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1 peroxynitrite formation in response to this octapeptide.
2 T lymphocytes (CTL) to the fusion partner's octapeptide.
3 a transcription repression domain called the octapeptide.
4 ch contributes to hypertension caused by the octapeptide.
5 ased contractile response to cholecystokinin octapeptide.
6 o generate dose-response curves for the free octapeptide.
7 ion 4 in beta-sheet A of this serpin with an octapeptide.
8 Ki = 0.40 +/- 0.03 microM) than the starting octapeptide.
9 n Pax-B, having both the homeodomain and the octapeptide.
10 the self-assembly of lanreotide, a cationic octapeptide.
11 contain a paired-type homeodomain and/or an octapeptide.
12 roduct was identified as the SLVELTSL (SEL8) octapeptide.
13 s, ursodeoxycholic acid, and cholecystokinin-octapeptide.
14 rnifin beta contains 21 tandem repeats of an octapeptide.
15 ned with the upstream di-arginine-containing octapeptide.
16 (-1) for a small organic molecule and for an octapeptide.
17 hown to be the case in 18-membered ring SRIF octapeptides.
18 various cancers expressing receptors for SST octapeptides.
19 ins of eight saccharides cross-linked by two octapeptides.
20 et bind to two and only two groups of nRNP A octapeptides.
21 mushrooms in the genus Amanita, are bicyclic octapeptides.
22 (IC(50) = 2-4 nM) cyclic somatostatin (SRIF) octapeptides.
23 ravenous injection of either cholecystokinin octapeptide (200 mug/kg in 0.3 mL saline) or vehicle pla
24 ) selectivity, substitution of Trp(8) in the octapeptide 9 by imBzl-l- or -d-His(8) results in loss o
26 e obelin label in a controlled manner to the octapeptide, a fusion protein was produced using recombi
32 of poisonous Amanita mushrooms are bicyclic octapeptides (amatoxins) or heptapeptides (phallotoxins)
33 The cholecystokinin (26-33) [CCK (26-33)] octapeptide analog Asp-Tyr-D-Phe-Gly-Trp(N-Me)-Nle-Asp-P
34 though a number of synthetic hexapeptide and octapeptide analogs of SRIF bind selectively to SSTR2.
36 e-dimensional NMR structures of eight cyclic octapeptide analogues of somatostatin (SRIF) are describ
37 ative L,5D6 antagonist motif on somatostatin octapeptide analogues with a cyclic hexapeptide core.
39 tic secretion in response to cholecystokinin octapeptide and reduced pancreatic digestive enzyme prot
40 as gastrin/carboxy-terminal cholecystokinin octapeptide and selective cholecystokinin antagonists, c
41 ess responsive to vesicular stomatitis virus octapeptide and unresponsive to weak peptide agonists, a
42 Due to the high specificity of the displayed octapeptides and avidity effect of their multicopy displ
43 synthesized a library of over half a million octapeptides and exposed it to light and air in pH 7.4 b
44 ginyl endopeptidase, we prepared a series of octapeptides and mutant legumin B and G4 glycinin subuni
45 -scanning studies with overlapping deca- and octapeptides and polygonal rabbit and human infant immun
46 se activity (using hydrolysis of a synthetic octapeptide), and MMP-8 (using a Western blot) and the b
47 (ELISA) screening against synthesized serial octapeptides, and ELISA screening, with anti-PM-Scl posi
51 ic forms of ACE both generate the vasoactive octapeptide angiotensin II (Ang II) with equal efficienc
52 eave angiotensin I (Ang I) to the vasoactive octapeptide angiotensin II (Ang II), but is also able to
55 ntification of novel disulfide-linked cyclic octapeptide antagonists of somatostatin is described.
57 as solubilized by adding the very polar FLAG octapeptide (Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys) to the N-t
58 of principle, we have appended an extraneous octapeptide at the N terminus of hepatitis B virus capsi
59 M were matched by incubating DC with cognate octapeptides at 1-10 pM, indicating that display of very
60 predicted to be essential for the binding of octapeptides based on the observation that SSTR1 can bin
63 entarity and greater number of contacts, the octapeptide binds with an affinity (KA = 2.5 x 10(5) M-1
65 H-2(b) mice specific for the VSV8 (RGYVYQGL) octapeptide bound to Kb, we identified a single weak ago
66 specific for the vesicular stomatitis virus octapeptide bound to the H-2K(b) molecule were compared
67 s high affinity for sulfated cholecystokinin octapeptide but has > or = 1000-fold lower affinity for
71 ubicin (AN-201) linked covalently to the SST octapeptide carrier RC-121 (D-Phe-Cys-Tyr-D-Trp-Lys-Val-
72 n applied to the discovery of a new class of octapeptide catalysts for the kinetic resolution of seco
74 for the ability of systemic cholecystokinin octapeptide (CCK) (0 or 10 microg/kg) to inhibit food in
75 Systemic administration of cholecystokinin octapeptide (CCK) slows gastric emptying, inhibits feedi
76 genic mice 5 min after 10 pM cholecystokinin octapeptide (CCK) stimulation was enhanced by 160% of co
77 2 mg/kg, i.p.), and sulfated cholecystokinin octapeptide (CCK-0.05 and 0.1 mg/kg, i.p.) were used to
79 cular (i.c.v.) injections of cholecystokinin-octapeptide (CCK-8) and somatostatin (SST) and the inter
81 by a continuous intravenous cholecystokinin octapeptide (CCK-8) infusion was determined by ultrasono
86 al injection of low doses of cholecystokinin octapeptide (CCK-8; 10-60 pmol); group B neurones respon
87 he density and distribution of sulphated CCK octapeptide (CCK8S) binding sites and preproCCK peptide
92 le amino acid carriers and to tripeptides or octapeptides containing tyrosine or histidine as central
93 nexpected functional properties of 1 and the octapeptide cyclo(3-14)H-Cys-Phe-Phe-Trp(8)-Lys-Thr-Phe-
94 the PG monomer revealed that the ramoplanin octapeptide D-Hpg-D-Orn-D-alloThr-Hpg-D-Hpg-alloThr-Phe-
95 MSO-d6, 300 K) and molecular modeling of the octapeptide D-Phe1-Cys2-Phe3-D-Trp4-Lys5-Thr6-Cys7+ ++-T
98 hapten-modified peptides, the immunodominant octapeptide derived from vesicular stomatitis virus nucl
99 TyrBm oxidation of three tyrosine-containing octapeptides derived from glycinin was analyzed by oxyge
102 helix with the additional involvement of the octapeptide domain and its N-terminal flanking amino aci
103 riant, c.547G>A (p.Gly183Ser), affecting the octapeptide domain of PAX5 that was found to segregate w
107 the contractile response to cholecystokinin octapeptide for up to 96 hours after endotoxin administr
108 N15 TCR [1-4] and its peptide-MHC ligand, an octapeptide fragment representing amino acids 52-59 of t
110 xyphenylalanine, is a potently antimicrobial octapeptide from the blood cells of the solitary tunicat
116 a)-methylated aminoglycine (Agl) scan of the octapeptide H-c[Cys(3)-Phe(6)-Phe(7)-dTrp(8)-Lys(9)-Thr(
117 pseudobactins from P. fluorescens A225, the octapeptide has the sequence Chr-Ser(1)-Ala-AcOHOrn-Gly-
118 A (D-ala(1)-peptide T-amide, a gp120-derived octapeptide homologous to VIP) prevent neuronal cell dea
120 +) release in response to angiotensin II, an octapeptide hormone that promotes cardiac hypertrophy.
122 nous application of sulfated cholecystokinin octapeptide in a reversible and concentration-dependent
124 the contractile response to cholecystokinin octapeptide in gallbladder strips 4 hours after endotoxi
125 support has been used to synthesize tri- to octapeptides in 28 to 97% yields using only 1.2 equiv of
128 rdiopulmonary resuscitation, cholecystokinin octapeptide induced mild hypothermia, attenuated postres
129 -free liposomes for 4 hours, cholecystokinin octapeptide-induced contraction, membrane cholesterol co
132 ce express a prion protein (PrP) with a nine-octapeptide insertion associated with a human familial p
133 sed Tg(PG14) mice, which express PrP with an octapeptide insertion associated with an inherited prion
134 olog of a mutant human PrP containing a nine octapeptide insertion associated with prion dementia.
135 ansgenic mice express PrP that harbor a nine-octapeptide insertional mutation homologous to one descr
136 monstrate that the incorporation of the FLAG octapeptide into the HI loop does not ablate fiber trime
137 d PA225-I, II), the serine(1) residue of the octapeptide is attached to the carboxylic acid group on
138 H3K79 methyltransferase, interacts with the octapeptide/leucine zipper domain of AF10, and this regi
139 substrate specificity using tetrapeptide and octapeptide libraries in a positional scanning format, e
141 ently revised receptor-bound model for CCK-B octapeptide ligands and are in good agreement with the D
142 eptin docking site was mapped to a divergent octapeptide loop in the AGR2 superfamily between amino a
143 r the suggestion that the Cys-110 to Cys-117 octapeptide loop of human AGRP mimics the conformation o
144 rangement of the disulfide bonds predicts an octapeptide loop, and the chemical properties of four re
145 rotein that contains the naturally processed octapeptide LTFNYRNL (LYL8) presented by the Kb MHC mole
148 e of the pathogen Shigella flexneri Y and an octapeptide (Met-Asp-Trp-Asn-Met-His-Ala-Ala), a functio
150 ng PEPSCAN each mAb reacted with a number of octapeptides, most of which were derived from within the
152 and vesicular stomatitis virus nucleoprotein octapeptide N52-59 relevant for the lymphocytic choriome
153 itioning of ions into a self-assembled (D,L)-octapeptide nanotube, cyclo[-(L-Ala-D-Ala)(4)-], are pre
158 9), and its interactions with the C-terminal octapeptide of cholecystokinin (CCK-8) have been determi
159 his study was undertaken to test whether the octapeptide of cholecystokinin (regular CCK-8) and pharm
160 The bimolecular complex of the C-terminal octapeptide of cholecystokinin, CCK-8, with the N-termin
163 EBNA-1 and the maximally overlapping unique octapeptides of EBNA-1 were tested by modified ELISAs.
164 receptor C-terminal sequence, as well as for octapeptides of eight other putative partner proteins of
165 uated the binding of lupus autoantibodies to octapeptides of nuclear ribonucleoprotein (nRNP) A, iden
166 sera by solid-phase scanning of overlapping octapeptides of variable domains (VDs) of the major oute
167 predominant that was converted to the final octapeptide only in presence of the appropriate MHC I mo
170 monitoring the generation of an OVA-derived octapeptide, OVA257-264 (SL8), and its C-terminally exte
171 portion a nuclear localization signal and an octapeptide (PPPRMPPP) with similarity to a major B cell
172 p beta C8Ala, AspCD2Ala) mutant bound to the octapeptide PQpYEEIPI (where pY indicates a phosphotyros
173 molecules that mimic this epsilonPKC agonist octapeptide provide a powerful therapeutic approach to p
174 we describe an epsilonPKC-selective agonist octapeptide, psiepsilon receptor for activated C-kinase
175 ensus epitope via in vitro evolution yielded octapeptides QPEQAFPE and PFPEQxFP that identified omega
176 d in protegrins and tachyplesins whereas the octapeptide R8 (RLYRKVYG) consists of an R4 and a degene
178 otoxic hybrid analogs of somatostatin (SST), octapeptides RC-160 (D-Phe-Cys-Tyr-D-Trp- Lys-Val-Cys-Tr
179 is experiments, confirmed the presence of an octapeptide receptor-binding domain toward the amino ter
180 d-type affinity for sulfated cholecystokinin octapeptide, receptors with increasing amino-terminal co
181 rion disease caused by a prion protein (PrP) octapeptide repeat insertion mutation originates from so
182 tations P102L, D178N, E200K and 2-, 4- and 6-octapeptide repeat insertions) and show that the glycofo
183 to bind to the protein in a highly conserved octapeptide repeat region (sequence PHGGGWGQ) near the N
186 nic strength, confirming that the N-terminal octapeptide repeat region of PrPSc is not required for b
188 ing sites are localized predominantly in the octapeptide repeat region, whereas sites that bind both
191 ecules expressing 7, 9, and 11 copies of the octapeptide repeat sequence showed altered cell surface
192 rion-related peptides differing in number of octapeptide repeat units (PHGGGWGQ), (PHGGGWGQ)(2), and
193 (IPD) include an insertion of six additional octapeptide repeats (6-OPRI) and a missense mutation (P1
194 on-protein-mediated zinc influx requires the octapeptide repeats and amino-terminal polybasic region
196 und that only a mutant containing nine extra octapeptide repeats failed to suppress Bax-induced cell
198 res the presence of at least one of the five octapeptide repeats normally present in the N-terminal h
199 oma cells, hamster PrP-sen with 5, 9, and 11 octapeptide repeats were expressed normally on the cell
200 e, hamster PrP molecules with greater than 7 octapeptide repeats were more aggregated and more protea
201 s a mutant prion protein (PrP) containing 14 octapeptide repeats whose human homologue is associated
202 express a pathogenic mutant with nine extra octapeptide repeats, also binds more strongly to GAG tha
205 tion of patients from the UK with four extra octapeptide repeats, which suggest that the risk of clin
215 ngly, the deduced BGAF sequence contained an octapeptide sequence (G(P/R)WGGSGG) repeated twice.
217 use treatment of patients with peptide T (an octapeptide sequence found in the human immunodeficiency
220 ) contains four copies of a highly conserved octapeptide sequence, PHGGGWGQ, that is flanked by two p
221 different amino acids in a highly-conserved octapeptide sequence, Z8, located within the region remo
223 confers a conjugative mating response to an octapeptide sex pheromone (cAD1) secreted by plasmid-fre
224 a mating response induced by exposure to an octapeptide sex pheromone, cAD1, secreted by plasmid-fre
226 r a series of tripeptides and for two larger octapeptides, showing that the diagnostic phosphate OH s
228 65), fused to a polypeptide that contains an octapeptide (SIYRYYGL) agonist for a particular T cell r
229 d on the observation that SSTR1 can bind the octapeptide SMS-201-995 with reasonable affinity after a
230 i-PMScl positive sera did not react with any octapeptide spanning the major epitope area (aa 207-246)
231 on of a mass-labeled leucine monomer from an octapeptide spiked standard was employed as a measure of
232 of 2-pyrrolinodoxorubicin (AN-201) linked to octapeptide SRIF carrier RC-121, may overcome this resis
233 ral CCK receptor agonist CCK8S (sulfated CCK octapeptide) strongly depolarized the neurons, and this
234 CoA analogue [S-(2-oxo)pentadecylCoA] and an octapeptide substrate (GLYASKLA) to 2.5 A resolution.
236 those functional groups in the high-affinity octapeptide substrate GLYASKLS-NH2 1a necessary for tigh
237 nhibitors of Candida NMT with respect to the octapeptide substrate GNAASARR-NH2 with Ki(app) = 30 and
239 anti-apoptotic effect of MN10021 and derived octapeptides suggesting that their potent vasoprotective
242 with a paired-type homeobox, as well as the octapeptide that is found in many paired-type homeobox g
244 cently we demonstrated that the fusion of an octapeptide to the C-terminus of a cysteine-free mutant
245 significantly better in the cholecystokinin octapeptide-treated animals when compared to the control
248 ommon ligand, the vesicular stomatitis virus octapeptide (VSV8) bound to H-2Kb, were studied to defin
250 heat capacity change (DeltaCp) for the 5HT2c octapeptide was determined to be -94 cal/mol, and a calc
252 ximal contraction induced by cholecystokinin octapeptide was significantly less in gallbladders with
253 -to-left synthetic approach to this bicyclic octapeptide was unsuccessful due to an inability to elab
254 ) and several lanthionine hexa-, hepta-, and octapeptides was carried out by using the method of cycl
255 nodoxorubicin (AN-201) linked to SST carrier octapeptide, was investigated in human renal cell carcin
256 sed approach and starting from a linear MLL1 octapeptide, we have designed a class of potent macrocyc
257 te formation induced by the full agonist CCK octapeptide were comparable for the wild-type receptor a
258 n response to 30 and 60 pmol cholecystokinin octapeptide were significantly lower in STZ-D rats compa
264 PLC) analysis of a tryptic digest yielded an octapeptide within the insert of PDE3A ((K)T(806)YNVTDDK
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