ライフサイエンスコーパス: olfactory neuron

1 heromone are mediated by a specific class of olfactory neuron.

2 at results in a single OR gene expressed per olfactory neuron.

3 number of individual receptors in any single olfactory neuron.

4 re dispensable for proper function of mature olfactory neurons.

5 eins are secreted into the fluid that bathes olfactory neurons.

6 input to genetically identified second-order olfactory neurons.

7 ic experiments showed that wnt5 functions in olfactory neurons.

8 rants and a large repertoire of receptors in olfactory neurons.

9 with OBP-dependent activation of a subset of olfactory neurons.

10 these proteins are expressed specifically in olfactory neurons.

11 ecause neither Gli3 nor Shh are expressed in olfactory neurons.

12 g antibodies lead to elevated cAMP levels in olfactory neurons.

13 eptors impart odor sensitivity to particular olfactory neurons.

14 ATP modulates odor sensitivity in mammalian olfactory neurons.

15 th odor specificity of functional classes of olfactory neurons.

16 olinergic neurotransmitter phenotype of most olfactory neurons.

17 degree of synchronization among second-order olfactory neurons.

18 for cholinergic locus expression in primary olfactory neurons.

19 ssion in a zonally confined subpopulation of olfactory neurons.

20 ctory neurons or into unique combinations of olfactory neurons.

21 elief that no mGC besides GC-D exists in the olfactory neurons.

22 in proliferative basal cells and in immature olfactory neurons.

23 the predominant adenylyl cyclase isoform in olfactory neurons.

24 odorants that are recognized by the two AWC olfactory neurons.

25 may promote uptake of vaccine proteins into olfactory neurons.

26 default state in common with three types of olfactory neurons.

27 ion of a CNG channel resembling that seen in olfactory neurons.

28 sed patches of soma plasma membrane from rat olfactory neurons.

29 s with the bilaterally symmetric pair of AWC olfactory neurons.

30 POU-domain transcription factor expressed in olfactory neurons.

31 e sensory transduction in photoreceptors and olfactory neurons.

32 ane domain odorant receptors to the cilia of olfactory neurons.

33 ve odorant 2-nonanone is detected by the AWB olfactory neurons.

34 R-10, which is normally expressed in the AWA olfactory neurons.

35 uroepithelium and within primary cultures of olfactory neurons.

36 tics 10 times slower than for K+ currents in olfactory neurons.

37 one of several odorants detected by the AWA olfactory neurons.

38 es in VNO neurons are distinct from those in olfactory neurons.

39 that activates at -60 mV and is not found in olfactory neurons.

40 on of the Caenorhabditis elegans AWC and AWB olfactory neurons.

41 e considered to be the direct progenitors of olfactory neurons.

42 nhancers and study their in vivo activity in olfactory neurons.

43 etrance of specific ciliopathy phenotypes in olfactory neurons.

44 ibiting antigenic variation and in mammalian olfactory neurons.

45 y promotes odor adaptation in C. elegans AWC olfactory neurons.

46 te in the HSN/PHB lineage, and adaptation in olfactory neurons.

47 ersed by ectopic expression of LBR in mature olfactory neurons.

48 t can lead to an improved coding capacity in olfactory neurons.

49 nd disrupts the targeting specificity of the olfactory neurons.

50 ed in a monogenic and monoallelic fashion in olfactory neurons.

51 , odour-specific sequence of activity across olfactory neurons.

52 a stage similar to ciliated and microvillous olfactory neurons.

53 e differentiated at a stage similar to other olfactory neurons.

54 on gene expression in Caenorhabditis elegans olfactory neurons.

55 back loop alters sensory dynamics in primary olfactory neurons.

56 f G(i2) is restricted to a sub-population of olfactory neurons, along the dorsal septum and the dorsa

57 Olfactory neurons also influence life span, and they act

58 anges dramatically during the lifetime of an olfactory neuron and is demonstrated by inducing the epi

59 e cGMP-dependent protein kinase EGL-4 in AWC olfactory neurons and an insulin signal from AIA interne

60 Loss of olfactory neurons and associated circuitry is linked to

61 is present in several tissues in addition to olfactory neurons and developing B-cells, O/E-2 and O/E-

62 AWC reporter gene inappropriately in the AWB olfactory neurons and fail to express an AWB reporter ge

63 ter that could regulate GABA levels to which olfactory neurons and glial cells are exposed.

64 for the regulation of signal transduction in olfactory neurons and likely in other neurons as well.

65 The identities of olfactory neurons and receptors required for attraction

66 odulates odor-evoked calcium dynamics in AWC olfactory neurons and requires INS-1, a neuropeptide rel

67 ODR-7 is expressed in the AWA olfactory neurons and specifies AWA sensory identity by

68 al analyses show that Snmp-1 is expressed in olfactory neurons and that the protein is localized to t

69 classes of sensory neurons: the AWA and AWC olfactory neurons and the male-specific CEM neurons.

70 een used to study the development of central olfactory neurons and the molecular basis of olfactory c

71 ial roles in the differentiation of otic and olfactory neurons and their integration into their non-n

72 permit the visualization of OCNC1-deficient olfactory neurons and their projections.

73 uggest that the odor response spectrum of an olfactory neuron, and perhaps the choice of receptor gen

74 eceptive fields of second and/or third order olfactory neurons, and by increases in the coherency of

75 family are expressed in distinct subsets of olfactory neurons, and certain family members are restri

76 bright green fluorescent protein in primary olfactory neurons, and S100beta-DsRed mice which express

77 ination revealed tuba1a expression in brain, olfactory neurons, and sensory cells of the lateral line

78 In photoreceptors, olfactory neurons, and some gustatory receptors, these c

79 iption factor involved in the development of olfactory neurons, and that missense alterations reduce

80 ecify the wiring and functional diversity of olfactory neurons are becoming increasingly well underst

81 eptors and signal transduction mechanisms in olfactory neurons are being elucidated; and an unusual n

82 The Caenorhabditis elegans AWA, AWB, and AWC olfactory neurons are each required for the recognition

83 Although some olfactory neurons are formed, they fail to generate olfa

84 is known about how the odor specificities of olfactory neurons are generated, a process essential to

85 Olfactory neurons are known to express beta-adrenergic r

86 ) ion channels of retinal photoreceptors and olfactory neurons are multimeric proteins of unknown sto

87 ing sensitivity regulation in insect primary olfactory neurons are poorly understood.

88 have long indicated that additional, non-VNO olfactory neurons are similarly necessary for pheromone

89 Cyclic nucleotide-gated (CNG) channels of olfactory neurons are tetramers and require three types

90 In vertebrates, individual olfactory neurons are thought to express a single odoran

91 , which were initially studied in retina and olfactory neurons, are activated by cytoplasmic cGMP or

92 a sweet receptors using the ab1C CO2-sensing olfactory neuron as a unique in vivo decoder.

93 f mature, olfactory marker protein (OMP) (+) olfactory neurons as compared to empty vector.

94 in vivo analysis of the P2 subpopulation of olfactory neurons as well as their projections to the ol

95 and deep omega-shaped turns triggered by AWC olfactory neurons, ASK gustatory neurons, and AIB intern

96 lm1, which is highly expressed in peripheral olfactory neurons at levels equivalent to Omp.

97 t produces two distinct neurons: ADF and the olfactory neuron AWB.

98 rmation processing by Caenorhabditis elegans olfactory neurons (AWC) and interneurons (AIB and AIY) t

99 ers that are expressed differentially in two olfactory neurons, AWC(ON) and AWC(OFF), we identify mut

100 five attractive odours with a single pair of olfactory neurons, AWC, but can distinguish among these

101 Response to fungal odors involves the olfactory neuron AWCs.

102 ys, colocalizes with OMP, a marker of mature olfactory neurons, but is not colocalized with the immat

103 r confers CO2 sensitivity on CO2-insensitive olfactory neurons, but neither gustatory receptor alone

104 Levels of H2BE are heterogeneous among olfactory neurons, but stereotyped according to the iden

105 Y-deficient mice develop significantly fewer olfactory neurons by adulthood.

106 ebris, even after widespread degeneration of olfactory neurons by unilateral bulbectomy and methimazo

107 With only five olfactory neurons, C. elegans can dynamically respond to

108 Caenorhabditis elegans uses one pair of olfactory neurons called AWC to sense many different odo

109 ric identities of two Caenorhabditis elegans olfactory neurons called AWC(ON) and AWC(OFF) are specif

110 We conclude that, although adult olfactory neurons can undergo plastic changes in respons

111 signaling between bilaterally symmetric AWC olfactory neurons causes them to express different odora

112 en two developing Caenorhabditis elegans AWC olfactory neurons causes them to take on asymmetric patt

113 ular zone (SVZ), a source of adult-generated olfactory neurons, changes reversed by CSA-WD.

114 essenger, could directly activate the native olfactory neuron channel.

115 tain the architecture of the specialized AWB olfactory neuron cilia in C. elegans.

116 ls express the three CNG subunits present in olfactory neurons (CNG2, -4.3, and -5) and exhibit funct

117 The axons of C. elegans left and right AWC olfactory neurons communicate at synapses through a calc

118 versus airborne stimuli respecified, or are olfactory neurons completely replaced?

119 Ectopic expression of Gr64e in an olfactory neuron conferred responsiveness to glycerol.

120 Primary cultures of immature olfactory neurons demonstrate neurotrophin-induced phosp

121 sent in the sensillum lymph bathing trichoid olfactory neuron dendrites.

122 al cells and secreted into the fluid bathing olfactory neuron dendrites.

123 amine whether neurotrophins are required for olfactory neuron development, we characterized in vivo t

124 lin-11 regulates AWA olfactory neuron differentiation by initiating expressio

125 sion is restricted to the terminal stages of olfactory neuron differentiation, and sensory neurons do

126 otes neuronal cell death, such that inactive olfactory neurons display higher levels of the variant a

127 rreversible genetic changes in the nuclei of olfactory neurons do not accompany OR selection, which m

128 ting that irreversible changes to the DNA of olfactory neurons do not accompany receptor gene choice.

129 ic disruption of the canonical CO(2)-sensing olfactory neurons does not alter in-flight attraction to

130 e there is considerable apoptosis of primary olfactory neurons during embryonic and postnatal develop

131 , these cues are sensed by a small number of olfactory neurons, each of which expresses several diffe

132 rception of the preferred diet's odor by AWB olfactory neurons elicits these adjustments by increasin

133 ulates robust activation of Or83c-expressing olfactory neurons, even at high dilutions.

134 contributions of particular conductances to olfactory neuron excitability and odor discrimination, w

135 Our results show that olfactory neurons exhibit a singular nuclear architectur

136 pported explanation for this ability is that olfactory neurons express a large number of seven transm

137 y epithelium, three morphologically distinct olfactory neurons express different marker proteins.

138 In mice, individual olfactory neurons express one of the thousand distinct o

139 Most Drosophila olfactory neurons express two types of odorant receptor

140 echanism that has yet to be elucidated, each olfactory neuron expresses a single receptor gene.

141 One set of Fru(+) olfactory neurons expresses the odorant receptor Or67d a

142 Olfactory neurons expressing a given odorant receptor pr

143 opmental problem: how to connect millions of olfactory neurons expressing different odorant receptors

144 Finally, we analyzed the responses of olfactory neurons expressing MOR161-2 in vivo using the

145 have also been reported upon manipulation of olfactory neurons expressing odorant receptor Or65a.

146 Olfactory neurons expressing the same odorant receptor c

147 Olfactory neurons expressing the same olfactory receptor

148 In olfactory neurons, expression of a single odorant recept

149 In Fezf1-deficient mice, olfactory neurons fail to mature and also express marker

150 hat they are attracted to and have dedicated olfactory neurons for detecting the scents produced by y

151 lecules that function within the third order olfactory neurons for normal olfactory learning.

152 Such supersustained responses may prevent olfactory neurons from reporting contemporaneous informa

153 ic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses

154 ugh it did not change the locations of other olfactory neurons, GnRH2 neurons, or brain patterning.

155 e the dynamic growth behaviors of individual olfactory neuron growth cones as they project to their g

156 Recently, the lifespan-shortening effect of olfactory neurons has been reported to be conserved in D

157 the subsequent cloning of related genes from olfactory neurons has sparked much progress over the pas

158 we now show that two clusters of third-order olfactory neurons have dimorphic pheromone responses.

159 the egg-laying system partly through the AWC olfactory neurons: High CO2 tonically activates AWC by a

160 In addition, basal olfactory neuron homeostasis was altered, shown by incre

161 ressive neuronal loss, suggesting defects in olfactory neuron homeostasis.

162 ion factors function to diversify C. elegans olfactory neuron identities, driving them from an AWC-li

163 icantly weaker expression of ppk25 occurs in olfactory neurons implicated in modulation of courtship

164 Here, we show that one olfactory neuron in Caenorhabditis elegans, AWC(ON), has

165 pecified by the olfactory receptor or by the olfactory neuron in which the receptor is activated.

166 ression of these genes in both gustatory and olfactory neurons in adult flies and larvae.

167 in odorant sensitivity in Drosophila primary olfactory neurons in both sexes.

168 cry to attract its nematode prey through the olfactory neurons in C. elegans and related species.

169 n ab8A neurons, a single functional class of olfactory neurons in Drosophila.

170 ured the rate of information transmission in olfactory neurons in intact, awake locusts (Schistocerca

171 iscontinuous receptive fields in the central olfactory neurons in mammals and insects, suggest genera

172 Mechanosensory and olfactory neurons in nompB mutants have missing or defec

173 logical recordings were made from 33 central olfactory neurons in the antennal lobes of both Helicove

174 y bulb, possibly via retrograde transport by olfactory neurons in the nasal epithelium, which may lim

175 e functional significance of this GEF in the olfactory neurons in vivo remains unknown.

176 y recapitulating neuronal differentiation of olfactory neurons in vivo.

177 is required for odor responsiveness in these olfactory neurons in vivo.

178 aracterized protein sorting and transport in olfactory neurons in vivo.

179 tially determine the chemical specificity of olfactory neurons in vivo.

180 The odor-induced signaling pathway in olfactory neurons includes a Gs-like protein (G(olf)) th

181 a receptor expressed in a large fraction of olfactory neurons including Or43b neurons, does not conf

182 al dendritic arborization pattern of central olfactory neurons, including an ability to colonize and

183 Stimulation of the olfactory neurones increased RGC activity.

184 ltage clamp recordings of odorant-stimulated olfactory neurons indicate that endogenous RGS2 negative

185 two different isoforms of Acj6 restricted to olfactory neurons indicates that additional trans factor

186 ound that expressing expanded CGG repeats in olfactory neurons interfered with this plasticity withou

187 pithelium without subsequent transport along olfactory neurons into the olfactory bulbs (OB).

188 e remarkable plasticity in integrating novel olfactory neurons into this circuitry.

189 Here, we show that the CO2-sensitive olfactory neuron is also a sensitive detector of human s

190 n" rule, in which the receptive field of the olfactory neuron is determined by the singular odorant r

191 The functional identity of an olfactory neuron is determined in large part by the odor

192 The AWC olfactory neuron is glutamatergic and also expresses the

193 second of two consecutive responses when the olfactory neuron is stimulated with two brief pulses.

194 However, expression of ppk25 in olfactory neurons is not required for male courtship und

195 Expression of both genes in olfactory neurons is primarily restricted to the same me

196 oked activity in secondary, but not primary, olfactory neurons is reduced.

197 Misexpression of IRs in different olfactory neurons is sufficient to confer ectopic odor r

198 d receptor activity across the population of olfactory neurons is then interpreted by the brain to id

199 signal transduction components in mammalian olfactory neurons is thought to be regulated by the O/E

200 Detection of volatile odorants by olfactory neurons is thought to result from direct activ

201 gamma-glomerulus, which receives input from olfactory neurons, is highly sensitive to temperature dr

202 orant receptor ODR-10, which acts in the AWA olfactory neurons; its similarity to other G-protein-reg

203 In addition, we demonstrate that olfactory neurons lacking Ric-8b (and consequently Galph

204 eristics respectively, and to repress an AWC olfactory neuron-like default fate.

205 n patterns of synaptic molecules through the olfactory neuron lineage.

206 VA activates a few dozen olfactory neurons located in T1 sensilla on the antenna

207 cVA is detected by a small set of olfactory neurons located in T1 trichoid sensilla on the

208 and anatomically independent collections of olfactory neurons located in the main olfactory epitheli

209 mechanisms that shape this ability as nasal olfactory neurons mature in mice.

210 ence of two additional O/E family members in olfactory neurons may provide redundancy and allow norma

211 wide range of derivatives, including CNS and olfactory neurons, non-neuronal cells, and olfactory ens

212 eceptor implicated in pain sensation; in AWC olfactory neurons, ODR-3 may interact with another signa

213 ry mechanisms lead to the expression in each olfactory neuron of one allele of only one of the 1000 o

214 olinergic reporter gene are all decreased in olfactory neurons of acj6 mutants.

215 While olfactory neurons of silk moths are well known for their

216 Complex synaptic connectivity between olfactory neurons of the AL ultimately determines the sp

217 ese are particularly enriched in third-order olfactory neurons of the lateral horn, where we provide

218 behavior of larvae with a single functional olfactory neuron on either the left or right side of the

219 this effect is governed by newly discovered olfactory neurons on the tip of the moth's proboscis.

220 es indicate that Dock and Pak do not control olfactory neuron (ON) differentiation, but specifically

221 detection of different odours into distinct olfactory neurons or into unique combinations of olfacto

222 conclude that oscillatory synchronization of olfactory neurons originates in the antennal lobe and th

223 terozygous animals share a common phenotype: olfactory neurons (ORN) fail to project to dorsal olfact

224 Whereas in olfactory neurons OSM-9 and OCR-2 function is dependent

225 expressed in an antisymmetric manner in the olfactory neuron pair AWC left (AWCL) and AWC right (AWC

226 diated asymmetric differentiation of the AWC olfactory neuron pair, and conferred significant ethanol

227 re we show that Thisbe, an FGF released from olfactory neurons, particularly from local interneurons,

228 hysiological function for H2be in modulating olfactory neuron population dynamics to adapt the OR rep

229 ctly expressed within various subsets of the olfactory neuron population.

230 Olfactory neurons project their axons to spatially invar

231 olfactory system of Drosophila: second order olfactory neurons (Projection Neurons) from the anterodo

232 In the absence of this signal, the olfactory neuron re-enters the selection process and swi

233 sms, we characterized the protein profile of olfactory neuron receptor membranes of the wild silk mot

234 matode Caenorhabditis elegans, gustatory and olfactory neurons regulate aging and longevity.

235 our unpublished observations), suggest that olfactory neurons require the presence of other similar

236 Ethanol-induced death of olfactory neurons requires both their neural activity an

237 daptation to odors sensed by the AWC pair of olfactory neurons requires the cGMP-dependent protein ki

238 AWC olfactory neurons respond to multiple odors with subseco

239 Olfactory neurons respond to odor stimuli with rapid and

240 Here, we show that the AWC olfactory neurons respond to temperature.

241 For example, are olfactory neurons retained during this transition with t

242 The mechanisms underlying an olfactory neuron's choice to project medially versus lat

243 Individual olfactory neurons send axonal projections to glomeruli i

244 ur findings show that, as they mature, mouse olfactory neurons sequentially express specific presynap

245 s, a subset of gustatory neurons, as well as olfactory neurons, shortens lifespan, whereas a differen

246 First- and second-order olfactory neurons show identical pheromone responses, su

247 Physiological analysis of individual olfactory neurons shows that in acj6 mutants, a subset o

248 n-coupled olfactory receptors within the AWC olfactory neuron signal through cGMP and a cGMP-gated ch

249 sduction occur at the dendritic membranes of olfactory neurons, signal propagation, axon sorting and

250 Here, we show that, in mouse olfactory neurons, silent olfactory receptor (OR) genes

251 Recently, an olfactory neuron-specific guanylyl cyclase was discovere

252 a binding site for a novel helix-loop-helix olfactory neuron-specific transcription factor (Olf-1).

253 lends, have different peripheral and central olfactory neuron specificities, as well as distinct arra

254 The C. elegans left and right AWC olfactory neurons specify asymmetric subtypes, one defau

255 rray are expressed individually in different olfactory neurons, suggesting that the discriminatory ca

256 physiological studies of glutamate-sensitive olfactory neurons, suggesting these binding sites are re

257 synaptic transmission in axon outgrowth and olfactory neuron survival.

258 t DEET actively repels insects by activating olfactory neurons that elicit avoidance behaviour.

259 We have found a subset of olfactory neurons that express the cGMP-stimulated phosp

260 is also found in duct/gland cells as well as olfactory neurons that innervate necklace glomeruli.

261 support the hypothesis that a cryptic set of olfactory neurons that respond to a small set of odorant

262 tory neuroepithelial injury included loss of olfactory neurons that showed reduced expression of the

263 responses are caused by the ability of other olfactory neurons (the AWA neurons) to be recruited at h

264 nsory neurons we examined, including the AWC olfactory neurons, the ASJ and ASK gustatory neurons, an

265 In the AWB and AWA olfactory neurons, the LIM homeobox gene lim-4 and the n

266 nstream receptor signaling and the wiring of olfactory neurons, the system remains poorly understood

267 In contrast to most other olfactory neurons, these neurons appear to project to a

268 h do not have a vomeronasal organ, and their olfactory neurons-three different morphological types-ar

269 cular-subventricular zone (V-SVZ), replenish olfactory neurons throughout life.

270 which probably contributes to the ability of olfactory neurons to discriminate odours.

271 nsy-5 is required for the left and right AWC olfactory neurons to establish stochastic, asymmetric pa

272 odorant receptor protein to the activity of olfactory neurons to higher processing centres and, ulti

273 t of a more general compensatory response by olfactory neurons to levels of odor in the environment.

274 exposure of mouse olfactory cilia or primary olfactory neurons to odorants stimulated phosphorylation

275 olfactory axons and function autonomously in olfactory neurons to regulate the precise wiring of the

276 Olfactory neurons transduce the binding of odorants into

277 During development, a subpopulation of olfactory neurons transiently expresses GABA.

278 derlying mechanisms that generate individual olfactory neuron types are only beginning to be understo

279 elaboration of ciliated endings of different olfactory neuron types in the nematode C. elegans.

280 specify other identity features of distinct olfactory neuron types.

281 transcribed at different levels in distinct olfactory neuron types.

282 he events that underlie the specification of olfactory neurons, we have examined the patterns of odor

283 s apoptotic death specifically of Drosophila olfactory neurons, which is accompanied by a loss of a b

284 those that produced large responses in mouse olfactory neurons, which is further evidence for a novel

285 In both mammals and insects, an olfactory neuron will usually select a single olfactory

286 pates in the regeneration and replacement of olfactory neurons within the adult rat olfactory neuroep

287 lls into the sensillum lymph that bathes the olfactory neurons within these sensilla.