ライフサイエンスコーパス: ob gene

1 he region of the human genome containing the OB gene.

2 transduced into increased expression of the ob gene.

3 al-like tranposon in the first intron of the ob gene.

4 om 78 families at markers flanking the human OB gene.

5 capable of directing expression of the mouse ob gene.

6 of leptin, the protein product of the obese (ob) gene.

7 treme obesity have an allelic variant of the OB gene, although other nearby genes could contribute to

8 We describe the structure of the human ob gene and initial functional analysis of its promoter.

9 The cloning of the ob gene and its gene product leptin has led to the eluci

10 isolation and partial sequence of the human OB gene and the screening of 105 obese patients for muta

11 f calories from fat) without mutation of the ob gene, and in four genetic models of obesity in mice:

12 Mice with mutations of the ob gene are extremely obese, and the human homologue (OB

13 Mice with mutations in the ob gene are obese and diabetic and manifest reduced phys

14 Animals with mutations in the ob gene are obese and lose weight when given leptin, but

15 Animals with mutations in the ob gene are obese and lose weight when given leptin, but

16 al adipose tissue-specific expression of the ob gene as well as enhanced expression by C/EBPalpha.

17 tially thought to be adipocyte-specific, the OB gene, as well as the leptin receptor, have been found

18 cal-by-descent for the region containing the OB gene at greater than chance levels (corrected P = 0.0

19 his was confirmed for the homeologous xTFIIS.oB gene by genomic PCR.

20 tivity to leptin, the protein encoded by the ob gene, cause obesity and diabetes in rodents.

21 A missense mutation in the ob gene causes leptin deficiency and morbid obesity.

22 The human ob gene consists of three exons and two introns and span

23 While the 5' flanking region of the mouse ob gene contains several consensus C/EBP binding sites,

24 Leptin, the product of the ob gene, controls food-intake and weight loss in the ob

25 oreover, we found that the expression of the ob gene could be manipulated by pharmacologically blocki

26 that mutations in the coding sequence of the OB gene do not constitute a common cause of increased bo

27 The mouse ob gene encodes leptin, an adipocyte hormone that regula

28 Cloned in 1994, the ob gene encodes the protein hormone leptin, which is pro

29 These data suggest that insulin regulates OB gene expression and leptin production indirectly, pro

30 nsulin and dexamethasone to acutely modulate ob gene expression and leptin secretion in rat adipocyte

31 In this report, we present evidence that ob gene expression in cultured cells suppresses acetyl-C

32 we provide evidence for rapid activation of ob gene expression in skeletal muscle by glucosamine.

33 In the presence of insulin in vitro, OB gene expression increased at 72 h (P < 0.01), followe

34 ob gene expression is increased in obese rodents and reg

35 These results show that ob gene expression is related to body weight and is not

36 ocorticoids, which supports the concept that ob gene expression is under hormonal control, which is e

37 of sequence elements and factors regulating ob gene expression should be of major importance in the

38 etes mellitus to examine the relationship of ob gene expression to obesity and non-insulin-dependent

39 L6 myocytes with glucosamine rapidly induces ob gene expression.

40 in lean animals glucose and insulin enhance ob gene expression.

41 taken to investigate the changes in obesity (OB) gene expression and production of leptin in response

42 by increased fat accretion, elevated obese (ob) gene expression, and high plasma leptin levels, simi

43 cytes, the presumptive promoter of the mouse ob gene facilitated luciferase expression.

44 Leptin, the protein product of the ob gene, has been linked to a faster heart rate in anima

45 Leptin, a fat-derived protein encoded by the ob gene, has been postulated to be a sensor of energy st

46 In humans, variants in the OB gene have not been detected and very little is known

47 this study we examined the expression of the ob gene in a dietary model in which moderate obesity dev

48 db/db mice, decreased the expression of the ob gene in these animal models of obesity and non-insuli

49 sults demonstrate that the expression of the ob gene is up-regulated in these two rodent models of di

50 ferentiation, expression of the mouse obese (ob) gene is immediately preceded by the expression of C/

51 Leptin, the product of the ob gene, is a hormone secreted by adipocytes that is kno

52 Leptin, the product of the ob gene, is a hormone secreted by adipocytes.

53 Leptin, the product of the ob gene, is a hormone, produced by adipose cells, that i

54 Leptin, the product of the human OB gene, is increased in obese individuals, suggesting r

55 Leptin, the product of the OB gene, is increased in obese individuals, suggesting r

56 ch is a 16 kilodalton protein-encoded by the OB gene, is involved in the regulation of food intake, b

57 the adipocyte-derived protein product of the ob gene, is related to amount of body fat.

58 Leptin, the product of the obese (ob) gene, is a regulator of food intake and energy metab

59 Leptin, the protein product of the obese (ob) gene, is a type-I cytokine hormone secreted by fat t

60 EP), the human homolog of the mouse obesity (ob) gene, is positioned near the linkage peak and is the

61 Leptin, a peptide encoded by the obese (ob) gene, is primarily secreted by adipocytes and is a c

62 Leptin, a product of the obese (ob) gene, is released from adipocytes.

63 Leptin, a product of the obese (ob) gene, is secreted by adipocytes and appears to act a

64 Leptin, the protein encoded by the obese (ob) gene, is secreted from adipose tissue and is thought

65 Leptin, the protein encoded by the obese (ob) gene, is synthesized and released in response to inc

66 Mutations in the obese (ob) gene lead to obesity.

67 The protein product of the ob gene (leptin) reduces body fat in mice when given exo

68 The product of the ob gene, leptin is a circulating hormone produced by whi

69 The product of the obese (ob) gene, leptin, is a secreted protein that is importan

70 Variation in the OB gene may be one genetically determined cause of obesi

71 tested the possibility that mutations in the OB gene may contribute to human obesity.

72 A mild decline in subcutaneous adipocyte ob gene mRNA and a marked fall in serum leptin were obse

73 Plasma leptin and ob gene mRNA levels were increased in mice following bac

74 iciency, we generated mice deficient in both ob gene product (leptin) and MCH neurons.

75 f the K(ATP) channel opener diazoxide or the ob gene product leptin mimicked the effect of glucose re

76 murine hematopoietic stem cells and that the ob gene product leptin stimulated hemato- and lymphopoie

77 Circulating levels of the ob gene product leptin were also significantly correlate

78 Leptin, the ob gene product, is a protein released from adipocytes a

79 The expression of leptin, the ob gene product, is increased in adipose tissue in respo

80 Leptin, the ob gene product, is produced by adipocytes, and it acts

81 The ob gene product, leptin, apparently exclusively expresse

82 The ob gene product, leptin, has been shown in several studi

83 The ob gene product, leptin, is a major hormonal regulator o

84 parallel changes in circulating level of the ob gene product, leptin.

85 recently published receptor for the obesity (ob) gene product (leptin) is an isoform of B219 with a n

86 db gene encodes the receptor for the obese (ob) gene product, leptin.

87 alpha as a transcriptional activator of the ob gene promoter and identify the functional C/EBP bindi

88 o 3T3-L1 cells with a series of 5' truncated ob gene promoter constructs activated reporter gene expr

89 ge inhibition patterns (footprinting) of the ob gene promoter revealed that recombinant C/EBP alpha,

90 It has recently been reported that the ob gene receptor was expressed on human and murine hemat

91 evidence for linkage between markers in the OB gene region and various traits, as follows: D7S514 an

92 es to the literature on linkage in the human OB gene region, we are able to show that the evidence fo

93 Leptin, the product of the ob gene, regulates food intake, energy expenditure, and

94 A mutation of the ob gene results in mice with severe hereditary obesity a

95 Mutation of the obese (ob) gene results in severe hereditary obesity and diabet

96 tely upstream of the first exon of the mouse ob gene revealed DNA sequences corresponding to presumpt

97 The human ob gene's three exons cover approximately 15 kb of genom

98 hese results indicate that expression of the ob gene serves as a sensor of fat cell hypertrophy, inde

99 Furthermore, one haplotype containing the OB gene was transmitted by heterozygous parents to extre

100 ene encoding the homolog of the mouse obese (ob) gene was isolated and partially characterized.

101 is a lack of leptin due to a mutation in the ob gene, we tested the hypothesis that leptin targets a

102 To address the regulation of the ob gene with regard to body weight and nutritional facto