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1 ) LPs in 22 patients showed CSF discordance, of which 10 (6.1%) LPs in 9 patients represented CSF esc
5 ic strokes, 369 occurred at age >/=80 years, of which 124 (33.6%) were in non-anticoagulated patients
6 nts with infantile epileptic encephalopathy, of which 13 had severe neurodevelopmental impairment and
7 ified 226 differentially expressed circRNAs, of which 189 were significantly upregulated and 37 were
8 of 83 volatiles was assigned in the purees, of which 19 were detected for the first time as papaya c
9 d 2923 rectal swabs from healthy volunteers, of which 19 were MCRPEC, and 1200 rectal swabs from pati
10 tudy identified 51,078 patients with sepsis, of which, 19,742 received calcium channel blocker treatm
12 A total of 3409 contacts were identified, of which 208 (6.1%), 274 (8.0%), and 318 (9.3%) met the
22 distinct VHH families binding trimeric Env, of which 6 neutralized heterologous primary isolates of
24 etabolite peaks (mass signals) were detected of which 681 and 684 metabolites revealed significant mo
25 tions with long-term data, the vast majority of which (74%) were initially nonhybridized, emphasizing
27 ionally essential for GBS survival in blood, of which 75% were members of the capsular polysaccharide
29 e identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3
30 e single nucleotide polymorphisms in-silico, of which 8,967 high value SNPs were incorporated into a
31 tients were discharged directly from the ED, of which 87% received further medical prescriptions for
36 or exposed to elevated cortisol stress, both of which activate glucocorticoid receptor signaling.
37 hich can be modulated by histidine, but both of which affect sensitivity to important anti-HAT drugs.
38 d a deleterious germline mutation, 31 (3.5%) of which affected known familial pancreatic cancer susce
39 dentified in many Archaea and some Bacteria, of which all Archaea and most Bacteria also encode an RN
40 jority of the Sigma67TEQ-PCN, concentrations of which also decreased significantly between 1975 to 20
42 ites predicted 146 competitive OCT1 ligands, of which an endogenous neurotoxin, 1-benzyl-1,2,3,4-tetr
43 ency, including the TGFbeta superfamily, all of which are aberrantly elevated in DND1-deficient PGCs.
44 cular calcification, and bone disorders, all of which are also associated with ageing in the general
46 Majeed syndrome, the clinical manifestations of which are ameliorated by strategies that block IL-1be
47 also identified 57 novel microRNAs, several of which are among the most highly differentially expres
49 in the 16p11.2 locus, copy number variations of which are associated with autism and schizophrenia.
50 contain abundant heteroxylan epitopes, some of which are associated with both pectin and xyloglucan.
52 we studied a total of 14 Cx32 mutations, 10 of which are associated with florid episodic CNS clinica
53 gained DNA methylation at CpG islands, some of which are associated with putative tumor suppressor g
54 oint inhibitors, or even anti-androgens, all of which are being evaluated in phase 1-3 clinical studi
55 hologs of Eco1, called Esco1 and Esco2, both of which are capable of modifying Smc3, but their relati
56 Rho family GTPases, the prototypical members of which are Cdc42, Rac1, and RhoA, are molecular switch
57 key features of human ZIKV infections, most of which are characterized by mild or asymptomatic disea
58 ter through different functional groups some of which are common for the two types of substrates.
61 ultitude of 18 iGluR receptor subunits, many of which are diversified by splicing and RNA editing, lo
62 ression in human lung epithelial cells, some of which are epigenetically programmed at the level of m
63 edictions about antibiotic resistance, cases of which are estimated to amount to 12500 per year in Fr
64 of both winter coldness and snow depth, both of which are expected to decline with climate change.
66 y manage wildly fluctuating populations, all of which are growing domains of ecological research.
67 D, G536R, S1076C, S1176L, and G1178S), three of which are homologous to the gating mutations of cysti
70 ine is reported, the (1)H and (13)C NMR data of which are in excellent agreement with those of (-)-ga
73 y and acutely altered bodily sensations-both of which are known to be associated with insular functio
75 bleaching events and disease outbreaks, both of which are linked to anthropogenic climate change.
76 bp), and the capsule biosynthetic locus, all of which are loci previously suggested to be associated
78 Moldova, Georgia, and Romania), 976 (75.1%) of which are multidrug or extensively drug resistant and
80 oesters, cyanoamides, dinitriles, etc., many of which are not readily accessible with alternative met
84 lation consists of many conserved RBPs, some of which are potential stage-specific mRNA interactors t
85 e diversity of coronaviruses (CoVs), several of which are related to zoonotic pathogens that cause se
86 inates the attenuation of beta-catenin, both of which are required to execute the osteoclast developm
88 hese residues generates short peptides, some of which are too small or uninformative for optimal anal
90 g diseases such as Zika and chikungunya, all of which are transmitted by the disease vector mosquito
93 ) and stem cell molecules CD44 and EZH2, all of which are validated as direct and functionally releva
95 gulated by common transcription factors, one of which, Ascl1, was confirmed to be directly controlled
97 cking) are enriched for regulatory variants, of which at least six (35%) alter transcription factor-D
99 roperties of oncolytic vaccinia viruses, all of which can be amplified by the multitargeted kinase in
100 plain 37% of father-to-son familial risk, 8% of which can be attributed to the 12 new signals reporte
101 et of independent SV assembly problems, each of which can be effectively solved to enhance the assemb
102 as the parasite ornithine transporters, one of which can be modulated by histidine, but both of whic
105 activity of the small GTPase CDC42, deletion of which caused severe defects in endothelial migration.
106 dria tether composed of four proteins, three of which contain a SMP (synaptotagmin-like mitochondrial
107 We identified 25 new susceptibility loci, 3 of which contain integrin genes that encode proteins in
108 streams are natural river and seawater, both of which contain not only monovalent ions but also dival
109 y drug resistant and 38.2%, 51.9%, and 36.3% of which contain X-ray, computed tomography (CT) scan, a
112 nts in the mammalian cochlea, the disruption of which contributes to the deafness phenotype observed
113 dbrain dopaminergic neurons, the dysfunction of which contributes to various neurological and psychia
115 es loops in a discrete region, the formation of which correlates with activation of HSP1; looping is
116 7/IL-7R pathway dysfunction in T cells, both of which could be associated with C-IRIS immunopathogene
118 tives and policies, and quality of care, all of which diminish its preparedness to care for a fifth o
120 ey are found in 14 different contexts, eight of which display Mg(2+) binding at the Hoogsteen edge of
121 e site of high-risk atherosclerotic plaques, of which early detection and therapeutic stabilization a
122 atment or within 30 days of discontinuation, of which eight (3%) and five (2%) deaths were deemed rel
123 miRNA:target or tasiRNA:target interactions, of which eight were further confirmed with the RLM 5'-RA
124 EEEKKK) and EK2R1 (AEEEKRK)) both form SAHs, of which EK2R1 is more helical and thermo-stable suggest
125 gies in current clinical imaging guidelines, of which European ones primarily recommend CXR/MRI, wher
126 a spectacular array of complex shapes, many of which exhibit elaborate curvature in three dimensions
127 es) and a clade of mammals (Carnivora), both of which exhibit substantial craniofacial diversity.
128 firmed by authentic reference standards, all of which exhibited an elevated bacterial toxicity to Ali
130 ABT-263/XL-184, and paclitaxel/nutlin-3, all of which exhibited synergistic antiproliferative and apo
132 ial structure and composition, abnormalities of which form the direct, pathophysiologic substrate for
135 ted miRNAs showed increased stability, 72.7% of which had DeltaDeltaG values less than -6.0 Kcal/mole
138 s suggested (P<0.005) for 14 SNP pairs, none of which had shown individual association with systolic
139 nimals mainly developed mammary tumors, most of which had transposon insertions in one of two RASGAP
141 ed eight novel interaction partners of EGFR, of which half strongly interacted with oncogenic, hypera
144 coupling, identifying two active sites, both of which have an under-coordinated surface square site a
145 least one gene-disrupting mutation, several of which have been associated with cancer or dysfunction
146 ies and photonic crystal microcavities, both of which have been developing rapidly over the past few
147 Cu(II)(carb)3](-) (carb = carbazolide), both of which have been identified under coupling conditions,
148 nities associated with data sets, nearly all of which have been observational, that are larger and mo
150 tion and CRY2-CIB1 hetero-dimerization, both of which have been widely used to optically control intr
151 d eosinophil count and serum periostin, both of which have demonstrated utility in identifying patien
152 rate of tandem gene duplications, the latter of which have given rise to 12 copies of alpha-gliadin g
153 than those in Ashkenazi Jews and Finns, both of which have high rates of recessive disease due to fou
154 uivalent) during the last deglaciation, both of which have implications for interpreting geodetic mea
155 , three of the four modified tyrosines, some of which have more than one modification, cluster in the
156 unambiguously identify these compounds, many of which have never been reported in breath so far.
157 levant for mitotic rounding, a large portion of which have not previously been linked to mitosis or c
158 of nature's most successful parasites, many of which have plagued humans throughout our history.
159 roteins in >650 independent cell lines, many of which have publically available genomic, transcriptom
161 genomic regions that affect parental care, 8 of which have sex-specific effects, suggesting that pare
162 cell-specific protein (MZB1), the expression of which identified MZB1(+)/CD38(+)/CD138(+)/CD27(+)/CD4
164 h, 30 were included in our study, only eight of which included detection of hepatitis D virus RNA amo
165 in the ULK1 5'-flanking region, the mutation of which increased ULK1 promoter activity, and rendered
166 unctional deficits of AIPL1 variations, some of which induce aberrant pre-mRNA AIPL1 splicing leading
167 d RNA (dsRNA) Reoviridae family, the members of which infect and cause disease in humans, animals, an
169 d, can result in chronic histological damage of which interstitial fibrosis and tubular atrophy are d
170 gulating executive function, the dysfunction of which is a factor in attention-deficit/hyperactivity
171 nd colloidenes, the spontaneous dissociation of which is achieved with precision and stage-by-stage c
173 an array of exciting job opportunities, one of which is as a faculty member or independent investiga
174 Some authors view 'energisation'-the loss of which is central in apathy-as a core executive functi
175 s of survival in drug development, the first of which is characterization of tissue distribution and
177 me non-polar biome on Earth, the core region of which is considered to represent the dry limit for li
178 ce through several different mechanisms, one of which is cytolysis, which is associated with release
180 (4) featuring five ethylene equivalents, one of which is dehydrogenated to an vinyl, -CH horizontal l
181 nse investigation along multiple fronts, one of which is how their structural and physical properties
182 -DM1 occurs through multiple mechanisms, one of which is impaired lysosomal proteolytic activity.
183 ovide evidence that Dnd1 protein, expression of which is low in oocytes, but increases dramatically a
184 on exists as a mixture of conformations, one of which is most likely the open-X structure which has u
188 gy may be computed in a series of steps, one of which is partly independent from syntactic hierarchy.
192 ulating PH5 phase, the structure and bonding of which is reminiscent of diborane, is also predicted t
195 eir group velocity, with real momentum, part of which is transmitted to the adsorbate through scatter
196 ently reported a series of (+/-)MOD analogs, of which JJC8-016 (N-(2-((bis(4-fluorophenyl)methyl)thio
198 duced cytidine deaminase (AID), the activity of which leads to DNA double-strand breaks (DSBs) within
200 ic mechanisms of a complex compound mixture (of which many are yet unidentified) rather than by singl
201 y regarding the role of AMPK in cancer, some of which may be due to functional differences between is
202 nding starting E- or Z-N'-alkenyl urea, each of which may be formed from the same N-allyl precursor b
203 als of repeated evolutionary selection, some of which may be linked to response to simian immunodefic
205 ive stress, and endothelial dysfunction, all of which may perpetuate a noxious microenvironment leadi
206 protein-protein interactions, the modulation of which may protect against cancer, radiation, and agin
207 We characterize 21 novel microRNAs, one of which may trigger phasiRNAs from numerous kinase tran
209 nity degeneracy of band-edge states, because of which multiexcitons are required to achieve the lasin
210 regulon also included eight non-coding RNAs, of which Ncr1071, Syr6 and NsiR7 were experimentally val
212 n, growth, migration, and rearrangement, all of which occur within physically constrained regions.
213 cases were recorded in 2015, more than half of which occurred in men who have sex with men (MSM).
214 and expansion of activated macrophages, both of which occurred prior to changes in body weight, lendi
215 o the volume of SOA formed, and an indicator of which of four oxidant precursors was used to initiate
216 1, participants made forced-choice judgments of which of two tactile distances felt bigger, one orien
218 p38 MAPK family is composed of four kinases of which p38alpha/MAPK14 is the major proinflammatory me
220 contains nine beta-amylase (BAM) genes, some of which play important roles in starch hydrolysis.
221 ir elaborate visual system, the most complex of which possesses 12 types of color photoreceptors and
222 ontributed a total of 1058 visits, 67 (6.3%) of which preceded new-onset BPSD within the next 5 years
225 wo natural killer (NK) cell populations, one of which recirculates while the other is tissue resident
226 ; among these is GADD34, the protein product of which recruits the alpha-isoform of protein phosphata
227 ble methylation patterns between lines, some of which reflect aberrant differences relative to embryo
228 s, thiocarbonates, and dithiocarbonates, all of which release COS that is quickly converted to H2S by
230 esiphon minutus, CmTMEM175, the architecture of which represents a completely different fold from tha
233 n an extended loop in RACK1, phosphorylation of which selects for translation of viral or reporter mR
234 experiment, the biological characterization of which should provide a better understanding of phosph
235 fied four genome-wide significant loci, none of which showed any association with disease susceptibil
237 and differentiation rely on cytokines, many of which signal through the JAK/STAT signaling pathway t
238 patients (38%) experienced bleeding events, of which six (16%) were associated with fatal outcomes.
240 xic signals can stimulate angiogenesis, both of which stimulated SRC-2 expression in vitro Furthermor
241 creasingly being applied to animal networks, of which stochastic actor-oriented models (SAOMs) are a
242 ntary methodological approaches, the results of which suggest that cultural phenomena pervade the liv
243 tion with reduced cardiac muscle cBIN1, both of which support cBIN1 release in MPs from human hearts.
244 es and resilience in sex-changing fish, many of which sustain highly valued and vulnerable fisheries
245 h oligosaccharyltransferase (OST) genes; two of which, TbSTT3A and TbSTT3B, are expressed in the bloo
246 ry metabolites including phenolic compounds, of which the coumarin scopoletin (7-hydroxy-6-methoxy-2H
247 result from a combination of two mechanisms, of which the first prevents multiple transposition burst
248 set of methoxybenzothiophene-2-carboxamides, of which the N-benzylated derivative showed enhanced Clk
249 n-coding ASCC3 mRNA to a shorter ALE isoform of which the RNA, rather than an encoded protein, is cri
252 pete motif libraries to provide a prediction of which trans -acting factors binding sites are disrupt
253 ntly modulated 44% of hypoxia-induced genes, of which two-thirds were downregulated including CA9 and
254 permits the release of organic wastes, some of which ultimately reaches the underlying sediments.
255 on-based methods, BirgRank and AptRank, both of which use PageRank to diffuse information on this two
256 athway must have an optimum level, the value of which varies according to the drug concentration.
257 The method also allows a discrimination of which viscoelastic relaxation model, for example, sta
258 ther gain- or loss-of-function changes, part of which was attributable to cysteine-mediated dimer for
259 ee distinct vaginal microbiome subtypes, one of which was characterized by extreme genital inflammati
260 a Y-junction microfluidic device, the design of which was optimized for each printer: fused depositio
262 31 participants in the once daily group (one of which was serious; none led to treatment discontinuat
263 nces revealed three clusters (subtypes), one of which was strongly associated with genital inflammati
264 ongst the major mango volatile compounds, 10 of which were already reported as being potential key fl
265 2+) clusters and low-spin Fe(II) hemes, most of which were associated with mitochondrial respiration.
267 with women with at least 2 pregnancies, all of which were delivered at term, women with a preterm fi
269 p-tag II, 18xHis, 13xMyc, and dual tags, all of which were driven from a strong constitutive promoter
270 permutation-based p=0.039, the gene targets of which were enriched for intracellular signaling pathw
271 otential exonic cryptic splice variants, two of which were experimentally evaluated and confirmed.
272 in 21 (8%) of 249 patients, the most common of which were fatigue (four [2%]), and asthenia, elevate
274 on-treatment adverse event, the most common of which were headache (in 45 [16%] given mepolizumab vs
275 spleen and liver weights to body weight, 36 of which were imprinted with different imprinting fashio
279 ing 11 (23%) composite complete responses, 5 of which were minimal residual disease negative by flow
281 ory alterations in Na channel activity, some of which were not seen in hippocampal or cortical neuron
282 13 new loci at genome-wide significance, 12 of which were on our previous list of loci meeting the 5
284 sistant EGFR-mutant tumor cells, the effects of which were overcome by combined treatment with osimer
285 igh-strength evidence from 28 trials (only 3 of which were placebo-controlled) shows that colchicine,
286 itaemia and 10% P. falciparum, by qPCR, both of which were predominantly sub-microscopic and asymptom
289 16 patients had serious adverse events, most of which were related to the underlying illness, includi
290 positively associated with wind speed, both of which were retained in models as a significant predic
291 w/w) glycerol solution, were generated, half of which were seeded with fluorescent dye for imaging pu
292 ort-run emphasis, and long-run emphasis, all of which were sensitive to the presence of uptake hetero
293 6 participants in the twice daily group (two of which were serious; two led to treatment discontinuat
296 calculated between 47 regions of interests, of which whole-brain and region-specific means were comp
297 recedented diversity of genomes, the content of which will expand the repertoire of microbe-based bio
298 iscounted), avert 25% of HIV infections (42% of which would be directly because of PrEP), and lead to
299 ational variants of HLA-I on SAB, assessment of which would increase the concordance between SAB and
300 an issue with TXS solubility, the resolution of which yielded a 25-fold improvement in taxadiene prod
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