ライフサイエンスコーパス: ocular

1 a rash in the mother and there are commonly ocular abnormalities in the newborn.

2 ika syndrome in the current study had severe ocular abnormalities, and all patients had bilateral inv

3 in primary vitreoretinal lymphoma (PVRL) and ocular adnexal (OA)-uveal DLBCL.

4 Fifty-five patients were included; ocular adnexal MCL was found to be most common in older

5 While primary ocular adnexal mucosa-associated lymphoid tissue (MALT)

6 Although there are distinct ocular advantages to anti-VEGF pharmacotherapy for some

7 Procedure-related complications and ocular adverse events (AEs) were assessed.

8 Ocular adverse events in the aflibercept group included

9 P) more than 10 mm Hg greater than baseline; ocular adverse events in the bevacizumab group included

10 ere mild to moderate in severity; no serious ocular adverse events were reported.

11 C107984558 was significantly associated with ocular and central nervous system (CNS) lesions and show

12 show that GPATCH3 is a new gene involved in ocular and craniofacial development.

13 Ocular and extraocular features were recorded using Huma

14 subjects such as age and sex; description of ocular and joint disease; surgical and other complicatio

15 5 children aged below 16 years with no other ocular and systemic anomalies who underwent lensectomy,

16 r cataract surgery in children with no known ocular and systemic anomalies.

17 ed recurrence of disease and unknown adverse ocular and systemic effects have caused concern from som

18 To describe associations of ocular and systemic factors with retinal pigment epithel

19 To evaluate the efficacy and ocular and systemic safety of netarsudil 0.02% ophthalmi

20 The primary endpoint was ocular and systemic safety, but exploratory data includi

21 ompensatory circuits including the vestibulo-ocular and vestibulo-collic reflex arcs.

22 ed 4 different VAS measuring overall, nasal, ocular, and asthma symptoms at least once.

23 Animal models of ocular angiogenesis: from development to pathologies.

24 ve eyelid formation correlated with profound ocular anomalies evident by postnatal days 1-4, includin

25 Ocular antigens are sequestered behind the blood-retina

26 Ocular arterial occlusive disorders were divided into ce

27 and myocardial ischemia differ among various ocular arterial occlusive disorders.

28 microbial susceptibility pattern of external ocular bacterial infections.

29 not only indicates a breakdown in the blood-ocular barrier, but also prompts further investigation i

30 ue to flying debris are more common, primary ocular blast exposure resulting from blast wave pressure

31 Although secondary ocular blast injuries due to flying debris are more comm

32 lative improvements in tear breakup time and ocular bulbar redness, compared with placebo, for both f

33 erebral Spinal Fluid in Space Flight Induced Ocular Changes and Visual Impairment in Astronauts" by A

34 cluding baseline demographic, treatment, and ocular characteristics on CP/FA and optical coherence to

35 Both children and adults were monitored for ocular chlamydial infection by polymerase chain reaction

36 important in clinical ophthalmology because ocular circulation abnormalities are early signs of ocul

37 Resident ocular communities of healthy female finches were charac

38 Ocular comorbidities were slightly more prevalent in DSB

39 Posterior uveitis is an ocular complication that can occur with reactivation of

40 oal of this study was to detect and describe ocular complications afflicting these survivors and to o

41 al uveitides suggests superior prevention of ocular complications and visual outcomes with immunosupp

42 Ocular complications most commonly seen during follow-up

43 Ocular complications were more frequent at enrolment tha

44 e measures included rates of visual loss and ocular complications.

45 o the extent of inflammation recurrences and ocular complications.

46 myocardial ischemia before or after onset of ocular condition was 52% in AF, 22% in OIS, 22% in BRAO,

47 quency of ED visits for urgent and nonurgent ocular conditions and how they changed over time.

48 artment (ED) visits for nonurgent and urgent ocular conditions and risk factors associated with ED us

49 identified all enrollees visiting an ED for ocular conditions identified by International Classifica

50 ed in overcoming the natural defenses of the ocular conjunctiva and transit through tissue.

51 Ocular contusion in childhood may not be reported by chi

52 complete absence of the nose with or without ocular defects.

53 The present study evaluated ocular delivery of RNA nanoparticles with various shapes

54 packaging motor were examined previously for ocular delivery.

55 To report ocular determinants of RE in a Chinese American populati

56 Horizontal and vertical ocular deviations at 9 different gaze positions of each

57 Ocular diagnoses were determined by International Classi

58 me measures were the prevalence of diagnosed ocular disease and use of eye care.

59 Any patient with no known ocular disease who desires a routine eye screening exami

60 nts were 120 individuals free of any retinal ocular disease.

61 rug delivery platforms for the management of ocular diseases affecting the anterior (dry eye syndrome

62 study aims to assess the awareness of these ocular diseases among Jordanian population.

63 hows that the level of awareness of the four ocular diseases among Jordanians is good and compares wi

64 ys" or "periodically" educate patients about ocular diseases associated with smoking, 142 (49%) "seld

65 Familiarity and knowledge about ocular diseases is essential as it would increase the ch

66 diagnosis, treatment, and follow-up of many ocular diseases, especially retinal and neuro-ophthalmol

67 tural changes and the development of certain ocular diseases, such as glaucoma, in these patients.

68 circulation abnormalities are early signs of ocular diseases.

69 Public awareness of four ocular diseases; cataract, glaucoma, diabetic retinopath

70 ital cataract is the most frequent inherited ocular disorder and the most leading cause of lifelong v

71 Dry eye disease (DED) is a highly prevalent, ocular disorder characterized by an abnormal tear film a

72 responses), abdominal pain (178 [22%]), and ocular disorders (142 [18%]).

73 Together with a shift in ocular dominance and large effects on unit activity duri

74 Brief monocular deprivation (MD) shifts ocular dominance and reduces the density of thalamic syn

75 s to the emergence of layers, retinotopy, or ocular dominance columns for the selective connectivity

76 Here, we show that initiation of ocular dominance plasticity was impaired with reduced CS

77 We used these estimates to calculate ocular dominance separately for excitation and suppressi

78 The sensitivity of ocular dominance to regulation by monocular deprivation

79 of these micelles as effective carriers for ocular drug delivery highlighting their performance in p

80 primates (NHPs) is a common animal model for ocular drug development.

81 salivary and lacrimal, resulting in oral and ocular dryness, although virtually any organ system can

82 has shown potentially serious and long-term ocular effects that are present more commonly after trea

83 ered behind the blood-retina barrier and the ocular environment protects ocular tissues from autoimmu

84 with TTR amyloidosis have been noted to have ocular, especially vitreous, involvement.

85 posterior vitreous detachment being a common ocular event affecting most individuals in an aging popu

86 This report demonstrated that a regular ocular exam should be recommended for several years afte

87 Subjects underwent a full ocular examination, electrophysiologic studies, spectral

88 Participants underwent a comprehensive ocular examination, including dilated fundus photography

89 ative OCT were performed along with standard ocular examination.

90 trasonography as part of their comprehensive ocular examination.

91 and 476 non-PEX controls underwent detailed ocular examinations, including specific ocular features

92 t test was used to assess for differences in ocular features between patients in XP subgroups with im

93 iled ocular examinations, including specific ocular features reflecting PEX.

94 cotomata at or connected to the blind spot), ocular findings (paucity of pigmentary changes with no s

95 Correlations between ocular findings and systemic features were analyzed.

96 lude rash in the mother during pregnancy and ocular findings in the newborn.

97 Clinical and histopathologic ocular findings of M. chimaera.

98 The ocular findings were correlated with the course of the s

99 without glomerulonephritis; and to correlate ocular findings with systemic features.

100 To describe the ocular findings, visual impairment, and association of s

101 ar pressure (IOP) via microbead occlusion of ocular fluid outflow in mice.

102 xidase (MPO) in tear washes of patients with ocular graft-vs-host disease (oGVHD).

103 These data are important to plan for ocular health care needs in the 21st century.

104 ble regression analyses were performed for 3 ocular health care outcomes.

105 A*0201-transgenic mice and reduced recurrent ocular herpes following UV-B-induced reactivation.

106 associated with protection against recurrent ocular herpes.

107 titis compared with control patients without ocular herpes.

108 esident CD8(+) T cell responses to recurrent ocular herpesvirus infection and disease using a well-es

109 (ZIKV) antigens and describe the associated ocular histopathologic features of 4 cases of CZS.

110 ications), as well as medical, surgical, and ocular histories, were collected.

111 Medical and ocular history, family history of glaucoma, visual acuit

112 portant host factor in immunopathogenesis of ocular HSV type 1 (HSV-1) infection.

113 Molecules that are necessary for ocular hypersensitivity reactions include the receptors

114 s a much lower penetrance for rs74315329 for ocular hypertension (and thus glaucoma), in comparison w

115 for the development of POAG in patients with ocular hypertension (OHT) and the predictive factors for

116 Glucocorticoid (GC)-induced ocular hypertension (OHT) is a serious adverse effect of

117 tolerated for the treatment of patients with ocular hypertension and open-angle glaucoma.

118 ata and an analysis of genetic data from the Ocular Hypertension Treatment Study.

119 tected high rate of suspicious optic nerves, ocular hypertension, and retinal pathology.

120 loss after the injection was associated with ocular hypertension, hemorrhagic retinopathy, vitreous h

121 or, in patients with open-angle glaucoma and ocular hypertension.

122 d both eyes of 100 patients with glaucoma or ocular hypertension.

123 in glaucomatous eyes, glaucoma suspects, and ocular hypertensives with 24-2 and 10-2 visual fields.

124 es were glaucoma suspects, and 108 eyes were ocular hypertensives.

125 After a washout of all pre-study ocular hypotensive medications, eligible patients were r

126 be a useful addition to the armamentarium of ocular hypotensive medications.

127 (VF) testing, fundus photography (FP), other ocular imaging (OOI), or none of these tests within the

128 Ocular imaging has been heavily incorporated into glauco

129 et GA and rate of GA area growth measured on ocular imaging, including FAF images of the study eyes.

130 ellular mechanisms underlying its effects on ocular immune homeostasis and host defense.

131 Ocular infection with HSV causes a chronic T cell-mediat

132 ny-stimulating factor 1 (CSF-1) DNA prior to ocular infection with HSV-1.

133 ndicating the critical role of HVEM in HSV-1 ocular infection.

134 Bacteria are the major contributor of ocular infections worldwide.

135 Ocular infections, if left untreated, can damage the str

136 monas aeruginosa are the leading isolates in ocular infections.

137 sing the Massachusetts Eye and Ear Infirmary Ocular Inflammation Database and electronic medical reco

138 eye drops in the treatment of postoperative ocular inflammation.

139 f the overriding need to control the primary ocular inflammatory disease.

140 All ocular injuries require a detailed ophthalmological exam

141 of this study was to determine the types of ocular injuries sustained in the earthquake in Nepal and

142 pment and closure, with subsequent impact on ocular integrity.

143 is, age >60 years, radiation dose, bilateral ocular involvement at presentation, and advanced stage w

144 and branch (BRAO) retinal artery occlusion, ocular ischemic syndrome (OIS), non-arteritic anterior i

145 iabetes mellitus with particular emphasis on ocular issues.

146 ion under the recessive model (TT vs. CT+CC: ocular lesion, Pc = 0.0099, OR = 1.56; CNS lesion, Pc =

147 Foxp3(+) Treg to effector Th1 CD4 T cells in ocular lesions and lymphoid tissues, with Treg becoming

148 to assess the stability of Treg function in ocular lesions.

149 tential to give rise to anlages of different ocular lineages, including retinal cells, lens cells, an

150 nts were randomized to receive eye care with ocular lubricants (n = 38), bandage contact lenses (n =

151 andage contact lenses and punctal plugs with ocular lubricants in preventing corneal damage in mechan

152 Compared with ocular lubrication, bandage contact lenses and punctal p

153 We compared the prevalence of ocular manifestations among reported syphilis cases by d

154 The ocular manifestations and sequelae of Zika virus infecti

155 e aim of this study was to compare the acute ocular manifestations between SJS and TEN.

156 The ocular manifestations documented using multimodal imagin

157 To document the ocular manifestations of xeroderma pigmentosum (XP), pre

158 Ocular manifestations were more prevalent among syphilis

159 d to include a spectrum of neuromuscular and ocular manifestations, including reduced vision with ret

160 5 and may be due to increased recognition of ocular manifestations, or a true increase in ocular syph

161 Despite immediate management including ocular massage and lowering of intraocular pressure, the

162 eakup time, corneal fluorescein staining, or ocular medications used by patients.

163 001), thickness >8 mm (4.44, P < 0.001), and ocular melanocytosis (2.75, P = 0.049).

164 or ciliary body location (53.91, P = 0.008), ocular melanocytosis (3.95, P = 0.038), and thickness >/

165 rs) with histologically confirmed metastatic ocular melanoma were enrolled.

166 to experimentally examine the impact of the ocular microbiome on host damage and pathogen virulence

167 Vertebrate ocular microbiomes are poorly characterized and virtuall

168 House finches with antibiotic-disrupted ocular microbiomes had more severe MG-induced conjunctiv

169 unknown how the brain measures the degree of ocular misalignment and uses it to compute the appropria

170 dult and child patients aged >/=6 years with ocular misalignment owing to congenital or acquired para

171 patients, meeting the clinical criteria for ocular MMP, as having a different disease.

172 e transformed our understanding of pediatric ocular motor disease at the prenuclear and infranuclear

173 The pathogenesis of complex ocular motor disorders, such as paradoxical pupillary co

174 ning our understanding of development of the ocular motor system.

175 involved in controlling the precision of the ocular movement.

176 rly reactive pupils (P < 0.001) and abnormal ocular movements (P = 0.03) compared with those in categ

177 es (DIF) in patients with clinically typical ocular mucous membrane pemphigoid (MMP).

178 Ocular neovascularization is strongly associated with in

179 samples were analyzed at a tertiary academic ocular oncology referral center using a customized bioin

180 al vision for >/=12 years and no significant ocular or systemic comorbidity.

181 No ocular or systemic safety signals were observed during t

182 dered as an efficient technique facilitating ocular, oral mucosal, gastrointestinal, ungual and vagin

183 Severity of ocular pain correlates with nonocular comorbidities such

184 ression analysis showed that the severity of ocular pain had a significant association with use of an

185 n reference populations (P < .01; except for ocular pain score) and similar to patients in other reti

186 quent HSK relapses had lower QoL related to "ocular pain" and "acknowledgement." Even during a quiesc

187 year included more severe dry eye symptoms, ocular pain, and neuropathic pain-like ocular symptoms.

188 a correlation was not observed in those with ocular pain.

189 presbyopic eyes, we investigated changes in ocular parameters and IOL power calculations attributabl

190 eractions between hormonal plasma levels and ocular parameters.

191 Common ocular pathogens, such as HSV-1, are increasingly recogn

192 cestry from the TwinsUK study cohort without ocular pathologic conditions.

193 of protection against HSV-1 pathogenesis and ocular pathology, yet the ability of Ab to protect again

194 Detailed ocular phenotyping identified early-onset (aged </=3 yea

195 chemotherapy (P = 0.01) and greater inherent ocular pigment also were significantly associated with a

196 the visual critical period causes shifts in ocular preference, or dominance, toward the open eye in

197 arter of enrollees who visited the ED for an ocular problem received a diagnosis of a nonurgent condi

198 ociated with ED use for nonurgent and urgent ocular problems.

199 Vestibulo-ocular reflexes (VORs) are the dominating contributors t

200 esults are consistent with the modulation of ocular reflexes during OVAR being primarily mediated by

201 diffuse large B-cell lymphoma (DLBCL) of the ocular region is rare, and the utility of surgery and ra

202 The CH and CRF were measured with the Ocular Response Analyzer (Reichert Ophthalmic Instrument

203 hysiologic and pathologic systemic and neuro-ocular responses have been documented in astronauts duri

204 the level of RPE65 expression, a decrease in ocular retinoid levels concomitant with low visual funct

205 ecessary to provide sufficient substrate for ocular retinoid production required for photoreceptor ce

206 Baseline ocular risk factors for severe dry eye symptoms at 1 yea

207 ' smoking status, educate patients regarding ocular risks of smoking, and discuss with patients smoki

208 moking status and educate patients regarding ocular risks of smoking.

209 To evaluate the available evidence on the ocular safety and efficacy of current therapeutic altern

210 oids are associated with increased potential ocular side effects (e.g., elevated intraocular pressure

211 meso-Zeaxanthin is an ocular-specific carotenoid for which there are no common

212 We also demonstrate that ocular-specific transcriptional enhancers were convergen

213 the precise quantification of additional key ocular structures, such as the individual retinal layers

214 atients in category 2 had significantly more ocular surface abnormalities than patients in category 1

215 capacity of licensed vaccines to protect the ocular surface against infection is limited.

216 Mild ocular surface and corneal disease may be treated effect

217 Initial correlation between OSA and ocular surface and eyelid markers was calculated through

218 resident commensal microbiome exists on the ocular surface and identify the cellular mechanisms unde

219 7 cells are critical effectors mediating the ocular surface autoimmunity in dry eye disease (DED).

220 clearly demonstrate that Th17 cells mediate ocular surface autoimmunity through both IL-17A and IFN-

221 treatment for periocular cancers and 2% for ocular surface cancers.

222 C function resulted in MG disease and severe ocular surface damage that phenocopied aspects of human

223 tative markers of eyelid laxity or secondary ocular surface disease in a sleep clinic population.

224 al microscopy (IVCM) and were surveyed using Ocular Surface Disease Index (OSDI) and Glaucoma Symptom

225 mic assessment including a detailed history, Ocular Surface Disease Index (OSDI) questionnaire, and o

226 Patient symptoms were assessed using the Ocular Surface Disease Index (OSDI) questionnaire.

227 al Function Questionnaire (NEI-VFQ), and the Ocular Surface Disease Index (OSDI) were included.

228 in (1) tear osmolarity and (2) DED symptoms (Ocular Surface Disease Index [OSDI] score) between days

229 articipants in the PROWL-2 study with normal Ocular Surface Disease Index scores were 44% (95% CI, 38

230 Eyelid laxity and ocular surface disease were assessed on bedside ophthalm

231 bsent ENaC function in the MG and associated ocular surface disease.

232 accine and therapeutic development for other ocular surface diseases.

233 ntity that can cause evaporative dry eye and ocular surface disruption, leading to dry eye symptoms i

234 n activates stress signaling pathways in the ocular surface epithelium and resident immune cells.

235 face Disease Index (OSDI) questionnaire, and ocular surface examination.

236 Recently, we showed an altered ocular surface homeostasis in unmanipulated NK1R(-/-) mi

237 suggesting the role of SP-NK1R signaling in ocular surface homeostasis under steady-state.

238 TOPIC: To discuss the pathology, causes, and ocular surface impact of meibomian gland disease (MGD),

239 terms of pathophysiology, risk factors, and ocular surface impact, and the relationship to dry eye.

240 that even PF formulations may lead to a mild ocular surface impairment.

241 Ocular surface inflammation was common during the acute

242 40% of SJS and 75% of TEN patients had acute ocular surface inflammation.

243 The ocular surface is a unique mucosal immune compartment in

244 vides evidence of neutrophil activity on the ocular surface of oGVHD patients.

245 Lid and periocular abnormalities, ocular surface pathologies, neuro-ophthalmologic abnorma

246 and without control children, suggests that ocular surface pyogenic granulomas respond to topical ti

247 ee corneal epithelial tissue engineering for ocular surface reconstruction.

248 To compare the surgical outcomes of ocular surface squamous neoplasia (OSSN) following wide

249 Ocular surface stability, best-corrected visual acuity (

250 ical signs (tear stability, tear production, ocular surface staining, bulbar and limbal redness, tear

251 icelles results in enhanced contact with the ocular surface while their small size allows better tiss

252 ntive and measurable impacts not only on the ocular surface, but on quality of life and visual functi

253 bnormalities were in the periocular skin and ocular surface, including interpalpebral conjunctival me

254 y innervated to sustain the integrity of the ocular surface.

255 um is altered, with a negative impact on the ocular surface.

256 r characterized by an abnormal tear film and ocular surface.

257 es, including retinal cells, lens cells, and ocular-surface ectoderm.

258 l of the SEAM, cells within it that resemble ocular-surface epithelia can be isolated by pipetting an

259 s with an interest in eye development and/or ocular-surface regeneration.

260 Patients with previous ocular surgery, postoperative endophthalmitis, postopera

261 g (n = 48) or placebo (n = 50) at the end of ocular surgery.

262 p >/=12 months, OH was unrelated to previous ocular surgery: risk factors at baseline (univariate log

263 Two-year Kaplan-Meier estimates of ocular survival and disease-free survival were 94.2% (95

264 The 36-month Kaplan-Meier estimates of ocular survival were 83.3% (95% confidence interval, 56.

265 Ocular survival, disease-free survival, and time to regr

266 ad no ophthalmic findings and did not report ocular symptoms during pregnancy.

267 0% of users with troublesome rhinitis and/or ocular symptoms suffered work impairment.

268 ession analysis, and the association between ocular symptoms was obtained through bivariate ordered l

269 toms, ocular pain, and neuropathic pain-like ocular symptoms.

270 mains unknown, space flight-associated neuro-ocular syndrome (SANS) has been adopted as an appropriat

271 In North Carolina, ocular syphilis increased from 2014 to 2015 and may be d

272 ocular manifestations, or a true increase in ocular syphilis.

273 No risk behaviors were associated with ocular syphilis.

274 This estimated the probability of ocular TB for each patient in two versions, first with a

275 The estimated probability of ocular TB was compared with treatment failure.

276 5 patients with clinical signs suggestive of ocular TB, 267 patients who had QFT and complete data we

277 These data, from an ocular tertiary referral center, suggest that conjunctiv

278 ort-term resolution of SRD was observed with ocular therapies including intravitreal injections of an

279 cryosectioning are good choices for studying ocular tissue morphology and structure, as they do not c

280 during degeneration of post-mitotic cells of ocular tissue.

281 was to quantify the morphological changes of ocular tissues caused by formalin fixation and cryosecti

282 barrier and the ocular environment protects ocular tissues from autoimmune attack.

283 aucoma suggests increased viscoelasticity of ocular tissues may have a protective role against glauco

284 In ocular tissues of healthy house finches, we identified 5

285 Ocular toxicities previously associated with pan-Hsp90 i

286 Ocular toxicity was evaluated by clinical findings and e

287 Ocular toxicity was evaluated by clinical findings and e

288 A total of 250 clinically suspected ocular toxocariasis cases referred by consultant eye sur

289 Immediate management of ocular trauma is critical in order to prevent blindness.

290 as the incidence of respiratory distress and ocular trauma observed in this class of dogs is highly c

291 The burden of ocular trauma resulting from the recent earthquakes in N

292 body contact, which may frequently result in ocular trauma.

293 Systemic and ocular treatment with the TR antagonists NH-3 and 1-850

294 agnostic work-up for patients with suspected ocular tuberculosis (TB) by QuantiFERON-TB Gold In-Tube

295 umor suppressor genes is a frequent event in ocular tumors, but also unmethylation is associated with

296 Visualizing ocular vasculature is important in clinical ophthalmolog

297 Photoacoustic microscopy (PAM) images the ocular vasculature without using exogenous contrast agen

298 evaluating the use of systemic sunitinib for ocular VHL lesions during a period of 9 months.

299 n present in the extracellular matrix and in ocular vitreous body.

300 ), no mental status change (91%), at least 1 ocular weakness finding (84%), and neuroimaging without