ライフサイエンスコーパス: octameric

1 addition of substrate FolB is predominantly octameric.

2 merase extracted from spinach leaves is also octameric.

3 yclic molecular aggregations, heptameric and octameric.

4 of hydrazide A-B monomers self-assemble into octameric [2]-catenanes with high selectivity for [1(3)2

5 The classical type of KATP channel is an octameric (4:4) complex of two structurally unrelated su

6 rease in the proportion of AOX-HA present in octameric active AOX, suggesting that newly synthesized

7 Wza creates an octameric alpha-helical channel spanning the OM, but the

8 The quaternary structure of the enzyme is octameric and can be aptly described as a tetramer of di

9 We ranked all possible H-2K(b) octameric and H-2D(b) nonameric epitopes that span the g

10 herichia coli, followed by separation of the octameric and hexameric assemblies on an ion-exchange co

11 and activated ATP-PRTs from both the hetero-octameric and hexameric families.

12 e R240A hexamer supports the hypothesis that octameric and hexameric morpheeins of PBGS are very clos

13 s by EM confirmed that the heterooligomer is octameric and revealed that the subunits are arrayed in

14 at centromere nucleosomes are unlikely to be octameric and that the exposed surfaces holding the nucl

15 erminal tyrosines is very high in monomeric, octameric, and DNA-complexed TBP and comparable to that

16 An octameric aniline molecule ("octaniline") was incorporat

17 esent a crystal structure of a funnel-shaped octameric apoptosome complex from the nematode Caenorhab

18 The octameric architecture of the intasome of mouse mammary

19 The quaternary octameric arrangement of hBD2 is conserved in two crysta

20 ution method is exemplified by revealing the octameric arrangement of Xenopus nuclear pore complexes

21 Crystal forms of the octameric assembly formed by this sequence exhibit unusu

22 organisms, in the absence of magnesium, the octameric assembly is significantly destabilized, and th

23 The structure shows an octameric assembly of integrase, in which a pair of inte

24 tor although it does appear to stabilize the octameric assembly of the protein.

25 ATP-sensitive K+ channels are an octameric assembly of two proteins, a sulfonylurea recep

26 -hydroxymethyl-7,8-dihydropterin, reveals an octameric assembly similar to that seen in crystal struc

27 an elongated structure which persists in the octameric assembly.

28 ith a dissociation constant of 4 muM, and is octameric at higher concentrations.

29 ylation and phosphate binding, the HisZ-HisG octameric ATP-PRT acquired the ability to initiate the s

30 Hetero-octameric ATP-PRTs consist of four HisGS catalytic subun

31 quaternary structures, hexameric and hetero-octameric ATRP-PRTs exhibit similar functional parameter

32 We have determined the structure of the octameric bacterial form of PRK to a resolution of 2.5 A

33 cruciferin complex of Brassica napus has an octameric barrel-like structure, which represents a very

34 a tetramer, successfully recapitulating the octameric beta-peptide bundle complex Zwit-1F.

35 h the downstream half-site was the preferred octameric binding site of TR (TNAGGTCA).

36 acting polypeptides, which assemble into the octameric biogenesis of lysosome-related organelles comp

37 ide that assembles, with dysbindin, into the octameric BLOC-1 complex.

38 have a subunit composition equivalent to an octameric building block.

39 of residues from at least two strands of the octameric bundle structure.

40 rotational correlation time appropriate for octameric but not dimeric species.

41 Unlike exclusively octameric canonical H3 nucleosomes, CENP-A nucleosomes h

42 ull-length NS5 protein from dengue virus, an octameric cap-0 viral RNA substrate bearing the authenti

43 stent with in vitro evidence for left-handed octameric CenH3 nucleosomes.

44 NP-A and H3 nucleosomes, and report that the octameric CENP-A core particles and nucleosomes display

45 The results imply the octameric channels are stable.

46 The calculated conductance of octameric channels is markedly higher than the conductan

47 n to fully assembled and correctly regulated octameric channels.

48 The octameric Chi (chi) sequence is a recombination hotspot

49 tly reported x-ray crystal structure for the octameric chicken mitochondrial CK indicates that its nu

50 in the structure and function of dimeric and octameric CK: (a) presence of seven basic amino acids in

51 nced (by 120-fold), by formation of a hetero-octameric complex between CM and DAH7PS.

52 f phenylalanine specifically promotes hetero-octameric complex dissociation, with concomitant reducti

53 The exocyst is an evolutionarily conserved octameric complex involved in polarized exocytosis from

54 The exocyst is an octameric complex mediating vesicle targeting and tether

55 Histones form an octameric complex of basic proteins important in regulat

56 thological conditions.The KATP channel is an octameric complex of two unrelated types of subunit: a p

57 The exocyst is an octameric complex required for polarized secretion.

58 The structure of the surprising hetero-octameric complex reveals the close interaction between

59 iedl syndrome protein complex (BBSome) is an octameric complex that transports membrane proteins into

60 rentially bind RNA, provided they were in an octameric complex with H2A and H2B.

61 uvA was octameric in solution, and formed an octameric complex with the DNA junction.

62 ally desensitized 910-kD Class-2 PEPC hetero-octameric complex, arises from a tight interaction betwe

63 or this SUMO ligase include a subunit of the octameric complex, Smc5, and the DNA repair protein Yku7

64 acid, and exists in dimeric, tetrameric, and octameric complexes resistant to proteolysis.

65 mposition that is consistent with the hetero-octameric configuration hypothesized for the related Mth

66 a change toward a significantly more compact octameric conformation.

67 An octameric consensus sequence with a conserved hexameric

68 omatin, individual nucleosome particles, nor octameric core histones reproduced any of these procoagu

69 key interactions at the heart of the CENP-A octameric core, wherein shearing of contacts within the

70 We also find that octameric Cse4 nucleosomes can be reconstituted in vitro

71 icroscopy reveals the formation of flexible, octameric cup-like structures, which are able to self-as

72 No binding of adenyl DNG with octameric cytidyl DNA was observed, indicating that the

73 E contains two GATA-binding motifs and three octameric direct repeats.

74 lator-effector complex and is revealed as an octameric disc.

75 rast, excitation of the mixtures of the homo-octameric donor and acceptor cages in solution did not l

76 ence of a strong ninth heptad interaction an octameric downstream half-site allosterically promotes R

77 w that Sec2p associates with the exocyst, an octameric effector of Sec4p involved in tethering secret

78 In plants GS is an octameric enzyme and is located either in the cytoplasm

79 dehydrogenase is an allosterically regulated octameric enzyme composed of four each of two homologous

80 dehydrogenase is an allosterically regulated octameric enzyme composed of four heterodimers of a cata

81 nase (IDH) of Saccharomyces cerevisiae is an octameric enzyme composed of four heterodimers of regula

82 ogenase (IDH) is an allosterically regulated octameric enzyme composed of two types of homologous sub

83 The packing of the octameric enzyme in this crystal form is unusual, becaus

84 The activated state of the octameric enzyme is characterized by an interstitial pho

85 The octameric enzyme possesses eight distinct binding sites,

86 odeaminase (FTCD), a 0.5 million Dalton homo-octameric enzyme, plays important roles in coupling hist

87 GS in plants is an octameric enzyme.

88 f wild-type (IDH1/IDH2) and IDH1/IDH2(C150S) octameric enzymes were conducted in the presence of dith

89 The octameric exocyst complex is associated with the junctio

90 We determined that the presence of an octameric exocyst complex is required for the formation

91 es regulate the assembly interface of a full octameric exocyst complex through interaction with Sec5

92 ned the steady state kinetics for the hetero-octameric form and characterized the active site by muta

93 .3 A, and the phosphoethanolamine (PE)-bound octameric form at 2.7 A.

94 tramer in solution and is transformed to its octameric form by autoacetylation.

95 The native octameric form has been refined at a resolution of 3 A,

96 orm found in all three kingdoms and a hetero-octameric form largely restricted to bacteria.

97 cal ultracentrifugation established that the octameric form of CrgA is the predominant species in sol

98 ore sensitive to neutralization by a soluble octameric form of the CD46 receptor, consistent with the

99 U is essential for the proper assembly of an octameric form, a key conformational feature that determ

100 the purified enzyme was found to exist as an octameric form.

101 sts in an equilibrium between tetrameric and octameric forms in the typical concentration range and b

102 A non-immunogenic octameric fusion underwent rearrangements in vivo result

103 eviously determined at 3.3 A and revealed an octameric gating ring composed of eight intracellular li

104 nd-binding domains, the RCK domains, form an octameric gating ring in which Ca(2+) binding induces co

105 supporting the notion that the formation of octameric gating ring is a functionally relevant event i

106 lization which is present in all dimeric and octameric guanidino kinases.

107 s might interrupt the global condensation of octameric H3 arrays and present an asymmetric surface fo

108 Its perienteric fluid contains an octameric haemoglobin that binds oxygen nearly 25,000 ti

109 r any larger quaternary structure similar to octameric hBD2.

110 In the octameric Hda-beta clamp complex, the inability of Hda t

111 e with SEPT7-containing hexamers to generate octameric heteromers.

112 SEPT9, K562 cells contain both hexameric and octameric heteromers.

113 components, we find that CENP-C reshapes the octameric histone core of CENP-A nucleosomes, rigidifies

114 lculated average molecular mass of an intact octameric holoprotein.

115 Unbound MleRuvA was octameric in solution, and formed an octameric complex w

116 ur findings suggest that CID nucleosomes are octameric in vivo and that CID dimerization is essential

117 ssembly of wild-type cI was determined to be octameric, in agreement with Senear et al.

118 crystallography, we determine an unexpected octameric integrase architecture for the intasome of the

119 We show that initial assembly of a small octameric intermediate is entropically driven, while fur

120 deduced amino-acid sequences for dimeric and octameric isoforms of creatine kinase (CK) from a protos

121 through membrane-embedded AQP0 in both its (octameric) junctional and (tetrameric) nonjunctional for

122 elongated, opposing (alphabeta gammadelta)2 octameric lobes.

123 e, this is the first report of a full-length octameric MCM helicase.

124 Bacterial phosphoribulokinases (PRKs) are octameric members of the adenylate kinase family of enzy

125 ric (sar-) and ubiquitous (ubi-) isoforms of octameric MiCK and muscle (M) and brain (B) isoforms of

126 The octameric MiCK cDNA is composed of 1703 nucleotides with

127 steps of dimerization that generate stable, octameric mini-filaments.

128 show that bipolar tetrameric, hexameric, and octameric minifilaments of AMII with the nonhelical tail

129 rminal 32 heptad repeats suffice to assemble octameric minifilaments; (4) A1378 is outside of the int

130 re demonstrated that the scattering curve of octameric MleRuvA in 65% and 100% 2H2O is explained by a

131 An octameric model channel has been constructed from the cr

132 f this enzyme family, the allosteric, hetero-octameric, NAD(+)-specific IDH from yeast in three forms

133 s, it has been debated whether the classical octameric nucleosomal arrangement of two copies of CENH3

134 nders with eight binding sites (representing octameric nucleosomal cores) into irregularly folded clu

135 ENP-A encodes enhanced distortability to the octameric nucleosome, which may allow for enhanced flexi

136 ed by the DNA sequence, leading to the final octameric nucleosome.

137 tible with symmetrical structures, including octameric nucleosomes and (Cse4/H4)2 tetrasomes.

138 els for hemisomes that briefly transition to octameric nucleosomes at specific cell cycle points or h

139 Reconstitution of octameric nucleosomes containing histones Cse4/H4/H2A/H2

140 some assembly factor, and that the resulting octameric nucleosomes do not contain Scm3 as a stably bo

141 , we find that CENP-A arrays are composed of octameric nucleosomes that assemble in a stepwise mechan

142 with its centromeric variant Cse4 results in octameric nucleosomes that organize DNA in a left-handed

143 lengths centered on 133 bp, consistent with octameric nucleosomes with DNA unwrapping at entry and e

144 one H3, human CENP-A chromatin complexes are octameric nucleosomes with two molecules of CENP-A at al

145 , yield one-half the dimensions of canonical octameric nucleosomes.

146 ease activity is subject to regulation by an octameric nucleotide sequence called chi.

147 We conclude that PA may form an octameric oligomeric state as a means to produce a more

148 in dimers and association of dimers to form octameric or decameric beta-barrels.

149 none (ANQ) were used to assemble either homo-octameric or mixed-ligand double cages.

150 anasal immunization of C57BL/6 mice with the octameric OVA peptide and CT produced similar results wi

151 Both heptameric and octameric PA complexes can translocate LF and EF with si

152 maturely adopt the channel conformation, but octameric PA complexes remain in their soluble prechanne

153 LT complexes containing octameric PA possess enhanced stability, channel-forming

154 te more readily than LT complexes containing octameric PA.

155 A model of octameric pea PBGS was built to predict the location of

156 hese B cells, we developed a novel approach, octameric peptide display, to follow the dynamics and lo

157 Arrays of octameric peptide libraries on cellulose paper were scre

158 -B8-restricted H-Y epitope is defined by the octameric peptide LPHNHTDL corresponding to aa residues

159 This octameric peptide was also presented on HLA-Cw1 with sim

160 s I MHC molecule HLA-A2 complexed with of an octameric peptide, Tax8 (LFGYPVYV), from human T cell ly

161 C pocket is responsible for the selection of octameric peptides as the preferred ligands for Kb and p

162 tides representing all possible hexameric or octameric peptides from the N. gonorrhoeae MS11 pilin se

163 , with weaker reactivity being seen with the octameric peptides in the other two VDs.

164 ins of mice reacted with several VD1 and VD3 octameric peptides, with weaker reactivity being seen wi

165 H-2Kb predominantly binds octameric peptides.

166 for bicomponent pore formation proposes that octameric pores, comprised of two separate secreted poly

167 reby forestalling the formation of complete, octameric pores.

168 The exocyst is an octameric protein complex essential for exocytosis and p

169 nclude the Sec5 component of the exocyst, an octameric protein complex implicated in tethering of ves

170 The exocyst is an octameric protein complex implicated in tethering post-G

171 The exocyst is an octameric protein complex implicated in the tethering of

172 The exocyst is an octameric protein complex required for tethering secreto

173 The exocyst is an octameric protein complex required to tether secretory v

174 The sec6/8 complex or exocyst is an octameric protein complex that functions during cell pol

175 ex, also known as the exocyst complex, is an octameric protein complex that has been implicated in te

176 The exocyst is an evolutionarily conserved octameric protein complex that tethers post-Golgi secret

177 yst, an essential phylogenetically conserved octameric protein complex.

178 Porphobilinogen synthase (PBGS) is a homo-octameric protein that catalyzes the complex asymmetric

179 c Ptr2, Ptr-H10 is a dimer; unlike Ptr2, the octameric Ptr-H16 poorly recruits TBP to the promoter, b

180 hibit distinguishing characteristics: unlike octameric Ptr2, Ptr-H10 is a dimer; unlike Ptr2, the oct

181 we found that both proteins could assume an octameric quaternary structure in vivo.

182 d Acid-1Y* fold spontaneously into discrete, octameric quaternary structures that we refer to as beta

183 species, the recombinant spinach enzyme was octameric rather than dimeric, as assessed by gel filtra

184 ia coli, its activities are regulated by the octameric recombination hotspot, chi (5'-GCTGGTGG), whic

185 iring certain regions such as the Cu-binding octameric repeat region and the hydrophobic core.

186 The N-terminus of the protein contains an octameric repeat region with each of the four repeats co

187 ding events have lower affinities within the octameric repeat region.

188 However, the first binding is that to the octameric repeat region.

189 ng events occur at the fifth site and at the octameric repeat region.

190 a model was proposed for the structure of an octameric repressor that forms both in the presence and

191 Retinoschisin, an octameric retinal-specific protein, is essential for ret

192 octamers and destabilized both monomeric and octameric retinoschisin.

193 The data showed that endocytosis of the octameric RGD derivative was significantly higher by com

194 oschisin forms a dimer of octamers with each octameric ring adopting a planar propeller structure.

195 in the absence of nucleotide cofactor as an octameric ring and in the presence of ATP as a helical f

196 evidence for the association between one RCK octameric ring and two KtrB membrane proteins.

197 elicase from Pyrococcus abyssi in its single octameric ring assembly.

198 sidues 12 to 60, depicts the formation of an octameric ring composed of antiparallel coiled-coil dime

199 structure of this protein in three different octameric ring conformations that resemble the RCK-domai

200 m of activation and show that the RCK-domain octameric ring model is generally applicable to other io

201 ase-DNA complex reveals that Hermes forms an octameric ring organized as a tetramer of dimers.

202 hus far only been observed to bind DNA as an octameric ring.

203 he pentraxin fold and a novel doubly stacked octameric ring.

204 1 but showed instead that this protein forms octameric rings and stacks of rings.

205 TRiC particle to be composed of two stacked octameric rings enclosing a folding cavity.

206 f Dronc-CARD that are sandwiched between two octameric rings of the Dark protein.

207 We show that hDmc1 forms octameric rings.

208 first of a novel subclass of LTTRs that form octameric rings.

209 Novel features detected in the octameric RNA assembly include a new crystal form, evide

210 Cdc3, Cdc10, Cdc11, and Cdc12 form an apolar octameric rod with Cdc11 at each tip, which polymerizes

211 hat Shs1 substitutes for Cdc11, resulting in octameric rods that do not polymerize into filaments but

212 septin protomers assemble into linear hetero-octameric rods with 2-fold rotational symmetry.

213 olecular dynamics simulations of PrP(90-231) octameric segments suggested that such linear fibrils, w

214 Thus, common octameric sequence elements are involved in periodic acc

215 We identified an evolutionarily conserved octameric sequence, CCCAGCAG, approximately 100 bases up

216 l gene regulation, including AP-1, GATA, and octameric sequences.

217 Translin is an octameric single-stranded DNA binding protein consisting

218 ein exists as a homodimer but converts to an octameric state in the mildly acidic environment of the

219 + binding stabilizes the RCK domains in this octameric state.

220 monomeric and tetrameric states but not the octameric state.

221 gomeric pore, which can assume heptameric or octameric states.

222 sight into the effect of the mutation on the octameric structure and biochemical activities of tsE NS

223 hose observed in vivo demonstrating that the octameric structure is physiologically relevant.

224 While this octameric structure is unique to both the phosphoribosyl

225 The octameric structure of MspA, its sharply defined constri

226 ouble mutation caused destabilization of the octameric structure of sMtCK and a profound reduction in

227 of protein-DNA complexes, translin forms an octameric structure that binds the DNA.

228 This revealed an octameric structure that strongly resembles that reporte

229 lorobium vibrioforme is shown to form a homo-octameric structure with 422 symmetry in which each subu

230 To test the relevance of the octameric structure, we developed a new method to probe

231 Mitochondrial creatine kinases form octameric structures composed of four active and stable

232 rried out on 11 different hexa-, hepta-, and octameric systems.

233 partially shields the DNA binding saddle in octameric TBP, shifting upon dissociation to monomers to

234 asmuch as binding of activator protein-1 and octameric transcription factor 1 to DNA was not affected

235 MspA, an octameric transmembrane channel protein from Mycobacteri

236 ssociates stoichiometrically with the hetero-octameric Tubulin Chaperone Protein-1 (TCP-1) complex, w

237 ed that the heterodimers form multimers with octameric units in three potential arrangements, which m

238 PBGS from most organisms was believed to be octameric until work on a rare allele of human PBGS reve

239 The unusual hetero-octameric version of ATP-PRT includes four HisG(S) catal

240 eveal a new layer aggregation, L4(4)8(8), as octameric water aggregates in a stair conformation which

241 The former two CKs are either dimeric or octameric while FlgCKs are contiguous trimers consisting

242 cates that CENP-A-containing nucleosomes are octameric with conventional left-handed DNA wrapping, in