ライフサイエンスコーパス: olfactory receptor

1 lelic neural genes (e.g., protocadherins and olfactory receptors).

2 byx mori enhanced the sensitivity of a mouse olfactory receptor.

3 lfactory sensory neurons expressing the same olfactory receptor.

4 ively transports its pheromone to a specific olfactory receptor.

5 ck by ablating or odorant targeting mosquito olfactory receptors.

6 epends on the selectivity and sensitivity of olfactory receptors.

7 presentation of odorants at the level of the olfactory receptors.

8 urons that did not receive direct input from olfactory receptors.

9 hange is in part driven by the expression of olfactory receptors.

10 elements of biological smell systems are the olfactory receptors.

11 man trace amine-associated receptor, and two olfactory receptors.

12 ionotropic receptor (IR) family of putative olfactory receptors.

13 , we also successful produced two additional olfactory receptors.

14 Two of these regions harbor genes for olfactory receptors.

15 mixtures are discriminated by relatively few olfactory receptors.

16 nsive rule in odorant detection by mammalian olfactory receptors.

17 somal genes were annotated, 22 of which were olfactory receptors.

18 ression and ligand-induced responses of some olfactory receptors.

19 e, we report cell-free production of a human olfactory receptor 17-4 (hOR17-4) using the wheat germ e

20 Mouse olfactory receptor 23 (MOR23, olfr16) and its human orth

21 ure up-regulated HBD-3 and LL-37 through the olfactory receptor 2AT4 and induced phosphorylation of e

22 Xiao originated from a 19p region encoding olfactory receptor 7E members after the human/ape diverg

23 This response requires olfactory receptor activity and the Notch ligand Delta.

24 It is also subject to regulatory inputs from olfactory receptor activity in other ORNs.

25 Frameshift (FS) indels are enriched in olfactory receptor activity while non-frameshift (NFS) i

26 cally overrepresented, while others such as 'olfactory receptor activity'-underrepresented.

27 isms with both developmentally hardwired and olfactory receptor activity-dependent components that es

28 valry involves both cortical and peripheral (olfactory receptor) adaptations.

29 methylase activity in activation of a single olfactory receptor allele and suppression of the rest of

30 produced by predators that activates a mouse olfactory receptor and produces an innate behavioral res

31 lfactory neuron will usually select a single olfactory receptor and repress remaining members of larg

32 s, but also constrains relationships between olfactory receptors and behavior.

33 sensory neurons that express highly related olfactory receptors and display similar central projecti

34 fluctuation, building on the linkage between olfactory receptors and HLA, we hypothesized that olfact

35 In contrast to mammalian and Drosophila olfactory receptors and mammalian taste receptors, which

36 bility to enhance heterologous expression of olfactory receptors and other difficult to express G pro

37 ny implausible genes (such as those encoding olfactory receptors and the muscle protein titin), sugge

38 To obtain soluble olfactory receptors and to increase yield, we directly a

39 in part due to poor functional expression of olfactory receptors and/or limited solubility of some od

40 recombination and segregation, gustatory and olfactory receptors, and proteins affecting synaptic fun

41 The olfactory receptors are employed as a biological element

42 Olfactory receptors are G protein-coupled receptors that

43 Our evidence suggests a model in which olfactory receptors are regulated epigenetically and the

44 e detected within genomic regions containing olfactory receptor, ATP-binding cassette, and major hist

45 e glial cells disappears after the period of olfactory receptor axon ingrowth, but may be important d

46 revious attempts at constructing a mammalian olfactory receptor-based artificial odorant sensing syst

47 ntial in the future development of practical olfactory receptor-based odorant sensors.

48 During the response of vertebrate olfactory receptor cells to stimulation, Ca(2+) enters t

49 These findings indicate that different olfactory receptor channels employ heterogeneous presyna

50 However, no ligands for fish olfactory receptor class A related genes (ORA) had been

51 lar structures where afferents from a single olfactory receptor class synapse with uniglomerular proj

52 aracterisation of the gene family coding the olfactory receptors contributed to the elaboration and d

53 ition was due to efficient blocking of Orco (olfactory receptor coreceptor) function.

54 The purified olfactory receptor displays a typical a alpha-helical CD

55 ignificant position is the Arginine from the Olfactory receptor "DRY" motif, which has more variants

56 We find that Olfr78, an olfactory receptor expressed in the kidney, responds to

57 thermophoresis measurements showed that one olfactory receptor expressed using peptide surfactants b

58 ns, in improving odor-mediated activation of olfactory receptors expressed in yeast.

59 can confer sensitive and robust responses of olfactory receptors expressed in yeast.

60 Moreover, Tet3 overexpression disrupts olfactory receptor expression and the targeting of axons

61 difference in PCDH20 expression may reflect olfactory receptor expression differences for gender-spe

62 urons (OSNs) at an immature state and alters olfactory receptor expression, but the mechanism remains

63 folded protein response in the regulation of olfactory receptor expression, unveiling molecular playe

64 Mammalian olfactory receptor families are segregated into differen

65 ctory system, with its hundreds of different olfactory receptors, far outperforms the other senses in

66 The identification of a sensitive zebrafish olfactory receptor for these diamines provides a molecul

67 lestone toward obtaining a large quantity of olfactory receptors for designing bionic sensors.

68 Overall HLOF genes are enriched for olfactory receptor function and are expressed in testes

69 he stabilization and establishment of single olfactory receptor gene choice.

70 Elements within the olfactory receptor gene cluster might play a regulatory

71 h and 94.7% DNA sequence identity located in olfactory receptor gene clusters, indicating nonallelic

72 s in mucosal sensitivities within and across olfactory receptor gene expression zones are fundamental

73 Olfactory receptor gene families are significantly expan

74 a tentative assignment of odor responses to olfactory receptor gene families.

75 The insect olfactory receptor gene family is absent from S. maritim

76 ated ora genes are a small, highly conserved olfactory receptor gene family of only six genes, whose

77 or allele and suppression of the rest of the olfactory receptor gene family, thereby locking in the e

78 Groups obtained include gene families (e.g. olfactory receptor gene family, zinc finger families), u

79 Here we show that the olfactory receptor gene Olfr78 is highly and selectively

80 An additional olfactory receptor gene, OR51B2, was identified by a nov

81 We found that orthologs for both classes of olfactory receptor genes (mORs and Oras) appear to be hi

82 he placenta also expressed most of the known olfactory receptor genes (Olfr), which may allow the pla

83 ted by heterozygosity hotspots, enriched for olfactory receptor genes and other genes with high level

84 We focused on the expression profiles of olfactory receptor genes and transcription factors-the t

85 obin gene expression whereas silent flanking olfactory receptor genes are unaffected.

86 -redundant fashion, and that individual main olfactory receptor genes can contribute substantially to

87 sh v2r genes are intermingled with all other olfactory receptor genes in a single sensory surface.

88 We also found extensive expansion of olfactory receptor genes in these turtles.

89 A novel region on chromosome 11 containing olfactory receptor genes OR51B5 and OR51B6 was identifie

90 Olfactory receptor genes, upstream effectors of the MAPK

91 positive selection acting on paralogous main olfactory receptor genes.

92 ompassing the beta-globin locus and flanking olfactory receptor genes.

93 34B7.4 gene, a novel antisense gene to three olfactory receptor genes.

94 is implicated in rodenticide resistance, and olfactory receptor genes.

95 alternative solution for amine detection by olfactory receptors highlights the tremendous structural

96 cient transport of food volatiles toward the olfactory receptors in the nasal cavity.

97 oked activity and reversible inactivation of olfactory receptors in the nasal epithelium significantl

98 te olfactory system, which requires that new olfactory receptors integrate into segregated and functi

99 approach to produce a high yield of purified olfactory receptor is a milestone toward obtaining a lar

100 r, which is due to the fact that each of the olfactory receptors is coded with different gene and usu

101 e nucleotide identities for orthologous main olfactory receptor (mOR) genes with nucleotide identitie

102 orant receptor gene defines a unique type of olfactory receptor neuron (ORN) and a corresponding type

103 n electron microscopy to reconstruct all the olfactory receptor neuron (ORN) axons that target a left

104 mbly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projectio

105 Odors typically activate multiple olfactory receptor neuron (ORN) classes and are therefor

106 hila olfactory circuit assembly, axons of 50 olfactory receptor neuron (ORN) classes and dendrites of

107 Drosophila uses 50 different olfactory receptor neuron (ORN) classes that are cluster

108 secreted semaphorin, Sema-2b, in Drosophila olfactory receptor neuron (ORN) development, we identifi

109 transcription factor combinations specifying olfactory receptor neuron (ORN) fates.

110 l that varied probabilistically depending on olfactory receptor neuron (ORN) input levels.

111 pulses, oscillations suddenly slowed as net olfactory receptor neuron (ORN) output decreased; thus,

112 zation scales with the total activity of the olfactory receptor neuron (ORN) population.

113 odor representations in vivo by imaging from olfactory receptor neuron (ORN) terminals during control

114 e report here the signaling threshold of the olfactory receptor neuron (ORN).

115 urons (PNs) postsynaptic to the same type of olfactory receptor neuron (ORN).

116 ach receiving input from a different type of olfactory receptor neuron (ORN).

117 to an inhibitory chemical synapse between an olfactory receptor neuron and an interneuron changed the

118 2 is unable to protect transected Drosophila olfactory receptor neuron axons in vivo, mutant Nmnat2s

119 pil that contain input and output processes: olfactory receptor neuron nerve terminals (input) and mi

120 Little is known about how an olfactory receptor neuron selects a receptor, or how the

121 l number are selected for expression by each olfactory receptor neuron.

122 We show that a bursting subset of primary olfactory receptor neurons (bORNs) in lobster has the un

123 lations of rhythmically active or 'bursting' olfactory receptor neurons (bORNs) to extract and encode

124 i using mice that express synaptopHluorin in olfactory receptor neurons (ORN).

125 as observed in the interstial spaces between olfactory receptor neurons (ORN).

126 ample is the olfactory system, as individual olfactory receptor neurons (ORNs) adopt unique sensory i

127 fly olfactory system, axons of 50 classes of olfactory receptor neurons (ORNs) and dendrites of 50 cl

128 In Drosophila, axons of first-order olfactory receptor neurons (ORNs) and dendrites of secon

129 synaptic-depression at the synapses between olfactory receptor neurons (ORNs) and neurons within the

130 on depends on the differential activation of olfactory receptor neurons (ORNs) and on the proper tran

131 SDns received glomerulus-specific input from olfactory receptor neurons (ORNs) and projection neurons

132 The synapse between olfactory receptor neurons (ORNs) and projection neurons

133 ion to a limited set of neurons that include olfactory receptor neurons (ORNs) and the mushroom body

134 Vertebrate olfactory receptor neurons (ORNs) are stimulated in a rh

135 re we show that compartmentalized Drosophila olfactory receptor neurons (ORNs) communicate with each

136 pulses and steps, but it remains unclear how olfactory receptor neurons (ORNs) detect the intensity a

137 Olfactory receptor neurons (ORNs) express the GABA(B) re

138 hat Psidin is required in several classes of olfactory receptor neurons (ORNs) for survival and subse

139 ophila, axons of approximately 50 classes of olfactory receptor neurons (ORNs) form one-to-one connec

140 phila antennal lobe, early-arriving axons of olfactory receptor neurons (ORNs) from the antenna are r

141 This study shows that olfactory receptor neurons (ORNs) function upstream of a

142 a, we show that Notch is activated in select olfactory receptor neurons (ORNs) in an odorant-specific

143 f olfactory epithelia (OE) and physiology of olfactory receptor neurons (ORNs) in cat models of MPS I

144 tegration of olfactory information begins in olfactory receptor neurons (ORNs) in Drosophila.

145 ypes of olfactory sensilla, which harbor the olfactory receptor neurons (ORNs) in the Drosophila ante

146 Olfactory receptor neurons (ORNs) in the nasal cavity de

147 hamsters and that induction of apoptosis in olfactory receptor neurons (ORNs) in the OSE resulted in

148 to bombykol and is expressed in specialized olfactory receptor neurons (ORNs) in the pheromone sensi

149 of the olfactory bulb, translate input from olfactory receptor neurons (ORNs) into projection-neuron

150 ensory identities of Drosophila melanogaster olfactory receptor neurons (ORNs) involved in sex-specif

151 Olfactory transduction in vertebrate olfactory receptor neurons (ORNs) involves primarily a c

152 uron (PN) receives two sources of input: the olfactory receptor neurons (ORNs) of the same glomerulus

153 ich are detected with extreme sensitivity by olfactory receptor neurons (ORNs) on the antennae of Cul

154 the three major types of sensilla that house olfactory receptor neurons (ORNs) on the Drosophila ante

155 Olfactory receptor neurons (ORNs) produce a constant syn

156 In Drosophila, most individual olfactory receptor neurons (ORNs) project bilaterally to

157 originates almost entirely from the primary olfactory receptor neurons (ORNs) rather than from spont

158 vertebrate nose and the insect antenna, most olfactory receptor neurons (ORNs) respond to multiple od

159 a supported, in part, by the assumption that olfactory receptor neurons (ORNs) respond to odorants wi

160 Little is known about how individual olfactory receptor neurons (ORNs) select, from among man

161 Individual olfactory receptor neurons (ORNs) selectively express on

162 In Drosophila, approximately 50 classes of olfactory receptor neurons (ORNs) send axons to 50 corre

163 In doing so, we identify three olfactory receptor neurons (ORNs) that are organized in

164 The V glomerulus receives projections from olfactory receptor neurons (ORNs) that coexpress two GPC

165 The basis for host odor responses resides in olfactory receptor neurons (ORNs) that express chemorece

166 The responses of olfactory receptor neurons (ORNs) to odors have complex

167 he FEZF1 product is known to enable axons of olfactory receptor neurons (ORNs) to penetrate the CNS b

168 information about odors is transferred from olfactory receptor neurons (ORNs) to projection neurons

169 and odorant receptors expressed in different olfactory receptor neurons (ORNs), but the origin of tem

170 In Drosophila olfactory receptor neurons (ORNs), DEET is detected thro

171 In squid olfactory receptor neurons (ORNs), physiological studies

172 inding to membrane receptors on the cilia of olfactory receptor neurons (ORNs), thereby activating a

173 eactive processes relative to each other, to olfactory receptor neurons (ORNs), to projection neurons

174 pond to odors depends on the function of its olfactory receptor neurons (ORNs), which in turn depends

175 iating inhibitory odorant input to mammalian olfactory receptor neurons (ORNs).

176 s from their presynaptic partners, the adult olfactory receptor neurons (ORNs).

177 g in patterning axon targeting of Drosophila olfactory receptor neurons (ORNs).

178 elated with changes in the firing pattern of olfactory receptor neurons (ORNs).

179 ng wiring and receptor characteristics of MP olfactory receptor neurons (ORNs).

180 almost exclusively, expressed in vertebrate olfactory receptor neurons (ORNs).

181 tion neurons (PNs) than in their presynaptic olfactory receptor neurons (ORNs).

182 blem: on the basis of noisy information from olfactory receptor neurons (the neurons that transduce c

183 The functional synaptic connectivity between olfactory receptor neurons and principal cells within th

184 nervous system occurs at the synapse between olfactory receptor neurons and second-order neurons in o

185 st two layers of this system: the peripheral olfactory receptor neurons and their postsynaptic target

186 a we have confirmed the connectivity between olfactory receptor neurons and their postsynaptic target

187 d to the kinetics of odor tracking in insect olfactory receptor neurons and to the latency of initial

188 ion times and pulse tracking capabilities of olfactory receptor neurons are faster than previously re

189 erties of presynaptic glutamate release from olfactory receptor neurons are similar between mitral an

190 amily ligand GDF11, regulates the genesis of olfactory receptor neurons by inhibiting proliferation o

191 Thus, insect olfactory receptor neurons can track stimuli of very sho

192 ly, LN innervation required interaction with olfactory receptor neurons during development, and some

193 In the mouse, each class of olfactory receptor neurons expressing a given odorant re

194 ansgenic lines of Anopheles gambiae in which olfactory receptor neurons expressing the odorant recept

195 Olfactory receptor neurons extend axons into the olfacto

196 In this insect, two olfactory receptor neurons housed in antennal sensilla p

197 cortex explaining incoming activity from the olfactory receptor neurons in terms of a mixture of odor

198 Although olfactory receptor neurons in the nose face similar stim

199 histochemistry revealed segregation of CR-ir olfactory receptor neurons in the olfactory mucosa and t

200 In the olfactory bulb, afferent olfactory receptor neurons respond to increasing concent

201 When olfactory receptor neurons respond to odours, a depolari

202 em has a three-layer architecture: The fly's olfactory receptor neurons send odor information to the

203 rganized into glomerular compartments, where olfactory receptor neurons synapse onto projection neuro

204 Primary olfactory receptor neurons terminate in anatomically and

205 times more pore plates and three times more olfactory receptor neurons than females.

206 rin repulsion regulates interactions between olfactory receptor neurons to help axons find their corr

207 The response of olfactory receptor neurons to odor mixtures is not well

208 early, severe loss of neural precursors and olfactory receptor neurons, and the subsequent collapse

209 etronasal odorants can effectively reach the olfactory receptor neurons, eliciting glomerular respons

210 rent odors excite overlapping populations of olfactory receptor neurons, so the central challenge of

211 In isolated olfactory receptor neurons, the Na(+)-K(+)-2Cl(-) cotran

212 Since cAMP mediates signal transduction in olfactory receptor neurons, this could contribute to the

213 We follow the progress from olfactory receptor neurons, through the first processing

214 Odours generate activity in olfactory receptor neurons, whose axons contact the dend

215 ce expressing the Ca(2+) indicator GCaMP3 in olfactory receptor neurons.

216 ular rind, overlapping with the terminals of olfactory receptor neurons.

217 y of citronellal-evoked action potentials in olfactory receptor neurons.

218 ll-autonomously for the production of mature olfactory receptor neurons.

219 ct with axons of their presynaptic partners, olfactory receptor neurons.

220 sitive transporters in Cl(-) accumulation in olfactory receptor neurons.

221 ells receive direct, monosynaptic input from olfactory receptor neurons.

222 ir through the nasal cavity to stimulate the olfactory receptor neurons.

223 ansiently expressed in newly differentiating olfactory-receptor neurons (ORNs) and has a key role in

224 A human taste receptor, hT2R4, and an olfactory receptor of Caenorhabditis elegans (C. elegans

225 Olfactory receptor (Olfr) genes comprise the largest gen

226 region in most mammals contains a cluster of olfactory receptor (OLFR) genes, but this gene cluster h

227 A short-chain fatty acid olfactory receptor Olfr78, recently implicated in CB fun

228 The activation of G-protein-coupled olfactory receptors on the olfactory sensory neurons (OS

229 ithelium (OE) each express a single dominant olfactory receptor (OR) allele from among roughly 1,000

230 anscriptional activation of one out of ?2800 olfactory receptor (OR) alleles is a poorly understood p

231 sect chemoreceptor superfamily comprises the olfactory receptor (Or) and gustatory receptor (Gr) mult

232 The molecular mechanisms regulating olfactory receptor (OR) expression in the mammalian nose

233 Olfactory receptor (OR) expression requires the transcri

234 expresses only one out of up to thousands of olfactory receptor (OR) gene alleles; at the organism le

235 containing about half of the members of the olfactory receptor (OR) gene family.

236 d of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000.

237 cular, our results showed contraction of the Olfactory Receptor (OR) gene repertoire in the last comm

238 because of the hierarchical structure of the olfactory receptor (OR) gene superfamily: expansion or c

239 We show that 98.9% of intact olfactory receptor (OR) genes are expressed in mature OS

240 how that, in the mouse olfactory epithelium, olfactory receptor (OR) genes are marked in a highly dyn

241 Olfactory receptor (OR) genes are of vital importance fo

242 The olfactory receptor (OR) genes are the largest mammalian

243 how that, in mouse olfactory neurons, silent olfactory receptor (OR) genes from different chromosomes

244 Furthermore, the organization, detection and olfactory receptor (Or) genes of MP-OSNs are conserved i

245 ese include genes subject to X-inactivation, olfactory receptor (OR) genes, and several classes of im

246 The ancestral locus, a cluster of olfactory receptor (OR) genes, lies internally on macaqu

247 In contrast to the broadly required olfactory receptor (OR) OR83b, which is essential for tr

248 Studies on olfactory receptor (OR) pharmacology have been hindered

249 The results indicated that olfactory receptor (OR), taste receptor type 2, and vome

250 ccording to the identity of the co-expressed olfactory receptor (OR).

251 vate ACIII, presumably through the canonical olfactory receptor (OR).

252 y stage of odorant recognition by the rat I7 olfactory receptor (OR-I7) is investigated.

253 d gene-sets related with sensory perception (olfactory receptors, OR) and phenylpyruvate tautomerase/

254 ixed, a response mainly due to the conserved olfactory receptor, Or42b.

255 ocarbons was suppressed by a mutation in the olfactory receptor Or47b.

256 propriate ORNs the expression of fru and two olfactory receptors (Or47b and Ir84a) involved in sex-sp

257 While the larval OSN expresses the olfactory receptor Or49a and is tuned to the Leptopilina

258 In this study we detected the olfactory receptor OR51E2 at the transcript and the prot

259 s detected through a mechanism employing the olfactory receptor, OR83b.

260 give rise to three major neuronal classes - olfactory receptor (ORNs), vomeronasal (VRNs) and gonado

261 ic expression of only one out of >1000 mouse olfactory receptor (ORs) genes requires the formation of

262 Olfactory receptors (ORs) are G protein-coupled receptor

263 Olfactory receptors (ORs) are G protein-coupled receptor

264 factory system, including those encoding the olfactory receptors (ORs) CpomOR1, CpomOR3 and CpomOR6a,

265 at the large-scale production of functional olfactory receptors (ORs) have not been successful to da

266 utilizes three large receptor families: the olfactory receptors (ORs) of the main nose and the vomer

267 ochemicals across the sensillum lymph to the olfactory receptors (ORs) within the antennal sensilla.

268 hat major components of olfaction, including olfactory receptors (ORs), olfactory-related adenylate c

269 f chemoreceptors in human keratinocytes, the olfactory receptors (ORs).

270 mmals sense odors through the gene family of olfactory receptors (ORs).

271 iated by the binding of odorant molecules to olfactory receptors (ORs).

272 heterologously overexpress and purify insect olfactory receptors (ORs).

273 ined how the degree of component similarity, olfactory receptor overlap, relative concentration of co

274 hereby locking in the expression of a single olfactory receptor per sensory neuron.

275 actory sensory neurons expressing particular olfactory receptors project to specific reproducible loc

276 neurons and the antisymmetric expression of olfactory receptor proteins in the AWC neurons.

277 ing affinity are ejected before reaching the olfactory receptor, rendering them susceptible to degrad

278 the TAARs are evolutionarily retained in the olfactory receptor repertoire to mediate high-sensitivit

279 otential to enable systems level analysis of olfactory receptor repertoires in organisms.

280 TAAR5 is an evolutionarily conserved olfactory receptor required for a species-specific behav

281 to an objective procedure to obtain specific olfactory receptor responses by manipulating mixtures in

282 ct with the PAMs membrane protein OR5M11, an olfactory receptor, resulting in the high-level secretio

283 neering analyses, the study reveals that the olfactory receptor selection system is optimally designe

284 ENT We have uncovered a mechanism underlying olfactory receptor sensitivity regulation in Drosophila

285 Our findings thus suggest that activation of olfactory receptor signaling by external compounds can i

286 in family, known to contain the chemosensory olfactory receptor subfamily.

287 ng color photoreceptor subtypes in flies and olfactory receptor subtypes in worms and mice.

288 unique subset of approximately 400 different olfactory receptor subtypes.

289 Furthermore, olfactory receptors that detect cadaverine and putrescin

290 second mode relies on the signaling from the olfactory receptors through CamK and histone acetyl tran

291 They use olfactory receptors to process chemical signals in their

292 rations of cadaverine expresses a particular olfactory receptor, trace amine-associated receptor 13c

293 a mouse chemosignal, trimethylamine, and its olfactory receptor, trace amine-associated receptor 5 (T

294 ith other GPCRs and the mechanisms governing olfactory receptor trafficking.

295 that each MOR23 neuron has higher levels of olfactory receptor transcripts and also expresses more C

296 wasps of all sizes to have a large number of olfactory receptor types, to maintain olfactory precisio

297 The function of expressed olfactory receptors was further validated using MDL12330

298 Olfactory receptors, which belong to the family of G-pro

299 genes (centered on p53, topoisomerase 1, and olfactory receptors) whose down-regulation caused the ce

300 at IR8a is a subunit that forms a functional olfactory receptor with IR64a in vivo to mediate odor de