ライフサイエンスコーパス: oculomotor

1 surgical disruption to the anatomy (retinal/oculomotor).

2 mbers of individuals with autism demonstrate oculomotor abnormalities implicating pontocerebellar and

3 The oculomotor abnormalities with isolated infarction of the

4 ith gait ataxia, dysarthria, dysmetria, mild oculomotor abnormalities, and diffuse cerebellar atrophy

5 For perceptual decisions linked to oculomotor actions, neural correlates of sensory evidenc

6 a quantifiable trial-by-trial reflection of oculomotor activation, comparable to the monosynaptic mo

7 e activity provides a sensitive indicator of oculomotor activation, we show that single pulses of TMS

8 timulation pulses and varied with endogenous oculomotor activity at the time of stimulation.

9 evoked from the FEFs increased when presumed oculomotor activity was higher at the time of stimulatio

10 The bilateral distributions of trigemino-oculomotor afferents, levator motoneurons, and their den

11 of the split LR muscle can achieve excellent oculomotor alignment in some cases of third nerve palsy.

12 ns and suggest that the interrelationship of oculomotor and attention-related mechanisms extends to p

13 wing condition, thereby producing equivalent oculomotor and behavioural engagement.

14 hat suggest fundamental similarities between oculomotor and cephalomotor control, as well as a concep

15 absent olfactory sulci, olfactory bulbs and oculomotor and facial nerves, which support underlying a

16 Details regarding age, medical history, oculomotor and neurological examinations, and result of

17 We evaluated the framework in a series of oculomotor and reaching decision tasks and found that it

18 The prefrontal cingulate area (Cg), visual, oculomotor, and auditory areas provide strong input to t

19 d cortical regions involved in skeletomotor, oculomotor, and executive control.

20 RI, clinical, cognitive, quantitative motor, oculomotor, and neuropsychiatric assessments.

21 and clinical, cognitive, quantitative motor, oculomotor, and neuropsychiatric measures.

22 Manual, oculomotor, and perceptual sequence learning all support

23 down effective connectivity between frontal, oculomotor, and subcortical regions.

24 onsistent phenotype of recessive ataxia with oculomotor apraxia (AOA).

25 hic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2).

26 1.0 per 100,000 population), and ataxia with oculomotor apraxia (prevalence, 0.4 per 100,000 populati

27 Ataxia with oculomotor apraxia 1 is caused by mutation in the APTX g

28 ith three neuropathological diseases: ataxia oculomotor apraxia 1, spinocerebellar ataxia with neuron

29 d by heritable APTX mutations in ataxia with oculomotor apraxia 1.

30 The neurodegenerative disorder ataxia with oculomotor apraxia 2 (AOA-2) is caused by defects in sen

31 istinct neurological disorders: AOA2 (ataxia oculomotor apraxia 2) and ALS4 (amyotrophic lateral scle

32 and that, if mutated, results in ataxia with oculomotor apraxia 4 (AOA4) and microcephaly with early-

33 gressive cerebellar degeneration, ataxia and oculomotor apraxia in man.

34 APTX-deficient cell lines, human Ataxia with Oculomotor Apraxia Type 1 (AOA1) and DT40 chicken B cell

35 Ataxia oculomotor apraxia type 1 (AOA1) is an autosomal recessi

36 ETX cause the recessive disorder ataxia with oculomotor apraxia type 2 (AOA2) and a dominant juvenile

37 two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral

38 Friedreich's ataxia (FRDA) and ataxia with oculomotor apraxia type 2 (AOA2) are the two most freque

39 Ataxia oculomotor apraxia type 2 (AOA2) is a rare autosomal rec

40 by congenital cerebellar ataxia, hypotonia, oculomotor apraxia, and mental retardation.

41 cterized by cerebellar dysfunction, oromotor/oculomotor apraxia, emotional lability and mutism in pat

42 e mid-hindbrain and cerebellar malformation, oculomotor apraxia, irregular breathing, developmental d

43 isability, profound ataxia, camptocormia and oculomotor apraxia.

44 urons within the frontal eye field (FEF), an oculomotor area of the prefrontal cortex.

45 pha2-chimaerin signaling is required for key oculomotor axon guidance decisions, and provide a zebraf

46 alpha2-chn function results in stereotypical oculomotor axon guidance defects, which are reminiscent

47 growth promoting and chemoattractant during oculomotor axon guidance.

48 pf as a key axon guidance "transition," when oculomotor axons reach the orbit and select their muscle

49 ic and misguided branching and hypoplasia of oculomotor axons; embryos had defective eye movements as

50 tions moreover showed that a single model of oculomotor behavior can explain the saccadic continuum f

51 ts through which Purkinje cells influence an oculomotor behavior controlled by the cerebellum, the ho

52 y, despite the drastic changes introduced by oculomotor behavior in real life.

53 The results suggest that free-viewing oculomotor behavior reveals cognitive and emotional fact

54 ideo of the real-life visual scene, and free oculomotor behavior were simultaneously recorded in huma

55 e and assess perceptual decisions that guide oculomotor behavior.

56 aging and single-cell electroporation during oculomotor behaviors to map VPNI neural activity in zebr

57 at exploration and fixation are two distinct oculomotor behaviors.

58 squirrel monkey ventral paraflocculus during oculomotor behaviors.

59 therefore essential for reliable read-out of oculomotor behaviour.

60 reflected in the ongoing neural activity in oculomotor brain circuits, it is not known whether the d

61 igate is the superior colliculus, a midbrain oculomotor center responsible for the generation of sacc

62 ccomplished as an integrated movement across oculomotor, cephalomotor, and skeletomotor effectors.

63 ct those of error-related CS activity in the oculomotor cerebellum, suggesting that CS activity serve

64 plays a key role in assembling a functional oculomotor circuit.

65 d find that contrary to the classical model, oculomotor circuits in hindbrain rhombomeres 5-6 develop

66 Information flows from prefrontal to oculomotor circuits in the striatum, and directional err

67 Probing the oculomotor circuits with these decision-irrelevant sacca

68 y for a comprehensive assembly of functional oculomotor circuits.

69 Both the corollary discharge of the oculomotor command and eye muscle proprioception provide

70 put, suggesting that the brain monitored the oculomotor commands as the saccade unfolded, maintained

71 the incoming retinal signals lead to robust oculomotor commands because corrections are observed if

72 ng electrically evoked saccades, we examined oculomotor commands that developed during motion viewing

73 uld prolong the window of time available for oculomotor commands to drive an eye movement.

74 s time-varying retinal signals into saccadic oculomotor commands.

75 sed saccade curvature to investigate whether oculomotor competition across eye movements is represent

76 formed a sequence of saccades and we induced oculomotor competition by briefly presenting a task-irre

77 fast automatic component of visual input to oculomotor competition.

78 We have chosen the chick midbrain oculomotor complex (OMC) as a model with which to study

79 lei related to motor function, including the oculomotor complex and motor nucleus of the fourth, fift

80 beled from tracer injections into the caudal oculomotor complex were distributed in a crescent-shaped

81 ntion [4-10] and for mediodorsal thalamus in oculomotor control [11].

82 s species for decades, circuit mechanisms of oculomotor control and adaptation remain elusive.

83 ntial greatly to expand our understanding of oculomotor control and our ability to use this system as

84 This paper introduces a model of oculomotor control during the smooth pursuit of occluded

85 ntate nuclei (DN) contribution to volitional oculomotor control has recently been hypothesized but no

86 ing the circuitry underlying attentional and oculomotor control is a long-standing goal of systems ne

87 tail and suggest that a reduced precision in oculomotor control may be responsible for the visual acu

88 ditionally to maintain the accuracy of these oculomotor control processes across the lifespan, ongoin

89 ally, text is presented binocularly, and the oculomotor control system precisely coordinates the two

90 include drifts and microsaccades, are under oculomotor control, elicit strong neural responses, and

91 c consequence of damage to the substrates of oculomotor control, often is resistant to pharmacotherap

92 Caffeine exerts a protective effect on oculomotor control, which could be related to up-regulat

93 bdivisions, with the former also involved in oculomotor control.

94 nts provides new opportunities for examining oculomotor control.

95 es a unique opportunity to study DN in human oculomotor control.

96 d apply these tools to a classic question in oculomotor control.

97 The properties of the oculomotor corollary discharge can be probed by asking s

98 To investigate the consequences of this oculomotor cycle on the dynamics of perception, we combi

99 ay builds on the information dynamics of the oculomotor cycle.

100 thought to mediate response selection during oculomotor decision tasks.

101 w that parietal cortical neurons involved in oculomotor decisions encode, before an information sampl

102 Similar oculomotor deficits have been reported in individuals wi

103 al/brainstem motor system generating greater oculomotors deficits and swallowing difficulty; atrophy

104 ational model of the PFC circuit involved in oculomotor delayed response task.

105 etal cortical areas in monkeys performing an oculomotor, delayed match-to-sample task.

106 new type of eye movement serving a distinct oculomotor demand, namely the resetting of eye torsion,

107 ual learning supported generalisation to the oculomotor direct tests but did not support the consciou

108 tively evaluate value-based decisions in the oculomotor domain, independent of other brain regions.

109 ppress saccade generation by attenuating the oculomotor drive command in structures like the superior

110 cades (SoMs), supporting the notion that the oculomotor drive is weakened in the presence of a blink.

111 contrast to informal clinical evaluations of oculomotor dysfunction frequency (previous studies: 38%,

112 eye's orbit and extra-ocular muscles, or in oculomotor dysfunctions.

113 These results suggest that transient oculomotor events such as microsaccades, saccades, and b

114 Our results demonstrate that oculomotor function can be affected by decision formatio

115 Oculomotor function critically depends on how signals re

116 h pre- and early HD, as was deterioration in oculomotor function in early HD.

117 re have been no systematic analyses of basic oculomotor function in this population.

118 isually evoked eye movements rapidly restore oculomotor function in wild-type mice but are profoundly

119 othesis that the NPH, beyond its traditional oculomotor function, plays a critical role in conveying

120 the AER, restoring lost higher control over oculomotor function.

121 ht to determine whether specific patterns of oculomotor functioning and visual orienting characterize

122 ons on the recovery of posturo-locomotor and oculomotor functions through behavioral tests.

123 m frontal areas that have been implicated in oculomotor functions, whereas area 6Va received stronger

124 r network, including skeletomotor as much as oculomotor functions.

125 the supplementary eye field (SEF) during an oculomotor gambling task.

126 360 involves retinal rotation and subsequent oculomotor globe counterrotation and is not without sign

127 al circuits subserving spatial awareness and oculomotor goal-directed actions.

128 ion value for paralyzed patients with severe oculomotor impairments.

129 finding reveals that the visual system uses oculomotor-induced temporal modulations to sequentially

130 the main target of stabilizing extra-retinal oculomotor influences.

131 d subjects' gaze, thus overlooking potential oculomotor influences.

132 These results show that oculomotor information variably enhances auditory spatia

133 tion comes from visually guided reaching and oculomotor integration, in which the time course and tra

134 sired eye position was imaged throughout the oculomotor integrator after saccadic or optokinetic stim

135 ioral benefit possibly arising from auditory-oculomotor interactions at an earlier level of processin

136 HCI H2-K(b)/H2-D(b) (K(b)D(b-/-)), exhibited oculomotor learning deficits.

137 Oculomotor learning supported the use of conscious knowl

138 o examine this process, we designed a set of oculomotor learning tasks with more than one visual obje

139 error signals to reach the flocculus during oculomotor learning.

140 these results, we suggest a novel theory for oculomotor learning: a distributed representation of lea

141 The oculomotor loop controls eye movements and can direct re

142 re of failure of prefrontal control over the oculomotor loop.

143 es, but also suggest nonmotor recruitment of oculomotor machinery in decision making.

144 tions in retinotopicaly organized visual and oculomotor maps.

145 ch have investigated group differences using oculomotor measures, and explained them in terms of cult

146 directly fit the synaptic connectivity of an oculomotor memory circuit to a broad range of anatomical

147 iour, it did influence spatial selection and oculomotor metrics in a free-choice control task.

148 Future oculomotor models of vergence should incorporate phoria

149 oculomotor targets rather than generation of oculomotor movements.

150 l specimens, the iris, the ciliary body, and oculomotor muscles.

151 ion of the lateral rectus muscle by aberrant oculomotor nerve branches, which form at developmental d

152 4 and 72 h postfertilization (hpf), with the oculomotor nerve following an invariant sequence of grow

153 ation of the lateral rectus by fibers of the oculomotor nerve in DRS is secondary to absence of the a

154 or absent abducens nerves in all four, small oculomotor nerve in one, and small optic nerves in three

155 a selective vulnerability of the developing oculomotor nerve to perturbations of the axon cytoskelet

156 The developing axons of the oculomotor nerve's superior division stall in the proxim

157 ervation of the lateral rectus muscle by the oculomotor nerve.

158 ervation of the lateral rectus muscle by the oculomotor nerve.

159 rum of abnormalities including hypoplasia of oculomotor nerves and dysgenesis of the corpus callosum,

160 motor structures in the midbrain, including oculomotor nerves or nuclei, vertical supranuclear sacca

161 The hippocampus and the oculomotor network are well connected anatomically throu

162 step trials, greater activation in a frontal oculomotor network, including frontal and supplementary

163 SIGNIFICANCE STATEMENT: The hippocampal and oculomotor networks have each been studied extensively f

164 neurite outgrowth during development of the oculomotor neural network and that defects in this inter

165 ontrolling jaw musculature and ALS-resistant oculomotor neurons (OMNs) controlling eye musculature in

166 RNAi knockdown of alpha2-chn or PlexinAs in oculomotor neurons abrogates Sema3A/C-dependent growth c

167 dorsal Edinger-Westphal nucleus of visceral oculomotor neurons and a ventral nucleus of somatic ocul

168 All subgroups of oculomotor neurons are present, as well as their input a

169 ion in zebrafish, and increase the number of oculomotor neurons in the developing mouse in vitro and

170 Manipulation of chimaerin signaling in oculomotor neurons in vitro led to changes in microtubul

171 ar muscles and cause growth cone collapse of oculomotor neurons in vitro.

172 further show that alpha2-chn is required for oculomotor neurons to respond to CXCL12 and hepatocyte g

173 fects ongoing motor commands upstream of the oculomotor neurons, possibly at the level of the superio

174 ution, suggesting they drive these trigemino-oculomotor neurons.

175 tor neurons and a ventral nucleus of somatic oculomotor neurons.

176 demonstrated with neural data from cortical oculomotor neurons.

177 Deficits across oculomotor, neuropsychological, and psychological domain

178 obe spatial and temporal organization of the oculomotor (nIII) and trochlear (nIV) nuclei in the larv

179 MIF motoneurons lie around the periphery of oculomotor nuclei and have premotor inputs different fro

180 the NPH has historically been defined as an oculomotor nuclei and therefore its role in contributing

181 jected axons to the ipsilateral abducens and oculomotor nuclei, respectively.

182 in the anteromedian nucleus and between the oculomotor nuclei.

183 ted ventrolaterally and rostrally within the oculomotor nucleus (III).

184 Burst-tonic activity of 21 MRMNs in the oculomotor nucleus were recorded from two monkeys with e

185 Within the oculomotor nucleus, a much sparser ipsilateral projectio

186 e MLF, the superior cerebellar peduncle, the oculomotor nucleus, and the interstitial nucleus of Caja

187 of A- and B-group motoneurons lay within the oculomotor nucleus, but those of the C-group motoneurons

188 In the oculomotor nucleus, CR was specifically found in punctat

189 c neuron, interneuron, abducens nucleus, and oculomotor nucleus, is developed to examine saccade dyna

190 ie adjacent to the dorsomedial border of the oculomotor nucleus, whereas MR neurons are located farth

191 ich lies rostral, dorsal, and ventral to the oculomotor nucleus.

192 re found caudally, dorsal and ventral to the oculomotor nucleus.

193 manual (key presses, without eye movements), oculomotor (obligatory eye movements), or perceptual (co

194 We injected an anterograde tracer into the oculomotor or abducens nuclei and combined tracer visual

195 tem, these may be vestibulospinal, vestibulo-oculomotor or vestibulocerebellar neurons.

196 The combination of the well-tolerated oculomotor paradigm and the sensitivity of the model-bas

197 Using a novel oculomotor paradigm, combined with reinforcement learnin

198 which neuronal responses remain invariant to oculomotor parameters and viewing conditions.

199 Other oculomotor parameters, such as the accuracy of saccades

200 he influence of the cerebellar cortex on the oculomotor pathway reduces the amplitude of ocular tremo

201 These results characterize a trigemino-oculomotor pathway that inhibits levator palpebrae moton

202 A non-oculomotor perceptual task (global motion processing) wa

203 Nonetheless, a monkey's oculomotor performance is accurate during this time.

204 e relative contribution of each input to the oculomotor physiology, single-unit recordings from media

205 t dorsal LIP (LIPd) is primarily involved in oculomotor planning, whereas ventral LIP (LIPv) contribu

206 suggest task specificity in the learning of oculomotor plans in response to changes in front-end sen

207 e domain-specific representations of learned oculomotor plans in the brain.SIGNIFICANCE STATEMENT The

208 instantiated in FEF as a competition between oculomotor plans, in agreement with model predictions.

209 idbrain is presented to drive a muscle fiber oculomotor plant during horizontal monkey saccades.

210 Accumulating evidence shows that the oculomotor plant is capable of implementing aspects of t

211 Here we test the capability of the oculomotor plant to rearrange itself as necessary for no

212 ications for the understanding of visual and oculomotor plasticity as well as for the development of

213 Such oculomotor plasticity has generally been studied under c

214 Here we examine oculomotor plasticity when error signals are independent

215 sing these interneuronal correlations yields oculomotor predictions that are more accurate and also l

216 ted with selective visual attention, and not oculomotor preparation.

217 P (LIPv) contributes to both attentional and oculomotor processes.

218 We suggest the posterior cortical atrophy oculomotor profile (e.g. exacerbation of the saccadic ga

219 Anterograde labeling of the trigemino-oculomotor projection indicates that it terminates bilat

220 successful implantation of a novel magnetic oculomotor prosthesis in a patient.

221 2-part, titanium-encased, rare-earth magnet oculomotor prosthesis, powered to damp nystagmus without

222 new field of implantable therapeutic devices-oculomotor prosthetics-designed to modify eye movements

223 oss blinks or might depend on a more general oculomotor recalibration mechanism adapting gaze positio

224 s both as the locus for fixations and as the oculomotor reference for saccades.

225 to be adaptively adjusted relative to other oculomotor reflexes and thereby ensuring image stability

226 ity of CDt neurons may be transmitted to the oculomotor region so that animals can choose high-valued

227 irst time, that Golgi cells express a unique oculomotor-related signal that can be used to provide st

228 auditory midbrain nucleus, shows visual and oculomotor responses [4-6] and modulations of auditory a

229 tion, as evident in trial-to-trial imprecise oculomotor responses.

230 st the C-group motoneurons serve a different oculomotor role than the others.

231 related with increased activation across the oculomotor saccade system.

232 Moreover, these decision-related oculomotor signals, along with the time needed to initia

233 ric disorders, producing measurable atypical oculomotor signatures.

234 atients to perform well in both paradigms is oculomotor skill and/or eye movement strategy.

235 interpreted as a priority map for saccades (oculomotor-specific) or a salience map of space (not eff

236 indicate that microsaccades are part of the oculomotor strategy by which the visual system acquires

237 t corollary discharge signal is generated by oculomotor structures and communicated to sensory system

238 ether the decision-related activity in those oculomotor structures interacts with eye movements that

239 Although the motor-related activity within oculomotor structures seems a likely source of the enhan

240 ive mixture of motor and decision signals in oculomotor structures, but also suggest nonmotor recruit

241 Oculomotor studies in ALS have described deficits in ant

242 Oculomotor surgery appears not to limit reading ability,

243 How would the oculomotor system adjust to a loss of foveal vision (cen

244 this study we examine central fatigue in the oculomotor system after prolonged exercise.

245 ings therefore demonstrate a coupling of the oculomotor system and ongoing heartbeat, which provides

246 Our findings implicate the oculomotor system as a potential substrate for how cogni

247 e results advance the suitability of the NHP oculomotor system as an animal model for TMS.

248 We found that the oculomotor system can detect fluctuations in the velocit

249 Here, we demonstrate that the oculomotor system can spontaneously and rapidly adopt a

250 Here, we show that the oculomotor system constantly recalibrates gaze direction

251 The oculomotor system contains a simple example, a hindbrain

252 The oculomotor system continually brings targets of interest

253 logically plausible, none have looked to the oculomotor system for design constraints or parameter sp

254 observation, it has been postulated that the oculomotor system has access to hand efference copy, the

255 A leading hypothesis is that the oculomotor system has access to hand motor signals.

256 It is currently thought that the primate oculomotor system has evolved distinct but interrelated

257 d clear evidence for dysfunctional CD in the oculomotor system in patients with schizophrenia.

258 The impact of central fatigue on the oculomotor system is currently unexplored.

259 The human oculomotor system is impaired by strenuous exercise of t

260 During behavior, the oculomotor system is tasked with selecting objects from

261 r also accompany covert orienting; hence the oculomotor system may provide an alternative substrate f

262 Encoding horizontal eye position in the oculomotor system occurs through temporal integration of

263 The oculomotor system of nonhuman primates (NHPs) offers a p

264 e fields (FEFs), a cortical component of the oculomotor system strongly connected to the intermediate

265 data reveal a basic guiding principle of the oculomotor system that prefers control simplicity over o

266 The oculomotor system therefore provides a plausible pathway

267 ned that, if the output of M1 is used by the oculomotor system to keep track of the target, on top of

268 resenting the peak of the map is used by the oculomotor system to target saccades and by the visual s

269 to a relevant contribution of the peripheral oculomotor system to the strabismic condition.

270 Efference copy from the oculomotor system to the visual system has been suggeste

271 ine-tuning eye movements extends even to the oculomotor system's smallest saccades and add to a growi

272 n previously, pursuit trials potentiated the oculomotor system, producing anticipatory eye velocity o

273 t, if hand motor signals are accessed by the oculomotor system, this is upstream of M1.

274 t, if hand motor signals are accessed by the oculomotor system, this is upstream of M1.SIGNIFICANCE S

275 fore the efference copy could be used by the oculomotor system.

276 visual stimulation, and are specific to the oculomotor system.

277 l analysis of the accommodation and vergence oculomotor systems with a view to understanding factors

278 cate greater impairment of identification of oculomotor targets rather than generation of oculomotor

279 accades and antisaccades, a well established oculomotor task for testing cognitive control.

280 Combining TMS with an oculomotor task revealed state dependency, with TMS evok

281 latta) that performed a metacognitive visual-oculomotor task.

282 lated functional MRI during a working-memory oculomotor task.

283 Many oculomotor tasks depend on integration of eye-velocity s

284 ing: (1) target selection in both manual and oculomotor tasks, (2) limb usage in a manual retrieval t

285 e of voluntary neurophysiological motor, and oculomotor tasks, and cognitive and neuropsychiatric dys

286 estigated PFC functions with arm-reaching or oculomotor tasks, thus leaving unclear whether, and to w

287 laminae provides a subcortical basis for the oculomotor theory of attention.

288 manual baseline condition and the manual to oculomotor transfer condition differed in the magnitude

289 f transgene expression, whereas those in the oculomotor, trigeminal, and facial nuclei are spared.

290 , and visual nuclei) and motor nuclei (e.g., oculomotor, trochlear, trigeminal motor, abducens, and v

291 m three anatomical nuclei of the normal rat, oculomotor/trochlear (cranial nerve 3/4), hypoglossal (c

292 n of neurons comprising the larval zebrafish oculomotor velocity-to-position neural integrator.

293 The oculomotor vermis (OMV) of the cerebellum is necessary f

294 n the direction of gaze called saccades, the oculomotor vermis (OMV) of the cerebellum must be intact

295 Optical stimulation of the oculomotor vermis caused saccade dysmetria.

296 Therefore, many P-cells in the oculomotor vermis exhibit changes in SS activity specifi

297 These results establish that the oculomotor vermis helps control the characteristics of n

298 lude that the plasticity at the level of the oculomotor vermis is more fundamentally important for fo

299 e we analysed Purkinje-cell discharge in the oculomotor vermis of behaving rhesus monkeys (Macaca mul

300 ed the activity of identified P-cells in the oculomotor vermis, lobules VIc and VII.