ライフサイエンスコーパス: obligate

1 cultative) and two did not downregulate SNF (obligate).

2 tnership has remained facultative and is not obligate.

3 The obligate 3(S)-4(R) stereochemistry at the nascent C3-C4

4 ncy virus type 1 (HIV-1)-infected population obligates a focus on the interaction between aging, como

5 e polarity at these positions is crucial for obligate acidic pH-dependent activity.

6 Obligate acidophilic members of the thaumarchaeotal genu

7 Bsg25A and Elba2 heterotrimerize with their obligate adaptor, Elba3 (i.e., the ELBA complex), to rec

8 xic origin through the GOE and ultimately to obligate aerobes [10-13].

9 that Gram-positive bacteria considered to be obligate aerobes may play previously unrecognized roles

10 o be in the interior, whereas facultative or obligate aerobes tend to be at the periphery of the cons

11 While considered obligate aerobes, little is known about how these bacter

12 f dioxygen, many free-living diazotrophs are obligate aerobes.

13 g prokaryotes as a hub between anaerobes and obligate aerobes.

14 (nonmethanogenic), facultative aerobes, and obligate aerobes.

15 The obligate aerobic diazotroph, Azotobacter vinelandii, emp

16 ittle is known about the mechanisms enabling obligate aerobic mycobacteria to cope with hypoxia, resu

17 Given that the myocardium is an obligate aerobic tissue and consumes large amounts of O2

18 o-culture of human epithelial cells with the obligate anaerobe Bacteroides caccae and LGG results in

19 uld be used to study the pathogenesis of the obligate anaerobe C. difficile.

20 obiota showed inter-individual variation and obligate anaerobe enrichment (e.g., Firmicutes).

21 ost reducing to most oxidizing: methanogens, obligate anaerobes (nonmethanogenic), facultative aerobe

22 f the microbes within the human body are the obligate anaerobes, Clostridium spp., in the internal po

23 trong relationship between cyanobacteria and obligate anaerobes, from which cyanobacteria presumably

24 ellular building blocks and all appear to be obligate anaerobes.

25 None of 10 control samples contained obligate anaerobes.

26 8 out of 18 patients (41%) had either obligate anaerobic (n = 5) or microaerophilic (n = 4, on

27 h is characterized by a reduced abundance of obligate anaerobic bacteria and an expansion of facultat

28 In general, PFOR is present in all obligate anaerobic bacteria, while oral commensal aerobe

29 This pathway, identified in the obligate anaerobic bacterium Eubacterium limosum, is com

30 Fusobacterium necrophorum, an obligate anaerobic bacterium, was recently reported to b

31 Although obligate anaerobic commensal bacteria have been associat

32 ysicochemical properties of small molecules, obligating analysts to seek multiplatform and multimetho

33 The presence of obligate and facultative anaerobes, including Clostridia

34 ustrial reactors harbor an abundance of both obligate and facultative anaerobes, many of which play s

35 A variety of obligate and facultative anaerobic species, not reported

36 We also demonstrate that both obligate and facultative marine hydrocarbon-degrading ba

37 udy examined interactions between a guild of obligate and opportunistic coral-feeding butterflyfishes

38 On an independent test set of obligate and transient complexes, our IntPred predictor

39 d by complementation remains problematic for obligates and is a highly sought-after goal.

40 The proteins form an obligate approximately 700-kDa superassembly with a broa

41 Strain MLMS-1 is the first reported obligate arsenate-respiring chemoautotroph which grows b

42 including ferns where 10% of all species are obligate asexuals.

43 Several obligate associate crabs and shrimps species may co-occu

44 yporinae, modern members of which exhibit an obligate association with soft-textured mushrooms.

45 Many eukaryotes have obligate associations with microorganisms that are trans

46 ure induced irreversible dissociation of the obligate ATC trimer, and as a consequence the DHO is als

47 The obligate bacterial symbiont Wigglesworthia glossinidia i

48 Obligate intracellular bacteria (obligates) belonging to Rickettsiales and Chlamydiales c

49 oiled-coil structure in association with its obligate bHLH-ZIP partner Max.

50 al data for mutations in XRCC4, encoding the obligate binding partner of LIG4, causing MPD.

51 sts divert up to 20% of photosynthate to the obligate biotrophic fungi.

52 The soil borne, obligate biotrophic fungus Synchytrium endobioticum caus

53 esistance to Golovinomyces cichoracearum, an obligate biotrophic fungus that penetrates the cell wall

54 Albugo candida is an obligate biotrophic parasite that consists of many physi

55 nity against infection by otherwise virulent obligate biotrophic powdery mildew fungi such as Golovin

56 latter exhibiting necrotrophy, biotrophy, or obligate biotrophy.

57 Ticks are obligate blood-feeders and serve as vectors of human and

58 leted comprehensive genomic analyses of this obligate blood-feeding insect.

59 this is the first direct demonstration of an obligate brainstem-to-hypothalamus circuit orchestrating

60 ected for for 244 individuals (132 proven or obligate C9orf72 carriers), of whom 147 were clinically

61 m 147 were clinically affected (89 proven or obligate C9orf72 carriers).

62 eased in abundance with elevated CO2 whereas obligate calcifying species, and non-calcareous macroalg

63 microRNA (miRNA) expression patterns in the obligate CAM plant pineapple [Ananas comosus (L.) Merr.]

64 of transgenic RNA interference lines of the obligate CAM species Kalanchoe fedtschenkoi with reduced

65 acterization of transgenic RNAi lines of the obligate CAM species Kalanchoe fedtschenkoi with reduced

66 pression data for Kalanchoe fedtschenkoi, an obligate CAM species within the core eudicots with a rel

67 In most cases, obligate carriers could be identified by ERG testing.

68 Among obligate carriers with affected fathers, sons, or both,

69 p mutation, 23 of them were positive, 6 were obligate carriers, and 2 were likely carriers.

70 Europe's obligate cave-dwelling amphibian Proteus anguinus inhabi

71 Here, we demonstrated that AIPL1 is an obligate chaperone of PDE6 and that it enables low yield

72 in-selection conditions that select against "obligate cheaters" quorum-sensing response null mutants.

73 Failure to realize an obligate CO causes homologs to attach independently to t

74 mutations in orco, the gene that encodes the obligate co-receptor of all ORs.

75 We report here that the mTORC2 obligate cofactor Rictor is enriched in HER2-amplified s

76 these proteins function cooperatively as an obligate complex in the brain.

77 th SPPIDER, using an independent test set of obligate complexes enhanced performance (MCC=0.381) whil

78 fy oncofetal fibronectin (FN) as a major and obligate component of the matrix assembled by stromal fi

79 romal cells along with FGF receptors and its obligate coreceptor, betaKlotho.

80 w that robust cellular balance hinges on the obligate coupling of divisions to apoptosis, which limit

81 two bacteria previously shown to display an obligate cross-feeding interdependency.

82 nvasion experiments reveal possible paths to obligate cross-feeding.

83 emal complex that functions as a cis-acting, obligate, crossover-counting mechanism.

84 nd fewer chiasmata, resulting in the loss of obligate crossovers and leading to chromosome mis-segreg

85 secondary transporters that have evolved an obligate dependence on a substrate-binding protein (SBP)

86 ed to other CPR bacteria, we predict similar obligate dependence on other organisms or the microbial

87 is particularly challenging because it is an obligate dimer in which the individual subunits are unst

88 t the small GTP-binding protein Rap2A is the obligate effector for, and GEF substrate of, Epac2 in me

89 on of D. coniospora to its almost completely obligate endoparasitic lifestyle led to the simplificati

90 Obligate endosymbiosis is operationally defined when los

91 mes are large and are not streamlined for an obligate endosymbiotic lifestyle, implying that they hav

92 olution and interactions between an ancient, obligate endosymbiotic prokaryote with its obligate plan

93 Here, we investigated the loss of an obligate enzyme in mitochondrial long-chain fatty acid o

94 It is an obligate epibiont of an Actinomyces odontolyticus strain

95 Binding, an obligate event for cell intoxication, is believed to occ

96 ses that l-serine transport occurs by either obligate exchange or nonobligate exchange coupled with f

97 d that accelerated decline in FEV1 is not an obligate feature of COPD.

98 For this strictly anaerobic, obligate fermentative bacterium, we propose the name '(U

99 teria(7)) are common in the tropics, whereas obligate fixers (less able to downregulate fixation) dom

100 This extension is mediated through obligate folding cooperativity of the intrinsically diso

101 a Fox family transcription factor, Foxc1, is obligate for appreciable sweat duct activity in mice.

102 betagamma is inhibitory to Ric-8 action but obligate for receptors.

103 Nest-associative behaviour is nearly obligate for some species, but facultative for others; t

104 logues, chaperone holdase activity is not an obligate function in the Hsp110 family.

105 4 backcross progeny from a cross between the obligate FW species An. coluzzii, and its closely relate

106 Sunfish were thought to be obligate gelatinous plankton feeders, but recent studies

107 in TYR was present in five of six CMM cases/obligate gene carriers in one family and a single popula

108 rther characterization of Wac in vivo showed obligate haploinsufficiency for this gene (which encodes

109 flies, in particular, are highly specialized obligate hematophagous ectoparasites that incidentally b

110 The common bed bug is an obligate hematophagous parasite of humans.

111 chemosensory repertoire of genes related to obligate hematophagy, host-symbiont interactions, and se

112 Finally, the fitness interests of obligate heritable symbionts are distinct from those of

113 Many insect species harbor obligate, heritable symbiotic bacteria that provision es

114 athway that converges on the Rag GTPases, an obligate heterodimer of two related GTPases.

115 ough the AM1 and AM2 receptors formed by the obligate heterodimerization of a G protein-coupled recep

116 , all the maize B class proteins bind DNA as obligate heterodimers and positively regulate their own

117 ubset of nuclear receptors (NRs) function as obligate heterodimers with retinoid X receptor (RXR), al

118 ur results are the first demonstration of an obligate heteromeric PRMT, and they suggest that enzyme-

119 These receptors are obligate heteromers containing glycine- and glutamate-bi

120 a protothecoides and the non-photosynthetic, obligate heterotroph Prototheca wickerhamii.

121 formations in each monomer of the asymmetric obligate homo-dimer.

122 hia coli phosphofructokinase-2 (Pfk-2) is an obligate homodimer that follows a highly cooperative thr

123 a target for antiproliferative drugs, is an obligate homodimer.

124 P2X7Rs are obligate homotrimers, with each subunit having two trans

125 d inhibitor of apoptosis protein (XIAP), are obligate Hsp70 clients that are rapidly (within approxim

126 Gonorrhea, an obligate human infection, is on the rise worldwide and g

127 Pertussis, or whooping cough, caused by the obligate human pathogen Bordetella pertussis is undergoi

128 Remarkably, we report that an obligate human pathogen secretes several cytokinins.

129 It is an obligate human pathogen with limited genetic diversity a

130 etics in the response of macrophages to this obligate human pathogen.

131 Little is known about the niche width of obligate human pathogens.

132 rate by some proximal cue, often weather) or obligate (i.e., those that migrate on a regular cycle).

133 p. and Biomphalaria pfeifferi) that serve as obligate intermediate hosts in the complex life cycle of

134 3 oxidation to nitrite (NO2(-)) via a single obligate intermediate, hydroxylamine (NH2OH).

135 aerobic NH3 oxidation by AOB occurs via two obligate intermediates, NH2OH and NO, necessitating a me

136 crescentus and an orthologous system from an obligate intracellular (rickettsial) pathogen.

137 larization system encoded in free-living and obligate intracellular alpha-proteobacteria.

138 Obligate intracellular bacteria (obligates) belonging to

139 Chlamydia spp. are obligate intracellular bacteria and, as such, should be

140 Obligate intracellular bacteria are an unusual group of

141 Although free-living and obligate intracellular bacteria are both polarized it is

142 ted fever group (SFG) Rickettsia species are obligate intracellular bacteria capable of infecting bot

143 the current state of the art for genetics in obligate intracellular bacteria could direct future tech

144 However, the presence of bacteriophages in obligate intracellular bacteria of eukaryotes may promot

145 Obligate intracellular bacteria replicate exclusively wi

146 Obligate intracellular bacteria such as Chlamydia tracho

147 n cycle compared with peptidoglycan-negative obligate intracellular bacteria such as Ehrlichia and An

148 Rickettsia species are obligate intracellular bacteria with both conserved and

149 ia and Anaplasma phagocytophilum, as well as obligate intracellular bacteria with classical peptidogl

150 Wolbachia are obligate intracellular bacteria(1) that infect arthropod

151 Of the two major groups of obligate intracellular bacteria, the cell wall has been

152 th a comparison to the methods used in other obligate intracellular bacteria.

153 ur data reveal a novel mechanism by which an obligate intracellular bacterial pathogen modulates ERAD

154 Despite Coxiella burnetii being an obligate intracellular bacterial pathogen, our recent st

155 in peptidoglycan metabolism across the major obligate intracellular bacterial species.

156 The obligate intracellular bacterium Chlamydia abortus is th

157 The obligate intracellular bacterium Chlamydia trachomatis i

158 Notably, the obligate intracellular bacterium Ehrlichia chaffeensis r

159 Orientia tsutsugamushi, an obligate intracellular bacterium that is auxotrophic for

160 Chlamydia is an obligate intracellular bacterium that relies on host cel

161 rile illness in tropical Asia, caused by the obligate intracellular bacterium, Orientia tsutsugamushi

162 Obligate intracellular Chlamydia trachomatis replicate i

163 Chlamydia trachomatis is an obligate intracellular epitheliotropic bacterial pathoge

164 fungal kingdom are Microsporidia, a group of obligate intracellular eukaryotes infecting multiple ani

165 Coxiella burnetii is an obligate intracellular Gram-negative bacterium that caus

166 Chlamydia trachomatis is an obligate intracellular human pathogen responsible for th

167 ckettsia belong to a family of Gram-negative obligate intracellular infectious bacteria that are the

168 Because of its obligate intracellular life style, genetic manipulation

169 ny animals that appear to have adapted to an obligate intracellular lifestyle by modifying the morpho

170 The obligate intracellular lifestyle of apicomplexan parasit

171 lei by genome reduction and adaptation to an obligate intracellular lifestyle.

172 ales, suggesting convergent adaptation to an obligate intracellular lifestyle.

173 uggesting common pathogenic mechanisms among obligate intracellular microbes.

174 lasma gondii is a classic model for studying obligate intracellular microorganisms as various genetic

175 In evolving to an obligate intracellular niche, Chlamydia has streamlined

176 Because A. marginale is an obligate intracellular organism, its adhesins that media

177 The obligate intracellular parasite Chlamydia trachomatis ha

178 The obligate intracellular parasite Chlamydia trachomatis ha

179 Toxoplasma gondii is an obligate intracellular parasite that invades host cells,

180 iasis, caused mainly by Leishmania major, an obligate intracellular parasite, is a disfiguring diseas

181 Viruses are obligate intracellular parasites and need to reprogram h

182 Obligate intracellular parasites must efficiently invade

183 phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals w

184 Microsporidians are obligate intracellular parasites that have minimized the

185 Viruses are obligate intracellular parasites that rely on host cell

186 As obligate intracellular parasites, they have significant

187 As obligate intracellular parasites, viruses depend on the

188 As obligate intracellular parasites, viruses manipulate the

189 Among the Apicomplexa phylum of obligate intracellular parasites, which cause veterinary

190 cies in phylum Apicomplexa are single-celled obligate intracellular parasites.

191 Chlamydia trachomatis is an obligate intracellular pathogen that replicates in a mem

192 Chlamydia trachomatis is an obligate intracellular pathogen that resides in a membra

193 As an obligate intracellular pathogen, the apicomplexan parasi

194 in the central metabolic properties of this obligate intracellular pathogen.

195 Obligate intracellular pathogens depend on their host fo

196 Chlamydiae sp. are obligate intracellular pathogens that cause a variety of

197 Rickettsiae are obligate intracellular pathogens that induce their uptak

198 Obligate intracellular pathogens undergo several cellula

199 Infection by unicellular, obligate intracellular Plasmodium parasites causes malar

200 Toxoplasma gondii, an obligate intracellular protozoan parasite, establishes a

201 Toxoplasma gondii is an obligate intracellular protozoan parasite.

202 llelic exchange in Ehrlichia chaffeensis, an obligate intracellular tick-borne bacterium responsible

203 Toxoplasma gondii is an obligate, intracellular eukaryotic apicomplexan protozoa

204 The obligate-intracellular pathogen Chlamydia trachomatis (C

205 shmaniasis, a vector-borne disease caused by obligate intramacrophage protozoa, threatens 350 million

206 NPVs are obligate killers, and the vast majority of transmission

207 Entomopathogenic nematodes are obligate lethal parasitoids of insect larvae that naviga

208 d to the synthesis of dolichyl phosphate, an obligate lipid carrier in protein glycosylation reaction

209 needs from their host hepatocytes during the obligate liver stage of infection, yet there remains spa

210 Here, we present the first documentation of obligate long-distance migrant birds undertaking a facul

211 Obligate methanotrophs belonging to the Phyla Proteobact

212 During migration, obligate migrants can curtail or delay flights in respon

213 However, it is not known whether obligate migrants undertake facultative migrations and m

214 roven difficult to study, as it must form an obligate modular homodimer containing the PDZ proteins s

215 is study, we examine the localization of the obligate mTORC2 component, mSin1, inside cells and repor

216 he successful transition from unicellular to obligate multicellular life.

217 rn in this family due to a mutation-negative obligate mutation carrier.

218 low nutrient regime, before collapse of the obligate mutualism, we find that the ratio rapidly reach

219 Herein we demonstrate that the obligate mutualist, Wigglesworthia, up-regulates express

220 s suggest that the intimate relationships of obligate mutualists may lead to selective pressures simi

221 est reproductive success of 'strong' (nearly obligate) nest associates was used to represent interact

222 kground but blood feed in one region and are obligate nonbiters in the rest of their range: Wyeomyia

223 ng genes that distinguish blood feeding from obligate nonbiting is hampered by the fact that these di

224 omyia smithii Contemporary blood-feeding and obligate nonbiting populations represent end points of d

225 enetic differences between blood feeding and obligate nonbiting.

226 volutionary transition from blood feeding to obligate nonbiting.

227 Our findings show that TatC functions as an obligate oligomer.

228 to develop therapies specifically targeting obligate oncohistone partnerships.

229 cancer screening trials are used to estimate obligate (or type 1) overdiagnosis rates for DCIS, invas

230 Obligate overdiagnosis occurs in 9% of DCIS and approxim

231 making a negligible contribution of 0.15% to obligate overdiagnosis of DCIS and a contribution of les

232 ry, starting at age 40 years) adds little to obligate overdiagnosis rates (0.15% for DCIS and less th

233 Results Obligate overdiagnosis rates depend strongly on the age

234 and a contribution of less than 0.1% to the obligate overdiagnosis rates of invasive breast cancer a

235 Purpose To determine obligate overdiagnosis rates, defined as the percentage

236 e modifications are read out, we designed an obligate pair of H3 heterodimers, termed H3X and H3Y, wh

237 Viruses are obligate parasites and thus require the machinery of the

238 ch is based on using label-free phages (T4), obligate parasites of bacteria, which are attractive for

239 Cyst and root-knot nematodes are obligate parasites of economic importance with a remarka

240 ed species of flies, nearly all of which are obligate parasites of nestling birds.

241 a comprise over 2,000 species of microscopic obligate parasites that use both invertebrate and verteb

242 onal reduction, and the establishment of the obligate parasitic lifestyle.

243 to soybean roots to initiate and maintain an obligate parasitic relationship.

244 Our findings suggest that the transition to obligate parasitism relaxes functional constraints on pl

245 selection in all plastid genes is linked to obligate parasitism, characterized by the parasite's dep

246 ted by ischemia-reperfusion injury (IRI), an obligate part of renal transplantation, is not yet well

247 We now show that in the obligate parthenogenetic species A. neomexicana the vast

248 ds developed are broadly applicable to other obligates, particularly to rickettsial pathogens, to rou

249 curring through the ASXH domain of ASXL2, an obligate partner for BAP1 enzymatic activity.

250 ably associated with specific, high-fidelity obligate partners throughout the tumour and its spread,

251 ssible implications in immune evasion of the obligate pathogen T. pallidum during infection.

252 y clear, with views ranging from it being an obligate pathogen to an opportunist pathogen that can ot

253 Aggressive strains of the obligate pathogenic fungus Puccinia graminis f.sp. triti

254 ysis points to F. acidiphilum Y(T) having an obligate peptidolytic oligotrophic lifestyle alongside w

255 ongatus PCC 7942, is a genetically tractable obligate phototroph that is being developed for the biop

256 MSP production is not solely associated with obligate phototrophs, the process need not be confined t

257 cell wall, all suggest that facultative and obligate plant parasites originate from fungivorous ance

258 f ants, three that have convergently evolved obligate plant-ant mutualism and four closely related sp

259 The obligate plant-symbiotic AMF host additional symbionts,

260 , obligate endosymbiotic prokaryote with its obligate plant-symbiotic fungal host.

261 Met is the obligate precursor of S-adenosylmethionine (SAM), the me

262 MGUS is considered an obligate precursor to several lymphoplasmacytic malignan

263 In Bdellovibrio bacteriovorus, an obligate predator of Gram-negative bacteria, cell growth

264 eriovorus and Micavibrio aeruginosavorus are obligate predators of Gram-negative bacteria, and have b

265 us are Gram-negative proteobacteria that are obligate predators of other Gram-negative bacteria and a

266 Hsp90 have partially non-overlapping sets of obligate protein clients in cancer cells.

267 We confirmed that S. subcuneata is an obligate pseudogamous apomict, but open-pollinated flowe

268 ASXL1 is the obligate regulatory subunit of a deubiquitinase complex

269 cell biological and biochemical basis of the obligate relationship between Perkinsela sp. and its amo

270 efficient system for targeted mutagenesis in obligates remains a major impediment in understanding mi

271 of differentiation and that aging is not an obligate requirement for a CD19(neg) state to be establi

272 taining Dehalococcoides mccartyi that has an obligate requirement for benzimidazole-containing corrin

273 mors upon anti-PD-1 treatment, suggesting an obligate requirement for both BLT1 and CXCR3 in mediatin

274 derstanding of the genomic organization, the obligate requirements, and the sexual nature of these fu

275 estriction and open an evolutionary path for obligate saprophytism in this facultative intracellular

276 The levels of the obligate signaling protein Bcl10 are reduced by RNF181 e

277 Each intron contains three obligate signals: a 5' splice site, a branch site, and a

278 on population rates of change of a sagebrush-obligate species, the greater sage-grouse, across the Gr

279 ses translocation of mTORC1 to lysosomes, an obligate step for activation.

280 An obligate step in the generation of such gross rearrangem

281 However, in many cell types, CHOP is an obligate step in the PERK pathway, which frames the conu

282 associated with elevated erythropoiesis, an obligate step towards erythroid recovery in response to

283 Thus, it is likely that ACP is not simply an obligate subunit but also exploits the 4-PP-conjugated a

284 yte-specific deletion of Sptlc1 Sptlc1 is an obligate subunit of serine palmitoyltransferase, the enz

285 ral-dwelling gall crabs (Cryptochiridae) are obligate symbionts of stony corals (Scleractinia).

286 fer from bacteria that are not their current obligate symbionts, and full or partial endosymbiont rep

287 Obligate symbionts, those required by their host, are co

288 Our work shows that obligate symbiosis is not static but instead is subject

289 ic variation in the regulation of a mutually obligate symbiosis, between the pea aphid (Acyrthosiphon

290 Many obligate symbiotic fungi are difficult to maintain in cu

291 the oldest, morphologically specialized, and obligate termitophiles from mid-Cretaceous Burmese amber

292 r interpretation that Cretotrichopsenius are obligate termitophiles, and Mesosymbion[3], a member of

293 the oldest, morphologically specialized, and obligate termitophiles, Cretotrichopsenius burmiticus (F

294 e to positive) on plants and the dependence (obligate to facultative) of the plant-fungal interaction

295 the hemodialysis population, clinicians are obligated to explore whether factors related to dialytic

296 Registry of Transplant Recipients (SRTR) is obligated to publicly report data on transplant program

297 cyte nuclear factor 1alpha (HNF1alpha) as an obligated trans-activator for PCSK9 gene expression and

298 MondoA and its obligate transcription partner Mlx are basic helix-loop-

299 arge RAV was evolutionarily conserved within obligate wetland species, communities were more phylogen

300 aling, but two stand out as constitutive and obligate Wnt-induced regulators: Axin2 and Nkd1.