ライフサイエンスコーパス: oligoadenylate

1 -stranded RNA polymerize ATP to 2'-5'-linked oligoadenylates.

2 that is activated by binding of 2',5'-linked oligoadenylates.

3 2'-5' oligoadenylate (2-5 (A)) synthetases are major component

4 idues 321 to 344 of the 9-2 isozyme of 2'-5'-oligoadenylate (2-5(A)) synthetase causes a loss of its

5 2'-5'-Oligoadenylate (2-5(A)) synthetases are a family of inte

6 In this study, analysis of 2',5'-Oligoadenylate (2-5A) binding and activation of the 80-

7 l endoribonuclease, RNase L, by 2',5'-linked oligoadenylate (2-5A) produces small RNA cleavage produc

8 udokinase that is activated by unusual 2,'5'-oligoadenylate (2-5A) second messengers and which impede

9 The 2',5'-oligoadenylate (2-5A) synthetase (OAS)-RNase L system is

10 e isoforms of the interferon-inducible 2',5'-oligoadenylate (2-5A) synthetase that require double-str

11 of the NLRP3 inflammasome involves the 2',5'-oligoadenylate (2-5A) synthetase(OAS)/RNase L system, a

12 Upregulation of key components of the 2',5'-oligoadenylate (2-5A) synthetase/RNase L pathway has bee

13 The IFN-inducible 2',5'-oligoadenylate (2-5A) synthetases (OASs) and ribonucleas

14 Multiple 2'-5' oligoadenylate (2-5A) synthetases are important componen

15 The human 2', 5'-oligoadenylate (2-5A) synthetases are members of a famil

16 uired for transcriptional induction of 2'-5'-oligoadenylate (2-5A) synthetases by interferon (IFN)-al

17 The 2',5'-oligoadenylate (2-5A) system is an RNA degradation pathw

18 ique oligonucleotide second messenger, 2',5'-oligoadenylate (2-5A), that binds and activates RNase-L.

19 RNase L is the 2',5'-oligoadenylate (2-5A)-dependent endoribonuclease that fu

20 to apoptosis by the RNase L activator, 2',5'-oligoadenylate (2-5A).

21 ainst human telomerase RNA linked to a 2',5'-oligoadenylate (2-5A).

22 requires 5'-triphosphorylated, 2',5'-linked oligoadenylates (2-5A) for its activity.

23 etases that produce 5'-phosphorylated, 2',5'-oligoadenylates (2-5A) from ATP.

24 hat produces 5'-phosphorylated, 2',5'-linked oligoadenylates (2-5A) in response to double-stranded RN

25 Activation of RNase L by 2',5'-linked oligoadenylates (2-5A) is one of the antiviral pathways

26 e L is activated by 5'-phosphorylated, 2'-5' oligoadenylates (2-5A) produced from IFN-inducible and d

27 NA, OAS is activated to produce 2'-5'-linked oligoadenylates (2-5A) that activate RNase L, which then

28 rferons, requires activation by 2',5'-linked oligoadenylates (2-5A) to cleave viral and cellular sing

29 sing double-stranded RNA, OAS produces 2',5'-oligoadenylates (2-5A), which activate RNase L.

30 A to produce 5'-phosphorylated, 2'-5'-linked oligoadenylates (2-5A), whose function is to activate RN

31 g to unusual 5'-phosphorylated, 2',5'-linked oligoadenylates (2-5A).

32 ic effectors 5'-phosphorylated, 2',5'-linked oligoadenylates (2-5A).

33 RNA, the OAS enzymes synthesize 2'-5' linked oligoadenylates (2-5As) that initiate an RNA decay pathw

34 structure-function relationship of the 2'-5' oligoadenylate [2-5 (A)] synthetases has been hampered b

35 tion by unique, 2'-5' phosphodiester-linked, oligoadenylates [2-5A, (pp)p5' A2'(P5'A2')]n, n >=2.

36 ermline mutations in the gene encoding 2'-5'-oligoadenylate(2-5A)-dependent RNase L (RNASEL) segregat

37 4-Aminopyridine derivatives yielded oligoadenylates as long as dodecamers with a regioselect

38 enine derivatives on montmorillonite yielded oligoadenylates as long as undecamer, and the 2-methylad

39 of the enzymatic conversion of ATP to 2',5'-oligoadenylates by 2-5A synthetase.

40 These studies demonstrate that 2',5' oligoadenylate covalently linked to antisense (2-5A-anti

41 Treatment of human cells with 2',5' oligoadenylate covalently linked to antisense (2-5A-anti

42 Ribonuclease L (RNase L), the 2',5'-oligoadenylate-dependent ribonuclease, is one of the cel

43 RNase L, the 2',5' oligoadenylate-dependent ribonuclease, is one of the enz

44 2',5'-Oligoadenylate-dependent RNase L functions in the interf

45 The2',5'-oligoadenylate-dependent RNase L gene functions in the i

46 Radiolabeled azido 2'-5'-oligoadenylate dimers were enzymatically synthesized and

47 '-monophosphate moiety, shortening the 2',5'-oligoadenylate domain, and substitution of 3',5'-linked

48 The zwitterionic oligoadenylate formed only 2Py:1Pu triplexes with comple

49 These findings suggest that the oligoadenylated fragment is a decay intermediate in a de

50 nded RNA and catalyze the synthesis of 2'-5' oligoadenylates from ATP.

51 h revealed that the fragments were, at most, oligoadenylated in nondeflagellated cells but had a long

52 Thus, 2-5A (5'-phosphorylated 2'-5'-linked oligoadenylate)-linked antisense against human telomeras

53 e IFN-gamma response can be blocked by 2',5'-oligoadenylate-linked antisense chimeras against PKR mRN

54 tor molecules consisting of the 2',5'-linked oligoadenylates, p1-3A(2'p5'A)>/=2 (2-5A).

55 duct that functions as an inhibitor of 2',5'-oligoadenylate phosphodiesterase (2'-PDE), a key regulat

56 eptomyces sp. SANK 61196 that inhibits 2',5'-oligoadenylate phosphodiesterase (2'-PDE), a key regulat

57 ol II specific but, unexpectedly, bound many oligoadenylated Pol III transcripts, predominately pre-t

58 its Cas10 subunit converts ATP into a cyclic oligoadenylate product, which allosterically activates C

59 the non-processive synthesis of 2'-5'-linked oligoadenylate products containing up to 30 residues.

60 Mapping oligoadenylated reads suggests that the endonuclease act

61 y, direct activation of RNase L with a 2',5'-oligoadenylate resulted in p62(SQSTM1) degradation, LC3B

62 en activated in the presence of 2',5'-linked oligoadenylates, RNase L can catalyze the cleavage of sy

63 ndrome-associated coronavirus antagonize the oligoadenylate-RNase L (OAS-RNase L) pathway.

64 The 2',5'-oligoadenylate/RNase L system is a virus-activated host

65 that bears striking conceptual similarity to oligoadenylate signalling in mammalian innate immunity.

66 ) and IFNgamma-responsive genes p56- and p69-oligoadenylate synthase (OAS).

67 ng Stat-1 tyrosine phosphorylation and 2',5'-oligoadenylate synthase and myxovirus resistance gene ex

68 iferation, apoptosis, and inflammation (2'5'-oligoadenylate synthase, cyclooxygenase-2, and an Ikappa

69 onstrate that HSV-1 infection inhibits 2'-5' oligoadenylate synthesis in interferon-stimulated primar

70 RNA-activated protein kinase (PKR) and 2',5'-oligoadenylate synthetase (2',5'-OAS) were down-regulate

71 ere we report that one of these targets, 2,5 oligoadenylate synthetase (2,5 OAS), is a mediator of BR

72 NA for IRF-1, p40, and p69 isoforms of 2'-5' oligoadenylate synthetase (2-5 AS) are detectable, respe

73 Interferon (IFN)-induced 2'-5' oligoadenylate synthetase (2-5A synthetase)/RNase L, PKR

74 of nitric oxide synthase 2 (NOS2) and 2', 5' oligoadenylate synthetase (OAS) 1 induction in response

75 etics, pharmacodynamic measurements of 2',5'-oligoadenylate synthetase (OAS) activity, and induction

76 IL-29 and IFN-alpha induced equivalent 2'5' oligoadenylate synthetase (OAS) and MX1 gene expression

77 The interferon-induced enzymes 2'-5'-oligoadenylate synthetase (OAS) and RNase L are key comp

78 (ISGs) such as myxovirus resistance 1 (Mx1), oligoadenylate synthetase (OAS) and viperin in unstimula

79 e eIF2alpha protein kinase PKR and the 2'-5' oligoadenylate synthetase (OAS) are both activated by do

80 2',5'-Oligoadenylate synthetase (OAS) enzymes and RNase-L cons

81 The oligoadenylate synthetase (OAS) enzymes are cytoplasmic

82 Twelve 2'-5' oligoadenylate synthetase (Oas) genes were identified in

83 +/-63.3) pg/ml increase (P < 0.01); and 2'5'-oligoadenylate synthetase (OAS) had a 163 (+/-120.6) pmo

84 The 2'-5' oligoadenylate synthetase (OAS) locus encodes for three

85 enza virus resistance allele Mx(+) and 2'-5' oligoadenylate synthetase (OAS) proteins was not regulat

86 s, including inhibitor of apoptosis-1, 2'-5' oligoadenylate synthetase (OAS), a 2'-5' OAS-like (OASL)

87 in the gene encoding the 1b isoform of 2'-5'-oligoadenylate synthetase (OAS), a member of the OAS/RNa

88 pG and correlated with serum levels of 2'-5' oligoadenylate synthetase (OAS), a validated interferon

89 ral interferon-stimulated gene product 2'-5' oligoadenylate synthetase (OAS), and the chemokines CXCL

90 udes conventional poly(A) polymerases, 2'-5' oligoadenylate synthetase (OAS), and yeast Trf4p .

91 une modulators-alpha interferon (IFN-alpha), oligoadenylate synthetase (OAS), CXCL9, and CXCL10-was p

92 SGs) with antiviral properties such as 2'-5' oligoadenylate synthetase (OAS), stimulated trans-acting

93 ponsive defenses controlled by PKR and 2'-5' oligoadenylate synthetase (OAS), which respectively inac

94 wild-type (WT) virus uses to block the 2',5'-oligoadenylate synthetase (OAS)-RNase L (RNase L) antivi

95 The oligoadenylate synthetase (OAS)-RNase L pathway is a pot

96 The oligoadenylate synthetase (OAS)-RNase L pathway is a pot

97 which blocks the interferon inducible 2',5'-oligoadenylate synthetase (OAS)-RNase L pathway to facil

98 nhibits activation of the interferon-induced oligoadenylate synthetase (OAS)-RNase L pathway.

99 immunologic surrogates, neopterin and 2'-5' oligoadenylate synthetase (OAS).

100 protein kinase R (PKR) and stimulating 2'5'-oligoadenylate synthetase (OAS).

101 mediated by protein kinase R (PKR) and 2'-5' oligoadenylate synthetase (OAS).

102 The importance of the 2'-5' oligoadenylate synthetase (OAS)/RNase L and double-stran

103 We hypothesized that the 2'-5' oligoadenylate synthetase (OAS)/RNase L system, an innat

104 was associated with increased expression of oligoadenylate synthetase (OAS)1a mRNA in the eye.

105 Myxovirus resistance protein 2 (Mx2), 2',5'-oligoadenylate synthetase (OAS-1), Virus inhibitory prot

106 tion of the IFN-induced antiviral gene 2',5'-oligoadenylate synthetase (OAS1a) but not dsRNA-dependen

107 all animals with increased intrahepatic 2'5' oligoadenylate synthetase 1 (2OAS-1) messenger RNA (mRNA

108 human sensor of double-stranded RNA (dsRNA) oligoadenylate synthetase 1 (hOAS1) polymerizes ATP into

109 Upon interferon activation by dsRNA, 2',5'-oligoadenylate synthetase 1 (OAS1A) is induced; it binds

110 stimulated gene expression (tracked by 2'-5'-oligoadenylate synthetase 1 and myxovirus (influenza vir

111 e of concerted evolution of paralogous 2'-5' oligoadenylate synthetase 1 genes was obtained in rodent

112 pregulation of endogenous IFN-beta and 2',5'-oligoadenylate synthetase 1 mRNA expression was also obs

113 creased expression of interferon-beta, 2',5'-oligoadenylate synthetase 1, interferon-alpha, and inter

114 nd no significant difference in IFNB1, 2'-5'-oligoadenylate synthetase 1, or myxovirus (influenza vir

115 ation, as evidenced by upregulation of 2',5'-oligoadenylate synthetase 1.

116 n and an IFN-inducible antiviral gene, 2',5'-oligoadenylate synthetase 1a (OAS), were determined by r

117 locus was previously identified as the 2'-5' oligoadenylate synthetase 1b (Oas1b) gene.

118 oted on the microarrays, such as STAT1, 2'5'-oligoadenylate synthetase 2, and ISG15, also supports an

119 tently increases expression of the antiviral oligoadenylate synthetase 2, but does not affect express

120 uding those coding for MHC I proteins, 2'-5' oligoadenylate synthetase [2'-5'(A)N], and IFN regulator

121 eta or interferon-stimulated gene (ISG; MX1, oligoadenylate synthetase [OAS], IFIT-1) response in the

122 activity was associated with reduced 2',5'-A oligoadenylate synthetase activity, a pathway well corre

123 sponsive genes OAS and ISG54 (encoding 2'-5' oligoadenylate synthetase and an IFN-stimulated gene pro

124 ll as the effector genes, for example, 2'-5'-oligoadenylate synthetase and myxovirus proteins, are hi

125 enzyme, a key component of the 2',5'-linked oligoadenylate synthetase antiviral pathway involved in

126 ass I, IFN regulatory factor-1, MxA and 2',5-oligoadenylate synthetase gene expression, transcription

127 We have addressed the evolution of the 2'-5' oligoadenylate synthetase gene family, in the light of b

128 e interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family.

129 One 2'-5'-oligoadenylate synthetase gene, Oas1b, was identified as

130 The RNase L activity associated with 2',5'-oligoadenylate synthetase is not activated or is blocked

131 he demonstration that the gene encoding 2'-5'oligoadenylate synthetase is responsible for murine susc

132 2'-5' oligoadenylate synthetase is stimulated by dsRNA to prod

133 ene 15 (ISG15), Interleukin 16 (IL16), 2',5'-Oligoadenylate Synthetase Like (OASL), and Adhesion G Pr

134 ld and myxovirus resistance gene 1 and 2',5' oligoadenylate synthetase mRNA expression (107- and 96-f

135 This crystal structure of a 2'-5'-oligoadenylate synthetase reveals a structural conservat

136 light of both this new member and new 2'-5' oligoadenylate synthetase sequence data from other speci

137 beta was supported by induction of the 2'-5' oligoadenylate synthetase, an indicator of IFN activity,

138 oteins interferon regulatory factor 1, 2',5'-oligoadenylate synthetase, and double-stranded-RNA-depen

139 RNA-dependent protein kinase R (PKR), 2',5'-oligoadenylate synthetase, and Mx1 mRNAs in swine cells.

140 luding myxovirus resistance protein A, 2',5'-oligoadenylate synthetase, and the IFN-stimulated gene 5

141 RNA for dsRNA-activated protein kinase, 2'5'-oligoadenylate synthetase, and Toll-like receptor 3, tra

142 as that of another IFN-inducible gene, 2'-5' oligoadenylate synthetase, but in contrast to 2'-5' olig

143 nes for IFN-regulatory factors 1 and 7, 2'5' oligoadenylate synthetase, Mx, and TNF superfamily prote

144 n 10, and preferential upregulation of 2',5'-oligoadenylate synthetase, Mx1, and indoleamine 2,3-diox

145 interferon-stimulated genes such as the 2'5'-oligoadenylate synthetase, MX1, IRF-7, and toll-like rec

146 enylate synthetase, but in contrast to 2'-5' oligoadenylate synthetase, TP/PD-ECGF mRNA levels remain

147 orylates eukaryotic initiation factor 2, nor oligoadenylate synthetase, which activates RNase L, was

148 Human 2'-5' oligoadenylate synthetase-1 (OAS1) is central in innate

149 Among them, the gene encoding 2'-5' oligoadenylate synthetase-like (OASL) underwent the grea

150 nflammatory (S100A8/A9/A12, CXCL1, and 2'-5'-oligoadenylate synthetase-like [OASL]) and barrier (MKi6

151 2'-5'-Oligoadenylate synthetase-like protein (OASL) is an inte

152 This protein, which we named p59 2'-5' oligoadenylate synthetase-like protein (p59OASL), shares

153 murine cDNA encoding an ovary-specific 2',5'-oligoadenylate synthetase-like protein, OAS1D, which dis

154 Several 2'-5' oligoadenylate synthetase-like proteins, which lack the

155 N-gamma against HSV-1; 2) antiviral pathways oligoadenylate synthetase-RNase L and protein kinase R a

156 ntagonist of the interferon-induced cellular oligoadenylate synthetase-RNase L pathway.

157 (PKR) and the endoribonuclease of the 2',5'-oligoadenylate synthetase-RNase L system (PKR(-/-) x RL(

158 component of the interferon-regulated 2',5'-oligoadenylate synthetase-RNase L system, demonstrated t

159 genes myxovirus resistance gene 1 and 2',5' oligoadenylate synthetase.

160 conserved among all known isozymes of 2'-5'-oligoadenylate synthetase.

161 e amino terminus of the 9-2 isozyme of 2'-5'-oligoadenylate synthetase.

162 Among these are the protein kinase R and oligoadenylate synthetase/RNase L pathways, both of whic

163 f the PKR/eIF2alpha phosphorylation and 2-5A oligoadenylate synthetase/RNase L pathways.

164 of IFN-stimulated antiviral proteins, 2'-5' oligoadenylate synthetase/RNase L, and dsRNA-dependent p

165 Specifically, we demonstrate that 2',5'-oligoadenylate synthetases (2-5AS), RNase L, and dsRNA-d

166 2'-5' Oligoadenylate synthetases (OAS) are a family of enzymes

167 0), CXC chemokines (IL-8, CXCL-10, CXCL-11), oligoadenylate synthetases (OAS) genes, and selectively

168 The 2'-5' oligoadenylate synthetases (OAS) represent a family of i

169 5A is produced by interferon-inducible 2',5'-oligoadenylate synthetases (OAS) upon activation by vira

170 ependent protein kinase (PKR), but not 2',5'-oligoadenylate synthetases (OAS), in vaginal tissue.

171 Among these sensors are dsRNA-activated oligoadenylate synthetases (OAS), which produce signalin

172 lude IFN-induced protein transcripts 1 to 3, oligoadenylate synthetases 1 and 3, and the T cell marke

173 The 2'-5'-oligoadenylate synthetases are activated by viral double

174 2'-5'-Oligoadenylate synthetases are interferon-induced enzyme

175 2'-5'-oligoadenylate synthetases are interferon-induced, doubl

176 The 2'-5' oligoadenylate synthetases form a well conserved family

177 Unlike other RNA polymerases, 2'-5' oligoadenylate synthetases, a family of interferon-induc

178 erminal domain with the known forms of 2'-5' oligoadenylate synthetases, but differs completely in it

179 We show that the human IFN-inducible oligoadenylate synthetases-like (OASL) protein has antiv

180 D receptor (VDR)(rs2228570AG, rs1544410CT), oligoadenylate synthetases-like (OASL)(rs1169279CT) and

181 s encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases.

182 ding sites of the P69 isozyme of human 2'-5'-oligoadenylate synthetases.

183 zyme of the medium size class of human 2'-5' oligoadenylate synthetases.

184 oplasmic dsRNA recognition and activation of oligoadenylate synthetases.

185 n been reported through the study of a model oligoadenylate system in the mirror image world.

186 ting that PARN stabilizes Y RNAs by removing oligoadenylated tails added by PAPD5, which would otherw

187 nzymes that polymerize ATP into 2'-5' linked oligoadenylates that activate RNase L and cause mRNA deg

188 Ns2 cleaves 2',5'-oligoadenylate, the product of OAS, to prevent activatio

189 osphodiesterase domain that can cleave 2'-5' oligoadenylates, thereby preventing RNase L activation.

190 te a cellular response by synthesizing 2'-5'-oligoadenylates, which in turn activate RNase L.

191 of the complexes formed by the zwitterionic oligoadenylate with poly(U) were 6-41 degrees C higher t