ライフサイエンスコーパス: oligoclonal

1 lpha and beta V regions in the cell line was oligoclonal.

2 ool, CMV-specific CTL remained monoclonal or oligoclonal.

3 accination and in unvaccinated controls were oligoclonal.

4 ociated TCRbeta were observed to be commonly oligoclonal.

5 l integration indicated that the disease was oligoclonal.

6 hat the vascular IgA response in acute KD is oligoclonal.

7 repertoire of Ara h 2-specific antibodies is oligoclonal.

8 ys suggested that the CBD-derived lines were oligoclonal.

9 -Hib PRP was restricted in heterogeneity and oligoclonal.

10 eactive response may be narrowly focused, or oligoclonal.

11 The potency of oligoclonal Ab was primarily due to a large increase in

12 tralized toxin, a combination of three mAbs (oligoclonal Ab) neutralized 450,000 50% lethal doses of

13 Both in humans and mice, OS is mediated by oligoclonal activated T and B cells.

14 nt revealed that protein vaccination induced oligoclonal activation of MAGE-A3-specific CD4+ T cells.

15 B cell response in MCB and showed that it is oligoclonal and directed against an intracellular protei

16 These expanded plasmablasts are oligoclonal and exhibit extensive somatic hypermutation,

17 e favored when the antiviral CTL response is oligoclonal and focused on a small number of immunodomin

18 Whether this oligoclonal and polyclonal IgG is directed against a dis

19 arly CD4(+) T cell response in these mice is oligoclonal and reflects the expansion of Vbeta4/ Valpha

20 age and, by 14 to 17 yr, the repertoire was oligoclonal and resembled the repertoire of individuals

21 a h 2-specific B-cell receptor repertoire is oligoclonal and somatically hypermutated and shares simi

22 f both pathogen-derived Ags and self-Ags are oligoclonal and typically private.

23 delta repertoire in adult human intestine is oligoclonal and unique in each individual.

24 and allergen specific, whereas IgE in AR is 'oligoclonal' and allergen specific.

25 -Abl, the virus-induced tumors are clonal or oligoclonal, and changes in the growth and oncogenic pot

26 olysaccharide Ab responses in mice are often oligoclonal, and the mechanisms involved in Ag-specific

27 These results indicate that oligoclonal aneuploidy and supernumerary centrosomes are

28 al potentials); and intrathecal synthesis of oligoclonal antibody (examination by lumbar puncture of

29 rate inflamed tissues in acute KD, producing oligoclonal, antigen-driven antibodies.

30 ntraepithelial T lymphocytes (IELs) that are oligoclonal, appear functionally to be cytolytic T cells

31 a revealed highly dynamic shaping of complex oligoclonal architectures, specifically upon treatment w

32 ccelerated by APRIL; both mouse strains were oligoclonal at 4 months.

33 rtual absence of B cells and the presence of oligoclonal autoreactive T cells.

34 s of rearranged VDJ genes revealed clonal or oligoclonal B cell expansions in all cases.

35 ases, ascites associated with monoclonal and oligoclonal B cell neoplasms.

36 These data suggest an in situ Ag-driven oligoclonal B cell response to a variety of tumor- and b

37 memory to polysaccharide Ags, we studied an oligoclonal B cell response to alpha-1,3 dextran (DEX) e

38 type mice and quasimonoclonal (QM) mice with oligoclonal B cells and TCR Vbeta diversity 7% that of w

39 ild-type values of 1.1 x 10(8); in mice with oligoclonal B cells, the TCR V beta diversity of thymocy

40 Isolated islets contained oligoclonal B lymphocytes enriched for the germinal cent

41 tigen targeted by the dominant clones in the oligoclonal B lymphoplasmacytic response in both patient

42 HCDR3 spectrotype analysis demonstrated oligoclonal B-cell activation and expansion after sepsis

43 These abnormal markers may be produced by oligoclonal B-cell populations or PTLD tumor cells and c

44 The oligoclonal B-cell response in MS cerebrospinal fluid is

45 ms, and suggest that further analysis of the oligoclonal B-cell response may be productive in the sea

46 progenitor cell expansion that evolved into oligoclonal B-lineage ALL in 3% of the transgenic zebraf

47 p to 2-fold differences in the odds of being oligoclonal band positive and 7.75% of the variation in

48 f rs9807334, near the ELAC1/SMAD4 genes, for oligoclonal band status (P = 8.45 x 10(-7)).

49 previously suggested association signals for oligoclonal band status in the major histocompatibility

50 haplotype (P = 1.59 x 10(-22)), shared with oligoclonal band status, and an additional independent e

51 However, the underlying differences between oligoclonal band-positive and -negative patients with mu

52 tries for two traits, presence or absence of oligoclonal bands (n = 3026) and immunoglobulin G index

53 Fifty-five patients (10%) had APB, 48 had oligoclonal bands (OB), and 23 had an apparent isotype s

54 By contrast, the findings of intrathecal oligoclonal bands (OCB) and beneficial effects of steroi

55 bsence of both immunoglobulin (Ig) G and IgM oligoclonal bands (OCB) was blindly examined in paired c

56 ence of cerebrospinal fluid immunoglobulin G oligoclonal bands (OCB; HR = 3.69, 95% CI = 2.32-5.86, p

57 Oligoclonal bands (OCBs) unique to the cerebrospinal flu

58 For example, the intrathecally synthesized oligoclonal bands (OGBs) in diseases such as subacute sc

59 ation in space, the presence of CSF-specific oligoclonal bands allows a diagnosis of multiple scleros

60 ral nervous system, expressed as presence of oligoclonal bands and/or an increased immunoglobulin G i

61 Studies have shown that these oligoclonal bands are antibodies directed against the ag

62 Increased IgG and oligoclonal bands are found in cerebrospinal fluid of hu

63 More importantly, the major CSF oligoclonal bands from MS patients did not react to C. p

64 amounts of intrathecally synthesized IgG and oligoclonal bands have long been recognized as a hallmar

65 The presence of oligoclonal bands in cerebrospinal fluid (CSF) in multip

66 presence of lipid-specific immunoglobulin M oligoclonal bands in cerebrospinal fluid (CSF; IgM bands

67 in lesions on MR images, and had two or more oligoclonal bands in cerebrospinal fluid.

68 oural change, raised CSF protein and matched oligoclonal bands in CSF and serum was associated with n

69 For example, the intrathecally synthesized oligoclonal bands in diseases such as subacute sclerosin

70 Of 12 patients who had oligoclonal bands in the cerebrospinal fluid at baseline

71 ectric focusing, we detected SPAG16-specific oligoclonal bands in the cerebrospinal fluid of 5 of 23

72 mal effect on circulating autoantibodies and oligoclonal bands in the cerebrospinal fluid.

73 There are reports of oligoclonal bands in the CSF of stroke patients, suggest

74 ultiple sclerosis); and cerebrospinal fluid (oligoclonal bands lacking).

75 more likely to have intrathecal synthesis of oligoclonal bands on presentation (64 versus 29%, not si

76 us and inflammatory diseases of known cause, oligoclonal bands represent antibody directed against th

77 CSF oligoclonal bands were found in only one, but bands matc

78 ronal antibodies were present in 43% and CSF oligoclonal bands were present in 46% of patients with p

79 with CIS (>/= 2 brain MRI lesions and >/= 2 oligoclonal bands) enrolled in the Observational Study o

80 nt risk factors for MS (spinal cord lesions, oligoclonal bands, and dissemination in time on MRI) and

81 particular sequences that correspond to the oligoclonal bands, and substantial somatic mutation of m

82 at presentation, sex ratio, the presence of oligoclonal bands, clinical symptoms or initial severity

83 cytosis with eosinophils and/or neutrophils, oligoclonal bands, glial fibrillary acidic protein in th

84 have high concentrations of IgG, manifest as oligoclonal bands, in the brain and CSF.

85 who only had temporal lobe epilepsy without oligoclonal bands, may represent restriction to the firs

86 forts to identify an antigenic target of CSF oligoclonal bands, the presence of idiotope (Id)-bearing

87 athecal synthesis of IgG and the presence of oligoclonal bands.

88 obulin G (IgG) synthesis and the presence of oligoclonal bands.

89 oncentration, and three of five examined had oligoclonal bands.

90 al fluid and brain contain increased IgG and oligoclonal bands.

91 normal, <5.9 mg/dL); however, there were no oligoclonal bands.

92 s, and the later features with appearance of oligoclonal bands.

93 MS are clinically silent MRI lesions and CSF oligoclonal bands; weak or uncertain risk factors includ

94 g the skin biopsies of patients with SSc are oligoclonal, beta-chain TCR transcripts from T cells inf

95 ells in vivo, it has been hard to prove that oligoclonal BV expansions are actually HIV specific.

96 Restricted (oligoclonal) BV family usage was not observed, as all of

97 er BMT was concomitant with the detection of oligoclonal CD3(+)CD8(+)CD45RO(+) cells.

98 g of T-cell receptor genes revealed distinct oligoclonal CD4(+) and CD8(+) T-cell repertoires in the

99 her, the results also suggest that the major oligoclonal CD4(+) T cell expansions present in RA joint

100 ized by noncaseating epithelioid granulomas, oligoclonal CD4(+) T cell infiltrates, and immune comple

101 Oligoclonal CD4+ T cells belong to the rare CD4+CD28- T-

102 involving T lymphocytes that are composed of oligoclonal CD4+ T cells.

103 petic skin lesions consistently demonstrated oligoclonal CDR3 DNA length distribution, indicating the

104 nt are in-frame until late gestation; 3) the oligoclonal CDR3 spectratype of 30-day fetal liver becom

105 unoglobulin heavy and light chains from each oligoclonal CLL-cell population.

106 We constructed genealogic trees of these oligoclonal CLL-cell subgroups and assessed the effects

107 the T-cell repertoire with the emergence of oligoclonal/clonal lymphoid populations have been found

108 In most patients, multiple monoclonal and oligoclonal complementarity-determining region 3 (CDR3)

109 cytotoxic T-lymphocyte activity, and had an oligoclonal component.

110 he antigen-specific serum immune response is oligoclonal, comprising antibodies encoding 34 different

111 Remarkably, the tumors were frequently oligoclonal, consistent with accelerated genetic changes

112 icity to MPO, 2) the anti-MPO Ab response is oligoclonal, consistent with Ag selection, and 3) MPO is

113 ecificity, we examined the TCR repertoire of oligoclonal CTL expansions found in human blood and tiss

114 l lesions and in atherosclerotic plaques are oligoclonal, derived from few expanding cells.

115 These results suggest a model of 2-step oligoclonal development of male germ cells in mice, the

116 erent samples consistent with multiclonal or oligoclonal disease in a significant proportion of MF pa

117 Interestingly, monoclonal or oligoclonal dominance was seen in the reactive Vbeta+ ce

118 The VDJ sequences of Vbeta6 chains were oligoclonal during the early stages of the infection, su

119 restriction of V genes is not chiefly due to oligoclonal expansion but reflects recurrent usage of st

120 ptor revision, codon insertion/deletion, and oligoclonal expansion had occurred within the B and plas

121 se T cell receptor Vbeta repertoires with an oligoclonal expansion in CDR3 of T cell receptor Vbeta14

122 autoreactive T-cells that likely arise from oligoclonal expansion in response to autoantigen exposur

123 In contrast to oligoclonal expansion observed in systemic autoimmune di

124 n antigen or infectious agent leading to the oligoclonal expansion of B and T cells is unknown.

125 We found evidence of oligoclonal expansion of single V beta 2-bearing TCRs in

126 d by CD8(+) and CD4(+) T cells and exhibited oligoclonal expansion of specific T cell subsets.

127 TCRbeta deep sequencing revealed oligoclonal expansion of specific TCRbeta clonotypes in

128 irus-specific CTL activity may be due to the oligoclonal expansion of TCR V beta subfamilies in IEL.

129 Intratumoral oligoclonal expansion of TIL-B was demonstrated by a pre

130 We observed a consistent oligoclonal expansion of Vbeta4(+) T cells during the pe

131 polyclonal TCR pattern, without evidence of oligoclonal expansion, or a preferred usage of certain V

132 genes but not for CD4(+) T cell activation, oligoclonal expansion, or accumulation in the liver.

133 d in some microdissected regions, suggesting oligoclonal expansion.

134 te in CNS lesions of MS patients and display oligoclonal expansion.

135 ewed TCR repertoires, which is indicative of oligoclonal expansion; these skewed repertoires and the

136 bly, these CD5(+) B cell populations include oligoclonal expansions already found in young healthy ad

137 ment-specific mAbs, we also established that oligoclonal expansions are predominantly found in the CD

138 Oligoclonal expansions in the CD8+ T cell subset were de

139 Biliary atresia is associated with oligoclonal expansions of CD4(+) and CD8(+) T cells with

140 Similarly, the most extreme oligoclonal expansions of CD4+CD57+ T cells occurred in

141 In utero CMV infection induced oligoclonal expansions of fetal CD4(+) and CD8(+) T lymp

142 We report massive oligoclonal expansions of intraepithelial CTLs that exhi

143 In addition, oligoclonal expansions of lung T cells have been observe

144 patients with rheumatoid arthritis (RA) have oligoclonal expansions of peripheral blood CD8+ T cells

145 nsplantation, and all patients had transient oligoclonal expansions of T cells expressing specific Vb

146 that chronic cigarette smoke exposure causes oligoclonal expansions of T cells isolated from the lung

147 is injury and determine whether the numerous oligoclonal expansions of this disease represent extreme

148 Moreover, they encompassed oligoclonal expansions paralleling an expansion of effec

149 ne smoking cessation for 6 mo, revealed that oligoclonal expansions persisted.

150 TCR Vbeta repertoire analyses revealed oligoclonal expansions predominantly occurred in lung CD

151 ical spastic paraparesis (HAM/TSP), mono- or oligoclonal expansions were detected in the CD4+ T cell

152 riable (TCRBV) sequencing confirmed that the oligoclonal expansions were largely related to HSV-speci

153 Identification of common TCR features in oligoclonal expansions within individual patients and be

154 four of five CBD patients studied, different oligoclonal expansions within the Vbeta3 subset were fou

155 acultative help for autoantibody production, oligoclonal expansions, and proliferations driven by an

156 o 66 (M158-66), which simultaneously lead to oligoclonal expansions, including the usage of a single

157 ased with LCMV epitope-specific T cells with oligoclonal expansions.

158 Finally, an oligoclonal family of Sec clones revealed a striking tre

159 at p53 knockout thymic lymphomas arose in an oligoclonal fashion, with tumors evolving dominant clone

160 toires are diverse and others restricted or "oligoclonal" has been unknown.

161 Furthermore, exome sequencing revealed that oligoclonal hematopoiesis emerged in Casp9-deficient bon

162 of AML cases demonstrated residual aberrant oligoclonal hematopoiesis.

163 ponses to immunodominant viral antigens were oligoclonal, highly skewed, and exhibited diverse clonot

164 Oligoclonal Ig bands (OCBs) of the cerebrospinal fluid a

165 than any other B-lineage neoplasm, exhibits oligoclonal Ig heavy chain (IgH) gene rearrangement in 1

166 uction by the malignant plasma cell clone or oligoclonal Ig production during recovery of B-cell func

167 These findings, and the fact that the oligoclonal IgA and IgM repertoires in a noninductive si

168 Previously, we showed that oligoclonal IgA plasma cells infiltrate coronary arterie

169 Molecular analysis of the oligoclonal IgA response in acute KD led to production o

170 The identification of an oligoclonal IgA response in KD strongly suggests that th

171 ions (>3 vertebral segments), and absence of oligoclonal IgG bands .

172 Oligoclonal IgG bands are rarely found in patients with

173 date infectious antigens, we showed that the oligoclonal IgG in cerebrospinal fluid of a patient with

174 ervous system infections have shown that the oligoclonal IgG is antibody directed against the agent t

175 hecal IgG synthesis, persistence of bands of oligoclonal IgG, and memory B-cell clonal expansion are

176 se in identifying and purifying the relevant oligoclonal IgGs in inflammatory central nervous system

177 We have previously reported that oligoclonal immunoglobulin A plasma cells infiltrate acu

178 mphocytes (7-32), elevated protein, multiple oligoclonal immunoglobulin bands, and CRMP-5-IgG.

179 ting the rheumatoid arthritis (RA) joint are oligoclonal, implicating an Ag-driven process, but the p

180 ining usage did not appear to be random, but oligoclonal in nature, with some preference shown for T

181 that although the response in each donor was oligoclonal in terms of variable gene usage, the combina

182 In contrast, oligoclonal innate lymphocyte populations are efficientl

183 opulation, leaving an expanded population of oligoclonal, intermediate affinity (and residual high af

184 persistence and expansion of a population of oligoclonal, intermediate affinity T cells is involved i

185 present for several years in AIE-associated, oligoclonal, intestinal T-cell infiltrate.

186 nses to serovar Typhi in Ty21a vaccinees are oligoclonal, involving multiple TCR Vbeta families.

187 ntigens important in the pathogenesis of KD, oligoclonal KD antibodies were prepared in vitro and tes

188 to the frequent description of such cases as oligoclonal leukemias.

189 Adoptive transfers of the oligoclonal lines into either C3H x Rag-/- or severe com

190 Monoclonal line PD-F4 and oligoclonal lines ND-R4 and TD-B4 were CD3(+)CD4(+)CD8(-

191 Nine CTL clones and two oligoclonal lines obtained from three unrelated individu

192 nor histocompatibility antigens, we detected oligoclonal liver Vbeta2(+) T cells in 40% of GVHD mice

193 CD4(+)CD28(null) T cells are oligoclonal lymphocytes rarely found in healthy individu

194 naive T cells, their partial replacement by oligoclonal memory populations, and the consequent const

195 (-)CD57(+)), highly proliferative (Ki67(+)), oligoclonal, memory-like CD4 and CD8 T cells (CCR7(-)CD4

196 vealed that all of the independently derived oligoclonal mouse tumors had a deletion in the Pten gene

197 FLT3-ITDs induced an oligoclonal myeloproliferative disorder in mice, charact

198 The findings also demonstrate the oligoclonal nature of retrovirus-induced lymphomas by de

199 Oligoclonal, NF-containing bursas lacked detectable c-my

200 Vbeta subsets from CD8-positive cells showed oligoclonal or monoclonal CDR3 size patterns.

201 on of a specific V beta gene, whereas 10 had oligoclonal or polyclonal expansion of several V beta fa

202 his selection occurred in the presence of an oligoclonal or polyclonal T cell response using soluble

203 lantation (BMT), patients' PBMC displayed an oligoclonal or skewed T cell repertoire, low TCR excisio

204 ease, including the coronary artery, and are oligoclonal, or antigen-driven.

205 a subsets, then cloned and sequenced skewed, oligoclonal, or monoclonal peaks.

206 nd fragment 1, which established at least an oligoclonal origin of LA IgG.

207 tive aggregates demonstrated a polyclonal or oligoclonal pattern of immunoglobulin (Ig) gene rearrang

208 Nonrandom oligoclonal patterns were found for VB6, VB14-16, VB21,

209 associated with a large number of clonal and oligoclonal patterns.

210 extra-thymic T-cell differentiation or from oligoclonal peripheral expansion.

211 8(-)) are approximately 90% reduced, whereas oligoclonal plasma cell precursors are 3-fold expanded,

212 T cells in 60% of the day 14 GVHD mice were oligoclonal, pointing to a response to minor histocompat

213 ifically identifying a peripherally expanded oligoclonal population of activated regulatory T lymphoc

214 n in embryonic bursal precursors leads to an oligoclonal population of developing bursal follicles, s

215 ls when they were introduced as a monoclonal/oligoclonal population versus being part of a polyclonal

216 undiversified by hypermutation while later, oligoclonal populations are dominated by mutated rearran

217 the T cell repertoire with the emergence of oligoclonal populations have been described in patients

218 Oligoclonal populations occupied 71%-95% of each expande

219 Clonal or oligoclonal populations of CD8+ T cells were found to do

220 Four infants had rash, lymphadenopathy, and oligoclonal populations of T cells in the periphery.

221 The presence of oligoclonal populations of T cells in the rejected graft

222 These expansions were composed of oligoclonal populations of T cells that had already been

223 nically resolved psoriatic lesions contained oligoclonal populations of T cells that produced IL-17A

224 Each Vbeta subset expansion was composed of oligoclonal populations of T cells.

225 ons from 8 of 10 patients with AAA contained oligoclonal populations of T cells.

226 -mutant pre-B cells resulted in long-latency oligoclonal pre-B-ALL, which demonstrates that loss of I

227 Oligoclonal predominance among tumor-infiltrating B cell

228 gesting the GCs were formed by a polyclonal (oligoclonal) process.

229 toires, consisting of absent, monoclonal, or oligoclonal profiles for the majority of Vbeta subfamili

230 in the chronic phase of infection by driving oligoclonal proliferation of infected T cells.

231 Full Treg reconstitution prevented the rapid oligoclonal proliferation that gives rise to pathogenic

232 /- 0.5 expansions/recipient) attributable to oligoclonal proliferations.

233 splenic lymphocytes from a single mouse with oligoclonal PtC-reactive cells, outgrowth of cells expre

234 ntibodies mimicked the disease pattern, with oligoclonal reactivity to a few antigens that varied bet

235 Further insight into this oligoclonal regulatory T-cell population will be fundame

236 ologous viral challenge resulted in a narrow oligoclonal repertoire with dominant clones with unpredi

237 towards specific genetic variants displayed oligoclonal repertoires, unique to each individual.

238 ell percentages were greatest in valves with oligoclonal repertoires.

239 Adventitial oligoclonal resident B cells of atherosclerotic patients

240 The patient's sera showed an oligoclonal response to Ro that increased in complexity

241 ce, limited bands on IEF gels, supporting an oligoclonal response, and use of genes from V(H)III and

242 CR Vbeta gene usage, consistent with a local oligoclonal response.

243 sponsive gamma9delta2 T cells, expressing an oligoclonal set of T cell receptor (TCR) sequences which

244 urthermore, regulatory T cells showed marked oligoclonal skewing, suggesting that their peripheral ex

245 e unable to clear RV, possibly because their oligoclonal specificities may be ineffective against RV

246 identified 2 patients with multiple related (oligoclonal) subgroups of CLL cells.

247 ressed on CD4(+)CD28(null) T cells, a highly oligoclonal subset of T cells that is expanded in patien

248 fatal cases of KD to determine whether it is oligoclonal, suggesting an Ag-driven process, or polyclo

249 Escape mutations were oligoclonal, suggesting fitness constraints.

250 ice, STI571-treated murine CML was generally oligoclonal, suggesting that STI571 eliminated or severe

251 id motifs, which strongly suggests Ag-driven oligoclonal T cell expansion.

252 ce showed a biased TCR repertoire indicating oligoclonal T cell expansion.

253 ileaflet aortic valves revealed considerable oligoclonal T cell expansion.

254 on, indicating the presence of monoclonal or oligoclonal T cell expansion.

255 n autoimmune muscle disease characterized by oligoclonal T cell infiltrates mediating myocytotoxicity

256 r, some of these variants were recognized by oligoclonal T cell lines from MSP2 vaccinates, indicatin

257 ls and with the expansion and persistence of oligoclonal T cell populations.

258 vealed surface expression of CD3 and CD8 and oligoclonal T cell populations.

259 Tregs to DCs and thereby inhibit spontaneous oligoclonal T cell proliferation.

260 l populations further revealed highly skewed oligoclonal T cell receptor repertoires comprising exclu

261 T cells that express mainly monospecific or oligoclonal T cell receptors (TCRs).

262 ed preferential activation of T cells and an oligoclonal T cell response with skewed expansion of cer

263 the Vbeta4 family in BALB.B mice, suggesting oligoclonal T cell responses to a limited number of miHA

264 hese expanded CD4(+) T cells are composed of oligoclonal T cell subsets, suggesting their recruitment

265 To determine whether oligoclonal T cells are present in coronary arteries of

266 atients, strongly suggesting the presence of oligoclonal T cells in these infiltrates.

267 The finding of oligoclonal T cells infiltrating the skin of patients wi

268 t rejection in the atypical subjects who had oligoclonal T cells that could cause rejection.

269 nated Bacillus Calmette-Guerin infection and oligoclonal T cells with no naive markers.

270 ns or who develop rash, lymphadenopathy, and oligoclonal T cells.

271 me polyclonal in patients who presented with oligoclonal T cells.

272 erved, clearly demonstrating the presence of oligoclonal T cells.

273 proliferation, elevated IgE, and hyperactive oligoclonal T cells.

274 r-like phenotype associated with progressive oligoclonal T-cell expansion (Vbeta/HPRT ratio) and grad

275 in the CD8/Treg ratio and further encourages oligoclonal T-cell expansion.

276 penia within 2 to 3 weeks, accompanied by BM oligoclonal T-cell infiltration and severe marrow hypopl

277 gs of subjects with severe emphysema contain oligoclonal T-cell populations, suggesting their accumul

278 ed spectratypes, representative of clonal or oligoclonal T-cell populations, was 7.6 in MDS patients

279 R3 size distribution deviation indicative of oligoclonal T-cell proliferation was increased (44% +/-

280 Oligoclonal T-cell receptor (TCR) Vbeta families and mis

281 ck in T-cell differentiation resulting in an oligoclonal T-cell receptor repertoire and enhanced cyto

282 The residual T lymphocytes had an oligoclonal T-cell repertoire and exhibited a profound T

283 gins to populate the thymus, as evidenced by oligoclonal T-cell-receptor gene rearrangements.

284 nt versus N nucleotide addition in a classic oligoclonal, T-independent Ab response (alpha 1-->3 dext

285 er(+) cells isolated from naive mice show an oligoclonal TCR repertoire with predominant usage of the

286 In contrast, NOD-derived monoclonal/oligoclonal TCR transgenic beta cell-autoreactive T cell

287 onal expansion occurred at the tumor site as oligoclonal TCRs were distinct from PBL TCRs from the sa

288 HIV-1 infections usually arise from mono- or oligoclonal transmission.

289 we demonstrate that CTC clusters arise from oligoclonal tumor cell groupings and not from intravascu

290 en (PyMT) gene (RCAS-PyMT) induced multiple, oligoclonal tumors within 3 weeks in infected mammary gl

291 R spectratyping of T suppressor cells showed oligoclonal usage of TCR-Vbeta families, indicating that

292 Further analysis of the oligoclonal Vbeta products showed dominant peaks in the

293 usage varied among volunteers, we identified oligoclonal Vbeta subset expansions in individual volunt

294 osal tissues of uninfected rhesus monkeys is oligoclonal, whereas the CD8(+) T cell repertoire in blo

295 d a TCR Vbeta repertoire that was strikingly oligoclonal, whereas the Vbeta repertoire of CD18(dim) T

296 ls that the DEJ CD8alphaalpha(+) T cells are oligoclonal with diverse usage of TCR variable-beta gene

297 response to the tolerogenic determinant was oligoclonal, with evident preferential usage of V alpha.

298 he human Ab response to certain pathogens is oligoclonal, with preferred IgV genes being used more fr

299 quencing has confirmed that most cancers are oligoclonal, with subpopulations of neoplastic cells har

300 23F pneumococcal capsular polysaccharide is oligoclonal within the individual, with one or two parat