to collapse and fuse together.

222 s eliminates excess germ cells that acted as nurse cells to provide cytoplasmic components to maturin

223 th the incomplete transfer of cytoplasm from nurse cells to the developing oocyte.

224 c movements, translocates nanos RNA from the nurse cells to the ooctye posterior.

225 In addition, final cytoplasm transport from nurse cells to the oocyte depends upon apoptosis of the

226 completion of fast cytoplasm transport from nurse cells to the oocyte, an event critical for the pro

227 he completion of cytoplasm transfer from the nurse cells to the oocyte.

228 nals that allow cytoplasm transport from the nurse cells to the oocyte.

229 is to transport cytoplasmic materials from 'nurse' cells to oocytes, a critical process for developi

230 ation within the early oocyte, distinct from nurse-cell-to-oocyte RNA transport.

231 the effect of viscous drag from surrounding nurse cells together with confinement of all of the cell

232 During Drosophila oogenesis, nurse cells transfer their cytoplasmic contents to devel

233 We find that nurse cells undergo three distinct types of endocycle wh

234 dcp-1- nurse cells were defective in the cytoskeletal reorganiz

235 ts of epidermal cells, mesoderm, trachea and nurse cells were identified, but the majority of the str

236 oping females and their associated syncytial nurse cells were significantly smaller than in control p

237 gration of oskar mRNA in real time, from the nurse cells where it is produced to the posterior cortex

238 kinesin I activity elevates RNP motility in nurse cells, whereas disruption of dynein activity inhib

239 three forms of particle movement within the nurse cells, while transport through the ring canals lin

240 owing the intracellular bridges that connect nurse cells with each o ther and to the developing oocyt

241 ession of Fascin increases, the frequency of nurse cells with high levels of nuclear actin, but neith

242 zygotes exhibit a reduction in the number of nurse cells with high nuclear actin levels.

243 could sense elevated cytoplasmic calcium; in nurse cells with reduced levels of Quail protein, villin

244 dhesions of developing germ cells to Sertoli nurse cells, with likely secondary degeneration of Serto

245 versing a network of large germ line-derived nurse cells within the ovary.

246 that many mutant egg chambers contain only 8 nurse cells without an oocyte which is phenocopied in di