ライフサイエンスコーパス: olfactory epithelium

1 ivates neural stem cells to reconstitute the olfactory epithelium.

2 BC) as the neural stem cell of the postnatal olfactory epithelium.

3 do not express the Galphaolf protein in the olfactory epithelium.

4 n may be among the roles of Sox2/Pax6 in the olfactory epithelium.

5 of OSNs in the olfactory placode to an aging olfactory epithelium.

6 y neurons (OSNs), which reside in the dorsal olfactory epithelium.

7 chemosensory signaling occurs outside of the olfactory epithelium.

8 reduced olfaction is due to a dysfunctional olfactory epithelium.

9 ons of the septal organ and also of the main olfactory epithelium.

10 ater becomes restricted to the ventrolateral olfactory epithelium.

11 rs extracellular space K(+) buffering in the olfactory epithelium.

12 expression in supportive cells of the nasal olfactory epithelium.

13 diated by the vomeronasal organ and the main olfactory epithelium.

14 ein and G-protein G(olf) in the cilia of the olfactory epithelium.

15 of a second family of receptors in the mouse olfactory epithelium.

16 nspire air (sniff) to convey odorants to the olfactory epithelium.

17 d end feet of the sustentacular cells of the olfactory epithelium.

18 nt embryos show impaired neurogenesis in the olfactory epithelium.

19 localize to cellular plasma membranes in the olfactory epithelium.

20 essential for antigen trafficking across the olfactory epithelium.

21 n and the enhancement of neurogenesis within olfactory epithelium.

22 se lineage tracing in the regenerating mouse olfactory epithelium.

23 val of olfactory sensory neurons in the main olfactory epithelium.

24 ll lineage commitment and development of the olfactory epithelium.

25 -deleted virus replicated efficiently in the olfactory epithelium.

26 vity cartilage and bony projections, and the olfactory epithelium.

27 n heterologous expression systems and in rat olfactory epithelium.

28 the distribution of sensory cells within the olfactory epithelium.

29 cross the extent and within the depth of the olfactory epithelium.

30 of M71 OR and beta(2)-AR expression in mouse olfactory epithelium.

31 ctory glomeruli after chemical damage of the olfactory epithelium.

32 brain and spinal cord, sensory ganglia, and olfactory epithelium.

33 eyond their role as odorant detectors in the olfactory epithelium.

34 is expressed in both the olfactory bulb and olfactory epithelium.

35 are thought to require interactions with the olfactory epithelium.

36 ation of GBCs is the neural stem cell of the olfactory epithelium.

37 The Dlx5-/- mutation reduces the size of the olfactory epithelium.

38 ed loss of olfactory receptor neurons of the olfactory epithelium.

39 ort of horseradish peroxidase applied to the olfactory epithelium.

40 ineage commitment and the development of the olfactory epithelium.

41 PACAP are expressed in developing and adult olfactory epithelium.

42 stricted to the same medial subregion of the olfactory epithelium.

43 unlike those of receptor neurons in the main olfactory epithelium.

44 ed after exposure of a large area of the rat olfactory epithelium.

45 mental role in information processing in the olfactory epithelium.

46 ulation of sensory neurons in the mouse main olfactory epithelium.

47 DM)-ventrolateral (VL) gradient in the mouse olfactory epithelium.

48 an, and chemosensory neurons within the main olfactory epithelium.

49 tation mouse embryo and the developing mouse olfactory epithelium.

50 highly sensitive to temperature drops at the olfactory epithelium.

51 hts into the dynamics of neurogenesis in the olfactory epithelium.

52 (mOSNs), the primary sensory neurons of the olfactory epithelium.

53 ife and that odorant environment affects the olfactory epithelium.

54 ntiation of multiple other cell types in the olfactory epithelium.

55 t was indeed eliminated in the mutant mice's olfactory epithelium.

56 of v2r family C, are restricted to the main olfactory epithelium.

57 enerate multiple mature cell lineages in the olfactory epithelium.

58 neurons, the primary sensory neurons of the olfactory epithelium.

59 function and OR representation in the adult olfactory epithelium.

60 ul for future studies of neurogenesis in the olfactory epithelium.

61 to develop a chronic BLM has focused on the olfactory epithelium.

62 The adult olfactory epithelium, a site for ongoing, life-long, rob

63 f that family during the recovery of the rat olfactory epithelium after methyl bromide lesion.

64 the initial site of replication or from the olfactory epithelium after viremic spread.

65 Temperature drops at the contralateral olfactory epithelium also induced responses in the gamma

66 eas within the most ventral zone of the main olfactory epithelium, although their expression patterns

67 amily members are known to be present in the olfactory epithelium and are thought to affect olfaction

68 studies of odor-elicited responses from the olfactory epithelium and bulb in the tiger salamander, A

69 We used the olfactory system (olfactory epithelium and bulb) because its attributes ma

70 ch has been learned about odor coding in the olfactory epithelium and bulb, but little is known about

71 ystem are nestled within the recesses of the olfactory epithelium and detect diverse odorants; howeve

72 nd a neurogenin1 reporter ingressed into the olfactory epithelium and differentiated into microvillou

73 Neuronal differentiation in the olfactory epithelium and directed growth of axons in the

74 develop altered head morphology, an expanded olfactory epithelium and disorganized peripheral axons.

75 re slowly and specifically depleted from the olfactory epithelium and display unusual patterns of pro

76 ed the expression of Pax6 and Sox2 in normal olfactory epithelium and during epithelial regeneration

77 the central and peripheral nervous systems, olfactory epithelium and endocrine pancreas.

78 establish normal connections with peripheral olfactory epithelium and help olfactory bulb recovery fr

79 mmalian homologs of which are coexpressed in olfactory epithelium and hematopoietic cells.

80 specific receptor representation in the main olfactory epithelium and in glomeruli within the olfacto

81 ining the spatial organization of the normal olfactory epithelium and in reestablishing the neuronal

82 is expressed at different levels across the olfactory epithelium and in restricted glomeruli across

83 n the olfactory nerve bundles underlying the olfactory epithelium and in the olfactory nerve layer an

84 otide exchange factor (GEF) expressed in the olfactory epithelium and in the striatum.

85 The olfactory epithelium and its projection onto the bulb ar

86 rderly projections of sensory neurons in the olfactory epithelium and may also involve chromatography

87 fic in both olfactory sensory neurons of the olfactory epithelium and mitral cells of the olfactory b

88 The volumes of the main olfactory epithelium and muscles regulating diameter of

89 gene expression, we found that the isolated olfactory epithelium and OB, but not the piriform cortex

90 and elimination of neurons within the adult olfactory epithelium and olfactory bulb allows for adapt

91 utants is observed in zebrafish in which the olfactory epithelium and olfactory bulb have been excise

92 r learning-induced structural changes in the olfactory epithelium and olfactory bulb in an odorant li

93 beta-Galactosidase distribution in the olfactory epithelium and olfactory bulb in Cx36 knockout

94 the expression of connexin 36 (Cx36) in the olfactory epithelium and olfactory bulb of adult mice.

95 ined that Sall3 is expressed by cells in the olfactory epithelium and olfactory bulb.

96 on is maintained in the developing and adult olfactory epithelium and olfactory nerve.

97 stem-cell self-renewal, as documented in the olfactory epithelium and other tissues.

98 bulb (OB) receives odor information from the olfactory epithelium and relays this to the olfactory co

99 head trauma, viruses, and toxic agents, the olfactory epithelium and sectors of the olfactory bulb h

100 We detected transcription of OR-A in both olfactory epithelium and testis tissue using RT-PCR ampl

101 organs in the vertebrate head, including the olfactory epithelium and the crystalline lens of the eye

102 rom contact with all other cells between the olfactory epithelium and the glomerulus of the olfactory

103 self-renewing interfollicular epidermis, the olfactory epithelium and the intestinal crypts of Lieber

104 icrovillous sensory neurons in the zebrafish olfactory epithelium and the mouse vomeronasal organ.

105 animals uncovered parallels between the main olfactory epithelium and the vomeronasal organ in the re

106 to the sustentacular cells of the unlesioned olfactory epithelium and to the adjoining respiratory ep

107 or for SDF-1, is expressed by neurons in the olfactory epithelium and VNO.

108 ceptors and signaling components of the main olfactory epithelium and vomeronasal organ involved in p

109 expressed in sensory cells in the developing olfactory epithelium and vomeronasal organ, with both li

110 s were expressed specifically in OSNs in the olfactory epithelium, and ANO2::EGFP fusion protein loca

111 oupled receptors that detect odorants in the olfactory epithelium, and comprise the largest gene fami

112 te buds including the epithelium of lips and olfactory epithelium, and ii) mechanosensory cells of ne

113 dorsal root ganglia, trigeminal ganglia, and olfactory epithelium, and less intense expression in the

114 Dlx5 is expressed in the olfactory placode, olfactory epithelium, and local circuit neurons of the o

115 O/E proteins are highly expressed in the olfactory epithelium, and O/E binding sites have been id

116 ell numbers, number of mature neurons in the olfactory epithelium, and reactive astrocyte numbers in

117 different patterns of deposition across the olfactory epithelium, and that these patterns are differ

118 s expressed in other tissues, such as brain, olfactory epithelium, and the inner ear, and may modulat

119 ithelium, were unaffected by blockade of the olfactory epithelium, and were independent of respiratio

120 onal distribution of ORs within zones of the olfactory epithelium appeared stable across development;

121 he only O/E family member expressed, but the olfactory epithelium appeared unaffected and olfactory m

122 tor cells residing in the basal layer of the olfactory epithelium are capable of reconstituting the n

123 Odorant receptors (ORs) in the olfactory epithelium bind to volatile small molecules le

124 We collected olfactory epithelium brushings and cerebrospinal fluid s

125 several regions of the brain, including the olfactory epithelium, bulb, peri/paraventricular nuclei,

126 involved in chloride ion accumulation in the olfactory epithelium, but it is also involved in OSN neu

127 2 expression, cadherin-4 is not found in the olfactory epithelium, but it is detected in the larval a

128 that the functional inactivation of the main olfactory epithelium, but not the vomeronasal organ, cau

129 not spatially organized at the level of the olfactory epithelium, but whose axonal projections form

130 oes compromise the integrity of parts of the olfactory epithelium by altering proliferation, neuronal

131 were investigated in the murine eye and the olfactory epithelium by analysing gene expression and di

132 Direct damage to the olfactory epithelium by inhalation of the olfactotoxin m

133 NPY is synthesized in the postnatal olfactory epithelium by sustentacular cells, previously

134 Odorants are detected in the nasal olfactory epithelium by the odorant receptor family, who

135 nerative capacity, recovery of the mammalian olfactory epithelium can fail in severely injured areas,

136 Within the olfactory epithelium, Cbr2 is a new anatomical marker fo

137 In the olfactory epithelium, CFAP69 is enriched in OSN cilia, w

138 Growing evidence suggests that the main olfactory epithelium contains a subset of olfactory sens

139 Thus, even in the adult, the olfactory epithelium contains neurons at various develop

140 Since the olfactory epithelium continues to generate new olfactory

141 symptom of AD with amyloid pathology in the olfactory epithelium correlating well to the brain patho

142 Confocal microscopy of the olfactory epithelium detected similar amounts of virus-s

143 ck of olfactory receptor neurons in the main olfactory epithelium, developing Mash1-/-;Tattler-4+/- m

144 r required for B-cell lineage commitment and olfactory epithelium development.

145 pression of Abeta40 or Abeta42 solely in the olfactory epithelium disrupts the olfactory sensory neur

146 Each neuron in the olfactory epithelium expresses only one allele of one OR

147 rane proteins, explants from Shep1 knock-out olfactory epithelium extend neuronal processes less effi

148 cclusion blocked access of odors to the main olfactory epithelium for the duration of the study.

149 iboprobes for eight odorant receptors on the olfactory epithelium from unilaterally methyl bromide-le

150 along the developmental lineage of the main olfactory epithelium-from multipotent stem cells through

151 son with the rest of the nervous system, the olfactory epithelium has an unparalleled ability to rene

152 y the vomeronasal organ, and not by the main olfactory epithelium, has recently been called into ques

153 trong expression of ABCG1 transcripts in the olfactory epithelium, hind brain, eye, and dorsal root g

154 gions with prolonged neurogenesis, e.g., the olfactory epithelium, hippocampus, basal forebrain and c

155 The olfactory epithelium houses chemosensory neurons, which

156 The olfactory epithelium in AQP4-null mice had identical app

157 of RT-QuIC analysis of nasal brushings from olfactory epithelium in diagnosing sporadic Creutzfeldt-

158 ctory receptor neurons extend axons from the olfactory epithelium in the antenna into the brain.

159 sis maintains the neuronal population of the olfactory epithelium in the face of piecemeal neuronal t

160 ed ethmoid turbinals supporting an expansive olfactory epithelium in the nasal cavity, allowing full

161 NiV initially predominantly targeted the olfactory epithelium in the nasal turbinates.

162 ory sensory neurons in the mature Chd7(Gt/+) olfactory epithelium indicate critical roles for Chd7 in

163 s affected in CHARGE syndrome including eye, olfactory epithelium, inner ear and vascular system.

164 The olfactory epithelium is a sensory neuroepithelium that s

165 In adult mammals, the olfactory epithelium is a uniquely robust neuroprolifera

166 Ventral olfactory epithelium is at particular risk for metaplasi

167 n Lhx2-deficient mice, the morphology of the olfactory epithelium is grossly normal.

168 The olfactory epithelium is mostly populated by ciliated olf

169 Adult neurogenesis in the olfactory epithelium is often depicted as a unidirection

170 al olfactory cavity (PC), whereas a separate olfactory epithelium lies in the vomeronasal organ (VNO)

171 These odors elicit responses in the olfactory epithelium, main olfactory bulb, and olfactory

172 on of mRNA encoding Cx36 was observed in the olfactory epithelium mainly in ventral and lateral regio

173 The olfactory epithelium maintains stem and progenitor cells

174 pathways, if they are active in normal adult olfactory epithelium, may play a minor role in this tiss

175 educes cAMP production by odorant-stimulated olfactory epithelium membranes, in which the alpha(s) fa

176 cle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction, and pharyn

177 Studies of the olfactory epithelium model system have demonstrated that

178 sumed that odorants are detected by the main olfactory epithelium (MOE) and pheromones are sensed thr

179 y distinct chemosensory structures: the main olfactory epithelium (MOE) and the vomeronasal organ (VN

180 olfactory sensory neurons (OSNs) in the main olfactory epithelium (MOE) are stimulated by volatile ch

181 The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odoran

182 The main olfactory epithelium (MOE) is an excellent model to stud

183 The main olfactory epithelium (MOE) is primarily involved in the

184 y sensory neurons (OSNs) located in the main olfactory epithelium (MOE) send their axons to glomeruli

185 etected by the vomeronasal organ or the main olfactory epithelium (MOE) trigger social behaviors in m

186 olfactory sensory neurons (OSNs) in the main olfactory epithelium (MOE), and on the coalescence of OS

187 ty: the vomeronasal organ (VNO) and the main olfactory epithelium (MOE).

188 ical role in the septal organ as in the main olfactory epithelium (MOE).

189 ATP released by the olfactory epithelium (OE) after noxious stimuli provides

190 r GFRalpha1 are prominently expressed in the olfactory epithelium (OE) and olfactory bulb (OB), but t

191 DCC is expressed by cells in the olfactory epithelium (OE) and VNO, and in cells migratin

192 tterns of receptor expression in the ventral olfactory epithelium (OE) are mirrored in the dorsal OE.

193 Macrophages infiltrated the olfactory epithelium (OE) by 16 hours post-OBX.

194 Olfactory epithelium (OE) contains a population of proge

195 Neurons in the olfactory epithelium (OE) each express a single dominant

196 velopment, axons from sensory neurons in the olfactory epithelium (OE) extend into the olfactory bulb

197 The capacity of the olfactory epithelium (OE) for lifelong neurogenesis and

198 The embryonic olfactory epithelium (OE) generates only a very few olfa

199 Neural precursors in the developing olfactory epithelium (OE) give rise to three major neuro

200 Olfactory epithelium (OE) has a lifelong capacity for ne

201 rgely completed by the end of gestation, the olfactory epithelium (OE) is a unique part of the centra

202 The olfactory epithelium (OE) is composed of olfactory senso

203 The vertebrate olfactory epithelium (OE) is known for its ability to re

204 The olfactory epithelium (OE) is one of the few tissues to u

205 development of the cerebral hemispheres and olfactory epithelium (OE) is severely reduced.

206 levels in the olfactory bulb (OB) following olfactory epithelium (OE) lesion in mice, and hypothesiz

207 The olfactory epithelium (OE) of mice deficient in cystic fi

208 neurons have been extensively studied in the olfactory epithelium (OE) of rodents but not in humans.

209 Mouse olfactory epithelium (OE) originates from ectodermally d

210 Neurons of the vertebrate olfactory epithelium (OE) regenerate continuously throug

211 e characterized two precursor classes in the olfactory epithelium (OE) shortly after it becomes a dis

212 In Shh-/-embryos, ORN axons exit a single olfactory epithelium (OE) that develops centrally within

213 The ability of the olfactory epithelium (OE) to regenerate after injury is

214 The remarkable capacity of the adult olfactory epithelium (OE) to regenerate fully both neuro

215 lfactory sensory neuron (OSN) axons from the olfactory epithelium (OE) to the olfactory bulb (OB) is

216 operties of sustentacular cells (SCs) in the olfactory epithelium (OE) were investigated in tissue sl

217 spatially restricted manner in the mammalian olfactory epithelium (OE), and this patterning probably

218 on globose basal cells (GBCs) of the rodent olfactory epithelium (OE), are described.

219 D1 is expressed in embryonic and adult mouse olfactory epithelium (OE), as well as during epithelial

220 y stem/progenitor cells is a hallmark of the olfactory epithelium (OE), beginning at the placodal sta

221 In the olfactory epithelium (OE), generation of new neurons by

222 if another neurogenic tissue, the peripheral olfactory epithelium (OE), might also exhibit changes af

223 In vertebrate olfactory epithelium (OE), neurogenesis proceeds continu

224 In the olfactory epithelium (OE), odorant receptor stimulation

225 emonstrated a reduced number of cells in the olfactory epithelium (OE), resulting in a thinner neuron

226 S was expressed in developing neurons in the olfactory epithelium (OE), while in the adult its expres

227 ly controlled manner specifically within the olfactory epithelium (OE).

228 system, and they have also been observed in olfactory epithelium (OE).

229 ctivation of resident macrophages within the olfactory epithelium (OE).

230 to identify possible sources of apoE in the olfactory epithelium (OE).

231 tor, enzyme PLC140, are present in the squid olfactory epithelium (OE).

232 fluences neuron development in the postnatal olfactory epithelium (OE).

233 icantly to tissue regeneration in the murine olfactory epithelium (OE).

234 chemical or biological agents therein is the olfactory epithelium (OE).

235 ate gyrus (DG), olfactory bulb (OB), and the olfactory epithelium (OE).

236 s, the horizontal basal cells (HBCs), in the olfactory epithelium (OE).

237 ially expressed in the developing and mature olfactory epithelium (OE): Axons elaborated by ventral a

238 but consistently through ventral and lateral olfactory epithelium (OE); and 3) projects to just two t

239 ssessed the expression of this marker in the olfactory epithelium of adult mice.

240 The olfactory epithelium of fish contains three intermingled

241 Reporter gene expression in the olfactory epithelium of H-lacZ6 transgenic mice mimics t

242 ly, this analysis also revealed that, in the olfactory epithelium of Mash1-/- animals, there is an ov

243 A protein that is found in the main olfactory epithelium of mice ensures that odour-sensing

244 general systems and in the model system, the olfactory epithelium of mouse.

245 ed ribosome immunoprecipitation of mRNA from olfactory epithelium of odor-stimulated mice followed by

246 e of microvillous sensory neurons within the olfactory epithelium of zebrafish embryos.

247 ire olfactory system, driving neurons in the olfactory epithelium, olfactory bulb (OB), and cortex.

248 Cadherin-2 is expressed in the olfactory epithelium, olfactory nerve, and olfactory bul

249 Here, we show that, in the mouse olfactory epithelium, olfactory receptor (OR) genes are

250 risingly, there was no evidence of PrP(d) in olfactory epithelium or olfactory nerve fascicles at any

251 expressing Cre in peripheral neurons of the olfactory epithelium or the retina reveals widespread, p

252 have found the expression of Ggamma13 in the olfactory epithelium, particularly in the cilia of the O

253 Persistent neurogenesis in the olfactory epithelium provides a unique model to study ne

254 The continuous replacement of neurons in the olfactory epithelium provides an advantageous model for

255 Olfactory sensory neurons (OSNs) in the main olfactory epithelium respond to environmental odorants.

256 Permanent zinc sulfate lesion of the olfactory epithelium resulted in a selective loss of the

257 ort of horseradish peroxidase applied to the olfactory epithelium revealed numerous axons of olfactor

258 ng to define a detailed map of the postnatal olfactory epithelium, revealing cell fate potentials and

259 n this preliminary study, RT-QuIC testing of olfactory epithelium samples obtained from nasal brushin

260 eaction showed that they were transcribed in olfactory epithelium (SORB, SORF, all SVR and Sasa CaSR

261 y aquatic larvae of Xenopus laevis, the main olfactory epithelium specialized for sensing water-borne

262 olfactory sensory neurons (OSNs) in the main olfactory epithelium starting from embryonic stage 11.5

263 lase transduction system in the cilia of the olfactory epithelium, suggesting a mechanism of the olfa

264 harmacologically induced degeneration of the olfactory epithelium, suggesting that it is intrinsicall

265 nd olfactory sensory neuron formation in the olfactory epithelium, suggesting that the loss of CHD7 m

266 des induce large EOG responses in the rodent olfactory epithelium, suggesting that these compounds ac

267 suggests that olfactory receptor neurons and olfactory epithelium supporting cells may share a common

268 This suggests that changes in the PC olfactory epithelium that are seen during metamorphosis

269 As a tissue of choice, we selected trout olfactory epithelium that has been previously suggested

270 ged into the adult "air nose," whereas a new olfactory epithelium, the adult "water nose," forms in t

271 urocrine tissues as diverse as the lens, the olfactory epithelium, the inner ear, the cranial sensory

272 of OAs with supporting cells throughout the olfactory epithelium, the lamina propria, the fila olfac

273 s are expressed in nearly all neurons of the olfactory epithelium, the vomeronasal organ, the septal

274 In the zebrafish olfactory epithelium, three morphologically distinct olf

275 e tuned the neurophysiologic response of the olfactory epithelium to ethanol odor at some expense to

276 ion of retroviral vectors into the embryonic olfactory epithelium to study the ORs' contribution to a

277 id cells provided a route of spread from the olfactory epithelium to TG neurons, while SSMs blocked s

278 now be obtained based on the global from the olfactory epithelium to the OB glomerular activity patte

279 ensory neurons (OSNs) project axons from the olfactory epithelium to the OB, where they form spherica

280 olfactory nerve (ON) and then grow from the olfactory epithelium to the olfactory bulb (OB), enter t

281 Axonal projections from the olfactory epithelium to the olfactory bulb are organized

282 These neurons extend their axons from the olfactory epithelium to the olfactory bulb located at th

283 veral subsystems that project axons from the olfactory epithelium to the olfactory bulb.

284 Sensory axons extend from the chick olfactory epithelium to the telencephalon well before th

285 neurons (OSNs) project their axons from the olfactory epithelium toward the olfactory bulb (OB) in a

286 lso shown that air pollution can contact the olfactory epithelium, translocate to the olfactory bulb,

287 ion was also found in the developing retina, olfactory epithelium, trigeminal ganglion, and hair foll

288 Moreover, within the main olfactory epithelium, v2r genes are expressed in a basal

289 ring development, expression of NCS-1 in the olfactory epithelium was localized in the dendritic knob

290 Olfactory epithelium was removed at autopsy from 13 pros

291 ature and mature OSNs coexisting in the same olfactory epithelium, we sought to use this unique syste

292 d as a spatial activation pattern across the olfactory epithelium, when odor is drawn into the nose t

293 ing odorant molecules to the portions of the olfactory epithelium where they are best detected.

294 tau aggregates in the Bowman's glands of the olfactory epithelium, which holds potential for an endos

295 The sense of smell is mediated by the olfactory epithelium, which is composed of a mosaic patt

296 I odorant receptors located in zone 1 of the olfactory epithelium, which projects to the dorsal aspec

297 n, which constitutes approximately 1% of the olfactory epithelium, will provide new insights into the

298 induces oxidative stress and inflammation in olfactory epithelium with concomitant effects on brain.

299 to facilitate the rapid repopulation of the olfactory epithelium with mature neurons during normal c

300 lots correlated loss of KLF7 activity in the olfactory epithelium with significant downregulation of