ライフサイエンスコーパス: obstacle

1 injuries to brain or spinal cord is a major obstacle.

2 of which limb was the first to step over the obstacle.

3 n the first and second dimensions as a major obstacle.

4 variety of medical, financial, and logistic obstacles.

5 ked RNAP, allowing RNAP to overcome stronger obstacles.

6 ty to detour around symmetric and asymmetric obstacles.

7 ormation, which poses ethical challenges and obstacles.

8 insights because it faces similar technical obstacles.

9 way for edge dislocations to overcome planar obstacles.

10 l or had to be abandoned because of anatomic obstacles.

11 igen-specific tolerance might overcome these obstacles.

12 ut succumbing to distractions and unforeseen obstacles.

13 by the overt recognition of such a potential obstacle, a panel of leading experts in the field attemp

14 Despite the obstacles, a diagnostic test for hidden hearing loss is

15 l service guarantee due to the communication obstacle among them with the growing number of mobile in

16 l or had to be abandoned because of anatomic obstacles, an anatomic ablation was moderately successfu

17 inical application of BChE is limited by two obstacles: an inadequate circulation half-life and limit

18 n adopt two main conformations to respond to obstacles and changes of protein density, while maintain

19 to overcome these previously insurmountable obstacles and improve the future of peptides as active a

20 the paradigm publicly available and describe obstacles and solutions to optimize future studies of co

21 t disturbances and change direction to avoid obstacles and to search for resources [1, 2].

22 nfluence the behavior of Pol II at chromatin obstacles, and establish that common genomic elements de

23 scription of my journey, with various roles, obstacles, and successes, will be both interesting and i

24 We show that, when boundaries, barriers, and obstacles are present, the optimal search strategy depen

25 We interpret each obstacle as an esker ridge formed from sediments deposit

26 BRAFi) in melanoma remains a common clinical obstacle, as is the case for any targeted drug therapy t

27 early indicate that YSK12-MEND overcomes the obstacle associated with non-viral vectors and can be co

28 ufficient to reduce interference and improve obstacle avoidance.

29 renal allograft transplantation has been an obstacle because of contraindications associated with IF

30 vely transport a large food item react to an obstacle blocking their path.

31 Obstacles blocking wider adoption of FIB-SEM include slo

32 We sought to address this obstacle by applying a centralized analysis pipeline to

33 responded to the presence of the other as an obstacle by increasing emissions, but hearing the sonar

34 olead and organotin compounds may present an obstacle by inhibiting the enzyme.

35 set out to develop a method to overcome this obstacle by utilizing the 6-amino-acid (CCPGCC) tetracys

36 Here, we have addressed these obstacles by engineering a second-generation, high-affin

37 These obstacles can be overcome with thoughtful study design t

38 collective oscillatory mode that facilitates obstacle circumvention.

39 Despite the obstacles cited above, OMICS research is expected to enc

40 force generation by actin polymerization at obstacles coated with actin "nucleation promoting factor

41 Therefore, these obstacles constrain their utilization at primary care cl

42 However, such a study is met with obstacles due to the inherent heterogeneous nature of ti

43 r, this protection mechanism is also a major obstacle during disease state since it dramatically hind

44 development of resistance represents a major obstacle for a cure.

45 Thus, Rtn4b seems to represent no major obstacle for axon regeneration in vivo because it is les

46 expression of nuclear transgenes remains an obstacle for basic and applied research.

47 nriched for inhibitory cells, posing a major obstacle for cancer immunity.

48 diversity of cells within tumors is a major obstacle for cancer treatment.

49 Ov-GRN-1 production is complex and poses an obstacle for clinical development.

50 p in higher organisms, it also poses a major obstacle for CNS repair later in life.

51 ity beyond early development is a formidable obstacle for conventional therapies to stimulate recover

52 nocompetent-small-primate models has been an obstacle for developing hepatitis C virus (HCV) vaccines

53 de, and find that it provides only a minimal obstacle for DNA polymerases.

54 The blood-tumor barrier (BTB) is a major obstacle for drug delivery to malignant brain tumors suc

55 for many cancer patients and remains a major obstacle for effective treatment.

56 entral nervous system (CNS) axons is a major obstacle for functional recovery in patients suffering n

57 with these catalytic domains imposes a major obstacle for investigation of the influence of protein-p

58 s is substantial correlated energy spread-an obstacle for key applications such as free-electron-lase

59 nt allograft vasculopathy (TAV) is the major obstacle for long-term survival of solid organ transplan

60 e to DDT and pyrethroids is a serious global obstacle for managing disease vectors.

61 -group minerals, has been a long-appreciated obstacle for proposed models of prebiotic organophosphat

62 pment of multidrug resistance (MDR), a major obstacle for successful chemotherapy in cancer.

63 ferences in epitope architecture might be an obstacle for TCR recognition, explaining the lack of T c

64 DApt-CS conjugate to function as a gate and obstacle for the access of redox probe to the surface of

65 y antineoplastic drugs is considered a major obstacle for the clinical application of inhaled chemoth

66 in the 1960s, presented a major and ongoing obstacle for the development of nonlive RSV vaccine cand

67 This circumstance is an obstacle for the production of known metabolites and the

68 injuries to brain or spinal cord is a major obstacle for tissue repair in central nervous system (CN

69 Methicillin resistance creates a major obstacle for treatment of Staphylococcus aureus infectio

70 This could represent an obstacle for universal vaccine development and warrants

71 A major obstacle for vaccine development has been the traditiona

72 Important obstacles for achieving TO were a prolonged hospital sta

73 peritrophic matrix and gut barrier-critical obstacles for Anaplasma colonization.

74 ered and constrained DNA structures could be obstacles for Cas9 and additionally provides insights in

75 Obstacles for comprehensive proteomic profiling include

76 ion limitations of optical systems are major obstacles for determining whether proteins are enriched

77 volume of BNST raises significant technical obstacles for functional imaging studies in humans.

78 imethylguanosine (m(2)2 G) cause significant obstacles for high-throughput RNA sequencing by impairin

79 onfirmed that we have overcome the two major obstacles for imaging GSK-3, namely, reasonable brain pe

80 of MOFs and eliminating fabrication-related obstacles for integration.

81 With no fundamental obstacles for scaling up, the technology's simplicity, e

82 This model highlights the obstacles for the development of safer NSAIDs.

83 y which RecBCD removes tightly bound protein obstacles from DNA.

84 long-term stability of CE-MS remains a major obstacle hampering its widespread application in metabol

85 the properties of native membranes, a major obstacle has been developing straightforward methods to

86 This obstacle has been overcome by energy-dispersive Laue dif

87 One obstacle has been the lack of quantitative data defining

88 onal advance for global gene analyses, novel obstacles have emerged, including the computational mana

89 To overcome this key obstacle hindering effective immunotherapy, we isolated

90 One obstacle hindering the elimination of TB is our lack of

91 at evolution solved the enzyme's key kinetic obstacle-how to maintain catalytic speed on a cooler Ear

92 s shown promise as a method to overcome this obstacle; however, the long-term effectiveness has not b

93 The major obstacle in addressing this question has been the lack o

94 ttenuated deISGylase activity has been a key obstacle in delineating the impact between deubiquitinas

95 de-doped materials, and this remains a major obstacle in designing materials with enhanced efficiency

96 disease (CAVD) pathogenesis remains a major obstacle in developing treatment strategies for this dis

97 ontrolled-release systems represents a major obstacle in drug delivery.

98 A major obstacle in luminescence imaging is the limited penetrat

99 The main obstacle in realization of a totally implantable hearing

100 A major obstacle in single-cell sequencing is sample contaminati

101 An obstacle in such an approach is that disease stage-defin

102 f cancer cells has remained as a significant obstacle in the achievement of efficient chemotherapy.

103 This issue has been a major obstacle in the consistency of reporting, meta-analysis

104 A main obstacle in the rational development of heterogeneous ca

105 A lack of written sources is a serious obstacle in the reconstruction of the medieval trade of

106 ies of heterogeneous catalysts poses a major obstacle in the targeted design of active and stable non

107 Cisplatin resistance is a major obstacle in the treatment of NSCLC, and its mechanism ha

108 s large, hydrophilic biomolecules is a major obstacle in their use and development against intracellu

109 , the WDESNs' calibration process is a major obstacle in them becoming the common practice.

110 hat moderate incomplete penetrance is not an obstacle in this gene-based burden testing approach but

111 A significant obstacle in training predictive cell models is the lack

112 A major obstacle in understanding metastatic lineages is the ext

113 ever, this characterization is a significant obstacle in work with plants because of the time require

114 s on a synergy between the NNS machinery and obstacles in chromatin.

115 One of the major obstacles in computational modeling is to build a mathem

116 susceptibility testing tools, and overcoming obstacles in discovery and research of new antibiotics.

117 t epitopes that can be exploited to overcome obstacles in drug design.

118 nces are time consuming and have been severe obstacles in employing metagenomic methods.

119 sugars and disaccharides are among the major obstacles in industrialization of sustainable biorefinin

120 toolkit that addresses commonly encountered obstacles in metabolic engineering, including chromosoma

121 Thus, one of the main obstacles in oncology is the lack of proper infection mo

122 ergistic mixtures, these remedies have faced obstacles in production and analysis.

123 We demonstrate how to overcome these obstacles in the lysogeny maintenance promoter of bacter

124 hat could be exploited to overcome the major obstacles in the prevention of and therapy for heart dis

125 cell (LSC) population remains one of several obstacles in treating this disease.

126 However, obstacles including insecurity, insufficient resources a

127 to eliminate the disease have faced various obstacles, including characteristics of the causative ba

128 n order to be realized must overcome several obstacles, including identification of suitable targets

129 pstream of the grounding line by large basal obstacles indenting the ice from below.

130 One major obstacle is development of magnetically active N-doped g

131 Here we show that this material obstacle is overcome by bulk crystals of lightly Sn-dope

132 One obstacle is that most rodent models have employed lighti

133 However, a key obstacle is the ambiguity that arises from the co-expres

134 A major obstacle is the extreme fragility of these qubits due to

135 One major obstacle is the immune-suppressive effects induced in bo

136 The second obstacle is the lack of a proven means of de novo phase

137 A major obstacle is the lack of an appropriate experimental mode

138 One strategy to overcome this obstacle is to remove the methyl group on these modified

139 One of the major obstacles is the cocaine-like addictive potential of the

140 media are generally plagued by two distinct obstacles: lack of sensitivity due to high dissociation

141 Two significant obstacles lie between transcriptome sequencing and funct

142 Nevertheless, the main obstacles lie in the accurate determination of the trap

143 However, various obstacles limit T-cell efficacy, including suboptimal T-

144 Long-term durability is a major obstacle limiting the widespread use of lithium-ion batt

145 euvers, and report here that bats navigating obstacles lowered emission rates when hearing artificial

146 ts by including real-life challenges such as obstacles, multiple pathways, and distracters that requi

147 nslatory optic flow-to successfully navigate obstacles: near objects appear larger and to move more q

148 lation disorders becomes widespread, several obstacles need to be overcome.

149 Despite these obstacles, novel LRAs are under development and beginnin

150 and oil environments and overcome a critical obstacle of achieving structural rigidity without compro

151 ant and promising approach to overcoming the obstacles of drug delivery to the highly inaccessible ch

152 efforts have been devoted to overcoming the obstacles of solid Li-metal batteries, such as low ionic

153 pecificity and, thus, overcoming a principle obstacle on the way of DQAMmiR becoming a practical miRN

154 principles will help to overcome some of the obstacles on the road from basic neuroscience to better

155 processing of replication forks encountering obstacles on the template strand.

156 n of replication forks that have encountered obstacles on the template strands.

157 enabling organisms to overcome work-related obstacles or constraints that separate them from signifi

158 Whether such points should now be viewed as obstacles or stepping stones is a matter of perspective.

159 e of several evening emergences with a novel obstacle placed in their flight path.

160 However, because of obstacles posed by repeat-rich heterochromatin, knowledg

161 ge tolerance (DDT) pathways that bypass such obstacles, postponing repair of the offending damage to

162 Because of technical obstacles, preclinical modeling of UTI in male mice has

163 When anatomic obstacles preclude radiofrequency catheter ablation of i

164 This obstacle presents a significant challenge to the nascent

165 A number of obstacles prevent HIV eradication, including low-level v

166 gnaled distance- or time-to-contact with the obstacle, regardless of which limb was the first to step

167 However, key obstacles remain in developing highly accurate quantitat

168 However, if an obstacle's resistance is excessive, Mfd dissociates the

169 The main obstacles so far are that skyrmions have been observed i

170 Two potential obstacles stand in the way.

171 rogress is slow largely because of practical obstacles, such as a lack of data, rather than insurmoun

172 hen driving a car, we need to quickly detect obstacles, such as pedestrians crossing the street, whil

173 letely understood, a potential translational obstacle that is challenging to surmount in neurons, whe

174 However, inactivation by O2 remains an obstacle that prevents them being used in many biotechno

175 view aims to highlight the opportunities and obstacles that exist with genomics and other related tec

176 apacity into intraocular tissues are the key obstacles that hinder the ophthalmic drug delivery of ma

177 the United States and provides a glimpse of obstacles that imaging practices may soon face or are al

178 Replication forks encounter obstacles that must be repaired or bypassed to complete

179 , and we outline what we believe are the key obstacles that need to be overcome for NDIs to see real

180 apies have been taken, there are substantial obstacles that will need to be overcome if CRISPR-Cas9 i

181 We overcame this obstacle through in vivo adenoviral transduction with ma

182 ght provide an opportunity to overcome these obstacles through affordable, targeted recruitment adver

183 circulating tumour cells must overcome many obstacles through mechanisms that we are only now starti

184 a few mucosal vaccines have surmounted these obstacles thus far.

185 ed of artificial heavy atom labels, the main obstacle to a broader application of high-resolution SWX

186 A major obstacle to a broadly neutralizing antibody (bnAb)-based

187 ncy virus persistence is therefore the major obstacle to a cure for AIDS.

188 the concern that dynamical scattering is an obstacle to ab initio phasing by MicroED and suggests th

189 Compensation of matrix effects is the main obstacle to achieve accurate quantification in LC-MS/MS.

190 A key obstacle to achieving optimal longevity is the progressi

191 or limiting factor to dose escalation and an obstacle to applying more promising new treatments for c

192 ervous system and thus presents an essential obstacle to brain transport of therapeutics.

193 Intratumoral heterogeneity is a major obstacle to cancer treatment and a significant confoundi

194 l population of origin, which constitutes an obstacle to clinical applications.

195 emia (AML) and other cancers remains a major obstacle to clinical management.

196 One identified obstacle to consistent usage of the ACMG-AMP guidelines

197 Insecticide resistance is a major obstacle to control of Anopheles malaria mosquitoes in s

198 ncer cells represents a significant clinical obstacle to curative therapy.

199 integrated HIV-1 provirus represents a major obstacle to curing HIV.

200 who spontaneously control viremia remains an obstacle to definitive treatment.

201 er, the choroid plexus epithelium remains an obstacle to delivery.

202 iolet sensors in air/vacuum has long been an obstacle to developing such detectors for practical appl

203 A key obstacle to development of semantic relatedness measures

204 in microvascular endothelial cells, poses an obstacle to drug delivery to the brain.

205 in tumor-bearing individuals and are a major obstacle to effective immunotherapy.

206 and cost of additional investigations are an obstacle to electrocardiographic (ECG) screening of youn

207 These reservoirs are considered the primary obstacle to eradicating HIV-1 from patients, and multipl

208 factor of early graft dysfunction and a key obstacle to expanding the donor pool in orthotopic liver

209 Thus, these cells may represent a major obstacle to finding a functional cure for HIV-1 infectio

210 als from non-layered materials has become an obstacle to further explore the physical properties and

211 as drug tolerance, represents a significant obstacle to global tuberculosis control.

212 Viral latency remains the most significant obstacle to HIV eradication.

213 ralizing antibodies (bnAbs) has been a major obstacle to HIV-1 vaccine development.

214 Managing excess nutrients remains a major obstacle to improving ecosystem service benefits of urba

215 on of flavor enhancers did not constitute an obstacle to L. casei 01 (>10(8)CFU/g) during storage.

216 One obstacle to large-scale implementation of cyanobacteria

217 eases, but its short in vivo half-life is an obstacle to long-term administration.

218 nsplant vasculopathy (TV) represents a major obstacle to long-term graft survival and correlates with

219 analysis, complexity has been regarded as an obstacle to overcome.

220 The major obstacle to persistence at low density is successful fer

221 -derived suppressor cells (MDSC) are a major obstacle to promising forms of cancer immunotherapy, but

222 of DNA nanostructures remains a substantial obstacle to realizing new applications of DNA nanotechno

223 ls for Campylobacter jejuni has long been an obstacle to research into this common enteric pathogen.

224 One major obstacle to study these mechanisms is that LCR exhibit c

225 A major obstacle to studying intrinsic brain activity has been t

226 The major obstacle to studying this phenomenon in plants is the di

227 r, the elephants had to see their body as an obstacle to success and first remove their weight from t

228 T-cell tolerance is a major obstacle to successful cancer immunotherapy; thus, devel

229 L, rituximab resistance remains an important obstacle to successful treatment of these tumors.

230 emia after ART interruption and is a central obstacle to the cure of HIV infection.

231 nt viral reservoir is considered the primary obstacle to the development of an HIV cure, and recent e

232 liable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-relat

233 ae (Sp), so nonvaccine serotypes are a major obstacle to the effective control of IPD.

234 er, the analysis of NGS data remains a major obstacle to the efficient utilization of the technology,

235 ate Abs may therefore represent an important obstacle to the evaluation of the antitumor efficacy of

236 nduced martensitic transformation is a major obstacle to the functional stability of shape memory all

237 rference has been identified as the greatest obstacle to the implementation of evidence-based measure

238 us-host disease (GVHD) remains a significant obstacle to the success of allogeneic hematopoietic cell

239 aused by its abnormal vasculature is a major obstacle to the treatment of cancer.

240 hing behavior in memristors has been a major obstacle to their adoption as the next generation of uni

241 rmation in other cells is therefore the main obstacle to therapeutic approaches for limb regeneration

242 A major obstacle to therapy in intensive care units is sepsis ca

243 ctical world of bioelectronics?" The central obstacle to this vision is the absence of versatile inte

244 ance among ExPEC strains constitutes a major obstacle to treatment and is implicated in increasing nu

245 n of fear following extinction therapy is an obstacle to treatment.

246 n particular the healing process, remains an obstacle to understand the pathophysiology of M. ulceran

247 A significant obstacle to understanding HTS etiology is the lack of to

248 A key obstacle to unidirectional transmission is retroactivity

249 electric substrates has long been a critical obstacle to using graphene for its niche applications th

250 pite antiretroviral therapy (ART) is a major obstacle to viral eradication.

251 ted cellular reservoirs represents the major obstacle to virus eradication in patients under antiretr

252 Microbial contamination is an obstacle to widespread production of advanced biofuels a

253 The major obstacles to achieving a functional cure are the presenc

254 ositive outcomes associated with a goal, the obstacles to achieving it, and concrete if-then plans to

255 ioned vessels are likely to present physical obstacles to axon growth.

256 mical or biological digestion presents major obstacles to both the production of second-generation bi

257 technologies for precision medicine and the obstacles to clinical application.

258 stic for local changes in climate identifies obstacles to communicating ongoing changes in climate to

259 reover, morphine conditioning may pose extra obstacles to controlling viral load during antiretrovira

260 ies and identify crucial facilitators of and obstacles to cooperation.

261 One of the key obstacles to developing successful therapeutic strategie

262 nt role in protecting genome integrity after obstacles to DNA replication.

263 We also discuss specific obstacles to drug delivery that make solid tumors diffic

264 ease patients and remains one of the primary obstacles to effective treatment.

265 xperiment Bioconductor package reduces major obstacles to efficient, scalable, and reproducible stati

266 An extensive literature addresses obstacles to global genomic data sharing, yet a series o

267 earance strategies has begun, but additional obstacles to HIV eradication may emerge.

268 Critical obstacles to immunotherapy in PDAC tumors include a high

269 One of the major obstacles to implement nucleic acid-based molecular diag

270 traindications in children and pregnancy are obstacles to implementing doxycycline as a public health

271 In this comment, we cover some potential obstacles to implementing self-control and how religion

272 A decade ago, the major obstacles to integration of palliative care into the int

273 lude there are no theoretical or statistical obstacles to making direct replication a routine aspect

274 e therapeutic food (RUTF) is among the major obstacles to scaling up community-based management of ac

275 Moreover, because obstacles to successful drug design can differ among hum

276 emia and hypoxia have been reported as major obstacles to successful recovery of the follicular pool

277 n and graft-versus-host disease remain major obstacles to the broader successful application of these

278 e review the key breakthroughs and remaining obstacles to the development of active and passive HIV-1

279 the paucity of commercial sources pose some obstacles to the general use of these reactive strategie

280 gents for purification, which presents major obstacles to the preparation and application of recombin

281 ty of PDA cells have long been thought of as obstacles to treatment, but are now considered exploitab

282 Because of limited evidence and current obstacles to use, capsule colonoscopy every 5 years is a

283 antiretroviral treatment represents a major obstacle toward cure.

284 retroviral therapy (cART) represents a major obstacle toward cure.

285 ht scientific and clinical opportunities and obstacles toward permanent correction of disease-causing

286 lish high-speed navigation through fields of obstacles using a suite of sensory modalities that blend

287 MCII was effective when a learner's primary obstacle was predictable and surmountable, such as every

288 To overcome this obstacle, we constructed AAV vectors carrying the channe

289 ng directly tested in vivo: to overcome this obstacle, we engineered strains of the budding yeast Sac

290 To overcome this obstacle, we have engineered and produced a soluble vers

291 To address this obstacle, we investigated (a) biogeographical patterns i

292 To overcome such obstacles, we utilize pan-neuronal calcium imaging to br

293 rom Asia has been eventful, as these natural obstacles were crossed westward by multiple waves of Tur

294 These obstacles were overcome by Teoc protection of the beta-a

295 ng on a treadmill and stepping over a moving obstacle whose speed of advance was varied (slowed or ac

296 on whereby information on the location of an obstacle with respect to the body is used to initiate th

297 mplemented reverse genetics to address these obstacles with a multifaceted LAV design that combined t

298 Many initial obstacles with TAVR have largely been overcome, includin

299 n pressure drop upon flow past a cylindrical obstacle within a microchannel.

300 ation across current approaches and specific obstacles within computational workflows limit the trans