ライフサイエンスコーパス: olefinic

1 bromoetherification and desymmetrization of olefinic 1,3-diols has been developed using a C2-symmetr

2 The observation of a large beta olefinic (13)C isotope effect and small alpha carbon iso

3 ange of aldehydes (aromatic, heteroaromatic, olefinic, acetylenic, aliphatic).

4 Catalytic bromolactonization of long-chain olefinic acids resulting in the efficient synthesis of m

5 tic bromolactonizations of alkyl-substituted olefinic acids that proceed via 5-exo mode cyclizations

6 yzed intramolecular carbonyl-ene reaction of olefinic aldehydes has been developed.

7 bertene by asymmetric cyclization of achiral olefinic alkyllithium precursors in the presence of (-)-

8 symmetric bromocyclization of trisubstituted olefinic amides that uses a C(2)-symmetric mannitol-deri

9 scribes the superacid-catalyzed chemistry of olefinic amines and related compounds.

10 A variety of olefinic amines are found to react with benzene in CF(3)

11 gs for the creation of diversely substituted olefinic amino acid systems.

12 shift of the resonances associated with the olefinic and allylic protons as a result of them residin

13 ast from the topological point of view, both olefinic and diene subunits; however, the stability of t

14 on works well with a wide range of aromatic, olefinic, and aliphatic aldehydes.

15 ructure, to include asymmetric substitution, olefinic, and cyclopropyl groups.

16 vinylogous reactions with methyl-substituted olefinic azlactones and butyrolactones.

17 ivity is demonstrated for methyl-substituted olefinic azlactones and butyrolactones.

18 Monitoring of the olefinic band elicited seizure-induced lipid peroxidatio

19 0BM-3 of a single oxidant species capable of olefinic bond epoxidation and sp3 carbon hydroxylation a

20 etathesis (RCM) strategy to form the C10-C11 olefinic bond failed.

21 al acid in the mechanism of reduction of the olefinic bond found in 2-cyclohexenone and codeinone.

22 While the 17,18-olefinic bond of eicosapentaenoic acid is epoxidized wit

23 Reactions involving the olefinic bond of the imide as well as its carbonyl group

24 rtion of the side chain including the C9-C10 olefinic bond, and the C10 methyl group.

25 Reduction of the 2,3-olefinic bond, as in (+/-)-dihydroquercetin, or glycosid

26 from the flavin to the beta-position of the olefinic bond, concomitant with or followed by uptake of

27 umor actions of n-3 PUFA may involve the n-3 olefinic bond.

28 ngle product with the Z configuration of the olefinic bond.

29 lude reduction and E-to-Z transitions of the olefinic bonds in the 14-carbon side chain of the molecu

30 catalyzed aerobic oxytrifluoromethylation of olefinic bonds of styrene derivatives using CF3SO2Na (La

31 ssymmetry, butterfly bending of the strained olefinic bonds was generally predicted.

32 tastatin A-4 (1c) were focused mainly on the olefinic bridge to determine the effects on cancer cell

33 ess by proton abstraction from electron-rich olefinic C(9).

34 The olefinic C-C bond distances in 2 and 3, 1.328(4) and 1.3

35 to proceed via a directed activation of the olefinic C-H bond followed by two migratory insertions,

36 insertion of the "Si(I)2" unit of 2 into the olefinic C-H bond of the imidazole ring of 1 and four-me

37 um-catalyzed intramolecular alkylation of an olefinic C-H bond to set two stereocenters.

38 port a facile C-H borylation of aromatic and olefinic C-H bonds with 2-aminophenylboranes.

39 talyzed Wolfe carboamination conditions with olefinic carbamate 7 to provide the racemic 2-(arylmethy

40 erse electronic and steric properties at the olefinic carbon alpha to the heteroatom of 1a-g and beta

41 (13)C isotope effect (1.024) at the terminal olefinic carbon and a smaller isotope effect (1.003-1.00

42 oxylic acid moiety, nitration at the 9 or 10 olefinic carbon, and unsaturation is required for XOR in

43 ega-dienes as functionalization reagents for olefinic carbon-hydrogen bonds has been rarely studied.

44 vanced formation of the C-O bond to the beta olefinic carbon.

45 isotope effect (1.003-1.004) at the internal olefinic carbon.

46 n of 2,4-dimethyl-3-isopropyl-2-pentene, the olefinic carbons exhibit small and nearly equal (13)C is

47 The sequence of hydrogen transfer to the two olefinic carbons is calculated to change based on substr

48 ds or initial nitrene-addition to one of the olefinic carbons.

49 d 1,4-hydrogen elimination from the proximal olefinic carbons.

50 saturated lipid content was imaged using the olefinic =CH stretching mode at 3012 cm(-1).

51 rface and unperturbed by the presence of the olefinic chain on the solvent-exposed surface of the pep

52 ing alcohols, aldehydes or acetate esters of olefinic chains of 10-22 carbons.

53 r conditions to 1,2-diols bonded to terminal olefinic chains.

54 e remaining pyrrole ring retains substantial olefinic character.

55 The olefinic compound 4-phenyl-3-butenoic acid (PBA) is the

56 he species by MS/MS showed a wide variety of olefinic compounds allowing the IMS of different lipid c

57 reagent in biphasic media in the presence of olefinic compounds dissolved in the organic layer or eve

58 Meanwhile, synthetic efforts en route to olefinic compounds led to the discovery that 2-pyridylet

59 uttering to LDI-IMS of cholesterol and other olefinic compounds presents a novel approach to improve

60 icles (AgNPs) is shown to selectively ionize olefinic compounds, e.g., cholesterol, 1-palmitoyl-2-ole

61 Strikingly, the olefinic construct proved inert to attempted alpha-ketol

62 advance as it does not require stereodefined olefinic coupling partners (vinyl halide or vinyl organo

63 dition and Bi(OTf)3-catalyzed intramolecular olefinic cyclization has been developed.

64 a potent RAR gamma-selective retinoid, while olefinic derivative 11 was found to be comparable to ret

65 irst time application of hydroformylation on olefinic derivatives of isosorbide and isomannide is sho

66 nyl substituted orthoquinone monoketals with olefinic dienophiles furnished functionalized ortho-endo

67 C-10 Olefinic dimers 7 and C-10 saturated dimers 8-13 all sho

68 s of these dipoles to typical acetylenic and olefinic dipolarophiles gave 4a-substituted 2a,2a(1)-dia

69 readily discernible with other less hindered olefinic donors.

70 ds between the binding site and the reactive olefinic double bond.

71 of metathesis as an instrument to reorganize olefinic double bonds, substantial progress has been att

72 differing only in the number or location of olefinic double bonds.

73 The ammonium-directed olefinic epoxidations of a range of differentially N-sub

74 el glycosyl-beta-azido ester 3 from glycosyl olefinic ester 1 under mild conditions has been devised.

75 rmed by the conjugate addition of ammonia on olefinic ester, undergoes a metal-catalyzed diazotransfe

76 l to the success of this work was the use of olefinic-ester cyclization reactions and the utilization

77 a stereochemical correlation between the two olefinic fragmentation products is preserved.

78 ted steric requirements for the insertion of olefinic functionalities into lanthanide-alkyl and -hete

79 regio- and stereoselective conversion of the olefinic functionality of a 5,6-dihydropyran-2-one to th

80 ion of beta-keto phosphonates that contained olefinic functionality proceeded more quickly than cyclo

81 etic elaboration through manipulation of the olefinic functionality.

82 on, and aerobic Wacker-type oxidation of the olefinic group of 6, followed by condensation of the res

83 cyclization by nucleophilic addition of the olefinic group to Cgamma of the ligand giving a boat-lik

84 ethylene units or inclusion of cis- or trans-olefinic groups greatly reduced antagonist potency at th

85 ted hexahydroindolinones containing tethered olefinic groups were prepared and found to undergo effic

86 the 1-position with 2-phenylethyl (or alkyl/olefinic groups) and at N-3 with hydrogen or methyl favo

87 ctams 1 that have been doubly alkylated with olefinic halides gives good yields of alpha,alpha-disubs

88 ly diverse microbes that produce long chain, olefinic hydrocarbons have received much attention as po

89 ally 'pincer'-ligated iridium complexes--and olefinic hydrogen acceptors.

90 interchange of the platinum hydride with the olefinic hydrogens in 1 was determined to be 19.2 kcal/m

91 s thermophilus IDI-2, we discovered that the olefinic hydrogens of a vinyl thiomethyl analogue of iso

92 of site exchange between the hydride and the olefinic hydrogens yielded DeltaG(++) = 15.6 (6a-Ir), 16

93 internal proton transfer in a tightly bound olefinic intermediate.

94 a-4(20),11(12)-diene were tested as possible olefinic intermediates in taxa-4(5),11(12)-diene formati

95 The olefinic interproton two-bond coupling constants (2)JH,H

96 e frondosin ring-system, it also resulted in olefinic isomers that were easily isomerized in acidic c

97 ransition state, based on a smaller terminal olefinic isotope effect (1.012-1.015).

98 The delta 7,8 olefinic linkages within (+)-calanolide A(1) and (-)-cal

99 lecular species contained exclusively Delta9 olefinic linkages.

100 egiospecificity and stereospecificity of its olefinic linkages; (2) the phospholipid subclass and ind

101 addition, while all the derivatives with an olefinic linker were antagonists, in quinpirole-stimulat

102 min analogs with a C7 linker bearing a C4-C5 olefinic linker with a single keto group at C3 (enone li

103 gen, the singlet oxygen produced cleaves the olefinic linkers in the complexes, resulting in precipit

104 We find that substituting acetylenic for olefinic linkers on the molecular cores significantly en

105 2]catenane copper complex, consisting of one olefinic macrocycle and one nonolefinic macrocycle, unde

106 ,2,3,4-tetrahydro-beta-carbolines, while the olefinic mechanism had been ruled out by experiments car

107 tical, general process that involved a 12,13-olefinic methyl ketone as a starting material obtained b

108 zyme catalyzed oxygen atom insertion into an olefinic moiety in various natural products, but they ha

109 "expected" results, that is, cleavage of the olefinic moiety with generation of 1,4-dicarbonyl 1,2-di

110 The primary products are toto-olefinic monocarboxylic acids with CO-derived COOH group

111 these polymerizations of nonpolar and polar olefinic monomers is prepared by in situ Zn reduction of

112 urn results from methyl group addition to an olefinic mycolate precursor.

113 ental evidence for the intermediacy of trans-olefinic mycolate precursors in trans-cyclopropane forma

114 The intramolecular reactions of olefinic N-heterocycles have been studied.

115 The olefinic nitro group renders these derivatives electroph

116 converted to the spiranic compound 5 and an olefinic nucleoside 6 by the construction of the heteroc

117 rves as a hydrogenation catalyst for various olefinic or acetylenic substrates.

118 of a methylene group of 7 or inclusion of an olefinic or cyclopropyl group also reduced potency.

119 The ammonium-directed olefinic oxidation of a range of cyclic allylic and homo

120 After diastereoselective olefinic oxidation of the resultant enantiopure tetrahyd

121 have been prepared using diastereoselective olefinic oxidations of a range of enantiopure tetrahydro

122 Kraus annulation of sulfonylphthalide with 3-olefinic oxindole has been performed.

123 By the application of 3-olefinic oxindoles and benzofuranone, biologically relev

124 By simply changing the olefinic partner, the synthesis of a carnitine acetyltra

125 ecause of interaction between Ag(+) ions and olefinic pi electrons of fatty acids and lipids.

126 strength of cation-pi interactions involving olefinic pi-bonds.

127 Instead, flexible ligands that permit olefinic pi-electrons to be oriented more favorably towa

128 re also tolerated substitution at a terminal olefinic position and at the allylic position of the die

129 vity as in earlier approaches involving 9,10-olefinic precursors.

130 ously supplied 3S-linalyl diphosphate to the olefinic product.

131 These olefinic products were then transformed into phosphine o

132 ployed as well and, when used, produce trans-olefinic products.

133 rocycle is still distorted, but the external olefinic protons are shifted downfield compared to 9.

134 stic based on the chemical shifts of the two olefinic protons located at the macrocyclic double bond

135 Transient structures of the olefinic-reaction intermediates such as the protonated c

136 considerable light on the diverse nature of olefinic reactions.

137 rroles, pentasubstituted pyrroles bearing C2-olefinic side-chain and spiro-2-pyrrolinones and their c

138 rcaptan to an acrylate containing a tethered olefinic site followed by RCM (ring-closing metathesis)

139 hemical dominance by the remote ester on the olefinic site.

140 by the remote activating group bound to the olefinic site.

141 ich a [Pd2]2+ unit is bound in pi-fashion to olefinic sites that are exocyclic to pyrrole rings of th

142 has enabled bond formation between aryl and olefinic (sp(2)) carbons in a selective and predictable

143 ne of these was also fully deuterated on the olefinic spacers.

144 agent in mass spectrometry (MS) for various olefinic species such as cholesterol and fatty acids.

145 on-interacting residues with a constraining, olefinic staple.

146 ere observed in CID, leading to formation of olefinic structures.

147 conjugate or Markovnikov-to the positions of olefinic substituents of the N-heterocycle.

148 imethylsilane tolerated allylic and terminal olefinic substitution and a range of functional groups.

149 ort the proposal that rate inhibition by the olefinic substrate and product is caused by formation of

150 anism in which both molecular oxygen and the olefinic substrate coordinate to the iron center, leadin

151 tution of a phosphine ligand (PR(3)) with an olefinic substrate.

152 The olefinic substrates 4-fluorostyrene, vinylferrocene, and

153 ative reactions, including the conversion of olefinic substrates to epoxides by oxygen insertion.

154 distributions of unsaturated compounds from olefinic substrates.

155 Modeling of an acyclic olefinic sulfonate ester substrate and the transition st

156 njugated linkage between the surface and the olefinic surface functionality, to allow for facile char

157 In both molecules, the chiral plane is an olefinic system, which is very rare among natural produc

158 ge of aryl, styrene, vinyl, and heterocyclic olefinic targets.

159 functionalized intermediates, such that the olefinic termini of the side chains could enter into int

160 he conjugate addition of hydride at the C(4) olefinic terminus using NADH to yield the cyclohexenol-c

161 cur when amido thioacetals possessing simple olefinic tethers were used.

162 three or four different substituents on the olefinic unit in a stereocontrolled fashion.

163 produced by selective transformation of the olefinic unit in the n-pentenyl glycoside to the four-ca

164 ol and the two terminal methyl groups on the olefinic unit shape the cyclization.

165 s via nucleophilic addition of the resulting olefinic unit to Calpha of 7.

166 ether enyne 3 with a cyclopentyl ring on the olefinic unit undergoes only single cyclization due to s