ライフサイエンスコーパス: odorant receptor

1 hemical communication (e.g., desaturases and odorant receptors).

2 each neuron normally expresses only a single odorant receptor.

3 ory receptor neuron (ORN) expresses a single odorant receptor.

4 ed into glomeruli according to the expressed odorant receptor.

5 responsive sensory neurons expressing the I7 odorant receptor.

6 teractions among neurons expressing the same odorant receptor.

7 (ORNs), which in turn depends ultimately on odorant receptors.

8 of the olfactory system, including OBPs and odorant receptors.

9 might limit rather than facilitate access to odorant receptors.

10 eptors is a previously unrecognized class of odorant receptors.

11 omplexity of odorant encoding in the bed bug odorant receptors.

12 and functional expression of representative odorant receptors.

13 in high throughput de-orphaning of mammalian odorant receptors.

14 ffective in eliciting responses from bed bug odorant receptors.

15 hen compared to other chemodetectors such as odorant receptors.

16 ive (GC-D+) neurons are not known to express odorant receptors.

17 nt is detected by a combination of different odorant receptors.

18 ggests a chemosensory function distinct from odorant receptors.

19 icts that it is coexpressed with a subset of odorant receptors.

20 ophobic odorants through an aqueous lymph to odorant receptors.

21 OSNs expressing mouse odorant receptor 23 (MOR23) are relatively broadly tuned

22 In vitro, ECB(Z) odorant receptor 3 (OR3), a sex pheromone receptor expre

23 able expansions of gustatory (116 genes) and odorant receptors (367 genes), an abundance of cytochrom

24 the expression and ligand-sensitivity of the odorant receptor AaegOr4, which we found recognizes a co

25 uantitative relationship between patterns of odorant receptor activation, the resulting internal repr

26 d model that captures the main mechanisms of odorant receptor activation.

27 s much of the conventional Anopheles gambiae odorant receptor (AgOR) repertoire was carried out in Xe

28 ctionally characterize the Anopheles gambiae odorant receptor (AgOr) repertoire.

29 have identified a subset of the An. gambiae odorant receptors (AgOrs) that are localized to discrete

30 hereas the other ORNs express characteristic odorant receptors (AgORs) that are responsible for their

31 nsory gene transcripts, although a subset of odorant receptors (AgOrs) was modestly enhanced in post-

32 functional differences at over 30% of their odorant receptor alleles.

33 dition of an N-terminal rhodopsin tag to the odorant receptors, along with the same set of accessory

34 determine how often genetic polymorphisms in odorant receptors alter receptor function.

35 s little effect on the ligand specificity of odorant receptors, although the amount of receptor expre

36 the ORNs that normally express a particular odorant receptor and find that PNs postsynaptic to the s

37 This modulation depends on the specific odorant receptor and the concentration and identity of t

38 that express a large repertoire of canonical odorant receptors and a much smaller repertoire of trace

39 d receptors: a large repertoire of canonical odorant receptors and a much smaller set of trace amine-

40 ype, for example, differential expression of odorant receptors and cell adhesion molecules across the

41 Functional characterization of two bed bug odorant receptors and co-receptors in response to human

42 partmentalize signaling molecules, including odorant receptors and cyclic nucleotide-gated (CNG) chan

43 rplay of odorant-binding proteins (OBPs) and odorant receptors and disrupting the normal responses to

44 We identified agonists for 18 odorant receptors and found that 63% of the odorant rece

45 in the sensory epithelium, and expression of odorant receptors and G-proteins.

46 se odor cues occurs through the interplay of odorant receptors and odorant-binding proteins (OBPs) th

47 elegans (most notably through a reduction of odorant receptors and other gene families), yet it has a

48 ear how chemical features encoded by diverse odorant receptors and segregated glomeruli in the main o

49 erologous expression system involving tagged odorant receptors and various accessory proteins promise

50 Gene family expansions (e.g., 344 functional odorant receptors) and pseudogene accumulation in chemor

51 ablished cell lines stably expressing insect odorant receptors are able to detect odorants with consi

52 Interestingly, the odorant receptors are also involved in a number of devel

53 Odorant receptors are among the fastest evolving genes i

54 pha)s or G(alpha)q pathways; and that insect odorant receptors are G-protein-coupled receptors or odo

55 Insect odorant receptors are heteromeric odorant-gated cation c

56 The OR class insect odorant receptors are ligand-gated ion channels comprise

57 SNs expressing about 1000 different types of odorant receptors are precisely organized and sorted out

58 ot differences in pheromone detection by the odorant receptors, are primarily responsible for the beh

59 , based on Sf21 cell lines expressing insect odorant receptors, are sensitive to the level of several

60 dentifies the dynamic expression of a single odorant receptor as a molecular mechanism for context-de

61 Humans have ~400 intact odorant receptors, but each individual has a unique set

62 rom direct activation of seven-transmembrane odorant receptors by odor molecules.

63 Perinatal expression of transgenic odorant receptor causes rerouting of like axons to new g

64 ch olfactory receptor neurons expressing the odorant receptor co-receptor (Orco) gene are labelled wi

65 /Or13 were each co-expressed with Agam/Orco (odorant receptor co-receptor subunit) in Xenopus oocytes

66 A small fraction of odorant-receptor combinations elicit remarkably long res

67 Odor receptor (Or) repertoire, yielding 525 odorant-receptor combinations.

68 The functional insect odorant receptor complex consists of a common co-recepto

69 odor-evoked currents mediated by the insect odorant receptor complex, comprising a ligand-binding su

70 odour-gated ion channel formed by the insect odorant receptor complex.

71 ry systems, which in addition to a family of odorant receptors, contains an approximately equal numbe

72 MP, or IP3 as second messengers; that insect odorant receptors couple to G(alpha)s or G(alpha)q pathw

73 nt 3535, and p-menthan-3,8-diol activate the odorant receptor CquiOR136 of the southern house mosquit

74 gets for sensory neurons expressing specific odorant receptors during a critical period in the format

75 n about the functional changes of individual odorant receptors during evolution.

76 ggesting that the expression of a functional odorant receptor elicits a feedback signal that terminat

77 ying a feedback mechanism in which the first odorant receptor expressed, generates a signal that stab

78 city of the interaction between odorants and odorant receptors expressed in different olfactory recep

79 rates an effective approach to deorphanizing odorant receptors expressed in neurons located in interm

80 ives from the existence of a large family of odorant receptors expressed in the cilia of the olfactor

81 with an earlier study, does not contain the odorant receptors expressed in the male antenna that det

82 deorphanize a subset of putative Drosophila odorant receptors expressed in trichoid sensilla using a

83 apical zone of olfactory marker protein and odorant receptor-expressing cells.

84 n embryonic development, specific subsets of odorant receptor-expressing neurons are progressively lo

85 ory bulb and sort from among 1,000 different odorant receptor-expressing types to converge upon the s

86 ells, previous studies have linked efficient odorant receptor expression with N-terminal modification

87 Because of increased odorant receptor expression, daf-2(e1370) mutants prefer

88 ted in the nasal olfactory epithelium by the odorant receptor family, whose approximately 1,000 membe

89 actory sensory neurons express only a single odorant receptor from a large family of genes, and this

90 lfactory sensory neuron expresses one single odorant receptor gene allele from a large family of odor

91 s and determined the positions of homologous odorant receptor gene alleles in relation to different n

92 d that the two homologous alleles of a given odorant receptor gene are frequently segregated to separ

93 More attention must be paid to odorant receptor gene choice and expression during devel

94 Each odorant receptor gene defines a unique type of olfactory

95 Moreover, the pattern of odorant receptor gene expression and the organization of

96 receptor neurons (ORNs) expressing the same odorant receptor gene share ligand-receptor affinity pro

97 Here, we demonstrate in the zebrafish that odorant receptor gene silencing is dependent on receptor

98 The signal transduction mechanism subserving odorant receptor gene silencing remains obscure, however

99 nsory neurons (OSNs) that express a specific odorant receptor gene.

100 ry neurons (OSNs) expressing the same unique odorant-receptor gene converge onto the same glomeruli i

101 ture neurons expressed only one of the ~1000 odorant receptor genes (Olfrs) available, and at a high

102 estigated whether genetic variation in human odorant receptor genes accounts in part for variation in

103 and sufficient to suppress the expression of odorant receptor genes and likely acts through histone m

104 variants that arise during the evolution of odorant receptor genes can contribute to individual vari

105 ptor gene expression and the organization of odorant receptor genes in cloned mice was indistinguisha

106 histone methylation to maintain the silenced odorant receptor genes in transcriptionally inactive het

107 Mutations in odorant receptor genes predict olfactory perception of c

108 st one out of a possible approximately 1,000 odorant receptor genes, reflecting an exquisite mode of

109 led by a single QTL containing at least four odorant receptor genes.

110 ory neurons causes them to express different odorant receptor genes.

111 these studies by characterizing 35 candidate odorant receptor genes.

112 ay play a critical role in the expression of odorant receptor genes.

113 receptor gene allele from a large family of odorant receptor genes.

114 phila olfactory neurons express two types of odorant receptor genes: Or83b, a broadly expressed recep

115 l cavity, allowing full expression of a huge odorant receptor genome.

116 Insect gustatory and odorant receptors (GRs and ORs) form a superfamily of no

117 A ligand-bound odorant receptor has a low probability of activating eve

118 lfactory receptor neurons expressing a given odorant receptor has convergent axonal projections to tw

119 These results reveal how this class of odorant receptor has evolved to accommodate ligands of v

120 , we reveal that transgenic expression of an odorant receptor has non-cell autonomous effects on axon

121 A large family of approximately 60 odorant receptors has been identified, and many of these

122 The accuracy of the odorant receptor heterologous expression system involvin

123 such as H. saltator, the 9-exon subfamily of odorant receptors (HsOrs) responds to CHCs, and ectopic

124 eview will focus on the diverse roles of the odorant receptor in the function and development of the

125 e first link between the function of a human odorant receptor in vitro and odour perception.

126 Mutants lacking odorant receptors in dendrites display constant low spik

127 has been challenging to functionally express odorant receptors in heterologous cells, previous studie

128 Odorant receptors in the MOE are coupled to the type 3 a

129 Odorant receptors in the periphery map precisely onto ol

130 t, and can amplify odorant signaling through odorant receptors in vitro However, the functional signi

131 e mechanisms underlying regulation of insect odorant receptors in vivoSIGNIFICANCE STATEMENT We have

132 Like odorant receptors, individual mouse TAARs are expressed

133 s by reducing the constitutive activities of odorant receptors, inhibiting the basal spike firing in

134 ORNs expressing the same odorant receptor innervate common targets in a highly or

135 In one model, once an odorant receptor is chosen for expression, other recepto

136 Thus, the activation of an odorant receptor is essential for blood progenitor maint

137 Here, we show that the Or47b odorant receptor is required for the copulation advantag

138 nd globally altered so that only one type of odorant receptor is universally expressed.

139 ein-coupled receptor that, unlike most other odorant receptors, is expressed in a large population of

140 The discovery of odorant receptors led to endeavors in matching them with

141 on that such odorants would activate class I odorant receptors located in zone 1 of the olfactory epi

142 95% of the sensory neurons express a single odorant receptor, M71.

143 An odorant receptor map in mammals that is constructed by t

144 Together, these data indicate that the odorant receptor map is developmentally linked to the ol

145 n the dorsal and ventral subdivisions of the odorant receptor map.

146 ing information from distinct regions of the odorant receptor map.

147 ant receptor, suggesting that other types of odorant receptors might exist.

148 In contrast, the mouse odorant receptor (MOR) locus, which lacks locus-wide sig

149 ndritic knobs of mouse OSNs that express the odorant receptor MOR23 along with the green fluorescent

150 nnal sensillae from wild-type, clock mutant, odorant-receptor mutant, and G protein-coupled receptor

151 KEY POINTS: The release probability of the odorant receptor neuron (ORN) is reportedly one of the h

152 Odorant receptor neurons (ORNs) express specific odorant

153 ic cue by insulin are integrated at specific odorant receptor neurons (ORNs) to modulate olfactory se

154 li in the antennal lobe region innervated by odorant receptor neurons from basiconic sensilla.

155 Thus, direct activation of an odorant receptor, not an ionotropic receptor, is necessa

156 n odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice

157 Chemoreception, mediated by the odorant receptors on the membrane of olfactory sensory n

158 subset of the olfactory sensory neurons, the odorant receptor ONE-GC guanylate cyclase is a central t

159 ila olfactory sensory neurons express either odorant receptors or ionotropic glutamate receptors (IRs

160 and Ggamma(13) but not of G protein-coupled odorant receptors or other components of the odorant sig

161 in insects involves heterodimers between an odorant receptor (OR) and a conserved seven-transmembran

162 Recent studies of odorant receptor (OR) expression, synaptic organization,

163 reveals a remarkable expansion of the insect odorant receptor (Or) family relative to the repertoires

164 e sense of smell is mediated by GPCRs in the odorant receptor (OR) family.

165 identified a honey bee [Apis mellifera (Am)] odorant receptor (Or) for the queen substance 9-oxo-2-de

166 In olfactory neurons, expression of a single odorant receptor (OR) from a repertoire of >1000 genes i

167 udied to date, neurons that express the same odorant receptor (Or) gene are scattered across sensory

168 sensory neurons (OSNs) that express the same odorant receptor (OR) gene coalesce into one or a few gl

169 The expression of a single odorant receptor (OR) gene from a large gene family in i

170 sensory neurons (OSNs) expressing a specific odorant receptor (OR) gene send axonal projections to sp

171 ies on the expression of approximately 1,100 odorant receptor (OR) genes across millions of olfactory

172 Recent molecular analysis of odorant receptor (OR) genes and circuits has led to a mo

173 Odorant receptor (OR) genes and proteins represent more

174 ence variants in six Drosophila melanogaster odorant receptor (Or) genes are associated with variatio

175 Studies using odorant receptor (OR) genes have provided insight into t

176 From the approximately 1,200 odorant receptor (OR) genes in the mouse genome, an olfa

177 ants have evolved a large and novel clade of odorant receptor (OR) genes to perceive hydrocarbon-base

178 ound for the ratio of the number of class II odorant receptor (OR) genes to that of class I genes, bu

179 ntennae-rich olfactory genes, second only to odorant receptor (OR) genes.

180 neuron of one allele of only one of the 1000 odorant receptor (OR) genes.

181 y sensory neurons (OSNs) expressing the same odorant receptor (OR) into the same glomeruli.

182 haviors requires the activity of heteromeric odorant receptor (OR) ion channel complexes and ligands

183 the expression of AgOR7, a highly conserved odorant receptor (OR) of the Afrotropical malaria vector

184 the OB, axons from OSNs expressing the same odorant receptor (OR) sort and converge to form molecula

185 pressed a male-specific, pheromone-sensitive odorant receptor (OR), BmorOR1, from the silkworm moth B

186 sensory neurons (OSNs) that express the same odorant receptor (OR).

187 Odorant receptors (OR) are strongly implicated in coales

188 nsable for the responses of the conventional odorant receptor OR22a to its short hydrocarbon fruit es

189 manipulation of olfactory neurons expressing odorant receptor Or65a.

190 The T1 neurons express the odorant receptor Or67d and are exquisitely tuned to cVA

191 et of Fru(+) olfactory neurons expresses the odorant receptor Or67d and responds to the male-specific

192 own to be required for cVA reception are the odorant receptor Or67d and the extracellular pheromone-b

193 ink between the in vitro function of a human odorant receptor, OR7D4, and in vivo olfactory perceptio

194 Here we show that a human odorant receptor, OR7D4, is selectively activated in vit

195 Furthermore, mutation of odorant receptor Or83b resulted in severe olfactory defe

196 potent and specific activator for the orphan odorant receptor Or83c.

197 he mouse nose is mediated by 1,000 different odorant receptors (ORs) and 14 trace amine-associated re

198 nts evolved via expansions in the numbers of odorant receptors (ORs) and antennal lobe glomeruli.

199 lions of odorants requires a large number of odorant receptors (ORs) and that each OR interacts selec

200 ncoded by large gene families, including the odorant receptors (ORs) and the variant ionotropic recep

201 mouse nose is mediated by >1, 000 different odorant receptors (ORs) and trace amine-associated recep

202 to examine the repertoires of rat and mouse odorant receptors (ORs) and type 1 pheromone receptors (

203 anntenogram (EAG) responses, suggesting that odorant receptors (ORs) and/or OR-dependent processes ar

204 A fundamental question in olfaction is which odorant receptors (ORs) are activated by a given odorant

205 Mammalian odorant receptors (ORs) are crucial for establishing the

206 Odorant receptors (ORs) are thought to act in a combinat

207 As odorant receptors (ORs) are thought to be critical deter

208 Odorant receptors (ORs) belong to a large gene family of

209 Here we report the expression of odorant receptors (ORs) belonging to the superfamily of

210 The mammalian odorant receptors (ORs) comprise a large family of G pro

211 Insect odorant receptors (ORs) comprise an enormous protein fam

212 Moreover, the mechanisms of expression of odorant receptors (ORs) constitute one of the biggest en

213 ant receptor neurons (ORNs) express specific odorant receptors (ORs) encoded by a dramatically expand

214 Odorant receptors (ORs) for sex pheromone substances hav

215 Odorant receptors (ORs) from moths, fruit flies, mosquit

216 of information about the structure of insect odorant receptors (ORs) hinders the development of more

217 rom >240,000 potential volatiles for several Odorant receptors (Ors) in the Drosophila antenna.

218 Ectopic expression and functions of odorant receptors (ORs) in the human body have aroused m

219 Odorant receptors (ORs) in the olfactory epithelium bind

220 The ciliary localization of odorant receptors (ORs) is evolutionary conserved and es

221 The repertoire of approximately 1200 odorant receptors (ORs) is mapped onto the array of appr

222 Activation of odorant receptors (ORs) leads to adenylyl cyclase III ac

223 The odorant receptors (ORs) make up the largest gene family

224 Odorants are initially detected by odorant receptors (ORs) on olfactory sensory neurons (OS

225 tinct odors but do not express either insect odorant receptors (ORs) or gustatory receptors (GRs).

226 tory sensory neurons (OSNs), suggesting that odorant receptors (ORs) or OR-dependent processes are un

227 Odorant receptors (ORs) provide the core determinant of

228 en a challenging task, with their effects on odorant receptors (ORs) remaining a debatable issue.

229 of activated glomeruli, reflecting different odorant receptors (ORs) stimulated in the nose.

230 is thought to recognize odors with multiple odorant receptors (ORs) that are activated by overlappin

231 eded by the paucity of information about the odorant receptors (ORs) that respond to a given odorant

232 lian olfactory system uses a large family of odorant receptors (ORs) to detect and discriminate among

233 Male moths are endowed with odorant receptors (ORs) to detect species-specific sex p

234 e receptors (M3-Rs) physically interact with odorant receptors (ORs) to promote odour-induced respons

235 we functionally characterize a subfamily of odorant receptors (Ors) with a nine-exon gene structure

236 arities between neurons expressing TAARs and odorant receptors (ORs), but also unexpected differences

237 s of a critical class of chemoreceptors, the odorant receptors (ORs), from the ponerine ant Harpegnat

238 Chemosensory receptor proteins, including odorant receptors (ORs), gustatory receptors (GRs) and i

239 hemosensory receptor families, including the odorant receptors (ORs), membrane proteins that form het

240 However, mammalian GPCR odorant receptors (ORs), when heterologously expressed i

241 discriminated through a divergent family of odorant receptors (ORs).

242 of a single member of a very large family of odorant receptors (ORs).

243 dors via a large family of G protein-coupled odorant receptors (ORs).

244 lapping zones of OSNs that express different odorant receptors (ORs).

245 These effects are specific to the odorant-receptor pair lyral-MOR23: there was no effect o

246 We conclude that the odorant receptor pathway is crucial for an anthropophili

247 to examine the contribution of Orco and the odorant receptor pathway to mosquito host selection and

248 sponsible for ensuring the expression of one odorant receptor per olfactory sensory neuron.

249 nsory axons from neurons expressing the same odorant receptor project with high precision to specific

250 Each OSN expresses a single functional odorant receptor protein and projects an axon from the s

251 ade in tracing olfactory perception from the odorant receptor protein to the activity of olfactory ne

252 Although odorant receptor proteins, and other molecules, are impl

253 signals are transduced by a large family of odorant receptor proteins, each of which corresponds to

254 he olfactory pathway, from the nature of the odorant receptor proteins, to perireceptor processes, to

255 tion of individual odors with subsets of the odorant receptor repertoire and mode of signaling that a

256 y, quantity, and duration are encoded by the odorant receptor repertoire of the Drosophila antenna.

257 th the corresponding Drosophila melanogaster odorant receptor repertoire.

258 of S. flava and characterized this species' odorant receptor repertoire.

259 tional level of synergism, inducing enhanced odorant receptor responses to odorants and thus defining

260 a et al. in this issue demonstrates that the odorant receptor's level of intrinsic activity-in the ab

261 activation of ionotropic receptor IR40a vs. odorant receptor(s).

262 Odorant receptor sequence, G-protein cAMP signaling, and

263 or, interacts with Galphaolf and can amplify odorant receptor signal transduction in vitro To explore

264 Odorant receptors signal through the olfactory-specific

265 ic) cell division, and Galpha(olf)-dependent odorant receptor signaling.

266 y bulb, lateral inhibition may occur between odorant receptor-specific glomeruli that are linked anat

267 indicating a reduction in the repertoire of odorant receptor-specific glomeruli.

268 called protoglomeruli well before they form odorant receptor-specific glomeruli.

269 Transgenic mice labeled at the M71 odorant receptor (specifically activated by the odorant

270 In the olfactory epithelium (OE), odorant receptor stimulation generates cAMP signals that

271 mic criteria was carried out across discrete odorant receptor subfamilies.

272 erly called OR83B), and one or more variable odorant receptor subunits that confer odour selectivity.

273 ensory neurons express a seven transmembrane odorant receptor, suggesting that other types of odorant

274 structed based on the responses from all the odorant receptors tested revealed that odorants within t

275 ed to as AgOr7), is remarkably similar to an odorant receptor that is expressed broadly in olfactory

276 factory neuron is determined by the singular odorant receptor that it expresses.

277 Or83b therefore encodes an atypical odorant receptor that plays an essential general role in

278 ork identifies an unanticipated cofactor for odorant receptors that is likely to have a widespread ro

279 by inhibiting subsets of heteromeric insect odorant receptors that require the OR83b co-receptor.

280 rved, in neurons that express the M71 or M72 odorant receptors, that Nrp1 inactivation leads to two d

281 ulb in stereotyped patterns according to the odorant receptors they express.

282 the sensitivity of an odour-specific insect odorant receptor to odour ligands and DEET.

283 We investigated the responses of odorant receptors to a large spectrum of semiochemicals,

284 s, we suggest that SNMP acts in concert with odorant receptors to capture pheromone molecules on the

285 e electro-physiological responses of bed bug odorant receptors to human odorants with the Xenopus exp

286 nts and theory that relate the properties of odorant receptors to the detailed wiring diagram of the

287 ry system function, from the distribution of odorant receptors to the functional organization of cent

288 tory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) i

289 Odorant receptors typically obey the "one receptor, one

290 odorant receptors and found that 63% of the odorant receptors we examined had polymorphisms that alt

291 actory sensory neurons (OSNs) with a defined odorant receptor, we demonstrate that OSNs exhibit funct

292 cally, with the use of Sf21 cells and insect odorant receptors, we demonstrated that the established

293 emosensory signal transduction downstream of odorant receptors, we identified and characterized the c

294 , and G(alphaolf), a diverse set of untagged odorant receptors were successfully expressed heterologo

295 alization, consistent with being mediated by odorant receptors, whereas amino acid responses overlap

296 Odorants are detected by odorant receptors, which are located on olfactory sensor

297 Orthologs of odorant receptors, which detect yeast volatiles in D. me

298 ge family of G protein-coupled receptors-the odorant receptors-which are the chemical sensors underly

299 contains 21 ORNs and a comparable number of odorant receptors whose properties have been examined in

300 junction with the large repertoire of insect odorant receptors, will aid in the development of practi