ライフサイエンスコーパス: olfactory

1 emonstrate that the famous sex difference in olfactory abilities likely originates in the primary sen

2 Moreover, humans have excellent olfactory abilities.

3 ice depend upon the concurrent processing of olfactory and gustatory signals from the mouth.

4 We find significant asymmetry in both olfactory and orbitofrontal cortical odor-evoked activit

5 so show a spatial overlap between gustatory, olfactory, and oral somatosensory representation in the

6 ransport was highlighted by the absence from olfactory axons of the calmodulin transcript Calm1, whic

7 ibute to the design and development of novel olfactory-based strategies to reduce both the biting nui

8 in coding odor stimuli and allows for robust olfactory behavior.

9 ulated range of response kinetics for robust olfactory behavior.SIGNIFICANCE STATEMENT Sensory recept

10 ecificity and increasing working lifespan of olfactory biosensors capable of detecting explosives.

11 lize odorant-evoked OSN synaptic output into olfactory bub glomeruli in unmanipulated (gonad-intact)

12 ivity in mitral cells of the mouse accessory olfactory bulb (AOB) emerges from interplay between intr

13 neurons.SIGNIFICANCE STATEMENT The accessory olfactory bulb (AOB) is a site of experience-dependent p

14 ons to both the main (MOB) and the accessory olfactory bulb (AOB).

15 In the main olfactory bulb (MOB), inhibitory circuits regulate the a

16 In the main olfactory bulb (MOB), the first station of sensory proce

17 n vivo recordings from two distinct regions: olfactory bulb (OB) and anterior piriform cortex (PC).

18 -subventricular zone (V-SVZ) produce diverse olfactory bulb (OB) neurons.

19 ors are encoded by mitral cells (MCs) in the olfactory bulb (OB) of male mice.

20 FICANCE STATEMENT Inhibitory circuits in the olfactory bulb (OB) play a major role in odor processing

21 rnal stimuli and transmit the signals to the olfactory bulb (OB) where they are integrated and proces

22 ration on SWR occurrence was eliminated when olfactory bulb activity was inhibited.

23 ood and no detectable silver measured in the olfactory bulb and brain.

24 arallel olfactory circuits, four in the main olfactory bulb and one in the accessory olfactory bulb.

25 ctions innervate multiple layers of the main olfactory bulb and strongly influence odor discriminatio

26 tations involve a dynamical loop between the olfactory bulb and the piriform cortex, with cortex expl

27 ocused on neurons and glial cells within the olfactory bulb because the virus enters the brain at thi

28 eripheral oscillators in the hippocampus and olfactory bulb become desynchronized, along with the beh

29 eurons innervate multiple layers in the main olfactory bulb but the precise circuitry of this input i

30 support the argument that odor coding in the olfactory bulb depends on the recent history of the sens

31 slices, we test how the two major classes of olfactory bulb interneurons differentially contribute to

32 Strikingly, Per1 and Fos expression in the olfactory bulb is reversed, mirroring the inverted olfac

33 naturalistic stimuli, afferent input to the olfactory bulb is subject to strong synaptic depression,

34 s provide direct evidence that the mammalian olfactory bulb likely participates in generating the per

35 verrepresented in piriform cortex but not in olfactory bulb mitral and tufted cells.

36 ed cells (TCs) comprise parallel pathways of olfactory bulb output that are thought to play distinct

37 cuitry of this cholinergic input to the main olfactory bulb remains unclear, however.

38 used single glomerular stimulation in mouse olfactory bulb slices to measure the synaptic dynamics o

39 Here, in acute mouse olfactory bulb slices, we test how the two major classes

40 the neuromodulator norepinephrine modulates olfactory bulb spontaneous activity and odor responses s

41 The olfactory bulb transforms not only the information conte

42 ultrastructural analyses of glomeruli in rat olfactory bulb under conditions in which specific cells

43 the eutopic neuroblast migration towards the olfactory bulb was observed.

44 Our results show that interneurons of the olfactory bulb were the primary cell type able to surviv

45 by inactivation of LC or pretreatment of the olfactory bulb with a broad-spectrum noradrenergic recep

46 accumulation in discrete areas of the brain (olfactory bulb, hippocampus, and midbrain) and reduction

47 he amygdala does not directly project to the olfactory bulb, joint pharmacological inactivation of th

48 It remains unclear whether the olfactory bulb, the brain structure that mediates the fi

49 two excitatory cell classes of the mammalian olfactory bulb, the mitral cells (MCs) and tufted cells

50 de array recordings of odor responses in the olfactory bulb, we find that concentration-invariant uni

51 ia the rostral migratory stream (RMS) to the olfactory bulb, where they differentiate into local inte

52 main olfactory bulb and one in the accessory olfactory bulb.

53 gene Fos in the SCN, dorsal hippocampus, and olfactory bulb.

54 during 28d Li-treatment, particularly in the olfactory bulb.

55 a basic feature of sensory processing in the olfactory bulb.

56 ide the initial sensory input to the brain's olfactory bulb.

57 not seen in axons innervating the accessory olfactory bulb.

58 ior forebrain along a defined pathway to the olfactory bulb.

59 ture adult-born-granule-cells (abGCs) in the olfactory bulb.

60 synapses of granule and mitral cells in the olfactory bulb.

61 d signal-to-noise ratio at the output of the olfactory bulb.

62 rate synchronized oscillations in the rodent olfactory bulb.

63 tion in the proportional size of the brain's olfactory bulb.

64 tatory mitral projection neurons of the main olfactory bulb; here, these two classes of neurons form

65 rrently used to assess antidepressant onset: olfactory bulbectomy, chronic mild stress, chronic force

66 The turkey vulture has the largest olfactory bulbs in absolute terms and adjusted for brain

67 aging is associated with an expansion of the olfactory bulbs of the brain in vertebrates, but no such

68 is widely expressed in many nuclei from the olfactory bulbs to the hindbrain, while vglut3 is restri

69 immunoreactive perikarya were present in the olfactory bulbs, ventral telencephalon, caudal preoptic

70 l cells is proportional to the size of their olfactory bulbs.

71 projections from both the main and accessory olfactory bulbs.

72 depolarizing chloride current by opening the olfactory Ca(2+)-activated chloride channel to amplify t

73 While odor-evoked excitation in peripheral olfactory cells is known to encode odor information, the

74 Second, peripheral sensory neurons-olfactory chemosensory neurons and nociceptor sensory ne

75 We discovered that the fruit fly olfactory circuit solves this problem with a variant of

76 During the assembly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) cl

77 An olfactory circuitry model suggests that cortical feedbac

78 lators and associated mRNAs in five parallel olfactory circuits, four in the main olfactory bulb and

79 mushroom body (MB) is critically involved in olfactory classical conditioning, and cAMP signaling mol

80 tudy provides a comprehensive picture of the olfactory coding mechanisms of bed bugs that will ultima

81 tic activation of NPF neuron is rewarding in olfactory conditioning experiments and that the preferen

82 g the synaptic output of Kenyon cells during olfactory conditioning reduces presynaptic calcium trans

83 non-topographic projections to and from the olfactory cortex may suggest a flat, non-hierarchical or

84 ribe a novel seizure pattern peculiar of the olfactory cortex that resembles focal seizures with low-

85 eveals a sequence of ictogenic events in the olfactory cortex that were never described before in oth

86 all of the pallial amygdala but also to the olfactory cortex, which hitherto was considered to arise

87 in independent subnetworks of neurons in the olfactory cortex.

88 itic inputs with coincidence excitation from olfactory cortex.

89 etween the bilateral OFC and between the OFC-olfactory cortex.

90 that they send profuse axonal projections to olfactory cortical areas, but not to the OB.

91 s suggest an inter-hemispheric asymmetry and olfactory cortical functional separation that may allow

92 Different olfactory cortical regions are thought to harbor distinc

93 he predicted covariation between an animal's olfactory cues and its glandular bacterial communities.

94 To simultaneously eliminate visual and olfactory cues associated with the position of the food,

95 models to investigate the role of visual and olfactory cues for the ecology and evolution of plant-an

96 c shift towards the use of visual instead of olfactory cues in risk evaluation.

97 prime anti-herbivore defenses in response to olfactory cues of insect pests.

98 window into exploring how social insects use olfactory cues to organize their collective behavior.

99 d the task using learned information and not olfactory cues.

100 ly clear that plants perceive and respond to olfactory cues.

101 erlying plant defense priming in response to olfactory cues.Plants are able to prime anti-herbivore d

102 rs OSN cilia during the response through the olfactory cyclic nucleotide-gated (CNG) channel and stim

103 arge and heterogeneous effects were seen for olfactory deficits in MCI relative to HOA (d=-0.76, 95%

104 ta-analysis was to investigate the nature of olfactory deficits in mild cognitive impairment (MCI).

105 seases, including Alzheimer's disease, where olfactory deficits precede detectable memory loss.

106 onclusion, patients with kidney disease have olfactory deficits that may influence their nutritional

107 iment, we investigated categorisation in the olfactory domain.

108 Given the ubiquitous but varying degrees of olfactory dysfunction among such diseases, it is conceiv

109 , would provide insight into the etiology of olfactory dysfunction associated with disease and mortal

110 Olfactory dysfunction is broadly associated with neurode

111 Enriching the olfactory environment of mice prolonged the period over

112 e ways in which an animal interacts with its olfactory environment, particularly as the animal shifts

113 own ex vivo from explants of embryonic mouse olfactory epithelia, we observed that axons dynamically

114 t al. (2017) and Lin et al. (2017) show that olfactory epithelial cells transit through unique and un

115 By using targeted knockout in olfactory epithelial stem cells in adult mice, we show t

116 The capacity of the olfactory epithelium (OE) for lifelong neurogenesis and

117 The remarkable capacity of the adult olfactory epithelium (OE) to regenerate fully both neuro

118 otide exchange factor (GEF) expressed in the olfactory epithelium and in the striatum.

119 tor cells residing in the basal layer of the olfactory epithelium are capable of reconstituting the n

120 Adult neurogenesis in the olfactory epithelium is often depicted as a unidirection

121 ssessed the expression of this marker in the olfactory epithelium of adult mice.

122 te buds including the epithelium of lips and olfactory epithelium, and ii) mechanosensory cells of ne

123 ng to define a detailed map of the postnatal olfactory epithelium, revealing cell fate potentials and

124 enerate multiple mature cell lineages in the olfactory epithelium.

125 ul for future studies of neurogenesis in the olfactory epithelium.

126 do not express the Galphaolf protein in the olfactory epithelium.

127 ivates neural stem cells to reconstitute the olfactory epithelium.

128 se lineage tracing in the regenerating mouse olfactory epithelium.

129 is facial and head motion during tactile and olfactory exploration.

130 irm the association between social lives and olfactory function and extend the notion by showing spec

131 Cognitively normal (CN) participants had olfactory function assessed using the Brief Smell Identi

132 quivocally mapped transcriptomes to specific olfactory function for six classes.

133 However, how inhibitory networks enhance olfactory function, and over what spatial scale they ope

134 ogical substrate causes these differences in olfactory function.

135 adal hormones in influencing male and female olfactory function.

136 This theory proposes that the activation of olfactory G protein-coupled receptors occurs by an inela

137 Ric-8b interacts with the olfactory Galphaolf subunit, and can amplify odorant sig

138 rent PN classes target dendrites to distinct olfactory glomeruli, while PNs of the same class exhibit

139 s, triggering long lasting depolarization of olfactory glomeruli.

140 conditional knock-out mice display impaired olfactory guided behavior.

141 tivity of principal cells precisely to drive olfactory-guided behavior.

142 ation immediately after formation, mediating olfactory-guided behavior.

143 Conventional measurements of olfactory health assess odor processing pathways within

144 tend the notion by showing specifically that olfactory identification ability is modulated by sex in

145 etermining food flavor, our understanding of olfactory impairment and of the olfaction-nutrition axis

146 Our preliminary results regarding olfactory improvement using intranasal theophylline warr

147 nto 1800 glomeruli in the OB, from which the olfactory information is delivered to and perceived by t

148 The integration of gustatory and olfactory information is essential to the perception of

149 n structure that mediates the first stage of olfactory information processing, participates in genera

150 al lobe, each of which represents a discrete olfactory information-processing channel.

151 However, how and where the different olfactory inputs interact has so far remained unknown.

152 mygdala selectively strengthened the weakest olfactory inputs to the brain.

153 ar cortex in the processing of gustatory and olfactory inputs, the exact location of olfactogustatory

154 ins several-but not all-types of associative olfactory learning and generalization by a few neural la

155 d genome-wide DNA methylation changes during olfactory learning and memory process in A. mellifera us

156 e involvement of DNA methylation in honeybee olfactory learning and memory process.

157 fruit fly, Drosophila melanogaster, aversive olfactory learning forms several phases of labile memory

158 We tested the effects of FLU on Apis cerana olfactory learning in larvae (lower dose of 0.033 microg

159 ould contribute to select behaviours such as olfactory learning or aggression.

160 cal connections with Kenyon cells for normal olfactory learning.

161 ated approach reveals the mechanisms guiding olfactory lineage trajectories and provides a model for

162 ncreased expression of genes atypical of the olfactory lineage.

163 on changes in a neuronal mRNA pool during an olfactory long-term associative memory (LTAM) in Caenorh

164 including GAP43, PGP9.5, but the absence of olfactory marker protein.

165 ila brain are involved in specific phases of olfactory memory.

166 ociated with disruption of either long-term (olfactory) memory or spontaneous alternation behavior.

167 asal forebrain regulation of this inhibitory olfactory microcircuit.Cholinergic neurons innervate mul

168 . oligospora likely evolved the means to use olfactory mimicry to attract its nematode prey through t

169 antibody were determined for lung and nasal olfactory mucosa (OM) from Cyp2abfgs-null, CYP2A13-human

170 rion protein in cerebrospinal fluid (CSF) or olfactory mucosa (OM) samples.

171 When the olfactory mucus was washed out by the injection of PBS t

172 e the existing maps to a new template map of olfactory networks with connections to all key secondary

173 purpose in two existing neuroimaging maps of olfactory networks.

174 ructural connectivity profile of the primary olfactory networks.

175 tworks with connections to all key secondary olfactory networks.

176 t that the parallelism observed in the adult olfactory neuroanatomy of ecological specialists extends

177 can exhibit parallel changes in their adult olfactory neuroanatomy.

178 It was subsequently also found in the rat olfactory neuroepithelium, especially at the apical junc

179 diated asymmetric differentiation of the AWC olfactory neuron pair, and conferred significant ethanol

180 elaboration of ciliated endings of different olfactory neuron types in the nematode C. elegans.

181 specify other identity features of distinct olfactory neuron types.

182 transcribed at different levels in distinct olfactory neuron types.

183 lm1, which is highly expressed in peripheral olfactory neurons at levels equivalent to Omp.

184 ic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses

185 cry to attract its nematode prey through the olfactory neurons in C. elegans and related species.

186 e functional significance of this GEF in the olfactory neurons in vivo remains unknown.

187 In addition, we demonstrate that olfactory neurons lacking Ric-8b (and consequently Galph

188 re we show that Thisbe, an FGF released from olfactory neurons, particularly from local interneurons,

189 fensive and aggressive responses elicited by olfactory or, to a lesser extent, vomeronasal stimuli.

190 , which display substantial asymmetry of the olfactory organs and forebrain.

191 Olfactory perception and behaviors critically depend on

192 uscular junction bouton structures, impaired olfactory perception, and severe neurodegeneration in br

193 The connection between olfactory performance and social lives could reflect soc

194 ory bulb is reversed, mirroring the inverted olfactory performance.

195 ed pluripotent cells into either cortical or olfactory placodal neurons.

196 of prey under artificial light at night when olfactory predator cues were present, indicating an oppo

197 ent and/or maintenance of the highly complex olfactory processing areas in the ant brain.

198 shown to influence sensory, and specifically olfactory processing at the behavioral and physiological

199 a distinct electrophysiological signature of olfactory processing in the human brain.

200 of odorant concentrations, but where in the olfactory processing pathway this invariance is generate

201 Drosophila olfactory projection neurons (PNs) are among the best-ch

202 rmint oil, known for their potent, mint-like olfactory properties.

203 native theory concerning the method by which olfactory proteins are activated has garnered attention.

204 Using a large olfactory psychophysical data set, teams developed machi

205 d of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000.

206 cular, our results showed contraction of the Olfactory Receptor (OR) gene repertoire in the last comm

207 ic expression of only one out of >1000 mouse olfactory receptor (ORs) genes requires the formation of

208 Mouse olfactory receptor 23 (MOR23, olfr16) and its human orth

209 Frameshift (FS) indels are enriched in olfactory receptor activity while non-frameshift (NFS) i

210 mbly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projectio

211 transcription factor combinations specifying olfactory receptor neuron (ORN) fates.

212 pulses and steps, but it remains unclear how olfactory receptor neurons (ORNs) detect the intensity a

213 The basis for host odor responses resides in olfactory receptor neurons (ORNs) that express chemorece

214 cortex explaining incoming activity from the olfactory receptor neurons in terms of a mixture of odor

215 ENT We have uncovered a mechanism underlying olfactory receptor sensitivity regulation in Drosophila

216 ixed, a response mainly due to the conserved olfactory receptor, Or42b.

217 iated by the binding of odorant molecules to olfactory receptors (ORs).

218 The olfactory receptors are employed as a biological element

219 aracterisation of the gene family coding the olfactory receptors contributed to the elaboration and d

220 eizure-like events (SLEs) are induced in the olfactory regions by acute treatment of both tangential

221 The olfactory response of Drosophila to ammonia has been stu

222 y roles in both mediating and regulating the olfactory response.

223 In contrast, in longer (7 d) exposures, olfactory responses remained impaired, but not in fish t

224 In 30 min OSPW exposures, olfactory responses to a food odorant and a pheromone we

225 Much is known about olfactory responses to pulses and steps, but it remains

226 gyrus and the first detailed description of olfactory sensations obtained by direct stimulation of m

227 rhynchus mykiss) could detect OSPW using its olfactory sense (smell) and whether exposure to it would

228 Shearwaters deprived of their olfactory sense before being displaced to distant sites

229 We observed plasticity in olfactory sensitivity after transition to reproductive s

230 ifferences matched the pattern of changes in olfactory sensitivity.

231 We present a model of connections between olfactory sensory input and bees' mushroom bodies [6], i

232 The mouse olfactory sensory neuron (OSN) repertoire is composed of

233 We show that, whereas TCs respond to olfactory sensory neuron (OSN) stimulation with short la

234 so are much more sensitive to stimulation of olfactory sensory neurons (OSNs) in bulb slices.

235 is a natural biosensor since its peripheral olfactory sensory neurons (OSNs) respond to the external

236 detect odorous chemicals through specialized olfactory sensory neurons (OSNs) that transduce odorants

237 In vertebrate olfactory sensory neurons (OSNs), Ca(2+) plays key roles

238 ually dimorphic neural coding of odorants by olfactory sensory neurons (OSNs), primary sensory neuron

239 C]GV1-57, that appears to specifically label olfactory sensory neurons (OSNs), which are essential fo

240 Quantification of the olfactory sensory neurons (OSNs), which detect odors wit

241 CD11b- and Iba-1-positive cells, and loss of olfactory sensory neurons (OSNs).

242 Here, we examined Drosophila olfactory sensory neurons and found that inhibitory odor

243 r-evoked inhibition and excitation in single olfactory sensory neurons increases the odor-coding capa

244 We report that deletion of Ric-8b in olfactory sensory neurons prevents stable expression of

245 by the odorant receptors on the membrane of olfactory sensory neurons, plays a vital role in their h

246 eptors, inhibiting the basal spike firing in olfactory sensory neurons.

247 mechanisms generate a highly individualized olfactory sensory system by promoting neuronal diversity

248 al developmental abnormalities in visual and olfactory sensory systems in Down syndrome model mice, w

249 d that piriform oscillatory activity conveys olfactory-specific information that can be decoded withi

250 We found that olfactory-specific Ric-8b knock-out mice of mixed sex do

251 Finally, behavioral tests showed that the olfactory-specific Ric-8b knock-out mice show an impaire

252 ing cell fate potentials and branchpoints in olfactory stem cell lineage trajectories.

253 Olfactory stem cells produce support cells via direct fa

254 Following injury, quiescent olfactory stem cells rapidly shift to activated, transie

255 p and long exploratory dives are promoted by olfactory stimulations.

256 Olfactory stimuli are first processed in the antennal lo

257 it is unknown how single GC neurons process olfactory stimuli emanating from the mouth.

258 ectivity underlying the neural processing of olfactory stimuli in normosmic adults.

259 involving pleasant, unpleasant, and neutral olfactory stimuli, designed to separate distinct phases

260 or bimodal, responding to both gustatory and olfactory stimuli.

261 s, the model can discriminate and generalize olfactory stimuli.

262 sensory neurons of the vomeronasal organ, an olfactory structure mediating innate avoidance behaviors

263 t the ACo is reciprocally connected with the olfactory system and basal forebrain, as well as with th

264 reby labeling immature OSNs in both the main olfactory system and vomeronasal organ.

265 The olfactory system appears to be generally enlarged and is

266 d serotonergic neurons within the Drosophila olfactory system as a model to establish a framework for

267 arbor in mature sensory neurons in the main olfactory system but not in the accessory olfactory syst

268 udy demonstrated that the in vivo biomimetic olfactory system could provide novel approaches to enhan

269 t that hormonal modulation of the peripheral olfactory system could underlie differences in how males

270 The anatomically relatively simple olfactory system demonstrates lateralization in both hum

271 nformation processing in the mouse accessory olfactory system guides the expression of social behavio

272 lopmental programs underlying the Drosophila olfactory system harbor a disproportionate amount of int

273 The olfactory system is a natural biosensor since its periph

274 The honeybee olfactory system is a well-established model for underst

275 ptional profiles in the adult and developing olfactory system of the six species suggest the possibil

276 ene expression during the development of the olfactory system of two specialist Drosophila species to

277 t genes or sets of genes underlie visual and olfactory system phenotypes.

278 e are congenitally anosmic and have abnormal olfactory system physiology, additionally Karstensen et

279 Therefore, the role of CFAP69 in the olfactory system seems to be to allow the olfactory tran

280 We propose that the early olfactory system uses approximate Bayesian inference to

281 Albeit located in parallel partitions of the olfactory system, 5-HT largely elicited MC excitation in

282 ion but also for the development of the CNS, olfactory system, and pancreas.

283 e first station of sensory processing in the olfactory system, GABAergic interneuron signaling shapes

284 In the mouse olfactory system, mitral cells (MCs) and tufted cells (T

285 the nervous system, including the peripheral olfactory system.

286 in olfactory system but not in the accessory olfactory system.

287 ed four critical developmental stages of the olfactory system: 3rd instar larval (prepatterning), 8 h

288 ent of the visual, auditory, vestibular, and olfactory systems, attributable to profound defects in s

289 to be functionally expressed in several non-olfactory systems.

290 e in the signal makes detection a formidable olfactory task.

291 Olfactory threshold of (S)-2-methylbutyl acetate was eva

292 t concentrations considerably lower than its olfactory threshold, 2-methylbutyl acetate was associate

293 considered negative regulatory mechanisms of olfactory transduction also play a role in setting the r

294 t there is a kinetic "damper" present in the olfactory transduction cascade of the mouse that slows d

295 he olfactory system seems to be to allow the olfactory transduction machinery to work at a precisely

296 unoreactive (-ir) perikarya were seen in the olfactory tubercle, striatum, medial septal nucleus, ver

297 field, we quantified Anopheles responses to olfactory, visual and thermal stimuli in Burkina Faso us

298 Similar local circuitry operates in the olfactory, visual, and auditory systems, suggesting a po

299 bodies, higher-order integration centers for olfactory, visual, gustatory and tactile information.

300 nces in how males and females experience the olfactory world.