ライフサイエンスコーパス: octamer

1 A-binding protein, non-POU-domain-containing octamer).

2 several aggregates (from dimers to at least octamers).

3 and oligomeric states (dimers, hexamers, and octamers).

4 oils of DNA wrapped around a central histone octamer.

5 rmation remained associated with the histone octamer.

6 dictates how DNA is wrapped around a histone octamer.

7 lation on the lateral surface of the histone octamer.

8 cilitating uncoiling of DNA from the histone octamer.

9 A is hindered by the presence of the histone octamer.

10 nucleosomal DNA partially uncoiled from the octamer.

11 affinity of these sequences for the histone octamer.

12 tal structure of ligand 10 shows it to be an octamer.

13 the formation of either the heptamer or the octamer.

14 eir monomeric and oligomeric forms up to the octamer.

15 water molecule in the classical cyclic water octamer.

16 intercalate between the DNA gyre and histone octamer.

17 ide of nucleosomal DNA away from the histone octamer.

18 extension plot and a >90 degrees flip of the octamer.

19 matin remodeler, SNF2h, distorts the histone octamer.

20 eosomal DNA to provide access to the histone octamer.

21 ely diffuse about the surface of the histone octamer.

22 apped around an H2A, H2B, H3, and H4 histone octamer.

23 ed a banding pattern more consistent with an octamer.

24 ly 147 bases of DNA wrapped around a histone octamer.

25 rm the peripheral appendages surrounding the octamer.

26 that it is nearly as abundant as the histone octamer.

27 e report a 3.2-A crystal structure of the PA octamer.

28 ering the position of DNA around the histone octamer.

29 ve affinity of DNA sequences for the histone octamer.

30 the underlying DNA sequence for the histone octamer.

31 tely 1.7 times around a central core histone octamer.

32 mer and all of its oligomeric forms up to an octamer.

33 nucleotides 4-7, on the 3' flank of the Chi octamer.

34 spectroscopic characterization of the water octamer.

35 Spr3-Cdc3-Cdc10-Cdc10-Cdc3-Spr3-Spr28 hetero-octamer.

36 achieved, as well as the two-fold symmetric octamer.

37 /H2B dimers that remains associated with the octamer.

38 al made up from DNA wrapped around a histone octamer.

39 ding sites changes the product to the cyclic octamer.

40 nces predicted to better accommodate histone octamers.

41 splay properties consistent with left-handed octamers.

42 one DNA molecule wrapped around two histone octamers.

43 at complement each other to exclusively form octamers.

44 ions of low salt and urea that dissociate H3 octamers.

45 th tunable ring size ranging from trimers to octamers.

46 thylation at R17 in CARM1-methylated histone octamers.

47 1-452) to form hydrodynamically well-behaved octamers.

48 N tetramers in contrast to one possessing IN octamers.

49 force-induced unwrapping of DNA from histone octamers.

50 istone marks, and a region devoid of histone octamers.

51 the relative proportions of PA heptamers and octamers.

52 heterotypic tetramers, rather than canonical octamers.

53 al potential and arrays of DNA-bound histone octamers.

54 s and these have been assembled into histone octamers.

55 amers but failed to produce an intasome with octamers.

56 ents are assembled from apolar septin hetero-octamers.

57 d the core domain/lateral surface of histone octamers.

58 ssociated with an expanded remaining pool of octamer 3/4 (Oct3/4)-positive progenitor cells localized

59 eric tetramers enabled assembly of SpyAvidin octamers (8 subunits) or eicosamers (20 subunits).

60 In this study, the effect of giving this octamer (8mer) as an eye drop 1 hour before ocular infec

61 ch were experimentally found to have histone octamer affinities comparable to the highest-affinity se

62 plication and repair in vivo and reduces DNA-octamer affinity in vitro.

63 her they face inward or outward from histone octamers along the DNA helix axis.

64 ting tetramers can then interact, forming an octamer and a loop of the intervening DNA.

65 The placement of SWI/SNF between the octamer and DNA could make it easier to disrupt histone-

66 mediate key interactions between the histone octamer and DNA in forming the nucleosomal particle.

67 ed to refold together, the mixture formed an octamer and exhibited rapid fibrillation kinetics, simil

68 moter transcription and the distance between octamer and proximal sequence element of U6 promoter is

69 ng of two DNA duplexes wrapped around a Cse4 octamer and separated by a gap efficiently split into he

70 ctive and inactive conformations in both the octamer and the filament.

71 For example, both singly protonated serine octamers and anionic octamers complexed with two halogen

72 mutation was found in the interface between octamers and destabilized both monomeric and octameric r

73 mes assembled with human recombinant histone octamers and nucleosome-positioning DNA containing cyclo

74 ons is that CENP-A nucleosomes cycle between octamers and tetramers in vivo.

75 retention, however a subset are secreted as octamers and the cause of their pathology is ill-defined

76 neutralizing the acidic patch of the histone octamer), and the removal of histone tails were investig

77 e lesions relative to the underlying histone octamer, and (iv) the distance between the lesion cluste

78 exists in monomer, dimer, tetramer, hexamer/octamer, and higher oligomeric forms that may be importa

79 s purified as a stable approximately 320-kDa octamer, and low levels of dimers but no hexamers were a

80 two DNA molecules wrapped around two histone octamers, and an altosome complex that contains one DNA

81 sheets that further associate into hexamers, octamers, and dodecamers: the hexamers are trimers of di

82 brane protrusion sites harbor VP40 hexamers, octamers, and higher order oligomers.

83 four LFs, and assembly routes leading to the octamer are populated with even-numbered, dimeric and te

84 The cyclic hexamer and octamer are predicted by density functional theory to ad

85 in lymphocytes and neural tissues, in which octamers are abundant but hexamers are rare.

86 ll the chemical steps of transposition, only octamers are active in vivo.

87 We also find that histone octamers are easily transferred in trans from ssNucs to

88 rallel NCCN and especially the parallel NCNC octamers are stable and exhibit a favorable binding ener

89 ers: the hexamers are trimers of dimers; the octamers are tetramers of dimers; and the dodecamers con

90 Transcription factors (TFs) and histone octamers are two abundant classes of DNA binding protein

91 which consist of DNA wrapped around histone octamers, are dynamic, and their structure, including th

92 DNA looping mediated by the formation of CI octamers arising through the interaction of pairs of dim

93 es showed that transmembrane domain directed octamers as well as C-tail clusters require Tha4's trans

94 1-286) determined whether an IN tetramer or octamer assembled with viral DNA.

95 pH but does not appear to be involved in the octamer assembly process.

96 Octamer assembly was shown to be a highly cooperative pr

97 It consists of a histone octamer associated with approximately 80 base pair (bp)

98 netics and thermodynamics of the DNA-histone octamer association that are required to remodel chromat

99 t CENP-A nucleosomes alter from tetramers to octamers before replication and revert to tetramers afte

100 dimers, which are in turn assembled into an octamer, best described as a tetramer of dimers.

101 s between nucleosomes, and transfers histone octamers between pieces of DNA.

102 elationship between DNA sequence and histone octamer binding affinity.

103 strength of both the chicken or frog histone octamer binding sites on each DNA, the results obtained

104 ny cells expressed stem cell markers such as octamer binding transcription factor 4 (Oct4) and stage-

105 amine rich (SFPQ), non-POU domain-containing octamer-binding protein (NONO), and RNA binding motif pr

106 riants are bound by the transcription factor octamer-binding protein 1 (Oct1/POU2F1) and TET2 and Oct

107 nt for the B-cell transcription factor OCT2 (octamer-binding protein 2, encoded by Pou2f2) in germina

108 ntrol of key pluripotency factors, including Octamer-binding protein 4 (Oct4) and Estrogen-related re

109 The transcription factor octamer-binding protein 4 (Oct4; encoded by POU5F1) has

110 n IP reveal that Oct-1 binds to the putative octamer-binding sequences of the dysregulated genes and

111 these cells expressed the stem cell markers octamer-binding transcription factor (Oct4) and stage-sp

112 quence analysis revealed a binding motif for octamer-binding transcription factor 1 (OCT-1) in the de

113 rase complex, and transcription factor OCT2 (octamer-binding transcription factor 2) bound cooperativ

114 K1/2) and AKT, as well as down-regulation of octamer-binding transcription factor 4 (Oct-4) expressio

115 Octamer-binding transcription factor 4 (OCT-4) is an imp

116 The octamer-binding transcription factor 4 (Oct3/4) is a mas

117 m from SALL4 TSS are within binding sites of octamer-binding transcription factor 4 (OCT4) and signal

118 Octamer-binding transcription factor 4 (Oct4) has been s

119 s, and this complex inhibits Sox2 binding to octamer-binding transcription factor 4 (Oct4)/Sox2 enhan

120 the pluripotency transcription factor Oct4 (octamer-binding transcription factor 4) plays an unappre

121 TH1 promoter activity was dependent upon the octamer-binding transcription factor OCT1.

122 Mass spectrometry demonstrates that the PA octamer binds four LFs, and assembly routes leading to t

123 oligomeric models (ranging from pentamer to octamer), built by incremental addition of peptides to s

124 ning sequences on the surface of the histone octamer but does cause minor perturbation of nucleosome

125 or the assembly of an intasome containing IN octamers but not for an intasome containing IN tetramers

126 2DeltaC) did not oligomerize to a hexamer or octamer, but formed a high molecular weight soluble aggr

127 splay low intrinsic affinity for the histone octamer, but its contribution to antagonizing RNA polyme

128 ationally phased with respect to the histone octamer by TG motifs.

129 The octamer can provide not only multiple specific DNA-bindi

130 Although the octamers cannot form nucleosomes, the target is nonethel

131 and histone combinations (H1, H2AH2B, H3H4, octamers) caused a dose-dependent aggregation of phospha

132 revisiae, four septins form an apolar hetero-octamer (Cdc11-Cdc12-Cdc3-Cdc10-Cdc10-Cdc3-Cdc12-Cdc11)

133 e two species of budding yeast septin hetero-octamers: Cdc11/Shs1-Cdc12-Cdc3-Cdc10-Cdc10-Cdc3-Cdc12-C

134 tions, which result in the formation of NSP2 octamer chains.

135 In the longest octamer, charge resonance vanishes and the cation is loc

136 ed integrase (IN), which forms a tetramer or octamer complex with the viral cDNA long terminal repeat

137 ingly protonated serine octamers and anionic octamers complexed with two halogen ions strongly prefer

138 ructure and at its heart is the histone core octamer composed of histones H4, H3, H2A and H2B.

139 ts of 147 bp of DNA wrapped around a histone octamer composed of two copies each of the histones H2A,

140 The octamer comprises approximately 20-30% of the oligomers

141 show that it is a two-fold symmetric hetero-octamer comprising an intertwined network of subunits wi

142 t the complex between M2R and holo-Gi1 is an octamer comprising four copies of each, and that activat

143 pt histone-DNA contacts by affecting histone octamer conformation and through extensive interaction w

144 ical methods and show that it forms a stable octamer containing two copies of the Cse4 protein and wr

145 rts the model that the Cse4 nucleosome is an octamer, containing two copies each of Cse4, H2A, H2B, a

146 The octamer contains an H3-H4 tetramer and two H2A-H2B dimer

147 Unlike human PBGS, the TgPBGS octamer contains magnesium ions at the intersections bet

148 Here, we investigate anionic serine octamers coordinated with two chloride ions using a nove

149 re plastic than previously imagined and that octamer deformation plays different roles based on the t

150 leave a small portion of DNA attached to the octamer despite extended pulling.

151 n intersubunit beta-sheet, stabilizing a pro-octamer dimer and preventing formation of hexamers that

152 Octamer dimerization is consistent with the adhesive fun

153 nesium ions at the intersections between pro-octamer dimers, which are presumed to function in allost

154 Preventing octamer distortion by site-specific disulfide linkages i

155 -ray crystal structure of the 2'-Se-modified octamer DNA (5'-GTG(Se)TACAC-3') was determined at a res

156 nificantly inhibited ATP-independent histone octamer-DNA sliding.

157 The Cse4-octamer does not preferentially form nucleosomes on its

158 enting the flap substrate toward the histone octamer does not significantly alter the rotational orie

159 are presumably tetramers and octamers, with octamers dominating above about 0.5 mM.

160 structure of a proflavine-bound 2',5'-linked octamer duplex with the sequence GCCGCGGC.

161 The CBS interacts with the histone octamer, engaging the H2A-H2B acidic patch in a manner s

162 nce and absence of L-arginine and a tetramer-octamer equilibrium that shifted towards tetramers upon

163 nucleosome sliding by SNF2h while promoting octamer eviction by the SWI-SNF complex, RSC.

164 gp16 forms oligomers, most likely octamers, exhibits no enzymatic activities, but stimulat

165 ping-rewrapping (breathing) dynamics and the octamer flips approximately 180 degrees and moves toward

166 The longer cross-link favors octamer formation, whereas the shorter one favors format

167 c model where tetramers are intermediates of octamer formation.

168 5T interferes with VP40 function by altering octamer formation.

169 The structure reveals a ring-like octamer formed by interweaved protein monomers with a hi

170 e nucleosome and prevent dissociation of the octamer from the DNA while facilitating its mobility alo

171 ate required for dissociation of the histone octamer from the promoter DNA.

172 DH trimers formed octamers in solution, each octamer harboring an amazing 192 c-type heme moieties.

173 ent with models in which a canonical histone octamer has been 'pushed' off of the end of the DNA.

174 NP-A nucleosomes have been shown to exist as octamers, hexamers, and tetramers.

175 rapping the nucleosomal DNA from the histone octamer (HO).

176 Tight wrapping of DNA around histone octamers, however, impedes access of repair proteins to

177 ystal structure of TgPBGS, which contains an octamer in the crystallographic asymmetric unit.

178 embrane domain in unstimulated membranes and octamers in membranes stimulated by precursor and the pr

179 11) at the junctions between adjacent hetero-octamers in paired filaments is highly cooperative.

180 iensis Interestingly, the HDH trimers formed octamers in solution, each octamer harboring an amazing

181 uantities of monomers, dimers, pentamers and octamers in the C-S-H structure are measured.

182 Here we report that Mit1 mobilizes histone octamers in vitro and requires ATP hydrolysis and conser

183 The enzyme exists as an octamer, in which four disulfide bonds form between inte

184 The protonated octamer incorporates some molecules statistically but ef

185 es extended surface areas encircling the gp1 octamer, indicating that DNA wraps around gp1 through ex

186 we demonstrated that histones (H1 or histone octamers) interact with negatively charged bilayers and

187 ted either as the result of a rapid dimer-to-octamer interconversion on the chromatographic time scal

188 hen, in a slower reaction, an entire histone octamer is lost.

189 omers on cells, but outside of the cell, the octamer is more stable than the heptamer under physiolog

190 a charged, discrete worm-like chain, and the octamer is treated as a rigid cylinder carrying a positi

191 ngly, transfer of H2A/H2B dimers and histone octamers is initiated on a time scale of seconds when as

192 rus nonstructural protein NSP2, a functional octamer, is critical for the formation of viroplasms, wh

193 acktracks and nucleosomal DNA recoils on the octamer, locking Pol II in the arrested state.

194 ind that the stability of nucleosomes toward octamer loss increases with array length and saturation,

195 omal barrier and displace the entire histone octamer, matching the observations in vivo.

196 of polymerisation (or size) from trimers to octamers (monomers and dimers did not precipitate BSA),

197 m latency to lytic reactivation, contains an octamer motif within its promoter.

198 ial affinity for an 8 bp DNA site termed the octamer motif, and are hence known as Oct proteins.

199 We reconstitute histone octamers, nucleosomes, and nucleosomal arrays bearing de

200 32 enzymes showed that formation of the SInv octamer occurs through a beta-sheet extension that seems

201 uples neighboring membranes together through octamer-octamer contacts, perhaps modulated by interacti

202 A monodisperse, C4-symmetric octamer of a guanine-perylene-3,4,9,10-bis(dicarboximide

203 ts support the idea that loops secured by an octamer of CI bound at oL1, oL2, oR1 and oR2 operators m

204 mately 150 base pairs of DNA wraps around an octamer of core histones to form the nucleosome, the bas

205 An octamer of histone proteins wraps about 200bp of DNA int

206 of 147 bp of DNA wrapped around a symmetric octamer of histone proteins.

207 he nucleosome: 147bp of DNA wrapped about an octamer of histone proteins.

208 risk variant S704C affects the formation of octamers of DISC1 and exhibits higher-order self-oligome

209 erent structures of tetramers, hexamers, and octamers of phosphorylated and unphosphorylated AMII mus

210 n with respect to the surface of the histone octamer on nucleosome structure and FEN1 activity in vit

211 resolved peaks could be observed for either octamer or dimer when analyzed at intermediate pH (5.5-6

212 eous on its own than when sequestered in the octamer or nucleosome.

213 , nucleosomes containing the canonical yeast octamer or, in particular, the Cse4 octamer were assembl

214 ed of IN subunits ranging from tetramers, to octamers, or to hexadecamers.

215 ls responded strongly and exclusively to the octamer peptide (173)SELEIKRY(180), HLA-B*44:03(+) indiv

216 Moreover, the octamer peptide bound more stably to HLA-B*18:01 than di

217 169)EECDSELEIKRY(180), which encompasses the octamer peptide.

218 roducts of the syntheses of the related T(8) octamers [PhSiO(1.5)](8) and [vinylSiO(1.5)](8).

219 Octamer plasticity may contribute to chromatin regulatio

220 ATP promotes octamer polymerization, whereas GTP promotes a compact,

221 yeast septin complexes and how these hetero-octamers polymerize into filaments in solution and on Pt

222 , even tetranucleosomal arrays with only two octamers possessing H4 tails recapitulate most of the in

223 The histone octamer presents different levels of constraints on BER,

224 tamer upon dimerization, suggesting that the octamer provides a stable interface for the construction

225 Gemin2 forms oligomers spanning the dimer to octamer range.

226 EPT9 expression level directs the hexamer-to-octamer ratio, and that the isoform composition and expr

227 rate cell lines with controllable hexamer-to-octamer ratios and that express single SEPT9 isoforms, w

228 Here, we show that Cse4 octamers remain intact under conditions of low salt and

229 While the histone octamer remains intact, the DNA is lifted from the surfa

230 ations in the lateral surface of the histone octamer remains unclear.

231 the steric constraints placed by the histone octamer remains unknown.

232 An OCRE (OCtamer REpeat of aromatic residues) domain found in RBM

233 onine peptide only when it is seeded with an octamer replicator containing eight units of a serine bu

234 etic data suggest that formation of the beta-octamer represents a rate-limiting step in the assembly

235 nt of the lysosome, and a failure to form an octamer results in suboptimal catalytic activity (most l

236 ort the structure at 4.1 A, revealing double octamer rings not observed before.

237 ree high-resolution crystal structures of an octamer RNA duplex [5'-GUA(f(5)C)GUAC-3']2 that have bee

238 eptamer (Saccharomyces cerevisiae) to hetero-octamer (Schizosaccharomyces pombe) to hetero-nonamer (M

239 f spectrin were prevalent, with hexamers and octamers seen between virtually every junctional complex

240 Recruitment of Oct-1 protein to the octamer sequence of U6 promoter is critical for optimal

241 Mutation in octamer sequence significantly reduced the SB202190-stim

242 tion can be observed only in the presence of octamer sequence.

243 on of lateral surface lysines in the histone octamer serves as a crucial regulator of nucleosomal dyn

244 Together, a total of 11 unique mutant octamer sets corroborated these observations and reveale

245 vator OCA-B, together with Oct-1/2, binds to octamer sites in promoters and enhancers to activate tra

246 ed particle at the functional centromere and octamer-sized particles on chromosome arms, reconcile se

247 The integrase octamer solves a conundrum for betaretroviruses as well

248 pectrometry showed stabilization of a double octamer species upon DNA binding.

249 ever, metal ions are not required for TgPBGS octamer stability.

250 ggesting that the C terminus is required for octamer stability.

251 sine 44 is the primary target in the case of octamer substrates, irrespective of the histones being n

252 of PrP was also found to stabilize the beta-octamer, suggesting that it can influence susceptibility

253 l similarity among all simulated K18 and K19 octamers, suggesting that similar folding of K18/K19 may

254 which a stretch of DNA peels off the histone octamer surface as a result of thermal fluctuations or i

255 Bulging of the DNA from the octamer surface is possible, and twisting is unavoidable

256 Histone octamer survives moderate transcription, but is evicted

257 outer turn of DNA unwraps gradually and the octamer swivels about the taut linkers and flips a furth

258 arity is negated when NSD2 is presented with octamer targets in conjunction with short single- or dou

259 New results show that FBN30 is a secreted octamer that binds to both P. berghei and clinically cir

260 6 bp of DNA wrapped around a histone protein octamer that controls DNA accessibility to transcription

261 o acid serine is known to form a very stable octamer that has properties that set it apart from serin

262 ched between two beta clamp rings to form an octamer that is stabilized by three discrete interfaces.

263 ntal unit of chromatin, comprising a protein octamer that wraps approximately 147 bp of DNA and has e

264 ne monophosphate dehydrogenase (IMPDH) forms octamers that polymerize into helical chains.

265 s partial unwrapping of DNA from the histone octamer; that the scaffolding protein XRCC1 enhances the

266 g the most to precipitate BSA (1000 mug) and octamer the least (50 mug).

267 dimer, and four dimers are assembled into an octamer through crystal symmetry.

268 votal role in stabilizing DNA binding to the octamer through direct interactions, core structural rea

269 locase domain to pump DNA around the histone octamer to enable sliding.

270 hrough its association with the core histone octamer to form the nucleosome core particle (NCP), a co

271 vitro; three provided 90-100% conversion of octamer to hexamer in a native PAGE mobility shift assay

272 proteins EZH2 and SUZ12 as well as HDAC2 to octamer transcription factor 1 (OCT1) (POU2F1) binding s

273 a the activation of the transcription factor octamer transcription factor 1.

274 ly, active BRAF upregulates HMGCL through an octamer transcription factor Oct-1, leading to increased

275 pectrometry (ESI MS) to monitor the dimer-to-octamer transition as a function of both solution pH and

276 Notably, the heptamer-octamer transition proceeds through the acquisition of t

277 MS provides strong evidence of the dimer-to-octamer transition state that occurs when the analysis i

278 mposed of nucleosomes, or repetitive histone octamer units typically enfolded by 147 base pairs of DN

279 e conformational change in the retinoschisin octamer upon dimerization, suggesting that the octamer p

280 wave numbers, which were assigned to the h16 octamer via detailed isotope dilution experiments.

281 Our results show that DISC1 forms octamers via dimers as building blocks and directly inte

282 s of different macrocycle size (hexamers and octamers), we observed the emergence of hexamer replicat

283 al yeast octamer or, in particular, the Cse4 octamer were assembled at distinct populations of locati

284 nins composed of epicatechin from monomer to octamer were isolated from cacao (Theobroma cacao, L.) s

285 e of calculated structural parameters of DNA octamers were used in combination to analyse the mechani

286 lliptical cylinder of size hexa-, hepta-, or octamer, whereas MALS data indicate a hexamer.

287 The chimeric proteins form circular octamers, whereas the wild-type WzzB from S. flexneri wa

288 bilization is dominated by hexa-, hepta- and octamers, which conduct water, ions and small dyes.

289 ur findings lead us to propose that the NSP2 octamer with multiple enzymatic activities is a principa

290 A multifunctional RNA-binding NSP2 octamer with nucleotidyl phosphatase activity is central

291 The multifunctional enzyme NSP2, an octamer with RNA binding activity, is critical for virop

292 Comparison of the octamer with the hexadecamer structure indicated little

293 Crystal structure analyses of RNA octamers with (R)- or (S)-5'-C-methyl-2'-deoxy-2'-fluoro

294 Retinoschisin forms a dimer of octamers with each octameric ring adopting a planar prop

295 en K18 and K19 aggregates, here, K18 and K19 octamers with repeat 3 (R3) in U-shaped, L-shaped, and l

296 in this study were derived from pure histone octamers with their native marks.

297 compounds (ranging in size from dimers to an octamer) with 5-5 and/or beta-O-4 linkages, and three sy

298 These are presumably tetramers and octamers, with octamers dominating above about 0.5 mM.

299 tudies suggest one PLCbeta binds to one C3PO octamer without a change in the number of TRAX/translin

300 riented away from the surface of the histone octamer, without significant disruption of histone-DNA i