ライフサイエンスコーパス: odontoblast

1 associated with pre-secretory ameloblast and odontoblast.

2 prevented their differentiation into mature odontoblasts.

3 functions in the kidney as compared with the odontoblasts.

4 genic and Bmp2-dependent VegfA production in odontoblasts.

5 removal of the Bmp2 gene in early-polarizing odontoblasts.

6 upted and erupted incisors that give rise to odontoblasts.

7 ntoblast polarization and reduced numbers of odontoblasts.

8 cells capable of generating ameloblasts and odontoblasts.

9 bserved in secretory stage ameloblasts or in odontoblasts.

10 , whereas Osx expression was clearly seen in odontoblasts.

11 ly undescribed novel gene synthesized by the odontoblasts.

12 g tooth enamel and reported to be present in odontoblasts.

13 hic chondrocytes, and ameloblasts as well as odontoblasts.

14 cell-specific expression of the DSPP gene in odontoblasts.

15 differentially regulated in osteoblasts and odontoblasts.

16 or the transcriptional regulation of DSPP in odontoblasts.

17 DNA binding site using nuclear extracts from odontoblasts.

18 ypes including neural cells, adipocytes, and odontoblasts.

19 e-related, inter-dependent, and regulated by odontoblasts.

20 l retrieval of total RNA from microdissected odontoblasts.

21 responsible for the formation of functional odontoblasts.

22 at a lower level in bone than in dentin and odontoblasts.

23 xpress active TGF-beta1 predominantly in the odontoblasts.

24 ion of this gene is tightly regulated in the odontoblasts.

25 ected TIP39 RNA in secretory ameloblasts and odontoblasts.

26 ential for differentiation of ameloblasts or odontoblasts.

27 is expressed exclusively in ameloblasts and odontoblasts.

28 resident ion channels in freshly dissociated odontoblasts.

29 and is restricted to mature osteoblasts and odontoblasts.

30 ajor transcripts of 4.4 and 2.2 kilobases in odontoblasts.

31 cytes, and, occasionally, in molar pulp horn odontoblasts.

32 pressed in the center of pulp niches but not odontoblasts.

33 te to tooth formation and differentiate into odontoblasts.

34 g osteocytes, hypertrophic chondrocytes, and odontoblasts.

35 scription was mediated by Dlx3 and/or Osx in odontoblasts.

36 DSP is mainly expressed in odontoblasts.

37 ontoblasts in comparison with WT and Dspp-Tg odontoblasts.

38 e number of DMP1-GFP(+) and DSPP-Cerulean(+) odontoblasts.

39 ranscriptional regulation of TRP channels in odontoblasts.

40 hymal stem cells that produce pulp cells and odontoblasts.

41 d TRPM8 that has previously been reported in odontoblasts.

42 exposure, ephrinB1 was strongly expressed in odontoblasts 4 wk postinjury.

43 oth structures formed that contained dentin, odontoblasts, a well-defined pulp chamber, putative Hert

44 These studies suggest that odontoblasts actively synthesize and secrete amelogenin

45 n 1 (DMP1) and dentin sialophosphoprotein in odontoblasts, along with a sharply reduced expression of

46 sor, but the rescued teeth exhibit a delayed odontoblast and ameloblast differentiation.

47 identify a further late function of Msx1 in odontoblast and dental pulp survival.

48 rocessed fragments in extracts from the pulp/odontoblast and dentin.

49 xpress marker genes of tooth-specific cells, odontoblasts and ameloblasts.

50 ecific markers for terminally differentiated odontoblasts and are encoded by a single gene DSPP (dent

51 t are expressed by terminally differentiated odontoblasts and are responsible for the formation of ti

52 Col2.3-GFP(+) cells composed of both Dspp(+) odontoblasts and Bsp(+) osteoblasts.

53 dditional late survival function for Msx1 in odontoblasts and dental pulp.

54 ovide evidence that continuous generation of odontoblasts and dentin on the labial and lingual sides

55 otein (DSPP) is a major secretory product of odontoblasts and is critical for proper dentin formation

56 otein (DSPP) is a major secretory product of odontoblasts and is critical for proper tooth dentin for

57 sis showed high expression levels of DMP4 in odontoblasts and low levels in osteoblasts and ameloblas

58 EphrinB1 was continuously expressed in odontoblasts and odontoblastic processes until the compl

59 tion to obtain homogenous populations of pre-odontoblasts and odontoblasts from tissue sections of mo

60 Odontoblasts and osteoblasts develop from multipotent cr

61 that DMP1 is essential in the maturation of odontoblasts and osteoblasts, as well as in mineralizati

62 formation as these cells differentiate into odontoblasts and osteoblasts, respectively.

63 Results showed that odontoblasts and osteocytes were specifically targeted,

64 ls for expression/deletion of other genes in odontoblasts and osteocytes.

65 These two proteins are expressed in odontoblasts and preameloblasts as a single cDNA transcr

66 n (Dspp) is mainly expressed in teeth by the odontoblasts and preameloblasts.

67 olling Bmp4 expression in mesenchyme-derived odontoblasts and pulp cells existed in other regions of

68 were injected either at the interface of the odontoblasts and the dentin or into the pulp core of man

69 ated immunoreactivity of pannexin 1 and 2 in odontoblasts and their processes extending into the dent

70 y that these cells can be a single source of odontoblasts and vascular networks in dental tissue engi

71 liferating dental epithelium, differentiated odontoblast, and also hair follicle matrix epithelium.

72 contribute to the formation of pulp cells or odontoblasts, and at ratios of 1:1, they inhibit tooth f

73 ed FAM20A in secretory-stage ameloblasts, in odontoblasts, and in the eruption pathway.

74 TBC1D19 colocalized with DLX3 expression in odontoblasts, and MT-DLX3 significantly reduced expressi

75 dental papilla specific cell types, such as odontoblasts, and produce dentin, if placed in contact w

76 ncrease of immature odontoblasts, few mature odontoblasts, and sharply reduced dentinal tubules; and

77 s 8/9-encoded proteins in ameloblasts, young odontoblasts, and stratum intermedium cells.

78 s that fill the extracellular space, support odontoblasts, and/or facilitate the transport function o

79 rated a mouse in which Tgfbr2 was deleted in odontoblast- and bone-producing mesenchyme.

80 t odontoblast cytodifferentiation leading to odontoblast apoptosis, and aberrations of dentin tubule

81 TUNEL assays indicated enhanced odontoblast apoptosis.

82 eth, such as mouse and human molars, primary odontoblasts are long-lived post-mitotic cells that secr

83 Odontoblasts are nonneuronal cells that possess many of

84 gical functions of this growth factor in the odontoblasts are not clearly understood.

85 In severe injury, necrotic odontoblasts are replaced by other pulp cells, which are

86 cascade of gene expression in the exogenous odontoblasts as the dentin formed de novo.

87 both the differentiation and maintenance of odontoblasts as well as in dentin formation.

88 is possible to study ionic mechanisms of the odontoblast at the level of the single cell.

89 ing quality RNA from discrete populations of odontoblasts at different stages of dentinogenesis.

90 lty of targeting the papilla and presumptive odontoblasts at early stages of tooth development.

91 d EphB2 were expressed in preodontoblast and odontoblasts at postnatal day 4.

92 ovides a novel tool for the investigation of odontoblast biology.

93 and nuclear translocation of Dlx3 and Osx in odontoblasts both in vitro and in vivo.

94 erentially bound dental mesenchyme cells and odontoblasts but not dental epithelial cells or nondenta

95 progenitors in pulp cultures into functional odontoblasts but prevented their differentiation into ma

96 PV1, and TRPV4 but not TRPM8 was detected in odontoblasts by reverse transcription polymerase chain r

97 Thus, a transformed odontoblast cell line was created with high proliferativ

98 Therefore, generation of an odontoblast cell line would be a valuable reproducible t

99 howed that the DSPP promoter is active in an odontoblast cell line, MO6-G3, with basal activity mappe

100 In this study an immortalized odontoblast cell line, which has the required biochemica

101 otein 1 (DMP1) is expressed in both pulp and odontoblast cells and deletion of the Dmp1 gene leads to

102 naling pathways from the mesenchymal derived odontoblast cells and the epithelially derived ameloblas

103 1 transgene was highly expressed in pulp and odontoblast cells during post-natal developmental stages

104 soforms were expressed in preodontoblast and odontoblast cells, and in situ hybridization assay showe

105 ialophosphoprotein is expressed primarily by odontoblast cells, but is also transiently expressed by

106 r interest to understand ionic mechanisms in odontoblast cells.

107 be tooth-specific being expressed mostly by odontoblast cells.

108 ctivation of inflammatory pathways while the odontoblast cluster showed greater disturbances in trans

109 licular type while 6/7 of the samples in the odontoblast cluster were of the plexiform type (p < 0.05

110 The pulp-odontoblast complex and dentin were extracted, chromatog

111 However, a mechanism by which odontoblasts could modulate neuronal activity has not be

112 e data indicate that MT-DLX3 acts to disrupt odontoblast cytodifferentiation leading to odontoblast a

113 decreased dentin was accompanied by altered odontoblast cytology that included disruption of odontob

114 preameloblasts and continuously expressed in odontoblasts demonstrating that this -5 kb rat promoter-

115 condensed dental mesenchyme, dental papilla, odontoblasts, dentine matrix, pulp, cementum, periodonta

116 mal stem cells giving rise to pulp cells and odontoblasts derive from neural crest cells after their

117 In contrast, odontoblasts did not express mRNA for type I collagen.

118 Ablation of Smad4 results in defects in odontoblast differentiation and dentin formation.

119 ficult to establish whether Osx functions in odontoblast differentiation and dentin formation.

120 , which were likely caused by disruptions in odontoblast differentiation and dentin formation.

121 neural crest results in major impairment of odontoblast differentiation and dentin production.

122 Studies of odontoblast differentiation and function have been limit

123 sed, whereas Runx2 was down-regulated during odontoblast differentiation and maturation.

124 xposure of pulp cells to FGF2 alone promotes odontoblast differentiation and provides critical insigh

125 studying the modulatory effects involved in odontoblast differentiation as well as the molecular eve

126 tin sialophosphoprotein (DSPP), an important odontoblast differentiation marker, is necessary for too

127 age-specific activation of transgenes during odontoblast differentiation to FGF2.

128 that BMP2 mediates DSPP gene expression and odontoblast differentiation via NF-Y signaling during to

129 n and reduced Dspp expression indicated that odontoblast differentiation was disrupted in the mutant

130 rated that the inhibitory effects of FGF2 on odontoblast differentiation were mediated through activa

131 owed that the stimulatory effects of FGF2 on odontoblast differentiation were mediated through FGFR/M

132 data suggest that DMP1 is a key regulator of odontoblast differentiation, formation of the dentin tub

133 is required for root formation by regulating odontoblast differentiation, maturation, and root elonga

134 ever, was apparently delayed, due to delayed odontoblast differentiation, mediated by a limited numbe

135 that Twist-1 plays a key role in restraining odontoblast differentiation, thus maintaining homeostasi

136 ous exposure of pulp cells to FGF2 inhibited odontoblast differentiation, whereas early and limited e

137 nx2 and Osx are necessary for osteoblast and odontoblast differentiation, while Dspp is important for

138 , respectively, during the advanced stage of odontoblast differentiation.

139 differentiation, while Dspp is important for odontoblast differentiation.

140 2 regulates DSPP gene transcription and thus odontoblast differentiation.

141 gulation of genes that control osteoblast or odontoblast differentiation.

142 emonstrate that Klf5 plays a pivotal role in odontoblast differentiation.

143 nflicting results regarding their effects on odontoblast differentiation.

144 age-specific activation of transgenes during odontoblast differentiation.

145 regulating the inhibitory effects of FGF2 on odontoblast differentiation.

146 conflicting results regarding its effects on odontoblast differentiation.

147 sue-specific promoter activity and prompting odontoblast differentiation.

148 ells to FGF2 resulted in marked increases in odontoblast differentiation.

149 egulating the stimulatory effects of FGF2 on odontoblast differentiation.

150 ption factors Dlx3 and Osx are essential for odontoblasts differentiation.

151 The expression of Klf5, odontoblast-differentiation markers, Dspp and Dmp1 was c

152 en expression by odontoblasts indicates that odontoblasts do not play an active role in attempts at r

153 trix protein-1 (DMP-1) gene is identified in odontoblasts during both embryonic and postnatal develop

154 opulation also makes a small contribution to odontoblasts during primary dentinogenesis.

155 o(+) cells to a small number of newly formed odontoblasts during primary dentinogenesis.

156 ble of giving rise to a second generation of odontoblasts during reparative dentinogenesis.

157 ne the contribution of perivascular cells to odontoblasts during the development, growth, and repair

158 n response to hypoxic challenge neurosensory odontoblasts express hypoxia-inducible factor-1alpha and

159 Odontoblasts expressed the gap junction protein, connexi

160 asts synthesizing enamel matrix proteins and odontoblasts expressed the gene.

161 Odontoblasts extending their cellular processes into the

162 ent third molar; (4) an increase of immature odontoblasts, few mature odontoblasts, and sharply reduc

163 xpression is required in both early and late odontoblasts for normal odontogenesis to proceed.

164 mogenous populations of pre-odontoblasts and odontoblasts from tissue sections of mouse molar cusp ti

165 Additionally, odontoblast function and pulp vitality are sustained whe

166 netic protein 2 (BMP2) plays a vital role in odontoblast function via diverse signal transduction sys

167 Odontoblasts have been suggested to contribute to therma

168 The DSP domain regulates DSPP expression and odontoblast homeostasis via a positive feedback loop.

169 at is initially expressed by ameloblasts and odontoblasts immediately prior to the onset of dentin mi

170 have shown that high Trps1 levels in mature odontoblasts impair their function in vitro and in vivo.

171 entify the formation of tooth pulp cells and odontoblasts in bioengineered teeth.

172 are detected in both Trps1-Tg and double-Tg odontoblasts in comparison with WT and Dspp-Tg odontobla

173 Odontoblasts in dentin and osteocytes in bone contain de

174 14 mRNA was expressed by preodontoblasts and odontoblasts in developing teeth.

175 well-characterized, cells giving rise to the odontoblasts in incisors have not been fully characteriz

176 Reactionary dentin is secreted by surviving odontoblasts in response to moderate stimuli, leading to

177 in osteoblasts in virtually all bones and in odontoblasts in teeth of both embryos and postnatal mice

178 apoptotic marker caspase-3 were increased in odontoblasts in TG mice as well as in odontoblastic-like

179 The odontoblasts in the Bmp2-cKO(od) do not mature properly

180 retention in mature ameloblasts and immature odontoblasts in the continually erupting incisor.

181 entin, a major tooth component, is formed by odontoblasts; in contrast, bone is produced by osteoblas

182 Lack of collagen expression by odontoblasts indicates that odontoblasts do not play an

183 deposition of dentin sialophosphoprotein by odontoblasts into the adjacent MDP hydrogel, indicating

184 rotein (Dspp) as a differentiation marker of odontoblasts is regulated by BMP-2.

185 OC expression in calvarial osteoblasts and odontoblasts is regulated in part via protein-protein in

186 the nucleus during early differentiation of odontoblasts, is able to bind specifically with the DSPP

187 preodontoblasts, while in mature, secretory odontoblasts, it is expressed at low levels.

188 In the odontoblasts, its primary function is in the extracellul

189 dentin matrix, is strongly down-regulated in odontoblasts lacking Dlx3.

190 showed only moderate disorganization of the odontoblast layer at 24 hours that completely re-organiz

191 Additionally, the odontoblast layer is structurally preserved in appositio

192 d functional ecto-ATPase activity within the odontoblast layer, subodontoblast layer, dental pulp ner

193 bundles, Raschkow's nerve plexus, and in the odontoblast layer.

194 was localized close to connexin43 within the odontoblast layer.

195 ing the nerve fibers and projecting into the odontoblast layer.

196 ripheral area of the tissue just beneath the odontoblast layer.

197 arity and organization of the ameloblast and odontoblast layers is disrupted.

198 The cells demonstrated odontoblast-like appearances with elongated bodies and l

199 systems on growth factor solubilization and odontoblast-like cell differentiation of human dental pu

200 Overexpression of Nma/BAMBI in the mouse odontoblast-like cell line MD10-A2 down-regulated expres

201 to the dental pulp cells and restored their odontoblast-like cell phenotype to a biologically signif

202 Dental pulp cells and mouse odontoblast-like cells (MDPC-23) (+/-) treated with G5-F

203 Odontoblast-like cells (MDPC-23) and undifferentiated pu

204 gulates expression of VEGF, we exposed mouse odontoblast-like cells (MDPC-23), undifferentiated pulp

205 Mouse odontoblast-like cells (MDPC-23), undifferentiated pulp

206 spreading and proliferation of encapsulated odontoblast-like cells (OD21), and the formation of endo

207 d functional TRP channel expression in human odontoblast-like cells and measured ATP release in respo

208 cells, which are able to differentiate into odontoblast-like cells and produce a reparative dentin.

209 ogenesis and processed into fragments in the odontoblast-like cells and the tooth compartments.

210 New odontoblast-like cells are only produced in response to

211 Cell lines that differentiate into odontoblast-like cells are useful tools for studying the

212 ivation of TRPA1 and TRPV4 channels in human odontoblast-like cells can stimulate ATP release.

213 and calcium microfluorimetry, we showed that odontoblast-like cells express TRPA1 and TRPV4 and that

214 cells to proliferate and differentiate into odontoblast-like cells in response to dentine damage.

215 ghout the scaffold with differentiation into odontoblast-like cells near the dentinal walls.

216 ression of human mitochondria, and contained odontoblast-like cells organized along the dentin, as as

217 zed by the expression of CD31, and contained odontoblast-like cells organized along the length of the

218 xin2-expressing cells differentiate into new odontoblast-like cells that secrete reparative dentine.

219 ted a dentin-like structure lined with human odontoblast-like cells that surrounded a pulp-like inter

220 Short treatment of odontoblast-like cells with tumor necrosis factor (TNF)-

221 In mouse odontoblast-like cells, Osx overexpression increased Dsp

222 tes Nma/BAMBI's expression levels in MD10-A2 odontoblast-like cells.

223 mesenchymal precursor cells into functional odontoblast-like cells.

224 e cells to differentiate and form functional odontoblast-like cells.

225 In this study, the regulation of odontoblast-like differentiation of DPSCs by canonical W

226 nical Wnt signaling negatively regulates the odontoblast-like differentiation of DPSCs.

227 showed that the effects of FGF2 on cells in odontoblast lineage were stage-specific and depended on

228 essing the alphaSMA-CreERT2 transgene to the odontoblast lineage.

229 and Osx in the regulation of osteoblast and odontoblast lineages may be independent of one another.

230 5 represses the expression of early and late odontoblast marker genes and stage-specific proteases in

231 ization as follows: 1) Trps1 is required for odontoblast maturation by supporting expression of genes

232 NA 665 (miR-665) as a potential repressor of odontoblast maturation.

233 nderstanding the physiological properties of odontoblasts may be important in understanding the mecha

234 ion along with the other cellular changes in odontoblasts may result in human hereditary dental disor

235 r ion channels that presumably reside in the odontoblast membrane, our results demonstrate that it is

236 s, we saw two separate anion channels in the odontoblast membrane.

237 entiation and cell fate, oral epithelial and odontoblast mesenchymal cells were reprogrammed by a two

238 ession in mouse preodontoblast (MD10-F2) and odontoblast (MO6-G3) cells.

239 In undifferentiated odontoblasts, Nrf1 and C/EBPbeta repress DSPP promoter a

240 lysin was detectable only in ameloblasts and odontoblasts of developing teeth.

241 otch expression in the dental pulp cells and odontoblasts of DSPP-null mice when compared with wild-t

242 neural crest cells do, in fact, give rise to odontoblasts of trunk dermal denticles.

243 ls give rise to the dentine-producing cells (odontoblasts) of teeth.

244 cribe an indirect effect of the Bmp2 gene in odontoblasts on formation of the vascular bed and associ

245 elin is expressed by ameloblasts, but not by odontoblasts or other cells in the dental pulp.

246 Altered odontoblast organization and reduced Dspp expression ind

247 of a variety of mesenchymal cells, including odontoblasts, osteoblasts, and cementoblasts.

248 ouble-Tg) mice in which Dspp was restored in odontoblasts overexpressing Trps1.

249 ized dental pulp cells were driven toward an odontoblast phenotype by culture in conditioned media.

250 xpression for progressive development of the odontoblast phenotype.

251 enoviral expression system failed to express odontoblast-phenotypic specific genes.

252 defects in the maturation of ameloblasts and odontoblasts point to an important and non-redundant rol

253 may contribute to the observed disruption of odontoblast polarity and apoptosis.

254 toblast cytology that included disruption of odontoblast polarization and reduced numbers of odontobl

255 d eruption rates, decreased proliferation of odontoblast precursors, and increased cell apoptosis in

256 s localized in the dentin, presumably in the odontoblast processes.

257 mechanisms that maintain the equilibrium of odontoblast progenitor cells in dental pulp are unknown.

258 A rat incisor tooth odontoblast pulp cDNA library was screened using probes

259 hen isolated from the developing tooth germ, odontoblasts quickly lose their potential to maintain th

260 olds are intercalated between dentin and the odontoblast region, a finding that has significant impli

261 critical and context-dependent functions in odontoblast-regulated mineralization as follows: 1) Trps

262 nd so the embryonic origin of trunk denticle odontoblasts remains unresolved.

263 Functional differentiation of odontoblasts requires unique sets of genes being turned

264 s 0 and 3, gene expression in laser-captured odontoblasts resembled that seen in vivo by in situ hybr

265 l-secreting ameloblasts and dentin-secreting odontoblasts, respectively.

266 etermine the role of TGF-beta1 in modulating odontoblast responses to oral bacteria.

267 ited TLR2 and TLR4 expression and attenuated odontoblast responses.

268 ffect of inflammation on the activity of the odontoblast's mechanosensitive channels remains unknown.

269 MDP scaffolds injected into the pulp core or odontoblast space.

270 periphery of MDP scaffolds injected into the odontoblast space.

271 ng the process of analyzing the 3' end of an odontoblast-specific cDNA which codes for dentin sialopr

272 Odontoblast-specific expression of TGF-beta1 in the toot

273 Odontoblast-specific gene expression was studied by RT-P

274 ctor) was not required for the expression of odontoblast-specific genes, indicating the involvement o

275 Tooth injury in mice with odontoblast-specific IGF-1 receptor ablation exhibited a

276 quickly lose their potential to maintain the odontoblast-specific phenotype.

277 cating the involvement of other unidentified odontoblast-specific transcription factors or coactivato

278 To identify genes that are odontoblast-specific, a subtractive hybridization techni

279 Osteoblasts and odontoblasts synthesize a polymeric collagenous matrix,

280 ains 2 additional exons; (2) ameloblasts and odontoblasts synthesize amelogenin 8/9; and (3) amelogen

281 In dentin, the odontoblasts synthesize several biomolecules that functi

282 expressed by chondrocytes, osteoblasts, and odontoblasts that functions in skeletal and dentin miner

283 s through the activity of specialized cells, odontoblasts, that are thought to be maintained by an as

284 In fully differentiated odontoblasts, the loss of interaction between Nrf1 and C

285 stribution of MMP9 and DSP overlapped in the odontoblasts, the predentin, and the mineralized dentin,

286 Terminal differentiation of odontoblasts, the principal cells in dentin formation, p

287 During cytodifferentiation of odontoblasts there is a constant change of actively tran

288 lls, fibroblasts to smooth muscle cells, and odontoblasts to adipocytes.

289 n the dentine that are believed to stimulate odontoblasts to secrete new "tertiary" dentine (reaction

290 Re-expression of Dmp1 in early and late odontoblasts under control of the Col1a1 promoter rescue

291 Damage to odontoblasts under injured dentin caused increased influ

292 binding protein expressed in osteoblasts and odontoblasts undergoing mineralization.

293 In contrast, re-expression of Dmp1 in mature odontoblasts, using the Dspp promoter, produced only a p

294 -protein interaction between Dlx3 and Osx in odontoblasts was detected by co-immunoprecipitation.

295 at the total RNA from three-day-old captured odontoblasts was sufficient in quantity and quality.

296 on differentiation of progenitor cells into odontoblasts were stage specific and dependent on the st

297 nsdifferentiation capacities into functional odontoblasts when transplanted into the root canal micro

298 weakly present in osteoblasts, but strong in odontoblasts where Osx was highly expressed.

299 acellular tubules, and then concentrates in odontoblasts, where it remains for weeks.

300 y stage ameloblasts but could be detected in odontoblasts, while transition-stage and maturation-stag