ライフサイエンスコーパス: octopamine

1 the beta-hydroxylation of tyramine to yield octopamine.

2 t dopamine is a stronger arousal signal than octopamine.

3 e neurons respond to in vitro application of octopamine.

4 ype levels by pharmacological treatment with octopamine.

5 esicular storage of dopamine, serotonin, and octopamine.

6 insensitive to the wake-promoting effects of octopamine.

7 other that detects another neurotransmitter, octopamine.

8 ne beta-hydroxylase to convert tyramine into octopamine.

9 ne, GABA, glutamate, serotonin, dopamine and octopamine.

10 0.5-1.5 microm), a subset of which contained octopamine.

11 ramine, beta-phenethylamine, tryptamine, and octopamine.

12 luminescence induced by the neurotransmitter octopamine.

13 ents, and from more nerves per segment, than octopamine.

14 ositive OC interneurons and its followers is octopamine.

15 e neurotransmitters dopamine, serotonin, and octopamine.

16 e effects are mimicked by the neuromodulator octopamine.

17 d from succinylation of the neurotransmitter octopamine.

18 orm appetitive memory, even in flies lacking octopamine.

19 ear to mediate the wake-promoting effects of octopamine.

20 hort-term appetitive memory is reinforced by octopamine.

21 ities as the less commonly reported feruloyl octopamine (1.2-5.2), 5-O-feruloyl quinic acid (0.1-7.5)

22 N-(11)C-guanyl-(-)-meta-octopamine ((11)C-GMO) has a much slower NET transport r

23 Bath application of octopamine, 5-HT, and dopamine at concentrations of 10(-

24 ocal axon modulation with the biogenic amine octopamine, abolished signal integration at the primary

25 We conclude that tyramine and octopamine act as neurotransmitters/modulators in distin

26 rate biogenic amines structurally related to octopamine acted as superagonists at the DmOctR but part

27 s define the cellular and molecular basis of octopamine action and suggest that the PI is a sleep:wak

28 Octopamine also affects metabolism in invertebrate speci

29 f Neuron, Watanabe et al. (2017) uncover how octopamine, an invertebrate norepinephrine analog, modul

30 Octopamine and 5-hydroxytryptamine are not active (< 100

31 a mutation in dTdc2 lack neural tyramine and octopamine and are female sterile due to egg retention.

32 ition, they reconcile previous findings with octopamine and dopamine and suggest that reinforcement s

33 ulatory circuits, especially those involving octopamine and dopamine.

34 changes in synaptic structure in response to octopamine and for starvation-induced increase in locomo

35 Octopamine and glutamate treatments increased the likeli

36 are wake-promoting and respond to dopamine, octopamine and light.

37 on of particular concentrations of the drugs octopamine and nicotine, but due to high environmental v

38 nd held at a potential sufficient to oxidize octopamine and the terminal stimulated by blue light.

39 dc expression contribute to a model in which octopamine and tyramine have distinct and separable neur

40 The two biogenic amines octopamine and tyramine have recently been shown to modu

41 Given various potential roles of octopamine and tyramine in the larval brain, such as loc

42 By using mutants having altered octopamine and tyramine levels and by genetic interferen

43 ng crowding and isolation, the activities of octopamine and tyramine signalings were respectively cor

44 Tbetah(nM18) mutants, with altered levels of octopamine and tyramine, have a locomotion deficit.

45 s well as an increase in cAMP in response to octopamine, and genetic manipulation of their electrical

46 ransport activity; norepinephrine, tyramine, octopamine, and histamine also have high affinity for th

47 mechanism involving the VEGF2-like receptor, octopamine, and its receptor.

48 we have defined the roles of tyramine (TA), octopamine, and neuropeptides in the inhibition of avers

49 lso have lower levels of hemolymph dopamine, octopamine, and serotonin.

50 selective alpha-adrenergic receptor agonist, octopamine, and the specific alpha(1) agonist, phenyleph

51 Octopamine- and tyramine immunostaining in the central c

52 ing machinery, provides direct evidence that octopamine- and tyramine-based neuromodulation can be me

53 ned the patterns seen with the tyramine- and octopamine antisera.

54 In contrast, octopamine appears to inhibit 5-HT stimulation by activa

55 sed cAMP and intracellular Ca2+ levels after octopamine application.

56 tants unable to synthesize the catecholamine octopamine are also impaired in their ability to develop

57 mine, beta-phenylethylamine, tryptamine, and octopamine are biogenic amines present in trace levels i

58 e neurotransmitters serotonin, dopamine, and octopamine are converted to a large extent into the corr

59 nattractive flowers, however, is mediated by octopamine-associated modulation of antennal-lobe neuron

60 Facilitation is mimicked by bath applied octopamine at 5 microM.

61 nism, activation of Octss2R autoreceptors by octopamine at octopaminergic neurons initiated a cAMP-de

62 re, we report the presence of an alternative octopamine autoreceptor, Octss1R, with antagonistic func

63 e-feedback mechanism that required Octbeta2R octopamine autoreceptors.

64 n intact neuronal circuit, with dopamine and octopamine bidirectionally influencing the generation of

65 Octopamine binds to receptors located on various cell ty

66 Mutations in the octopamine biosynthesis pathway produced a phenotype of

67 Octopamine biosynthesis requires tyrosine decarboxylase

68 e absence of TBH protein and blockage of the octopamine biosynthesis.

69 , the enzyme that catalyzes the last step in octopamine biosynthesis.

70 ult locomotion and startle behavior required octopamine, but a complementary role was observed for se

71 Additionally, the tyrosine analogue octopamine can replace topoisomerase I derived peptides

72 that mimic those observed during flight, and octopamine cells that project to the optic lobes increas

73 We have examined the role of the octopamine-containing buccal OC interneuron in the ficti

74 rties of synaptic connections from the three octopamine-containing OC interneurons to identified bucc

75 defect in egg laying is associated with the octopamine deficit, because females that have retained e

76 rivation was accompanied by an activity- and octopamine-dependent extension of octopaminergic arbors

77 Moreover, octopamine-dependent memory formation requires signallin

78 energic-like OCTbeta2R receptor reveals that octopamine-dependent reinforcement also requires an inte

79 Investigating the biogenesis of these octopamine-derived ascarosides, we found that succinylat

80 The biogenic amine octopamine did not elicit pheromone production in isolat

81 igate the effect of several neuromodulators (octopamine, dopamine, acetylcholine, serotonin and proct

82 ransmitter release by biogenic amines, e.g., octopamine, dopamine, or serotonin.

83 They also block the octopamine-evoked inhibition of B3, N2 and N3 neurons.

84 Octopamine-evoked neuropeptide release also requires end

85 Pharmacological application of octopamine evokes responses in quiescent flies that mimi

86 OCTR-1, a putative octopamine G protein-coupled catecholamine receptor (GPC

87 Additionally, octopamine had direct effects on the STG, including the

88 insects, such as honeybees and fruit flies, octopamine has been shown to be a major stimulator of ad

89 Instead, octopamine has historically been considered to be the si

90 hed in seven steps in 10% overall yield from octopamine hydrochloride (17), N-(Boc)glycine (16), and

91 mine, in contrast, was strikingly similar to octopamine immunolabeling.

92 idence that the neurotransmitter between the octopamine-immunopositive OC interneurons and its follow

93 meres except in abdominal ganglion 5) and 48 octopamine-immunoreactive cell bodies (in brain and thor

94 The pattern of appearance of octopamine-immunoreactive cells is cell type-specific.

95 ods to examine the sequence of appearance of octopamine-immunoreactive neurons during development, an

96 ells appear at about the same time the first octopamine-immunoreactive neurons show staining.

97 ntennal lobes are supplied by at least three octopamine-immunoreactive neurons.

98 discussed with respect to recent studies on octopamine-immunoreactive organization in honey bees and

99 Octopamine-immunoreactive processes from one or more cel

100 In both taxa octopamine-immunoreactive processes invade only the gamm

101 markably similar to the previously described octopamine immunoreactivity in Drosophila.

102 onfocal immunocytochemistry revealed intense octopamine immunoreactivity in the anterior lateral asso

103 In contrast, octopamine immunostaining was present in two bilateral p

104 that underlies the wake-promoting effects of octopamine in Drosophila.

105 The role of the biogenic amine octopamine in modulating cholinergic synaptic transmissi

106 tion center, thus confirming the presence of octopamine in neuropil regions containing fSR/BA1 synaps

107 e roles of the biogenic amines serotonin and octopamine in regulating locomotion behaviors associated

108 discussed with respect to possible roles of octopamine in sensory integration and association.

109 s and cockroaches and the suggested roles of octopamine in sensory processing, learning, and memory.

110 ut little is known about the distribution of octopamine in the brain.

111 g for TBH, the enzyme converting tyramine to octopamine, in contrast, was strikingly similar to octop

112 lyzes the synthesis of the neurotransmitter, octopamine, in insects.

113 Octopamine increases the cycle frequency of the pyloric

114 When applied only to the stn-son junction, octopamine induced action potentials in the axons of the

115 (10(-6) M) had no significant effect on the octopamine-induced decrease in ACh responses.

116 Octopamine is a major monoamine in invertebrates and aff

117 Octopamine is a neuroactive monoamine that functions as

118 Octopamine is a neuromodulator that mediates diverse phy

119 he first evidence that endogenous release of octopamine is involved in state-dependent modulation of

120 Octopamine is likely to be an important neuroactive mole

121 ate protein source in mated females and that octopamine is specifically required to mediate homeostat

122 ramine are the preferred substrates, whereas octopamine is transported less efficiently, and serotoni

123 re we show that a Drosophila biogenic amine, octopamine, is a potent wake-promoting signal.

124 ve behavioral imaging, we show that 5-HT and octopamine jointly influence locomotor activity and quie

125 systemic injection with the receptor ligand octopamine leads to increased cAMP levels in this specif

126 eptor whose activation by its natural ligand octopamine leads to rapid and transient increases in cAM

127 T beta h-null flies are octopamine-less but survive to adulthood.

128 ensitivity to CO(2) in flight via changes in octopamine levels, along with Ir64a, quickly switches th

129 in as well as many midline perikarya provide octopamine-like immunoreactive processes to circumscribe

130 e brain as well as midline perikarya provide octopamine-like immunoreactive processes to the optic lo

131 clonal antibody to study the distribution of octopamine-like immunoreactivity in the brain of the haw

132 of octopamine, the receptor responsible for octopamine-mediated modulation could not be characterize

133 These results suggest that octopamine mediates consolidation of a component of olfa

134 Dopamine and octopamine modulated intracellular cAMP in spatially dis

135 uding L-3,4-dihydroxyphenylalanine, N-acetyl octopamine, N-acetyldopamine, naTA, N-acetylserotonin, O

136 We further show that octopamine neurons are required for sustained behavioral

137 toinhibition is seen in spontaneously active octopamine neurons but is absent from spontaneously acti

138 The first octopamine neurons express their transmitter phenotype a

139 We investigated the role of octopamine neurons in the flight-dependent modulation ob

140 ng flight, and blocking synaptic output from octopamine neurons inverts the valence assigned to CO(2)

141 In addition, octopamine neurons regulated the expansion of excitatory

142 genetic tools to manipulate the activity of octopamine neurons, we find that they are both necessary

143 ity seems plausible: the three pairs of claw octopamine neurosecretory cells show immunostaining as a

144 There is ample evidence linking octopamine (OA) and tyramine (TA) to several neurophysio

145 t that the biogenic amines tyramine (TA) and octopamine (OA) in Drosophila melanogaster females play

146 Here, we show a role of the neuromodulator octopamine (OA) in the female postmating response.

147 In Caenorhabditis elegans, tyramine (TA) and octopamine (OA) inhibit aversive responses to 100%, but

148 with a reduction in dMBD-R2 specifically in octopamine (OA) neurons exhibit courtship toward diverge

149 pathway requiring an alpha2A-adrenergic-like octopamine (OA) receptor, OCTR-1, and a 5-HT1A-like sero

150 Ovulation requires octopamine (OA) signaling from the central nervous syste

151 Octopamine (OA), a biogenic amine similar to norepinephr

152 r biogenic amines, such as dopamine (DA) and octopamine (OA), have yet to be completed.

153 the response of tubules to the related amine octopamine (OA), indicating that OA can activate TAR2.

154 clude dopamine, epinephrine, norepinephrine, octopamine (OA), L-3, 4-dihydroxyphenylalanine, tyramine

155 Octopamine (OA), the insect homolog of NE, is known to p

156 Octopamine (OA), the invertebrate counterpart of norepin

157 nalytes, such as N-acetyltyramine (naTA) and octopamine (OA).

158 the Oamb gene, which encodes a receptor for octopamine (OA, the invertebrate homologue of norepineph

159 Thus, the invertebrate-specific octopamine-OARalpha and tyramine-TAR signalings respecti

160 noamines dopamine (DA), serotonin (5HT), and octopamine (Oct) can each sculpt a unique motor pattern

161 sion assays indicate that the neuromodulator octopamine (OCT) is necessary for Drosophila males to co

162 ially by insulin, suggesting that effects of octopamine on metabolism are independent of its effects

163 , we investigated its role in the effects of octopamine on sleep.

164 Effects of octopamine on sleep:wake are mediated by the cAMP-depend

165 if insulin signaling mediates the effects of octopamine on sleep:wake behavior, we assayed flies in w

166 These results demonstrate the dual action of octopamine on synaptic growth and behavioral plasticity,

167 ) has a hyperpolarizing agonist effect (like octopamine) on these neurons and also blocks their chemi

168 aggression has shown that the biogenic amine octopamine plays a role in the modulation of aggressive

169 Octopamine plays central roles in various learning types

170 To test more specifically what role octopamine plays in the antennal lobe, we used two treat

171 rward pairing of neuronal depolarization and octopamine produced a subadditive effect on cAMP.

172 Octopamine, produced by the RIC neurons, acts via SER-3

173 Local perfusion of 10(-4) M octopamine produces the same inhibitory membrane respons

174 Moreover, electrical silencing of octopamine-producing cells decreased wakefulness, wherea

175 e findings may be relevant to the control of octopamine production in insect cells.

176 stablished that, in Drosophila, dopamine and octopamine promote increased arousal.

177 Octopamine promotes wakefulness in the fly by acting thr

178 te-gated chloride channel (avermectins), the octopamine receptor (amitraz metabolite), and the calciu

179 hat dopaminergic neurons expressing the OAMB octopamine receptor [6] specifically convey the short-te

180 RNA interference verified that octopamine receptor alpha (OARalpha) signaling in gregar

181 mushroom bodies (OAMB), was identified as an octopamine receptor because human and Drosophila cell li

182 Furthermore, octopamine receptor disruption, and FAC-mediated oxidati

183 to mianserin/dsRNA treatment did not reverse octopamine receptor disruption-mediated inhibitory respo

184 l lobe, we used two treatments to disrupt an octopamine receptor from Apis mellifera brain (AmOAR) fu

185 equency of a mutation in the beta-adrenergic octopamine receptor gene (RmbetaAOR).

186 One new receptor, octopamine receptor in mushroom bodies (OAMB), was ident

187 To identify an octopamine receptor mediating this function in Drosophil

188 Moreover, an octopamine receptor mRNA is selectively enriched in l-LN

189 aging) induced by starvation was elevated in octopamine receptor mutants, despite their high propensi

190 The octopamine receptor OAMB has two isoforms (OAMB-K3 and O

191 d expression of a Galphas-coupled Drosophila octopamine receptor selectively in mouse hippocampal exc

192 on the heterologous expression of an Aplysia octopamine receptor, a G-protein-coupled receptor whose

193 The alpha-like octopamine receptors (OctR) are believed to be the evolu

194 previously identified one of the Drosophila octopamine receptors named OAMB that produces increases

195 ns, the biogenic amines serotonin (5-HT) and octopamine regulate a number of food-related behaviors.

196 The biogenic amine octopamine regulates critical physiological processes du

197 Furthermore, after consolidation, octopamine release becomes essential for recall, which s

198 Octopamine release by one such pathway in the honeybee a

199 anipulation in Type II varicosities to study octopamine release in Drosophila.

200 Tyramine and octopamine released from neurons expressing tyrosine dec

201 We observe 22700+/-4200 molecules of octopamine released per vesicle.

202 lation (-89.0 mV, S.E.M.=14.1, n=10) and the octopamine response of the B3 neurons (-84.7 mV, S.E.M.=

203 ct mechanisms: light-mediated suppression of octopamine responses was regulated by the circadian cloc

204 Although other Drosophila mutants that lack octopamine retain eggs completely within the ovaries, dT

205 A serum raised against octopamine reveals in cockroaches and honey bees structu

206 A serum raised against conjugated octopamine reveals structurally comparable systems of pe

207 These results demonstrate that serotonin and octopamine reversibly modulate the activity of the ASHs,

208 Octopamine's effects on cycle frequency require an under

209 AMB receptor is a key molecule mediating the octopamine's signal for appetitive olfactory learning an

210 MB in the mushroom body neurons mediates the octopamine's signal for appetitive olfactory learning.

211 Part of the octopamine signal requires the alpha-adrenergic-like OAM

212 icate that sweet taste engages a distributed octopamine signal that reinforces memory through discret

213 es are decreased in mutants with compromised octopamine signaling and elevated in flies with increase

214 otein kinase A (PKA) is a putative target of octopamine signaling and is also implicated in Drosophil

215 Moreover, flies with increased octopamine signaling do not suppress sleep in response t

216 We then blocked octopamine signaling in random areas of the fly brain an

217 to assume food-appropriate behavior, whereas octopamine signaling is required for animals to assume f

218 Genetic and pharmacologic approaches suggest octopamine signaling transmits changes in aggression upo

219 he starvation response of flies with altered octopamine signaling.

220 r dopamine overturns the previous model that octopamine signalled reward and dopamine punishment.

221 Serotonin, dopamine, and octopamine stimulate locomotion and grooming, showing di

222 gs initiate egg laying when transferred onto octopamine-supplemented food.

223 ng several mechanisms, notably through GABA, octopamine synapses, and the inhibition of acetylcholine

224 BH likely being the rate-limiting enzyme for octopamine synthesis in a small subpopulation of TDC-con

225 ed in the absence of extracellular Ca(2+) by octopamine, the arthropod homolog to norepinephrine.

226 We investigated the role of octopamine, the invertebrate counterpart of adrenaline a

227 Octopamine, the invertebrate homolog of mammalian adrena

228 and tolazoline both mimicked the actions of octopamine, the receptor responsible for octopamine-medi

229 Application of tyramine or octopamine to live preparations silenced dopaminergic ne

230 Octopamine triggers an increase in intracellular calcium

231 neurons immunoreactive with antisera against octopamine, tyramine, and the enzymes required for their

232 es to stimulate Ca(2+) increases through the octopamine/tyramine receptor (Oct-TyrR) and the transien

233 The expression of a cloned Drosophila octopamine/tyramine receptor (OctyR99AB) is described in

234 maps to 99B3-5, close to the position of the octopamine/tyramine receptor gene at 99A10-B1, suggestin

235 ractive behaviors, we have cloned a putative octopamine/tyramine receptor.

236 ify the roles of tyramine and its metabolite octopamine, we have cloned two TDC genes from Drosophila

237 human primates with [11C]1e, N-[11C]guanyl-m-octopamine, which has a slow NET transport rate, showed

238 tion of Type II boutons evokes exocytosis of octopamine, which is detected through oxidization at the

239 before and after mating: the biogenic amine octopamine, which regulates ovulation rate in Drosophila