ライフサイエンスコーパス: obese

1 llion children and 603.7 million adults were obese.

2 ildren with CP classified them as overfat or obese.

3 trophic/lost weight; 2) gained weight; or 3) obese.

4 0% of which occurred in persons who were not obese.

5 d, especially for children who were severely obese.

6 rtion of women start pregnancy overweight or obese.

7 ) spans the entire range from underweight to obese.

8 Patients without COPD were primarily obese.

9 aving a high body mass index (BMI) and being obese.

10 Of 18 337 patients (118 centers), 16% were obese, 15% were overweight, 53% were normal weight, 7% w

11 7% vs 45%), and less likely to be overweight/obese (50% vs 61%).

12 Participants included 150 overweight and obese 8- to 12-year-old children and their parents.

13 ment, including weight loss if overweight or obese, a Dietary Approaches to Stop Hypertension (DASH)-

14 rated increased numbers of B2 lymphocytes in obese adipose tissue and have shown that high-fat diet-i

15 , and describe a distinct "endophenotype" in obese adolescents characterized by a thin superficial la

16 applied the IDF criteria to 1,162 overweight/obese adolescents recruited during 1998-2000 from pediat

17 uble fiber supplementation in overweight and obese adults on outcomes related to weight management [b

18 BPF, and BPS concentrations were observed in obese adults than non-obese adults.

19 We included obese adults who underwent bariatric surgery as an instr

20 Among 56277 obese adults who underwent bariatric surgery, compared t

21 retion in vitamin D-deficient, overweight or obese adults, despite using high-dose vitamin D suppleme

22 ed diabetes was more common in overweight or obese adults, older adults, racial/ethnic minorities (in

23 ric and metabolic outcomes in overweight and obese adults, thereby indicating that supplementation ma

24 tions were observed in obese adults than non-obese adults.

25 y with the risk of infectious diseases among obese adults.

26 40(-/-), and p35(-/-) mice fed an HFD become obese after 12 weeks and exhibit glucose intolerance and

27 idated in a second cohort of 20 children (10 obese and 10 normal-weight children) by using quantitati

28 We enrolled 11 severely obese and 12 nonobese patients and obtained 294 blood sa

29 dy mass index (BMI) of 30.2 (3.5) kg/m(2) in obese and 19.4 (2.2) kg/m(2) in normal-weight groups wer

30 tial gene expression was compared between 21 obese and 21 normal-weight children by using directional

31 o improve glucose and insulin sensitivity in obese and diabetic mice.

32 trations and elevated glycated hemoglobin in obese and diabetic patients.CCK responsiveness varies wi

33 unique remodeling event in the myocardium of obese and diabetic rodents is an increase in docosahexae

34 null control males and females were morbidly obese and exhibited delayed puberty onset, no evidence o

35 Treated persons were more likely to be obese and have cirrhosis, but less likely to have stage

36 Effects of ozone were also assessed in obese and lean mice deficient in gammadelta T cells and

37 al lymphocyte populations were found between obese and normal-weight hip OA patients.

38 C57BL/6J mice were rendered obese and pre-diabetic by feeding a high-fat diet for 15

39 Trained, Obese and T2DM subjects were matched for total IMCL cont

40 re taken from eight Trained, Lean sedentary, Obese and T2DM subjects.

41 One third of U.S. adults are obese and therefore can expect higher rates of diabetes

42 n non-Hispanic European American women to be obese and to be diagnosed with triple-negative breast ca

43 clozapine or olanzapine, were overweight or obese, and had prediabetes.

44 special populations, including women and the obese, and the role of inflammation are discussed.

45 adipocytes as well as the adipose tissue of obese animals and humans.

46 Diet-induced obese animals received either Lactobacillus paracasei NF

47 on of metabolic health and energy balance in obese animals, and suggest that specifically reducing di

48 tabolomics of exhaled breath condensate from obese asthmatic (OA) patients, lean asthmatic (LA) patie

49 tome-wide differential gene expression among obese asthmatic children was enriched for genes, includi

50 el target that is upregulated in TH cells of obese asthmatic children, suggesting its role in nonatop

51 Obese asthmatic subjects have lower cut points for IgE l

52 2.99-6.22 [for children who were overweight/obese at all visits compared with normal weight children

53 e obesity, the chance they will no longer be obese at the age of 35 years fell from 21.0% (95% UI, 7.

54 rtainly interval [UI], 55.2 to 60.0) will be obese at the age of 35 years, and roughly half of the pr

55 tly highest for women who were overweight or obese at the beginning of pregnancy.These findings sugge

56 consisted almost entirely of women who were obese before pregnancy and was associated with a >2-fold

57 ownregulated and lipid oxidation enhanced in obese BLKO mice.

58 rweight (BMI 24 to <28 kg/m(2)) and 517 were obese (BMI >/= 28 kg/m(2)).

59 1.10; 95% CI, 1.09-1.12), and the extremely obese (body mass index, >/= 50.0; relative risk, 1.10; 9

60 allel intervention study of 44 overweight or obese (body mass index, 28-40 kg/m(2)) prediabetic men a

61 ajor serine phosphorylation site in SIRT1 in obese, but not lean, mice, and this phosphorylation was

62 onic infusion of an RGD synthetic peptide to obese C57BL/6 mice improved glucose clearance and insuli

63 re required to establish the role of RKT for obese candidates but preliminary data are encouraging.

64 assify children into normal, overweight, and obese categories.

65 es (RR = 1.08) complied more, but overweight/obese children (RR = 0.81), earlier maturing children (R

66 In obese children a moderate to good correlation between CA

67 icroarray platform on sorted monocytes of 35 obese children and 16 lean controls.

68 patic steatosis in a series of overweight or obese children by using the imperfect gold standard meth

69 Obese children displayed a distinctive monocyte gene exp

70 Obese children were 3-6 times more likely to have hypert

71 is associated with increased morbidity among obese children with asthma and may partly explain their

72 compared the CD4(+) T-cell transcriptome in obese children with asthma with that in normal-weight ch

73 anners offers advantages for examinations of obese, claustrophobic and paediatric patients.The aim of

74 nce interval [CI], 1.62-2.35 [for overweight/obese compared with normal weight children]) and the lon

75 and stroke) in adults who are overweight and obese compared with those who are a healthy weight.

76 consumption rate (Vo2) was disrupted in aged obese CT-1-deficient (CT-1(-/-)) mice (12 mo).

77 y the effects of maternal androgen excess in obese dams on metabolism, placental function and fetal g

78 Lean wildtype and obese db/db mice were pretreated with antibodies blockin

79 For morbidly obese decedents (BMI >/=40 kg/m2), the predicted probabi

80 donors, 2001-2016, proportions who were very obese decreased and proportions who were mildly obese or

81 Early preclinical experiments using the non-obese diabetic (NOD) mouse model reported mucosal admini

82 In patients with T1D and mice of the non-obese diabetic (NOD) strain, we detected alterations in

83 in the islets of Langerhans of 3-wk-old non-obese diabetic (NOD), NOD.Rag1(-/-), and B6.g7 mice.

84 Furthermore, treatment of non-obese diabetic mice with a Y1 receptor antagonist delays

85 the development of type 1 diabetes in a non-obese diabetic mouse model.

86 th type 2 diabetes, and in the beta cells of obese diabetic rodents.

87 can be used for special groups of consumers (obese, diabetic).

88 t diet-induced obese mice and in genetically obese-diabetic Lepr(db)mice.

89 ein kinase 5 (Erk5) is lost in the hearts of obese/diabetic animal models and that cardiac-specific d

90 ssion of Ctbp2 was increased in diet-induced obese (DIO) mice as compared with age-matched lean contr

91 high-fat intake and obesity in diet-induced obese (DIO) mice.

92 ort that in the NTS of high-fat diet-induced obese (DIO) rats, the apoA-IV mRNA level is significantl

93 t gain relative to control in a diet-induced obese dog model, suggesting the importance of systemic i

94 lation difference was >/=0.2 in four or more obese donors.

95 ed from 1.10 for overweight to 1.93 for very obese donors.

96 n 2 and SGLT1 expression was detected in the obese duodenum.

97 Five week old lean and obese female C57BL6/J mice were mated with chow fed male

98 otion activity in response to stress whereas obese female mice did not.

99 le for the impaired E2's anorectic action in obese females.

100 Systemic glucose tolerance was improved in obese GR-deficient mice, which was associated with incre

101 placement was significantly increased in the obese group ( P < 0.001), and after adjusting for confou

102 from those in the normal weight or extremely obese groups.

103 ficant differences among the NAFL, NASH, and obese groups.

104 Subjects with obese HFpEF (body mass index >/=35 kg/m(2); n=99), nonob

105 rrelated with body mass and plasma volume in obese HFpEF (r=0.22 and 0.27, both P<0.05) but not in no

106 se HFpEF and control subjects, subjects with obese HFpEF displayed increased plasma volume (3907 mL [

107 The increase in heart volumes in obese HFpEF was associated with greater pericardial rest

108 ction, and reserve capacity in subjects with obese HFpEF, those with nonobese HFpEF, and control subj

109 from periprostatic white adipose tissue from obese HiMyc mice at 6 months of age revealed a dramatic

110 nce staining of ventral prostate tissue from obese HiMyc mice revealed high levels of CXCL12 in the s

111 diabetes embody metabolic characteristics of obese human patients with type 2 diabetes, such as sever

112 ined the mediobasal hypothalamus (MBH) of 57 obese human subjects and 54 age- and sex- matched nonobe

113 ata show that mIndy is increased in liver of obese humans and nonhuman primates with NALFD.

114 In obese humans, B cell IL-6 secretion was lowered and IgM

115 In obese, hyperglycemic, hyperinsulinemic female Lepr(db/db

116 the associations among metabolically healthy obese individuals and 4 different presentations of incid

117 iatric surgery (MBS) leads to weight loss in obese individuals and reduces comorbidities such as type

118 vascular comorbidities are more prevalent in obese individuals and remain the basis for pretransplant

119 menting commensal, was markedly decreased in obese individuals and was inversely correlated with seru

120 ulin-stimulated SCAT glucose uptake rates in obese individuals are proportional to whole-body fat mas

121 Overweight and obese individuals carrying the AMY1-AMY2 rs11185098 geno

122 rt failure in normal weight, overweight, and obese individuals increased with increasing number of me

123 res of FGF2 or inhibit FGFR-1 in abdominally obese individuals may be important cancer prevention str

124 functions, satiation, satiety, and weight in obese individuals over 16 weeks.

125 The relative odds of impairment for obese individuals versus normal-weight individuals signi

126 ociation of S/P with the metabolic status of obese individuals was further validated in a cross-secti

127 Our findings have primary relevance to obese individuals who are at an increased risk of develo

128 hanges in adiposity among 692 overweight and obese individuals who were randomly assigned to diets va

129 lactulose:mannitol (Lac:Man) permeability in obese individuals with and without liver steatosis under

130 During a mean follow-up of 5.4 years, obese individuals with no metabolic abnormalities had a

131 pecies (DCAS) was significantly increased in obese individuals with type 2 diabetes (T2DM) from a cas

132 GE also occurs faster in obese individuals, and is associated with increased bloo

133 ncreatic ductal adenocarcinoma (PDAC) and in obese individuals, but whether it contributes to PDAC de

134 iated microbial and metabolic alterations in obese individuals, including the decreased abundance of

135 the gut, characterize other vital organs in obese individuals.

136 increased risk of liver tumor development in obese individuals.

137 ences of cardiovascular events and cancer in obese individuals.

138 ol is able to improve glucose homeostasis in obese individuals.

139 In obese, insulin-resistant patients with nonalcoholic fatt

140 n (HdbWnox1), lean Nox1 knockout (HdbKnox1), obese (KdbWnox1), and obese KK (KdbKnox1).

141 1 knockout (HdbKnox1), obese (KdbWnox1), and obese KK (KdbKnox1).

142 ), subcutaneous fat, and insulin kinetics in obese Latino and African American children with habitual

143 Overweight and obese Latino children (8-15 years; n = 314) were enrolle

144 splant population, the optimal management of obese liver transplant candidates remains undefined.

145 review, we examine current practices in the obese liver transplant population, offer recommendations

146 anxiogenic effects of the high fat diet, and obese male mice showed decreased locomotion activity in

147 st circumference: <94 cm) and 54 abdominally obese men (waist circumference: 102-110 cm) participated

148 d PYY, and decreased lipolysis in overweight/obese men.

149 ta1 (TGF-beta1) in mammary adipose tissue in obese mice activates SMAD3 signaling, causing phospho-SM

150 L) are significantly reduced in the liver of obese mice and humans.

151 evels of FGF21 in both high-fat diet-induced obese mice and in genetically obese-diabetic Lepr(db)mic

152 -defective SIRT3-K57R mutant in diet-induced obese mice decreased acetylation of mitochondrial long-c

153 Here, we show that hepatocytes from obese mice displayed significantly diminished SOCE as a

154 Furthermore, AT from obese mice exhibits an increased sensitivity to IL-4 sti

155 rtantly, short-term knockdown of BIM rescued obese mice from insulin resistance, evidenced by reduced

156 In contrast, obese mice lacking hepatic activating transcription fact

157 FSF11A or NDUFAB1 in the MBH of diet-induced obese mice reverses mitochondrial elongation and reduces

158 GM-CSF neutralization in diet-induced obese mice significantly reduced immunosuppression, intr

159 ng assays and in vivo metabolic profiling in obese mice to investigate the effects of IGFBP-1 and its

160 the metabolic impact of exercise training in obese mice with cardiac and skeletal muscle disruption o

161 Treating obese mice with NAT3 or AAT3 decreases adiposity and inc

162 mprove blood glucose control in diet-induced obese mice with pre-existing metabolic syndrome.

163 Expression of both genes was elevated in obese mice, and induction of Cadm1 in excitatory neurons

164 ligation, nonalcoholic steatohepatitis, and obese mice, as well as EVs released from hepatocytes exp

165 In obese mice, ozone increased lung IL-13+ innate lymphoid

166 re we show that in hypercaloric diet-induced obese mice, persistently activated microglia in the MBH

167 ose and insulin tolerance at 16 weeks HFD in obese mice.

168 fat mass loss without calorie restriction in obese mice.

169 d hepatic steatosis in high-fat diet-induced obese mice.

170 n the augmented effects of ozone observed in obese mice.

171 erived macrophages and high-fat diet-induced obese mice.

172 IL-33 drives augmented responses to ozone in obese mice.

173 nd improve glucose tolerance in diet-induced obese mice.

174 f lean mice to more closely resemble that of obese mice.

175 show that UCB monocytes from babies born to obese mothers generate a dampened response to LPS stimul

176 rd blood (UCB) monocytes from babies born to obese mothers generate a reduced IL-6/TNF-alpha response

177 isk of epilepsy in children of overweight or obese mothers was not explained by obesity-related pregn

178 cally challenged (HFD-consuming offspring of obese mothers).

179 SC) from offspring born to normal-weight and obese mothers, we tested the hypothesis that changes in

180 months of age, particularly in offspring of obese mothers.

181 n UCB monocytes obtained from babies born to obese mothers.

182 l exercise and NMN injection in offspring of obese mothers.

183 levels, and wound healing in a pre-clinical obese mouse model of OA.

184 in live tissues from a high-fat diet-induced obese mouse model.

185 In vivo infusion of (15)N-glutamine in obese mouse models of PDA demonstrates enhanced nitrogen

186 on of BAT mass not only in lean, but also in obese, mouse phenotypes, in which this tissue is invisib

187 The metabolically unhealthy non-obese (MUNO) subjects (hazard ratio [HR], 1.29; 95% conf

188 dietary and hepatic cholesterol in human non-obese NAFLD/NASH patients.

189 patients, lean asthmatic (LA) patients, and obese nonasthmatic (ONA) subjects could recognize specif

190 nalyzed transcriptome changes in AT from 191 obese, nondiabetic patients within a multicenter, contro

191 n and body weight (i.e., lean nonstimulated, obese nonstimulated, and obese stimulated).

192 o observed in obese-stimulated compared with obese-nonstimulated groups (P < 0.01).

193 e uptake rate was lower by 33% (P < 0.01) in obese-nonstimulated mini-pigs but was no different in ob

194 However, synovial fibroblasts from obese OA patients were found to secrete greater amounts

195 tration of resistin was higher in overweight/obese OA patients, compared to normal-weight OA patients

196 f IL-6 detected in the synovial fluid of the obese OA patients.

197 In high-fat diet fed and genetically obese ob/ob mice, P300 translocates from the nucleus int

198 Furthermore, modulation of these neurons in obese (ob/ob) mice suppresses food intake and body weigh

199 Obese (odds ratio, 1.28; P=0.008), severely underweight

200 ght: odds ratio, 2.02; 95% CI, 1.15 to 3.56; obese: odds ratio, 3.76; 95% CI, 1.81 to 7.80).

201 In this clinical trial involving 160 obese older adults, we evaluated the effectiveness of se

202 effective in improving functional status of obese older adults.

203 Overweight and obese older people face a high risk of muscle loss and i

204 n of women from Shanghai area are overweight/obese or exhibit excessive GWG, both high pre-pregnancy

205 ng drug treatment, in pregnant women who are obese or overweight have not had sufficient impact on pr

206 se decreased and proportions who were mildly obese or overweight increased.

207 Obese Ossabaw swine were subjected to gradually developi

208 anasal oxytocin (24 IU) in ten overweight or obese, otherwise healthy men.

209 Obese outpatients (body mass index >/=30 kg/m2) who lost

210 n levels were not different between lean and obese participants (P = 0.41).

211 MR) imaging over 48 months in overweight and obese participants compared with participants of stable

212 d controlled trial, 61 healthy overweight or obese participants followed either a 5-wk very-low-calor

213 Children who were overweight or obese, particularly those with asthma, had higher odds o

214 Results In this obese patient population (mean body mass index = 40.3 kg

215 Better survival for overweight and obese patients after ST-segment-elevation myocardial inf

216 e data demonstrating a different response in obese patients compared with normal-weight patients duri

217 Obese patients demonstrate greater adverse LV remodeling

218 Approximately 20-30% of obese patients do not achieve successful weight outcomes

219 0.001), and after adjusting for confounders, obese patients had a significantly higher rate of tooth

220 no significant differences in infarct size, obese patients had significantly more impaired LV global

221 Obese patients have impaired vasodilator reactivity and

222 aradox, morbidity and mortality are lower in obese patients undergoing cardiac surgery, although the

223 A survival advantage for overweight and obese patients was observed in this large cohort of crit

224 om 16 mechanically ventilated critically ill obese patients were analyzed.

225 osing of 16 g/2 g/24 hr continuous infusion, obese patients were more likely than nonobese patients t

226 Compared with normal/underweight patients, obese patients were younger and more likely to have diab

227 Atelectasis develops in critically ill obese patients when undergoing mechanical ventilation du

228 We conclude that PI3Kgamma inhibition in obese patients who are predisposed to beta-cell failure

229 reduced BW and portal pressure in overweight/obese patients with cirrhosis and portal hypertension.

230 se with nonobese HFpEF and control subjects, obese patients with HFpEF displayed worse exercise capac

231 collected from normal-weight or over-weight/obese patients with hip OA.

232 rgy diet (LED) reduces weight effectively in obese patients with knee osteoarthritis, but the role of

233 ry was both effective and cost-effective for obese patients with NASH, regardless of fibrosis stage;

234 uman mINDY may have therapeutic potential in obese patients with nonalcoholic fatty liver disease.

235 am improves gut barrier function and whether obese patients with or without liver steatosis differ in

236 Intestinal permeability is increased in obese patients with steatosis compared with obese patien

237 peptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surge

238 obese patients with steatosis compared with obese patients without.

239 Compared to obese patients, nonobese patients had lower NAFLD activi

240 r fitness and survival in some overweight or obese patients.

241 mpared bariatric surgery with usual care for obese patients.

242 disease and may have a better prognosis than obese patients.

243 tly related to electroanatomic remodeling in obese patients.

244 of mice fed a high-fat diet (HFD) as well as obese patients.

245 bin or fibrin(ogen) may limit pathologies in obese patients.

246 for achieving clinical control of asthma in obese patients.

247 ever, according to the insurance hypothesis, obese people are food insecure, and this causes them to

248 Compared with normal weight participants, obese people had an RR of 1.87 (95% CI = 1.38-2.52), whe

249 red with intensive lifestyle modification in obese people.

250 carbohydrates may predispose offspring to an obese phenotype, indicating a potential role for nutriti

251 solution to quantify BAT mass, especially in obese phenotypes, in which this tissue may be present bu

252 ted with obesity phenotypes in sedentary and obese populations, but rarely with skeletal muscle and e

253 trate and energy metabolism in overweight or obese prediabetic men and women.

254 previously showed that cortisol is lower in obese pregnancy.

255 posure to lower glucocorticoid levels during obese pregnancy.

256 For this purpose, we used diet-induced obese rats and rats administered thapsigargin, and by co

257 Diet-induced obese rats were randomized to isocaloric diets: Control,

258 been associated with anti-obesity actions in obese rats.

259 and insulin sensitivity when administered to obese recipients.

260 d and cholesterol metabolism in diet induced obese rodents.

261 lean nonstimulated, obese nonstimulated, and obese stimulated).

262 stimulated mini-pigs but was no different in obese-stimulated compared with lean mini-pigs.

263 tal glucose uptake rate was also observed in obese-stimulated compared with obese-nonstimulated group

264 [CI], 1.22-1.37) and metabolically unhealthy obese subjects (MUO; HR, 1.33; 95% CI, 1.26-1.41) had a

265 Participants were recruited from the Swedish Obese Subjects (SOS) study, which was a matched (nonrand

266 Obese subjects exhibited T2 hyperintensity in the left b

267 In fact, in obese subjects none of the biomarkers of inflammation si

268 ge fluid from 23 lean, 12 overweight, and 20 obese subjects were examined for SP-A.

269 Obese subjects were studied before and after intestinal

270 Eight healthy volunteers and eight severely obese subjects with insulin resistance were studied.

271 Fasting Adipo-IR was increased twofold in obese subjects with NGT and IGT versus lean subjects wit

272 tudy and decreased in the remission group of obese subjects with T2DM after metabolic surgery.

273 In obese subjects, elevation of both IMCL and EMCL content

274 nce as compared to metabolically healthy non-obese subjects.

275 T-1 profiles in normal-weight and overweight/obese subjects.

276 In obese syngeneic mice, metformin treatment mimicked the e

277 f S. aureus to the unique environment of the obese/T2D host accounts for its increased virulence and

278 says demonstrated a hypercoagulable state in obese/T2D mice that was comparable to that of diabetic p

279 eposition surrounding bacterial abscesses in obese/T2D mice.

280 Obese Tg mice remained insulin sensitive, had increased

281 ulation, participants were less likely to be obese, to smoke, and to drink alcohol on a daily basis a

282 s have mechanistically linked obesity and an obese tumor microenvironment with signaling pathways tha

283 tional intervention study 46 healthy and non-obese twin pairs consumed recommended low fat diets for

284 genesis and increases blood flow recovery in obese type 2 diabetic mice by an endothelial nitric oxid

285 mpared with placebo.Sixty-five overweight or obese, vitamin D-deficient (25-hydroxyvitamin D [25(OH)D

286 d EMCL content in individual calf muscles in obese vs. normal healthy human subjects.

287 Being overweight or obese was associated with dysanapsis in both the cross-s

288 schemic stroke patients, being overweight or obese was not associated with decreased mortality or bet

289 guidelines, and being either underweight or obese were associated with poor health status.

290 al administration of Pep19 into diet-induced obese Wistar rats significantly reduces adiposity index,

291 sarean delivery for the prevention of SSI in obese women (prepregnancy BMI >/=30) who had received st

292 In obese women 15 to 44 years of age, the incidence was 22.

293 Among obese women undergoing cesarean delivery who received th

294 To determine rates of SSI among obese women who receive prophylactic oral cephalexin and

295 The association was strongest among obese women with intentional weight loss (HR, 0.44; 95%

296 n addition, it has been noted that pregnant, obese women, compared with lean subjects, have decreased

297 were similar in normal-weight and overweight/obese women.

298 n cholesterol (LDL-C), is frequently seen in obese women.

299 to ATIS (adipose disposition index [DI]) in obese youth with impaired glucose tolerance (IGT) versus

300 tor reactivity within the skeletal muscle of obese Zucker rats (OZR) is impaired.